Published in J Clin Invest on September 01, 1997
Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia | NCT00001716
The oxyhemoglobin reaction of nitric oxide. Proc Natl Acad Sci U S A (1999) 1.99
Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability. Blood (2014) 1.45
Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial. JAMA (2011) 1.38
Extrapulmonary effects of inhaled nitric oxide: role of reversible S-nitrosylation of erythrocytic hemoglobin. Proc Am Thorac Soc (2006) 1.15
Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. J Clin Invest (1999) 1.15
Sickle cell disease and aortic valve replacement: use of cardiopulmonary bypass, partial exchange transfusion, platelet sequestration, and continuous hemofiltration. Tex Heart Inst J (1999) 1.02
Physiological reactions of nitric oxide and hemoglobin: a radical rethink. Proc Natl Acad Sci U S A (1999) 0.87
Protein glutathionylation in cardiovascular diseases. Int J Mol Sci (2013) 0.83
Nitric oxide reduces sickle hemoglobin polymerization: potential role of nitric oxide-induced charge alteration in depolymerization. Arch Biochem Biophys (2011) 0.82
The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin. Free Radic Biol Med (2008) 0.82
The role of beta93 Cys in the inhibition of Hb S fiber formation. Biophys Chem (2007) 0.81
Pharmacological management of sickle cell disease. P T (2008) 0.79
The pulmonary physician in critical care * Illustrative case 6: Acute chest syndrome of sickle cell anaemia. Thorax (2003) 0.77
Inhaled nitric oxide applications in paediatric practice. Images Paediatr Cardiol (2002) 0.76
Reaping of nitric oxide by sickle cell disease. Proc Natl Acad Sci U S A (2002) 0.75
Hemoglobin oxygen affinity in patients with cystic fibrosis. PLoS One (2014) 0.75
NO therapy? J Clin Invest (1997) 0.75
Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis. PLoS One (2016) 0.75
Can we just say NO to sickle cell anemia? J Clin Invest (1999) 0.75
Inhaled nitric oxide delivery and monitoring. J Clin Monit Comput (1999) 0.75
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med (1995) 13.59
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature (1996) 6.63
Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med (1993) 6.22
Sickle cell hemoglobin polymerization. Adv Protein Chem (1990) 4.48
Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med (1997) 3.13
Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation (1991) 2.62
Hemoglobin S gelation and sickle cell disease. Blood (1987) 2.41
Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest (1996) 2.31
Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet (1991) 2.30
Reaction of nitric oxide with heme proteins and model compounds of hemoglobin. Biochemistry (1987) 1.76
Requirement for therapeutic inhibition of sickle haemoglobin gelation. Nature (1978) 1.58
Cooperativity in the dissociation of nitric oxide from hemoglobin. J Biol Chem (1976) 1.55
Nitric oxide and the lung. Am J Respir Crit Care Med (1994) 1.18
Sickle cell disease of transgenic SAD mice. Blood (1994) 1.12
The effects of cyanate in vitro on red blood cell metabolism and function in sickle cell anemia. J Clin Invest (1972) 1.07
Oxygen affinity as an index of hemoglobin S polymerization: a new micromethod. Anal Biochem (1978) 1.06
Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization. J Biol Chem (1986) 1.04
Performance characteristics of Hemox-Analyzer for assessment of the hemoglobin dissociation curve. Haematologica (1996) 1.00
The effect of methemoglobin formation in sickle cell disease. J Clin Invest (1961) 0.99
Covalent binding of glutathione to hemoglobin. II. Functional consequences and structural changes reflected in NMR spectra. J Biol Chem (1986) 0.97
The effect of carbon monoxide on red cell life span in sickle cell disease. Blood (1975) 0.97
Gelation of sickle hemoglobin. III. Nitrosyl hemoglobin. J Mol Biol (1975) 0.94
Deoxygenated sickle hemoglobin. Modulation of its solubility by 2,3-diphosphoglycerate and other allosteric polyanions. J Biol Chem (1985) 0.91
Intracellular polymerization. Disease severity and therapeutic predictions. Ann N Y Acad Sci (1989) 0.90
Nitric oxide can modify amino acid residues in proteins. Biochem Biophys Res Commun (1992) 0.89
Antisickling effects of 2,3-diphosphoglycerate depletion. Blood (1995) 0.85
Gelation of sickle cell haemoglobin. II. Methaemoglobin. J Mol Biol (1974) 0.84
Effect of nitric oxide on the oxygen transport of human erythrocytes. J Toxicol Environ Health (1977) 0.84
Hb Okazaki [beta 93(F8) Cys----Arg], a new hemoglobin variant with increased oxygen affinity and instability. FEBS Lett (1984) 0.82
Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (1995) 9.86
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (2000) 7.46
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood (2001) 6.35
Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med (1993) 6.22
Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment. Proc Natl Acad Sci U S A (1982) 5.74
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell (1999) 4.69
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc Natl Acad Sci U S A (1983) 4.68
Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA (1979) 3.69
Receptor-mediated endocytosis of transferrin in K562 cells. J Biol Chem (1983) 3.65
Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet (1992) 3.30
Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med (1997) 3.13
Clotrimazole inhibits cell proliferation in vitro and in vivo. Nat Med (1995) 2.76
Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation (1991) 2.62
Repetitive high-pressure recruitment maneuvers required to maximally recruit lung in a sheep model of acute respiratory distress syndrome. Crit Care Med (2001) 2.49
Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage. Hepatology (2000) 2.44
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem (1992) 2.25
Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis. Genes Dev (1987) 2.24
Current definitions of acute lung injury and the acute respiratory distress syndrome do not reflect their true severity and outcome. Intensive Care Med (1999) 2.22
E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell (2000) 2.21
Effects of targeted neuronal nitric oxide synthase gene disruption and nitroG-L-arginine methylester on the threshold for isoflurane anesthesia. Anesthesiology (1995) 2.13
Pulmonary hypertension in severe acute respiratory failure. N Engl J Med (1977) 2.09
Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways. Cell (1986) 1.98
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet (1998) 1.98
Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice. Circulation (2001) 1.89
The pulmonary vascular lesions of the adult respiratory distress syndrome. Am J Pathol (1983) 1.88
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell (1996) 1.85
Inaccuracies of nitric oxide delivery systems during adult mechanical ventilation. Anesthesiology (1997) 1.75
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest (1998) 1.72
Regulation of erythrocyte cation and water content in sickle cell anemia. Science (1986) 1.65
Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res (1997) 1.63
Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology (1993) 1.63
Medication nebulizer performance. Effects of diluent volume, nebulizer flow, and nebulizer brand. Chest (1996) 1.59
Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med (2001) 1.58
Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice. Proc Natl Acad Sci U S A (1999) 1.57
cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem (1998) 1.56
Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor. J Med Chem (1996) 1.54
Ventilatory and cardiovascular responses to inspired He-O2 during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1998) 1.53
Nucleotide sequences of the human and mouse atrial natriuretic factor genes. Science (1984) 1.51
Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol Cell Biol (2000) 1.49
Treatment of sickle cell anemia with hydroxyurea and erythropoietin. N Engl J Med (1990) 1.47
Inhaled nitric oxide improves exercise capacity in patients with severe heart failure and right ventricular dysfunction. Am J Cardiol (1998) 1.47
Platelet factor 4 injection produces acute pulmonary hypertension in the awake lamb. Anesthesiology (1995) 1.46
The American-European Consensus Conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure! Med Intensiva (2012) 1.44
Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem (1990) 1.43
Efficacy of different dosing regimens for recombinant human erythropoietin in a simulated perisurgical setting: the importance of iron availability in optimizing response. Am J Med (1994) 1.43
Activated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits. Shock (1998) 1.43
Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy. J Clin Invest (1988) 1.42
Weekly ventilator circuit changes. A strategy to reduce costs without affecting pneumonia rates. Anesthesiology (1995) 1.40
Expiratory phase and volume-adjusted tracheal gas insufflation: a lung model study. Crit Care Med (1998) 1.40
Reinterpretation of the RACTK1 K+ channel. Am J Physiol (1997) 1.40
The relationship between gas delivery patterns and the lower inflection point of the pressure-volume curve during partial liquid ventilation. Chest (2000) 1.39
A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy. Blood (1996) 1.39
Effect of iron chelators on the transferrin receptor in K562 cells. J Biol Chem (1984) 1.38
Erythropoietin, iron, and erythropoiesis. Blood (2000) 1.36
Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilation. Anesthesiology (1988) 1.35
Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest (1992) 1.34
Adenovirus-mediated gene transfer of cGMP-dependent protein kinase increases the sensitivity of cultured vascular smooth muscle cells to the antiproliferative and pro-apoptotic effects of nitric oxide/cGMP. J Biol Chem (1998) 1.34
Thawing fresh frozen plasma in a microwave oven. A comparison with thawing in a 37 degrees C waterbath. Am J Clin Pathol (1992) 1.34
The vascular biology of nitric oxide and its role in atherogenesis. Annu Rev Med (1996) 1.34
Seal lungs collapse during free diving: evidence from arterial nitrogen tensions. Science (1985) 1.30
Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells. J Clin Invest (1997) 1.28
Thromboxane receptor blockade prevents pulmonary hypertension induced by heparin-protamine reactions in awake sheep. Circulation (1990) 1.28
Use of recombinant human erythropoietin outside the setting of uremia. Blood (1997) 1.28
Pulmonary fibrosis in severe acute respiratory failure. Am Rev Respir Dis (1979) 1.27
Inhaled nitric oxide in congenital heart disease. Circulation (1993) 1.26
Hemoglobin concentrations and blood gas tensions of free-diving Weddell seals. J Appl Physiol (1985) (1986) 1.25
Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger. J Biol Chem (1998) 1.25
Identification and characterization of a leukocyte-specific component of the nuclear body. J Biol Chem (1996) 1.24
Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. Science (1982) 1.23
Platelet consumption and sequestration in severe acute respiratory failure. Am Rev Respir Dis (1980) 1.22
Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease. J Clin Invest (1985) 1.22
Regional blood flow during simulated diving in the conscious Weddell seal. J Appl Physiol Respir Environ Exerc Physiol (1979) 1.21
Anemia in hemodialysis patients: variables affecting this outcome predictor. J Am Soc Nephrol (1997) 1.21
Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence. J Biol Chem (1990) 1.21
Cell volume, K transport, and cell density in human erythrocytes. Am J Physiol (1987) 1.19
Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy. Blood (1994) 1.19
Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice. Circulation (2000) 1.19
Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res (1996) 1.19
Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. J Clin Invest (1999) 1.19
A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem (2001) 1.19
Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. J Clin Invest (1994) 1.18
Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A. J Clin Invest (1998) 1.17
Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res (1998) 1.16
Expression of the potent vasoconstrictor endothelin in the human central nervous system. J Clin Invest (1990) 1.16
Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. Anesthesiology (1991) 1.15
Pulmonary artery remodeling and pulmonary hypertension after exposure to hyperoxia for 7 days. A morphometric and hemodynamic study. Am J Pathol (1984) 1.15
Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. Am J Physiol (1999) 1.14
A dose-finding and safety study of novel erythropoiesis stimulating protein (NESP) for the treatment of anaemia in patients receiving multicycle chemotherapy. Br J Cancer (2001) 1.13
The effects of ascorbic acid on the intracellular metabolism of iron and ferritin. J Biol Chem (1986) 1.13
Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. Proc Natl Acad Sci U S A (1988) 1.13
Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep. Circulation (1990) 1.12
Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene (2007) 1.11
Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract. J Histochem Cytochem (1995) 1.10