Role of dopamine D1 and D2 receptors in the nucleus accumbens in mediating reward.

PubWeight™: 1.55‹?› | Rank: Top 4%

🔗 View Article (PMID 9334429)

Published in J Neurosci on November 01, 1997

Authors

S Ikemoto1, B S Glazier, J M Murphy, W J McBride

Author Affiliations

1: Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

Articles citing this

Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev (2007) 6.36

Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology (2008) 2.80

Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc Lond B Biol Sci (2006) 2.03

Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory. Neurosci Biobehav Rev (2010) 1.57

Methylmercury and nutrition: adult effects of fetal exposure in experimental models. Neurotoxicology (2008) 1.57

Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell. Eur J Neurosci (2009) 1.56

Effects of intra-nucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat. Psychopharmacology (Berl) (2005) 1.54

Primary reinforcing effects of nicotine are triggered from multiple regions both inside and outside the ventral tegmental area. J Neurosci (2006) 1.52

Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective. Brain Res Rev (2007) 1.50

Striatal dopamine D2/3 receptor availability in treatment resistant depression. PLoS One (2014) 1.44

Ultrasonic vocalizations induced by sex and amphetamine in M2, M4, M5 muscarinic and D2 dopamine receptor knockout mice. PLoS One (2008) 1.43

The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid? J Neurosci (2005) 1.43

Retinal dopamine mediates multiple dimensions of light-adapted vision. J Neurosci (2012) 1.42

Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats. Eur J Neurosci (2005) 1.37

The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A (2009) 1.30

Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression. Psychopharmacology (Berl) (2006) 1.16

Differential roles of ventral pallidum subregions during cocaine self-administration behaviors. J Comp Neurol (2013) 1.11

Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity. Alcohol Clin Exp Res (2009) 1.09

Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats. Psychopharmacology (Berl) (2007) 1.06

Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents. Neuroimage (2012) 1.06

Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study. Pharmacol Biochem Behav (2009) 1.06

The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. Int J Neuropsychopharmacol (2006) 1.06

Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens. PLoS One (2014) 1.04

The midbrain raphe nuclei mediate primary reinforcement via GABA(A) receptors. Eur J Neurosci (2007) 1.03

Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking. Alcohol (2010) 1.02

Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats. Neuropsychopharmacology (2011) 1.01

Overlapping intracellular and differential synaptic distributions of dopamine D1 and glutamate N-methyl-D-aspartate receptors in rat nucleus accumbens. J Comp Neurol (2005) 1.01

Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropharmacology (2007) 1.01

Satiating effects of cocaine are controlled by dopamine actions in the nucleus accumbens core. J Neurosci (2011) 0.96

Divergent activation of ventromedial and ventrolateral dopamine systems in animal models of amphetamine sensitization and schizophrenia. Int J Neuropsychopharmacol (2011) 0.95

Controlled iontophoresis coupled with fast-scan cyclic voltammetry/electrophysiology in awake, freely moving animals. ACS Chem Neurosci (2013) 0.93

Striatal signal transduction and drug addiction. Front Neuroanat (2011) 0.91

Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle. Psychopharmacology (Berl) (2008) 0.91

Frequency-dependent gating of synaptic transmission and plasticity by dopamine. Front Neural Circuits (2007) 0.91

Neurocircuitry of drug reward. Neuropharmacology (2013) 0.90

Basal ganglia circuit loops, dopamine and motivation: A review and enquiry. Behav Brain Res (2015) 0.90

Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction. Psychopharmacology (Berl) (2008) 0.88

Involvement of local serotonin-2A but not serotonin-1B receptors in the reinforcing effects of ethanol within the posterior ventral tegmental area of female Wistar rats. Psychopharmacology (Berl) (2009) 0.88

Cocaine-induced mu opioid receptor occupancy within the striatum is mediated by dopamine D2 receptors. Brain Res (2009) 0.87

Phasic excitation of ventral tegmental dopamine neurons potentiates the initiation of conditioned approach behavior: parametric and reinforcement-schedule analyses. Front Behav Neurosci (2014) 0.86

The medial preoptic area modulates cocaine-induced activity in female rats. Behav Neurosci (2013) 0.86

Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. PLoS One (2015) 0.86

Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. Behav Brain Res (2013) 0.85

Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. Psychopharmacology (Berl) (2005) 0.85

CART peptide inhibits locomotor activity induced by simultaneous stimulation of D1 and D2 receptors, but not by stimulation of individual dopamine receptors. Synapse (2011) 0.85

Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption. Alcohol (2013) 0.84

Inhibition of 50-kHz ultrasonic vocalizations by dopamine receptor subtype-selective agonists and antagonists in adult rats. Psychopharmacology (Berl) (2012) 0.83

Unconditional hyperactivity and transient reinforcing effects of NMDA administration into the ventral tegmental area in rats. Psychopharmacology (Berl) (2003) 0.82

Presynaptic dopamine modulation by stimulant self-administration. Front Biosci (Schol Ed) (2013) 0.81

Rewarding and incentive motivational effects of excitatory amino acid receptor antagonists into the median raphe and adjacent regions of the rat. Psychopharmacology (Berl) (2012) 0.80

The reinforcing effects of ethanol within the posterior ventral tegmental area depend on dopamine neurotransmission to forebrain cortico-limbic systems. Addict Biol (2014) 0.80

Impact of medial orbital cortex and medial subthalamic nucleus inactivation, individually and together, on the maintenance of cocaine self-administration behavior in rats. Behav Brain Res (2012) 0.80

Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target(1,2,3). eNeuro (2015) 0.80

Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contact. Behav Neurosci (2008) 0.80

Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats. Pharmacol Biochem Behav (2013) 0.79

The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice. Int J Neuropsychopharmacol (2015) 0.78

MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ (2013) 0.77

Effects of protein kinase A inhibitor and activator on rewarding effects of SKF-82958 microinjected into nucleus accumbens shell of ad libitum fed and food-restricted rats. Psychopharmacology (Berl) (2011) 0.75

Functional Interaction between the Shell Sub-Region of the Nucleus Accumbens and the Ventral Tegmental Area in Response to Morphine: an Electrophysiological Study. Basic Clin Neurosci (2013) 0.75

Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion. Psychopharmacology (Berl) (2016) 0.75

Articles by these authors

Performance of a five-item mental health screening test. Med Care (1991) 8.76

Uncertainty in predictions of the climate response to rising levels of greenhouse gases. Nature (2005) 7.46

Performance of screening and diagnostic tests. Application of receiver operating characteristic analysis. Arch Gen Psychiatry (1987) 4.62

Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng (1998) 4.54

Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res (2001) 3.06

Mind and mood in modern art, II: Depressive disorders, spirituality, and early deaths in the abstract expressionist artists of the New York School. Am J Psychiatry (1994) 2.85

Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol (2007) 2.65

Protecting severely abused and neglected children. An unkept promise. N Engl J Med (1990) 2.58

Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer. J Clin Oncol (2001) 2.41

Combined spinal and epidural anaesthesia for major abdominal surgery in infants. Can J Anaesth (1997) 2.34

Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behav Brain Res (1999) 2.26

Use of the Pediatric Symptom Checklist to screen for psychosocial problems in pediatric primary care: a national feasibility study. Arch Pediatr Adolesc Med (1999) 2.23

Protecting seriously mistreated children: time delays in a court sample. Child Abuse Negl (1992) 2.01

Hunger in children in the United States: potential behavioral and emotional correlates. Pediatrics (1998) 1.99

The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun (1999) 1.97

Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin Cancer Res (2007) 1.97

Affective disorders and mortality. A general population study. Arch Gen Psychiatry (1987) 1.95

Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene. J Neuropathol Exp Neurol (2004) 1.76

Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol. Alcohol (2006) 1.75

Multiple informants: mortality associated with psychiatric disorders in the Stirling County Study. Am J Epidemiol (2001) 1.67

Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats. Alcohol (1995) 1.67

Diet, breakfast, and academic performance in children. Ann Nutr Metab (2002) 1.61

General dental practitioners' perception of their role within child protection: a qualitative study. Eur J Paediatr Dent (2003) 1.60

Brief psychosocial screening in outpatient pediatric practice. J Pediatr (1986) 1.56

Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats. Psychopharmacology (Berl) (2000) 1.55

Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT). Breast Cancer Res Treat (2010) 1.54

Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions. Behav Neurosci (1997) 1.54

Pediatric Symptom Checklist: screening school-age children for psychosocial dysfunction. J Pediatr (1988) 1.51

A comparison of three psychiatric screening tests using receiver operating characteristic (ROC) analysis. Med Care (1989) 1.48

The Pediatric Symptom Checklist. Support for a role in a managed care environment. Arch Pediatr Adolesc Med (1995) 1.48

Psychiatric outcome of burned children and adolescents. J Am Acad Child Adolesc Psychiatry (1989) 1.44

Regional differences within the rat ventral tegmental area for muscimol self-infusions. Pharmacol Biochem Behav (1998) 1.43

Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol (1992) 1.43

Effects of scheduled access on ethanol intake by the alcohol-preferring (P) line of rats. Alcohol (1986) 1.42

Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats. Alcohol Clin Exp Res (2001) 1.42

Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol (1993) 1.41

Progress toward a voluntary oral consumption model of alcoholism. Drug Alcohol Depend (1980) 1.36

Alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after repeated deprivations. Alcohol Clin Exp Res (2000) 1.33

The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations. Alcohol Clin Exp Res (2000) 1.29

Two contiguous outbreaks of dengue type 2 in north Queensland. Med J Aust (1998) 1.26

Psychiatric labeling in cross-cultural perspective. Science (1976) 1.25

Utility of psychosocial screening at a school-based health center. J Sch Health (2000) 1.25

GABA(A) receptor blockade in the anterior ventral tegmental area increases extracellular levels of dopamine in the nucleus accumbens of rats. J Neurochem (1997) 1.23

Rodent lines selected for factors affecting alcohol consumption. Alcohol Alcohol Suppl (1987) 1.23

Consumption of sweet, salty, sour, and bitter solutions by selectively bred alcohol-preferring and alcohol-nonpreferring lines of rats. Alcohol Clin Exp Res (1994) 1.20

Blocking GABA(A) receptors in the anterior ventral tegmental area attenuates ethanol intake of the alcohol-preferring P rat. Psychopharmacology (Berl) (1998) 1.19

Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats. J Pharmacol Exp Ther (2004) 1.19

Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. Genes Brain Behav (2005) 1.17

Ethanol and negative feedback regulation of mesolimbic dopamine release in rats. Psychopharmacology (Berl) (1998) 1.17

Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats. Pharmacol Biochem Behav (1982) 1.16

An epidemic of dengue 3 in far north Queensland, 1997-1999. Med J Aust (2001) 1.16

Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell (2001) 1.16

Different sensitivities to ethanol in alcohol-preferring and -nonpreferring rats. Pharmacol Biochem Behav (1982) 1.15

Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring lines of rats. Pharmacol Biochem Behav (1986) 1.13

Illustrated review of new imaging techniques in the diagnosis of abdominal wall hernias. Br J Surg (1999) 1.12

Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. Alcohol Clin Exp Res (2001) 1.12

Diagnosis and outcome: depression and anxiety in a general population. Psychol Med (1986) 1.12

Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. Pharmacogenomics J (2006) 1.11

Up-regulation and differential expression of the hyaluronan-binding protein TSG-6 in cartilage and synovium in rheumatoid arthritis and osteoarthritis. Osteoarthritis Cartilage (2001) 1.10

The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions. Alcohol Clin Exp Res (1998) 1.09

Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. Science (1984) 1.08

Low-dose stimulatory effects of ethanol during adolescence in rat lines selectively bred for high alcohol intake. Alcohol Clin Exp Res (2004) 1.07

Effects of neuropeptide Y on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcohol Clin Exp Res (2003) 1.07

Ethanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats. Alcohol Clin Exp Res (1992) 1.06

Serotonin-3 receptor and ethanol-stimulated somatodendritic dopamine release. Alcohol (1997) 1.06

Initial sensitivity and acute tolerance to ethanol in the P and NP lines of rats. Pharmacol Biochem Behav (1983) 1.05

Contents of monoamines in forebrain regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacol Biochem Behav (1987) 1.04

A comparison of the inhibitory effects of taurine and GABA on identified Purkinje cells and other neurons in the cerebellar cortex of the rat. Brain Res (1978) 1.04

Development of alcohol drinking behavior in rat lines selectively bred for divergent alcohol preference. Alcohol Clin Exp Res (1998) 1.04

Corkscrew-like shortening in single smooth muscle cells. Science (1987) 1.03

Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions. Pharmacol Biochem Behav (1996) 1.03

Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol (1990) 1.03

Experimental pretargeting studies of cancer with a humanized anti-CEA x murine anti-[In-DTPA] bispecific antibody construct and a (99m)Tc-/(188)Re-labeled peptide. Bioconjug Chem (2000) 1.01

Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats. Pharmacol Biochem Behav (1982) 1.01

Screening for psychosocial problems in 4-5-year-olds during routine EPSDT examinations: validity and reliability in a Mexican-American sample. Clin Pediatr (Phila) (1996) 1.01

Screening for psychosocial disorders in pediatric practice. Am J Dis Child (1988) 0.99

Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats. Alcohol (1989) 0.98

An approach to pediatric perioperative care. Parent-present induction. Nurs Clin North Am (1997) 0.98

Chronic ethanol tolerance through free-choice drinking in the P line of alcohol-preferring rats. Pharmacol Biochem Behav (1987) 0.97

Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats. Alcohol (1989) 0.97

Chronic alcohol consumption in alcohol-preferring P rats attenuates subsequent conditioned taste aversion produced by ethanol injections. Psychopharmacology (Berl) (1991) 0.97