PubRank

J Reinstein

Author PubWeight™ 48.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones. Proc Natl Acad Sci U S A 1999 3.30
2 The role of ATP in the functional cycle of the DnaK chaperone system. J Mol Biol 1995 3.00
3 The bottleneck in AZT activation. Nat Med 1997 2.61
4 Nucleotide-induced conformational changes in the ATPase and substrate binding domains of the DnaK chaperone provide evidence for interdomain communication. J Biol Chem 1995 2.53
5 Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding. Structure 1996 2.53
6 The second step of ATP binding to DnaK induces peptide release. J Mol Biol 1996 1.96
7 Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nat Struct Biol 1997 1.77
8 Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nat Struct Biol 2001 1.61
9 GrpE accelerates nucleotide exchange of the molecular chaperone DnaK with an associative displacement mechanism. Biochemistry 1997 1.48
10 Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity. Biochemistry 1996 1.23
11 Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative. Biochemistry 1997 1.22
12 Assessment of the ATP binding properties of Hsp90. J Biol Chem 1996 1.21
13 C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle. J Mol Biol 2000 1.18
14 Interaction of fluorescently labeled dideoxynucleotides with HIV-1 reverse transcriptase. Biochemistry 1991 1.16
15 Microsecond folding of the cold shock protein measured by a pressure-jump technique. Biochemistry 1999 1.12
16 Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation. Biochemistry 1998 1.10
17 Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate. Structure 2000 1.10
18 The chaperone function of ClpB from Thermus thermophilus depends on allosteric interactions of its two ATP-binding sites. J Mol Biol 2001 1.09
19 Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proc Natl Acad Sci U S A 1998 1.09
20 Evaluation of human immunodeficiency virus type 1 reverse transcriptase primer tRNA binding by fluorescence spectroscopy: specificity and comparison to primer/template binding. Biochemistry 1996 1.08
21 ATP-binding properties of human Hsp90. J Biol Chem 1997 1.06
22 Functional properties of the molecular chaperone DnaK from Thermus thermophilus. J Mol Biol 1998 1.06
23 Modifying human thymidylate kinase to potentiate azidothymidine activation. J Biol Chem 1999 1.03
24 Folding properties of the nucleotide exchange factor GrpE from Thermus thermophilus: GrpE is a thermosensor that mediates heat shock response. J Mol Biol 2001 0.95
25 pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog. Nat Struct Biol 1999 0.95
26 Adenylate kinases from thermosensitive Escherichia coli strains. J Mol Biol 1989 0.90
27 The functional cycle and regulation of the Thermus thermophilus DnaK chaperone system. J Mol Biol 1999 0.89
28 Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. J Mol Biol 2000 0.84
29 Structural and functional consequences of amino acid substitutions in the second conserved loop of Escherichia coli adenylate kinase. J Biol Chem 1991 0.83
30 Complexes of Escherichia coli adenylate kinase and nucleotides: 1H NMR studies of the nucleotide sites in solution. Biochemistry 1990 0.83
31 Crystallization and preliminary X-ray analysis of UMP/CMP-kinase from Dictyostelium discoideum with the specific bisubstrate inhibitor P1-(adenosine 5')-P5-(uridine 5')-pentaphosphate (UP5A). FEBS Lett 1995 0.82
32 The DnaK/ClpB chaperone system from Thermus thermophilus. Cell Mol Life Sci 2002 0.81
33 Regulation of ATPase and chaperone cycle of DnaK from Thermus thermophilus by the nucleotide exchange factor GrpE. J Mol Biol 2001 0.81
34 Design of the optimal topical system for fluocinonide. Acta Derm Venereol Suppl (Stockh) 1971 0.80
35 Proton-nuclear magnetic resonance studies of the aromatic spin systems of Escherichia coli adenylate kinase. J Mol Biol 1988 0.79
36 Nucleotide binding to the heat-shock protein DnaK as studied by ESR spectroscopy. Eur J Biochem 1996 0.78
37 The novel fluorescent CDP-analogue (Pbeta)MABA-CDP is a specific probe for the NMP binding site of UMP/CMP kinase. Protein Sci 1999 0.76
38 2'Halo-ATP and -GTP analogues: rational phasing tools for protein crystallography. Protein Sci 1999 0.75
39 Novel nucleotide analogues as potential substrates for TMPK, a key enzyme in the metabolism of AZT. Nucleosides Nucleotides Nucleic Acids 2003 0.75