Published in J Clin Endocrinol Metab on October 01, 1997
Type 2 diabetes mellitus in Canada's first nations: status of an epidemic in progress. CMAJ (2000) 5.33
Paraoxonase gene polymorphisms and haplotype analysis in a stroke population. BMC Med Genet (2006) 0.90
Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer. J Lipids (2012) 0.88
Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes. J Lipid Res (2009) 0.87
Identification of paraoxonase 3 in rat liver microsomes: purification and biochemical properties. Biochem J (2003) 0.81
Relationship between PON1L55M and Q192R gene polymorphisms and high APO B/APO A-I ratios. Indian J Clin Biochem (2009) 0.79
Antioxidant properties of HDL. Front Pharmacol (2015) 0.78
Association of polymorphism of ser311cys paraoxonase-2 gene with type 2 diabetes mellitus in iran. Int J Prev Med (2013) 0.77
Susceptible gene of stasis-stagnation constitution from genome-wide association study related to cardiovascular disturbance and possible regulated traditional Chinese medicine. BMC Complement Altern Med (2015) 0.75
An improved polymerase chain reaction-restriction fragment length polymorphism assay for the detection of a PON2 gene polymorphism. Biomed Rep (2016) 0.75
Identification of the cystic fibrosis gene: genetic analysis. Science (1989) 33.61
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet (2006) 15.32
Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA (2001) 8.80
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet (1997) 6.83
Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker. Science (1985) 5.81
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet (1996) 5.70
A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein. Nature (1990) 5.42
A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7. Nature (1985) 5.07
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest (2001) 4.98
1998 clinical practice guidelines for the management of diabetes in Canada. Canadian Diabetes Association. CMAJ (1998) 4.95
The relation between genotype and phenotype in cystic fibrosis--analysis of the most common mutation (delta F508). N Engl J Med (1990) 4.70
Mutation analysis for heterozygote detection and the prenatal diagnosis of cystic fibrosis. N Engl J Med (1990) 4.60
A 1.5 million-base pair inversion polymorphism in families with Williams-Beuren syndrome. Nat Genet (2001) 4.58
Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Genomics (1991) 4.27
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell (1996) 4.13
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell (1990) 3.70
Development of bioinformatics resources for display and analysis of copy number and other structural variants in the human genome. Cytogenet Genome Res (2006) 3.68
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development (1997) 3.66
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet (2001) 3.59
Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance. Cell (1991) 3.56
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet (1996) 3.50
Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell (1997) 3.42
Ramipril and the development of diabetes. JAMA (2001) 3.38
Cystic fibrosis: genotypic and phenotypic variations. Annu Rev Genet (1995) 3.27
Stability of insulin lispro in insulin infusion systems. Diabetes Care (1997) 3.16
Multi-ion pore behaviour in the CFTR chloride channel. Nature (1993) 3.14
A suggested nomenclature for designating mutations. Hum Mutat (1993) 3.10
Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res (2001) 2.89
High-resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc Natl Acad Sci U S A (1992) 2.72
Rapid nonradioactive detection of the major cystic fibrosis mutation. Am J Hum Genet (1990) 2.72
Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem (1993) 2.69
The prevalence of NIDDM and associated risk factors in native Canadians. Diabetes Care (1997) 2.68
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor. Nat Genet (1996) 2.65
A mutation in CFTR produces different phenotypes depending on chromosomal background. Nat Genet (1993) 2.64
Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells. Mol Cell Biol (1982) 2.59
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene (1993) 2.59
Simple screening tests for peripheral neuropathy in the diabetes clinic. Diabetes Care (2001) 2.57
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet (2001) 2.55
Controlled outcome evaluation of the First Step Program: a daily physical activity intervention for individuals with type II diabetes. Int J Obes Relat Metab Disord (2004) 2.54
Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat Genet (1998) 2.51
Genetic determination of exocrine pancreatic function in cystic fibrosis. Am J Hum Genet (1992) 2.48
Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Nat Genet (2000) 2.38
Modes of DAPI banding and simultaneous in situ hybridization. Chromosoma (1993) 2.38
Two patients with cystic fibrosis, nonsense mutations in each cystic fibrosis gene, and mild pulmonary disease. N Engl J Med (1990) 2.37
Impact of diabetes on coronary artery disease in women and men: a meta-analysis of prospective studies. Diabetes Care (2000) 2.34
Characterization of the human beta-crystallin gene Hu beta A3/A1 reveals ancestral relationships among the beta gamma-crystallin superfamily. J Biol Chem (1986) 2.31
Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. Hum Mol Genet (1996) 2.29
Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science (1987) 2.27
Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions. J Gen Physiol (1997) 2.26
EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines. Genomics (2009) 2.26
Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trials. Diabetes Obes Metab (2012) 2.23
Use of ethnographic methods for applied research on diabetes among the Ojibway-Cree in northern Ontario. Health Educ Q (1996) 2.16
Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc Natl Acad Sci U S A (1998) 2.16
Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. J Biol Chem (1999) 2.15
The efficacy of stethoscope placement when not in use: traditional versus "cool". CMAJ (2000) 2.11
Canadian heart health surveys: a profile of cardiovascular risk. Survey methods and data analysis. Canadian Heart Health Surveys Research Group. CMAJ (1992) 2.09
Identification of mutations in exons 1 through 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Genomics (1991) 2.07
Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes Obes Metab (2009) 2.04
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci U S A (1998) 1.93
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature (2000) 1.93
Methods for analysis of multiple cystic fibrosis mutations. Hum Genet (1991) 1.88
Intensive insulin therapy with insulin lispro: a randomized trial of continuous subcutaneous insulin infusion versus multiple daily insulin injection. Diabetes Care (2001) 1.88
The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein. Nat Genet (1999) 1.87
Comparison of insulin degludec with insulin glargine in insulin-naive subjects with Type 2 diabetes: a 2-year randomized, treat-to-target trial. Diabet Med (2013) 1.84
Overweight among children and adolescents in a Native Canadian community: prevalence and associated factors. Am J Clin Nutr (2000) 1.76
Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study. Diabetes Obes Metab (2010) 1.76
Mutation spectrum and predicted function of laforin in Lafora's progressive myoclonus epilepsy. Neurology (2000) 1.73
Identification of revertants for the cystic fibrosis delta F508 mutation using STE6-CFTR chimeras in yeast. Cell (1993) 1.72
Insulins today and beyond. Lancet (2001) 1.71
Correlation of sweat chloride concentration with classes of the cystic fibrosis transmembrane conductance regulator gene mutations. J Pediatr (1995) 1.70
Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease. Genomics (1997) 1.70
DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis. Am J Hum Genet (1989) 1.66
The rupture rate of acute flexor tendon repairs mobilized by the controlled active motion regimen. J Hand Surg Br (1994) 1.60
Molecular analysis of the PDS gene in Pendred syndrome. Hum Mol Genet (1998) 1.58
Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol (1999) 1.57
Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. Genomics (1999) 1.56
Serum immunoreactive leptin concentrations in a Canadian aboriginal population with high rates of NIDDM. Diabetes Care (1997) 1.55
Specific patterns of food consumption and preparation are associated with diabetes and obesity in a Native Canadian community. J Nutr (1998) 1.53
Use of surnames to identify individuals of Chinese ancestry. Am J Epidemiol (1993) 1.52