PubRank

R M Eglen

Author PubWeight™ 110.35‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons. J Biol Chem 1996 2.28
2 Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol 1997 2.18
3 A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. J Biol Chem 1997 1.91
4 RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology 1997 1.83
5 Muscarinic receptor subtypes: a critique of the current classification and a proposal for a working nomenclature. J Auton Pharmacol 1986 1.79
6 Characterization and distribution of putative 5-ht7 receptors in guinea-pig brain. Br J Pharmacol 1995 1.71
7 Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J Neurosci 1998 1.67
8 A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proc Natl Acad Sci U S A 1999 1.66
9 The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. Br J Pharmacol 1995 1.57
10 Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation. Circulation 1999 1.54
11 Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol Pharmacol 1995 1.42
12 The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br J Pharmacol 1995 1.41
13 Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997 1.39
14 Muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladder. Life Sci 1999 1.33
15 Peripheral 5-HT4 receptors. FASEB J 1996 1.32
16 Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol 1997 1.29
17 Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol 1998 1.26
18 Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury. Pain 1999 1.25
19 Action of agonists and antagonists at muscarinic receptors present on ileum and atria in vitro. Br J Pharmacol 1985 1.24
20 Antagonist characterization of atypical beta adrenoceptors in guinea pig ileum: blockade by alprenolol and dihydroalprenolol. J Pharmacol Exp Ther 1990 1.23
21 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch Pharmacol 1990 1.20
22 5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases. Br J Pharmacol 1995 1.18
23 Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia. J Neurochem 1998 1.17
24 Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol 1997 1.15
25 Characterization of prostanoid receptor-evoked responses in rat sensory neurones. Br J Pharmacol 1998 1.15
26 Pharmacological characterization of muscarinic receptors in rabbit isolated iris sphincter muscle and urinary bladder smooth muscle. Br J Pharmacol 1998 1.14
27 Competitive and non-competitive antagonism exhibited by 'selective' antagonists at atrial and ileal muscarinic receptor subtypes. Br J Pharmacol 1987 1.13
28 The role of IP prostanoid receptors in inflammatory pain. Trends Pharmacol Sci 1998 1.09
29 Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum. Eur J Pharmacol 1995 1.07
30 A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain 1998 1.07
31 Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther 1999 1.06
32 In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol 1999 1.05
33 7TM receptors: the splicing on the cake. Trends Pharmacol Sci 1999 1.03
34 Differential distribution of the tetrodotoxin-sensitive rPN4/NaCh6/Scn8a sodium channel in the nervous system. J Neurosci Res 2000 1.01
35 Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptor. Biochim Biophys Acta 1995 1.01
36 5-Hydroxytryptamine stimulates cyclic AMP formation in the tunica muscularis mucosae of the rat oesophagus via 5-HT4 receptors. Eur J Pharmacol 1992 1.01
37 Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle. Br J Pharmacol 2001 0.99
38 RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacol 1995 0.99
39 Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms. FEBS Lett 1998 0.97
40 Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. Br J Pharmacol 1991 0.97
41 RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol 1999 0.97
42 Characterization of putative 5-ht7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein. Br J Pharmacol 1996 0.97
43 Characterization of the interaction between muscarinic M2 receptors and beta-adrenoceptor subtypes in guinea-pig isolated ileum. Br J Pharmacol 1995 0.95
44 Effects of muscarinic M2 and M3 receptor stimulation and antagonism on responses to isoprenaline of guinea-pig trachea in vitro. Br J Pharmacol 1994 0.94
45 Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature. Adv Prostaglandin Thromboxane Leukot Res 1995 0.94
46 Regulation of Na+ channel distribution in the nervous system. Trends Neurosci 2001 0.93
47 Labelling of 5-hydroxytryptamine3 receptors with a novel 5-HT3 receptor ligand, [3H]RS-42358-197. J Neurochem 1993 0.93
48 Muscarinic activity of McN-A-343 and its value in muscarinic receptor classification. Br J Pharmacol 1987 0.92
49 Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice. Br J Pharmacol 1999 0.92
50 Pharmacological properties of 5-Hydroxytryptamine(4) receptor antagonists on constitutively active wild-type and mutated receptors. Mol Pharmacol 2000 0.91
51 Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human. Br J Pharmacol 2000 0.90
52 Analysis of muscarinic cholinoceptors mediating phosphoinositide hydrolysis in guinea pig cardiac muscle. Eur J Pharmacol 1992 0.90
53 The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 1997 0.90
54 Quantitative autoradiography of 5-HT4 receptors in brains of three species using two structurally distinct radioligands, [3H]GR113808 and [3H]BIMU-1. Neuropharmacology 1994 0.90
55 Regulation of glial cell line-derived neurotrophic factor release from rat C6 glioblastoma cells. J Neurochem 1998 0.90
56 Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells. Br J Pharmacol 1999 0.90
57 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists. J Med Chem 1993 0.89
58 Evidence for purinergic neurotransmission in the urinary bladder of pithed rats. Eur J Pharmacol 1998 0.89
59 Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle. Br J Pharmacol 2001 0.87
60 Characterization of muscarinic receptor and beta-adrenoceptor interactions in guinea-pig oesophageal muscularis mucosae. Eur J Pharmacol 1995 0.87
61 Evidence for the involvement of 5-hydroxytryptamine 4 receptors in 5-hydroxytryptophan-induced diarrhea in mice. J Pharmacol Exp Ther 1994 0.87
62 Estimation of apparent agonist affinity constants using desensitization of the ileal muscarinic receptor. J Pharmacol Exp Ther 1987 0.86
63 Characterization of [3H]GR 113808 binding to 5-HT4 receptors in brain tissues from patients with neurodegenerative disorders. Behav Brain Res 1996 0.86
64 Characterization of the muscarinic receptor in isolated uterus of sham operated and ovariectomized rats. Br J Pharmacol 1999 0.86
65 Determination of the muscarinic receptor subtype mediating vasodilatation. Br J Pharmacol 1985 0.86
66 EP3, but not EP2, FP, or TP prostanoid-receptor stimulation may reduce intraocular pressure. Invest Ophthalmol Vis Sci 1990 0.86
67 Analysis of concentration-response relationships by seemingly unrelated nonlinear regression (SUNR) technique. J Pharmacol Toxicol Methods 1992 0.86
68 Characterization of alpha 2-adrenoceptors mediating contraction of dog saphenous vein: identity with the human alpha 2A subtype. Br J Pharmacol 1997 0.85
69 The structure and signalling properties of 5-HT receptors: an endless diversity? Trends Pharmacol Sci 1998 0.85
70 Differential regulation of glial cell line-derived neurotrophic factor (GDNF) expression in human neuroblastoma and glioblastoma cell lines. J Neurosci Res 1999 0.83
71 A homogeneous cell-based assay to measure nuclear translocation using beta-galactosidase enzyme fragment complementation. Assay Drug Dev Technol 2006 0.83
72 Pharmacological characterization of 5-hydroxytryptamine3 receptors in murine brain and ileum using the novel radioligand [3H]RS-42358-197: evidence for receptor heterogeneity. J Neurochem 1993 0.83
73 Characterization of the interaction of zamifenacin at muscarinic receptors in vitro. Eur J Pharmacol 1995 0.82
74 Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist. J Pharmacol Exp Ther 1995 0.82
75 Characterization of a promoter for the human glial cell line-derived neurotrophic factor gene. Brain Res Mol Brain Res 1999 0.82
76 Different densities of 5-HT3 receptors are labeled by [3H]quipazine, [3H]GR 65630 and [3H]granisetron. Neuropharmacology 1993 0.81
77 Enhanced delayed matching performance in younger and older macaques administered the 5-HT4 receptor agonist, RS 17017. Psychopharmacology (Berl) 1998 0.81
78 Gene substitution/knockout to delineate the role of alpha 2-adrenoceptor subtypes in mediating central effects of catecholamines and imidazolines. Ann N Y Acad Sci 1999 0.80
79 Investigation of the 5-hydroxytryptamine receptor mediating the "transient" short-circuit current response in guinea-pig ileal mucosa. Naunyn Schmiedebergs Arch Pharmacol 1995 0.80
80 Acetylpromazine administration: its effect on canine haematology. Vet Rec 1979 0.80
81 Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues. Eur J Pharmacol 1999 0.80
82 Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors. J Neurochem 1995 0.80
83 [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. J Pharmacol Exp Ther 1993 0.80
84 Ondansetron improves cognitive performance in the Morris water maze spatial navigation task. Psychopharmacology (Berl) 1995 0.80
85 5-HT3 receptor ligands lack modulatory influence on acetylcholine release in rat entorhinal cortex. Naunyn Schmiedebergs Arch Pharmacol 1993 0.79
86 Muscarinic receptor antagonists. Pulm Pharmacol Ther 1999 0.79
87 [3H]RS-23597-190, a potent 5-hydroxytryptamine4 antagonist labels sigma-1 but not sigma-2 binding sites in guinea pig brain. J Pharmacol Exp Ther 1994 0.79
88 Comparison of 5-HT4 receptors in guinea-pig colon and rat oesophagus: effects of novel agonists and antagonists. Naunyn Schmiedebergs Arch Pharmacol 1996 0.79
89 5-HT4 receptor mediated stimulation of gastric emptying in rats. Naunyn Schmiedebergs Arch Pharmacol 1995 0.79
90 Differential effects of pertussis toxin and lithium on muscarinic responses in the atria and ileum: evidence for receptor heterogeneity. Br J Pharmacol 1987 0.79
91 Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus. Br J Pharmacol 1998 0.78
92 Behavioral effects of RS-45041-190, a selective I2 imidazoline ligand, in rats. Ann N Y Acad Sci 1999 0.78
93 Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors. Br J Pharmacol 2000 0.78
94 Role of muscarinic M2 and M3 receptors in guinea-pig trachea: effects of receptor alkylation. Eur J Pharmacol 1995 0.78
95 Muscarinic M3 receptors mediate contractions in rabbit, endothelium-denuded aorta in vitro. J Auton Pharmacol 1994 0.78
96 M3 muscarinic receptors on murine HSDM1C1 cells: further functional, regulatory, and receptor binding studies. Neurochem Res 1995 0.77
97 Characterization of angiotensin II receptors in smooth muscle preparations of the guinea pig in vitro. J Pharmacol Exp Ther 1993 0.77
98 Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin. Prostaglandins 1991 0.77
99 Absorption and brain penetration of a high affinity, highly selective 5-HT2C receptor antagonist, RS-102221. Ann N Y Acad Sci 1998 0.77
100 Cardiovascular effects of R-alpha-methylhistamine, a selective histamine H3 receptor agonist, in rats: lack of involvement of histamine H3 receptors. Eur J Pharmacol 1994 0.76
101 The effect of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety. Eur J Pharmacol 1993 0.76
102 Chronic manipulation of dietary salt modulates renal physiology and kidney dopamine receptor subtypes: functional and autoradiographic studies. Gen Pharmacol 1995 0.76
103 Characterization of 5-hydroxytryptamine-induced depolarizations in rat isolated vagus nerve. Eur J Pharmacol 1994 0.76
104 High-affinity interactions of ligands at recombinant guinea pig 5HT7 receptors. J Comput Aided Mol Des 2001 0.76
105 Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes. Br J Pharmacol 2000 0.76
106 Comparison of crude methanolic CDS extracts from various tissues. Ann N Y Acad Sci 1999 0.75
107 [3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors. Neuropharmacology 1997 0.75
108 Enhancement of adenosine A1 receptor functions by benzoylthiophenes in guinea pig tissues in vitro. Naunyn Schmiedebergs Arch Pharmacol 1995 0.75
109 Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry. Br J Pharmacol 2001 0.75
110 The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. Neuroreport 1996 0.75
111 Effects of enprostil on cardiovascular and respiratory parameters in the dog, and on hematologic parameters in the rat, monkey, and human. Arzneimittelforschung 1989 0.75
112 No evidence for activation of alpha(2)-adrenoceptors by methanolic extracts of bovine brain and lung containing clonidine-displacing substance. Ann N Y Acad Sci 2003 0.75
113 A pharmacological comparison of [3H]GBR12935 binding to rodent striatal and kidney homogenates: binding to dopamine transporters? Neurochem Int 1992 0.75
114 Pharmacological properties of endothelin in vitro. Proc West Pharmacol Soc 1989 0.75
115 Stereoselective effects of (R)- and (S)-zacopride on cognitive performance in a spatial navigation task in rats. Neuropharmacology 1996 0.75
116 Pharmacological characterization of the muscarinic receptors mediating contraction of canine saphenous vein. J Auton Pharmacol 1995 0.75
117 alpha 2A-adrenoceptors, not I1-imidazoline receptors, mediate the hypotensive effects of rilmenidine and moxonidine in conscious mice. In vivo and in vitro studies. Ann N Y Acad Sci 1999 0.75
118 Pharmacological profile of the dopamine (DA) agonists, RS-12254. Proc West Pharmacol Soc 1991 0.75
119 Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor. J Cardiovasc Pharmacol 1998 0.75
120 Quantitative autoradiography demonstrates selective modulation of rat brain regional dopamine (D1 and D2) receptor subtypes after chronic manipulation of dietary salt. Neurochem Res 1995 0.75
121 Interleukin-1 beta induces nerve growth factor release and gene expression in human glioblastoma cells. Proc West Pharmacol Soc 1995 0.75
122 Pharmacological profile of the dopamine agonist, RS-45946. Proc West Pharmacol Soc 1990 0.75
123 The evaluation of a haemoperfusion device in conscious dogs. Int J Artif Organs 1981 0.75
124 The identification of heterogeneity of 5-HT3 receptors with [3H]RS-42358-197. Adv Exp Med Biol 1995 0.75
125 Isolation of RP-HPLC pure clonidine-displacing substance from NG108-15 cells. Eur J Pharmacol 2000 0.75