Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 1218712)

Published in Biochem J on September 01, 1997

Authors

S H Bae1, Y K Paik

Author Affiliations

1: Department of Biochemistry and Bioproducts Research Center, College of Science, Yonsei University, Seoul, Korea.

Articles citing this

Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am J Hum Genet (2001) 1.88

Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A (1998) 1.49

Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol (2014) 1.31

Biosynthesis of cholesterol and other sterols. Chem Rev (2011) 1.30

Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro. J Lipid Res (2012) 0.98

Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. Front Plant Sci (2013) 0.92

Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. Biochem J (2002) 0.88

Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. Biochem J (2001) 0.87

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Elife (2015) 0.86

Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C. EBioMedicine (2015) 0.83

Photosensitivity in Smith-Lemli-Opitz syndrome: a flux balance analysis of altered metabolism. Bioinformation (2007) 0.81

Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation. Biosci Rep (2012) 0.80

From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D. Adv Nutr (2014) 0.78

Desmosterolosis: an illustration of diagnostic ambiguity of cholesterol synthesis disorders. Orphanet J Rare Dis (2014) 0.77

The mechanism of the effect of U18666a on blocking the activity of 3β-hydroxysterol Δ-24-reductase (DHCR24): molecular dynamics simulation study and free energy analysis. J Mol Model (2016) 0.76

Nuclear hormone receptors put immunity on sterols. Eur J Immunol (2015) 0.76

Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. Curr Pharm Biotechnol (2011) 0.76

Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed. Dev Neurosci (2014) 0.75

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages. Cell Rep (2017) 0.75

Articles cited by this

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29. J Biol Chem (1960) 1.93

The transfer of hydrogen from C-24 to C-25 in ergosterol biosynthesis. Biochem J (1967) 1.76

Sterol biosynthesis. Annu Rev Biochem (1981) 1.47

Cholesterol metabolism during ketoconazole treatment in man. J Lipid Res (1988) 1.27

Studies of cholesterol biosynthesis. III. The desmosterol reductase system in liver. J Biol Chem (1961) 1.25

Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase. J Biol Chem (1992) 1.22

Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo. J Biol Chem (1992) 1.19

NB-598: a potent competitive inhibitor of squalene epoxidase. J Biol Chem (1990) 1.14

Imidazole antimycotics: inhibitors of steroid aromatase. Biochem Pharmacol (1985) 1.10

Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process. J Biol Chem (1986) 1.07

The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Lipid Res (1982) 1.06

Studies of cholesterol biosynthesis. IV. Reduction of lanosterol to 24,25-dihydrolanosterol by rat liver homogenates. J Biol Chem (1963) 1.04

Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase. J Biol Chem (1986) 1.01

Effect of triarimol on cholesterol biosynthesis in rat-liver subcellular. Biochem Biophys Res Commun (1976) 1.01

Effects of 3 beta-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures. Biochemistry (1983) 0.97

Inhibition of cholesterol synthesis and cell growth by 24(R,S),25-iminolanosterol and triparanol in cultured rat hepatoma cells. J Biol Chem (1989) 0.93

In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. J Biol Chem (1987) 0.93

Modulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by azole antimycotics requires lanosterol demethylation, but not 24,25-epoxylanosterol formation. J Biol Chem (1987) 0.87

Purification and characterization of cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from pig liver microsomes. Biochim Biophys Acta (1991) 0.85

Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. J Biol Chem (1984) 0.84

A mammalian mutant cell lacking detectable lanosterol 14 alpha-methyl demethylase activity. J Biol Chem (1988) 0.84

Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 8-isomerase. J Biochem (1995) 0.84

Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 14-reductase. Biochim Biophys Acta (1995) 0.82

Restoration of the conversion of desmosterol to cholesterol in L-cells after hybridization with human fibroblasts. Proc Natl Acad Sci U S A (1974) 0.82

Effects of ketoconazole on cholesterol synthesis. J Pharmacol Exp Ther (1986) 0.80

Identification of cholesta-7,24-dien-3 beta-ol and desmosterol in hamster cauda epididymal spermatozoa. Lipids (1989) 0.79

Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol. Biochem J (1989) 0.79

The map of chromosome 20. J Med Genet (1988) 0.78

Articles by these authors

Mutations in the Delta7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome. Proc Natl Acad Sci U S A (1998) 2.22

Nucleotide sequence and structure of the human apolipoprotein E gene. Proc Natl Acad Sci U S A (1985) 2.16

Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A (1998) 1.49

Structure and expression of the human apolipoprotein A-IV gene. J Biol Chem (1987) 1.17

Genotyping of mitochondrial aldehyde dehydrogenase in blood samples using allele-specific oligonucleotides: comparison with phenotyping in hair roots. Hum Genet (1989) 1.07

Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. J Biol Chem (1999) 1.03

Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase. J Biol Chem (1986) 1.01

Evolution of Pacific/Asian populations inferred from HLA class II allele frequency distributions. Tissue Antigens (2000) 1.00

Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates. J Lipid Res (1986) 0.95

Electrophoretic variability in island populations of Drosophila simulans and Drosophila immigrans. Biochem Genet (1976) 0.95

Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression. J Biol Chem (2001) 0.94

Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. J Antimicrob Chemother (1999) 0.94

Giant polytene chromosomes from the ovaries of a Drosophila mutant. Science (1981) 0.92

Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability. Br J Cancer (2001) 0.91

Pharmacological analysis of sterol delta8-delta7 isomerase proteins with [3H]ifenprodil. Mol Pharmacol (1998) 0.91

Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. J Biol Chem (1984) 0.84

HWY-289, a novel semi-synthetic protoberberine derivative with multiple target sites in Candida albicans. J Antimicrob Chemother (2001) 0.84

Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 8-isomerase. J Biochem (1995) 0.84

Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors. J Biol Chem (1990) 0.83

Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 14-reductase. Biochim Biophys Acta (1995) 0.82

Red cell and serum protein polymorphisms in three population groups of South Korea. Gene Geogr (1987) 0.82

Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele. Hum Genet (1989) 0.82

Red cell enzyme and serum protein polymorphisms in South Korea. Hum Hered (1989) 0.79

Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen. Mol Cells (1998) 0.78

Angiosarcoma of the heart: ultrastructural study. Cancer (1981) 0.78

Expression of the human apolipoprotein E gene in cultured mammalian cells. J Biol Chem (1986) 0.77

Characterization of an upstream regulatory element of the human apolipoprotein E gene, and purification of its binding protein from the human placenta. J Biochem (1995) 0.77

Histo- and cytochemical studies on the distribution of acetylcholinesterase-positive nerve fibers in the goat adrenal gland. Anat Histol Embryol (1990) 0.76

Biochemical basis for a cholesterol-lowering activity of 2-[2"-(1",3"-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6- nitro-2H-1-benzopyran (SKP-450), a novel antihypertensive agent. Biochem Pharmacol (1999) 0.76

Structure and evolution of human apolipoprotein genes: identification of regulatory elements of the human apolipoprotein E gene. Ciba Found Symp (1987) 0.75

Solution structure of a designed amphipathic antimicrobial synthetic peptide, PGAa. Biochem Biophys Res Commun (2000) 0.75

Cloning and expression of the human apolipoprotein E gene. Methods Enzymol (1986) 0.75

Distribution of HL-A antigens in Korean population. Hawaii Med J (1976) 0.75

Polymorphism of 6-PGD in South Korea: a new genetic variant 6-PGD Korea. Hum Genet (1986) 0.75

A quantitative study of environmental asbestos exposure in Honolulu. Hawaii Med J (1998) 0.75

Urinary C-reactive protein and lysozyme in renal homotransplantation. Hawaii Med J (1972) 0.75

Overexpression and characterization of the cDNA encoding the coat protein of cucumber mosaic virus (Strain ABI) isolated in Korea. Mol Cells (1998) 0.75

[Comparative and topographical anatomy of the fowl. LVII. The vascular system of the pancreas in the fowl]. Nihon Juigaku Zasshi (1969) 0.75

[Comparative and topographical anatomy of the fowl. LXIV. Sympathetic nervous system of the fowl. 3. Plexus celiacus and plexus mesentericus cranialis]. Nihon Juigaku Zasshi (1973) 0.75

First bone marrow transplant for leukemia in Hawaii. Hawaii Med J (1979) 0.75

An unusual combination of trisomy 21 and partial trisomy 5q. J Korean Med Sci (1992) 0.75

Clostridium perfringens cultured from a Hawaiian sardine, Sardinella marquesensis. Hawaii Med J (1979) 0.75

[Comparative and topographical anatomy of the fowl. 62. Distribution of the fine blood vascular system in the pancreas]. Nihon Juigaku Zasshi (1970) 0.75

Studies of blood groups, immunoglobulins and isoagglutinins in multiple myeloma and various hematological disorders in the Honolulu area. Hawaii Med J (1966) 0.75

Letter: Homing of lymphocytes. Lancet (1974) 0.75

The synthesis and in vitro activity of some delta 7,9(11)-lanostadienes. Steroids (1997) 0.75