Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes.

PubWeight™: 1.61‹?› | Rank: Top 4%

🔗 View Article (PMID 9322529)

Published in Gastroenterology on October 01, 1997

Authors

D Fau1, M Lekehal, G Farrell, A Moreau, C Moulis, G Feldmann, D Haouzi, D Pessayre

Author Affiliations

1: INSERM Unité 24, Hôpital Beaujon, Clichy, France.

Articles by these authors

Factors affecting epirubicin pharmacokinetics and toxicity: evidence against using body-surface area for dose calculation. J Clin Oncol (1998) 3.81

Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells. Curr Biol (1998) 2.98

Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial. Gut (2000) 2.55

Primary central nervous system lymphomas in 72 immunocompetent patients: pathologic findings and clinical correlations. Groupe Ouest Est d'étude des Leucénies et Autres Maladies du Sang (GOELAMS) Am J Clin Pathol (1998) 2.35

NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem (2001) 2.22

Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci (1999) 2.16

Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment. J Cell Biol (1998) 2.16

Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit. J Exp Med (1978) 2.10

Clinical operational tolerance after kidney transplantation. Am J Transplant (2006) 2.09

Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut (2005) 1.99

Hindlimb patterning and mandible development require the Ptx1 gene. Development (1999) 1.96

A non-invasive test for assessing embryo potential by gene expression profiles of human cumulus cells: a proof of concept study. Mol Hum Reprod (2008) 1.95

Meeting report ESC forum on drug eluting stents, European Heart House, Nice, 27-28 September 2007. EuroIntervention (2009) 1.94

An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice. Gastroenterology (1999) 1.92

The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol (2004) 1.87

Osseointegrated oral implants. A Swedish multicenter study of 8139 consecutively inserted Nobelpharma implants. J Periodontol (1988) 1.83

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther (1995) 1.78

Immune complex type glomerulonephritis in cirrhosis of the liver. Am J Pathol (1975) 1.63

Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology (1998) 1.58

Effects of digitonin on the intracellular content of rat hepatocytes: implications for its use in the study of intralobular heterogeneity. J Histochem Cytochem (1993) 1.56

Marcaine in oral surgery. A clinical comparative study with carbocaine. Acta Anaesthesiol Scand Suppl (1966) 1.55

Expression of complement-regulatory proteins in normal and UW-preserved human liver. Gastroenterology (1994) 1.54

Hepatitis after intravenous buprenorphine misuse in heroin addicts. J Hepatol (2001) 1.51

Both macrophages and endothelial cells of the human hepatic sinusoid express the CD4 molecule, a receptor for the human immunodeficiency virus. Hepatology (1990) 1.48

Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice. J Hepatol (1996) 1.46

Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation. J Hepatol (2001) 1.44

The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab (2004) 1.43

Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization. Am J Pathol (1999) 1.42

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. Oncogene (2001) 1.42

Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria. Cell Death Differ (2002) 1.42

The effect of posture on three objective audiological measures. Br J Audiol (1992) 1.41

[Idiopathic portal hypertension associated with connective tissue disease similar to systemic lupus erythematosus]. Gastroenterol Clin Biol (1989) 1.39

Exacerbation of multiple sclerosis after the administration of recombinant human interferon alfa. JAMA (1989) 1.38

Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases. Hum Pathol (1997) 1.38

Pretransplant sensitization against angiotensin II type 1 receptor is a risk factor for acute rejection and graft loss. Am J Transplant (2013) 1.36

Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator. Cell Death Differ (2000) 1.36

Proteolytic activation of rat liver adenylate cyclase by a contaminant of crude collagenase from Clostridium histolyticum. J Biol Chem (1977) 1.30

Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant. Biochem Pharmacol (1990) 1.25

Synchronous increase of four acute phase proteins synthesized by the same hepatocytes during the inflammatory reaction: a combined biochemical and morphologic kinetics study in the rat. Lab Invest (1981) 1.22

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437. Oncogene (2001) 1.22

Drug-induced prolonged cholestasis in adults: a histological semiquantitative study demonstrating progressive ductopenia. Hepatology (1992) 1.22

Detection of hepatitis B antigen in circulating immune complexes in acute and chronic hepatitis. Scand J Immunol (1977) 1.20

Heterozygous alpha 1-antitrypsin deficiency and cirrhosis in adults, a fortuitous association. Lancet (1975) 1.20

Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther (2001) 1.19

Phosphohistone H3 labelling for histoprognostic grading of breast adenocarcinomas and computer-assisted determination of mitotic index. J Clin Pathol (2006) 1.19

Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines. J Hepatol (1997) 1.18

Polymorphism of dextromethorphan oxidation in a French population. Br J Clin Pharmacol (1987) 1.17

Hepatotoxicity due to mitochondrial dysfunction. Cell Biol Toxicol (1999) 1.16

The liver in alpha 1-antitrypsin deficiency. Digestion (1974) 1.16

Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients. J Hepatol (1997) 1.16

In situ immunophenotyping study of endothelial cells of the human hepatic sinusoid: results and functional implications. Hepatology (1991) 1.16

Hepatotoxicity of antitubercular treatments. Rationale for monitoring liver status. Drug Saf (1996) 1.16

Idiopathic portal hypertension (perisinusoidal fibrosis) after renal transplantation. Gut (1979) 1.15

[Hepatitis caused by diclofenac]. Gastroenterol Clin Biol (1983) 1.15

Selective lysis of autologous tumor cells by recurrent gamma delta tumor-infiltrating lymphocytes from renal carcinoma. J Immunol (1995) 1.15

Acute and chronic drug-induced hepatitis. Baillieres Clin Gastroenterol (1988) 1.15

Pitx3 activates mouse tyrosine hydroxylase promoter via a high-affinity binding site. J Neurochem (2001) 1.15

Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease. Gastroenterology (2001) 1.14

Cigarette smoking-induced changes in the number and differentiated state of pulmonary dendritic cells/Langerhans cells. Am Rev Respir Dis (1989) 1.13

Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver. Am J Pathol (1993) 1.13

Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas-mediated hepatic apoptosis in mice. Hepatology (2000) 1.13

Perhexiline maleate-induced cirrhosis. Gastroenterology (1979) 1.12

Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology (1993) 1.11

Effects of erythromycin on hepatic drug-metabolizing enzymes in humans. Biochem Pharmacol (1983) 1.11

Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther (1990) 1.10

Ultrastructural lesions of the liver in human peliosis. A report of 12 cases. Am J Pathol (1984) 1.10

Mechanism for reduced drug clearance in patients with cirrhosis. Gastroenterology (1978) 1.10

Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis. J Hepatol (1997) 1.10

Inhibition by colchicine of fibrinogen translocation in hepatocytes. J Cell Biol (1975) 1.08

Epithelioid hemangioendothelioma of the liver. Diagnostic features and role of liver transplantation. Gastroenterology (1988) 1.07

Amodiaquine-induced hepatitis. A report of seven cases. Ann Intern Med (1986) 1.07

Expression of cadherins and alpha-catenin in primary epithelial tumors of the liver. Gastroenterology (1996) 1.07

Formation of plasma membrane domains in rat hepatocytes and hepatoma cell lines in culture. J Cell Sci (1988) 1.06

The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Mol Cell Biol (1998) 1.06

The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut (2007) 1.06

Amodiaquine-induced fulminant hepatitis. J Hepatol (1988) 1.05

Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat. Gastroenterology (1992) 1.05

The transcytotic pathway of an apical plasma membrane protein (B10) in hepatocytes is similar to that of IgA and occurs via a tubular pericentriolar compartment. J Cell Sci (1996) 1.05

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. J Clin Invest (1990) 1.04

Effect of rifampicin on liver function in man. Gut (1972) 1.04

Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes. J Pharmacol Exp Ther (1992) 1.04

Cellular analysis by in situ hybridization and immunoperoxidase of alpha-fetoprotein and albumin gene expression in rat liver during the perinatal period. J Cell Biol (1986) 1.04

18F-fluorodeoxyglucose-positron emission tomography before, during and after treatment in mature T/NK lymphomas: a study from the GOELAMS group. Ann Oncol (2010) 1.03

Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer. Gut (1999) 1.02

Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes. Hepatology (1996) 1.01