Published in Ann Surg on October 01, 1997
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev (2003) 8.27
Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology (2008) 3.95
Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis. Neoplasia (2005) 2.03
Clinical implications and utility of field cancerization. Cancer Cell Int (2007) 1.91
Branch-duct intraductal papillary mucinous neoplasms of the pancreas: to operate or not to operate? Gut (2006) 1.91
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol (2001) 1.89
Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol (2000) 1.81
PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res (2006) 1.63
BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Lett (2006) 1.46
Molecular signatures of pancreatic cancer. Arch Pathol Lab Med (2011) 1.46
Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am J Pathol (2004) 1.40
Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br J Cancer (2001) 1.36
Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas. Mod Pathol (2008) 1.22
Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas. J Gastroenterol (2010) 1.20
Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Ann Surg (2009) 1.17
Intraductal papillary and mucinous pancreatic tumour: a new extracolonic tumour in familial adenomatous polyposis. Gut (2002) 1.10
Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg (1999) 1.08
Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression. J Gastroenterol (2011) 1.02
Precursor lesions of pancreatic cancer. Gut Liver (2008) 1.01
Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res (2013) 1.00
PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas. Langenbecks Arch Surg (2008) 0.94
K-ras mutations correlate with atypical cytology and elevated CEA levels in pancreatic cystic neoplasms. Dig Dis Sci (2011) 0.91
Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas. Pancreas (2008) 0.89
Intraductal papillary mucinous neoplasms of the pancreas--a surgical disease. Nat Rev Gastroenterol Hepatol (2012) 0.89
Management of mucin-producing cystic neoplasms of the pancreas. Oncologist (2009) 0.89
Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats. Ann Surg (2001) 0.89
Oncocytic-type intraductal papillary mucinous neoplasm (IPMN)-derived invasive oncocytic pancreatic carcinoma with brain metastasis - a case report. World J Surg Oncol (2012) 0.87
Genetic markers of malignant transformation in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis. Pancreas (2012) 0.86
Pathology and molecular genetics of pancreatic neoplasms. Cancer J (2012) 0.85
Duodenum-preserving total pancreatic head resection for cystic neoplasm: a limited but cancer-preventive procedure. Langenbecks Arch Surg (2008) 0.82
[Intraductal neoplasms of the pancreas: cystic and common]. Pathologe (2005) 0.81
Intraductal papillary mucinous neoplasm of the pancreas: an update. Scientifica (Cairo) (2012) 0.81
In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab Invest (2010) 0.81
Intraductal papillary-mucinous neoplasia of the pancreas: Histopathology and molecular biology. World J Gastrointest Surg (2010) 0.81
EZH2 is associated with malignant behavior in pancreatic IPMN via p27Kip1 downregulation. PLoS One (2014) 0.80
[Classification and malignant potential of pancreatic cystic tumors]. Pathologe (2015) 0.79
Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas. Br J Cancer (2009) 0.79
The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. Mod Pathol (2016) 0.79
[Precursor lesions of pancreatobiliary cancer]. Pathologe (2011) 0.78
Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. Cancer Biol Ther (2017) 0.78
Malignant potential of intraductal papillary mucinous neoplasms of the pancreas. Surg Today (2010) 0.77
Exploring the Functional Disorder and Corresponding Key Transcription Factors in Intraductal Papillary Mucinous Neoplasms Progression. Int J Genomics (2015) 0.75
Plectin-1 as a Biomarker of Malignant Progression in Intraductal Papillary Mucinous Neoplasms: A Multicenter Study. Pancreas (2016) 0.75
Intraductal Papillary Mucinous Neoplasm of the Pancreas: Current Perspectives. Int Surg (2015) 0.75
Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas. World J Gastroenterol (2014) 0.75
ras genes. Annu Rev Biochem (1987) 22.59
ras oncogenes in human cancer: a review. Cancer Res (1989) 22.03
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell (1988) 10.29
Pancreatic carcinoma. N Engl J Med (1992) 7.25
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol (1993) 3.56
Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg (1990) 3.46
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res (1988) 3.31
Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature. Members of the Pancreas Clinic, and Pancreatic Surgeons of Mayo Clinic. Gastroenterology (1996) 2.33
Intraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology (1991) 2.14
Structural and functional properties of ras proteins. FASEB J (1989) 1.93
High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas. Int J Cancer (1989) 1.79
Intraductal papillary mucinous tumours of the pancreas. Clinical and therapeutic issues in 32 patients. Gut (1996) 1.74
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch (1994) 1.54
Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases. Cancer (1991) 1.47
Mucin-hypersecreting tumors of the pancreas: assessing the grade of malignancy preoperatively. Am J Surg (1996) 1.46
Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect (1991) 1.44
Pancreatic mucinous ductal ectasia and intraductal papillary neoplasms. A single malignant clinicopathologic entity. Ann Surg (1997) 1.40
Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients. Jpn J Cancer Res (1989) 1.40
Mucin-producing neoplasms of the pancreas. Intraductal papillary and mucinous cystic neoplasms. Ann Surg (1996) 1.36
Mucin-producing tumor of the pancreas: natural history and serial pancreatogram changes. Am J Gastroenterol (1993) 1.36
Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology (1992) 1.33
Mucin-producing tumor of the pancreas. Cancer (1991) 1.23
Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. J Mol Med (Berl) (1996) 1.18
Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene. Ann Surg (1991) 1.12
Mutational activation of the c-K-ras gene in human pancreatic carcinoma. Baillieres Clin Gastroenterol (1990) 1.10
Frequent glycine-to-aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese. Jpn J Cancer Res (1990) 1.09
Frequency and spectrum of c-Ki-ras mutations in human sporadic colon carcinoma, carcinomas arising in ulcerative colitis, and pancreatic adenocarcinoma. Environ Health Perspect (1991) 1.07
c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res (1991) 1.07
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas (1996) 1.04
Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer. Genes Chromosomes Cancer (1991) 1.03
Intraductal mucin-producing tumors of the pancreas. Am J Gastroenterol (1992) 1.02
Mucin-producing tumor of the pancreas: a unique clinical entity. Am J Gastroenterol (1991) 1.01
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia. Surgery (1997) 1.00
Mucin-hypersecreting tumor of the pancreas with mucin extrusion through an enlarged papilla. Am J Gastroenterol (1991) 0.97
Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas. Oncogene (1989) 0.97
Villous adenoma of the main pancreatic duct: a potentially malignant tumor? Am J Gastroenterol (1990) 0.89
Papillary adenoma of the pancreas with excessive mucin secretion. Pancreas (1992) 0.87
Intraductal mucin-hypersecreting neoplasms of the pancreas. Gastroenterology (1992) 0.87
The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas. Int J Pancreatol (1993) 0.86
Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas. J Surg Oncol (1994) 0.86
Expression of oncogene products, anti-oncogene products and oncofetal antigens in intraductal papillary-mucinous neoplasm of the pancreas. Histopathology (1996) 0.85
Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma. Pancreas (1996) 0.82
Pancreatic carcinoma. N Engl J Med (1992) 7.25
Enzymatic defect in Fabry's disease. Ceramidetrihexosidase deficiency. N Engl J Med (1967) 5.63
Risk factors for pancreatic cellular injury after cardiopulmonary bypass. N Engl J Med (1991) 4.66
Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch Surg (2001) 4.59
Effect of hospital volume on in-hospital mortality with pancreaticoduodenectomy. Surgery (1999) 4.31
P-TEFb kinase recruitment and function at heat shock loci. Genes Dev (2000) 4.07
High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation. Genes Dev (2000) 3.79
Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med (1984) 3.70
Standards for pancreatic resection in the 1990s. Arch Surg (1995) 3.66
Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am J Roentgenol (1989) 3.59
Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg (1990) 3.46
On the validity of the Beck Depression Inventory. A review. Psychopathology (1998) 3.16
Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology (1996) 3.15
Intravenous contrast medium accentuates the severity of acute necrotizing pancreatitis in the rat. Gastroenterology (1994) 2.91
High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography. Gastrointest Endosc (2000) 2.84
A better model of acute pancreatitis for evaluating therapy. Ann Surg (1992) 2.81
Relationship between hospital volume and late survival after pancreaticoduodenectomy. Surgery (1999) 2.79
Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer (2000) 2.59
Improving depression outcomes in community primary care practice: a randomized trial of the quEST intervention. Quality Enhancement by Strategic Teaming. J Gen Intern Med (2001) 2.56
Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology (1997) 2.54
Diagnosis of specialized intestinal metaplasia by optical coherence tomography. Gastroenterology (2001) 2.53
Effect of marathon running on inflammatory and hemostatic markers. Am J Cardiol (2001) 2.50
Small intestinal permeability to macromolecules. Transmission of horseradish peroxidase into mesenteric lymph and portal blood. Lab Invest (1971) 2.46
Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol (1994) 2.44
Gastrointestinal stromal tumor versus intra-abdominal fibromatosis of the bowel wall: a clinically important differential diagnosis. Am J Surg Pathol (2000) 2.38
Incisional hernia rate 3 years after midline laparotomy. Br J Surg (2013) 2.37
Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. Gut (2008) 2.36
Carcinoma of the anal canal. N Engl J Med (2000) 2.22
Pancreatic ischaemia in experimental acute pancreatitis: mechanism, significance and therapy. Br J Surg (1990) 2.21
Human papillomavirus DNA sequences in esophagus squamous cell carcinoma. Gastroenterology (1994) 2.20
Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis? J Vasc Interv Radiol (1998) 2.17
Resection margins in carcinoma of the head of the pancreas. Implications for radiation therapy. Ann Surg (1993) 2.15
Obesity adversely affects the outcome of antireflux operations. Surg Endosc (2001) 2.11
Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Mol Cell (2001) 2.00
TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein. Proc Natl Acad Sci U S A (1993) 2.00
Pain in chronic pancreatitis. Patients, patience, and the impatient surgeon. Gastroenterology (1984) 1.99
Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Ann Surg (1993) 1.97
Cystic tumors mistaken for pancreatic pseudocysts. Ann Surg (1987) 1.97
Metastases to the pancreas and their surgical extirpation. Arch Surg (1998) 1.89
Factors associated with successful laparoscopic cholecystectomy for acute cholecystitis. Ann Surg (1993) 1.88
Acute pancreatitis: analysis of factors influencing survival. Ann Surg (1977) 1.88
Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat. Gastroenterology (1995) 1.84
Persistent obstructive jaundice, cholangitis, and biliary cirrhosis due to common bile duct stenosis in chronic pancreatitis. Gastroenterology (1976) 1.84
Cystic tumors of the pancreas. Surg Clin North Am (1995) 1.82
History and design of the INCAP longitudinal study (1969-77) and its follow-up (1988-89). J Nutr (1995) 1.79
Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats. Gastroenterology (1993) 1.76
Outcome of pancreaticoduodenectomy with pylorus preservation or with antrectomy in the treatment of chronic pancreatitis. Ann Surg (2000) 1.76
Introduction of appendiceal CT: impact on negative appendectomy and appendiceal perforation rates. Ann Surg (1999) 1.75
Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy. Surg Gynecol Obstet (1985) 1.73
Role of serum carbohydrate antigen 19-9 and carcinoembryonic antigen in distinguishing between benign and invasive intraductal papillary mucinous neoplasm of the pancreas. Br J Surg (2010) 1.73
Susceptibility of the pancreas to ischemic injury in shock. Ann Surg (1978) 1.71
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab (1996) 1.70
Morphometric characteristics and homogeneity of a new model of acute pancreatitis in the rat. Int J Pancreatol (1992) 1.69
Débridement and closed packing for the treatment of necrotizing pancreatitis. Ann Surg (1998) 1.68
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem (2000) 1.68
Pancreatic-phase versus portal vein-phase helical CT of the pancreas: optimal temporal window for evaluation of pancreatic adenocarcinoma. AJR Am J Roentgenol (1999) 1.67
Comparison of CD4 cell count by a simple enzyme-linked immunosorbent assay using the TRAx CD4 test kit and by flow cytometry and hematology. Clin Diagn Lab Immunol (1995) 1.66
Pancreatic abscesses. N Engl J Med (1972) 1.65
Impact of zinc supplementation on morbidity from diarrhea and respiratory infections among rural Guatemalan children. Pediatrics (1997) 1.64
Cultured epithelial autografts for giant congenital nevi. Plast Reconstr Surg (1989) 1.63
Acute pancreatitis. Lancet (1993) 1.62
Timing of surgical drainage for pancreatic pseudocyst. Clinical and chemical criteria. Ann Surg (1985) 1.61
The electronic phase diagram of the LaO(1-x)F(x)FeAs superconductor. Nat Mater (2009) 1.60
Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis. Neurology (2004) 1.60
Interstitial trypsinogen release and its relevance to the transformation of mild into necrotizing pancreatitis in rats. Gastroenterology (1999) 1.60
Clinical significance of liver ischaemia after pancreatic resection. Br J Surg (2011) 1.59
The use of EUS to diagnose malignant portal venous system invasion by pancreatic cancer. Gastrointest Endosc (1996) 1.59
A region of deletion on chromosome 22q13 is common to human breast and colorectal cancers. Cancer Res (2000) 1.58
Angiodysplasia of the right colon: a cause of gastrointestinal bleeding. AJR Am J Roentgenol (1977) 1.58
Improved survival in 45 patients with pancreatic abscess. Ann Surg (1985) 1.55
Cell cycle dysregulation in oral cancer. Crit Rev Oral Biol Med (2002) 1.54
Isovolemic hemodilution with dextran prevents contrast medium induced impairment of pancreatic microcirculation in necrotizing pancreatitis of the rat. Am J Surg (1995) 1.54