Published in Development on October 01, 1997
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab (2011) 3.68
Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells (2008) 2.54
Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. Genome Res (2007) 2.27
A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons. Proc Natl Acad Sci U S A (2008) 2.19
Understanding the rhythm of breathing: so near, yet so far. Annu Rev Physiol (2012) 2.01
Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.93
Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in congenital central hypoventilation syndrome. Pediatr Res (2008) 1.86
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Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. Development (2004) 1.54
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Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity. Nat Neurosci (2013) 1.36
Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest (2014) 1.33
Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes Dev (2002) 1.32
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Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol Cell Biol (2001) 1.28
Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev (2001) 1.28
Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J (2001) 1.17
Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. J Neurosci (2011) 1.16
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development (2009) 1.15
Evidence of an asymmetrical endophenotype in congenital fibrosis of extraocular muscles type 3 resulting from TUBB3 mutations. Invest Ophthalmol Vis Sci (2010) 1.15
Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors. J Physiol (2007) 1.14
CFEOM1, the classic familial form of congenital fibrosis of the extraocular muscles, is genetically heterogeneous but does not result from mutations in ARIX. BMC Genet (2002) 1.14
Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. PLoS Genet (2014) 1.12
Retrotrapezoid nucleus and parafacial respiratory group. Respir Physiol Neurobiol (2010) 1.12
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development (2009) 1.11
Pre-Bötzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons. J Comp Neurol (2012) 1.11
Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nat Neurosci (2014) 1.10
Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A (2010) 1.09
MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. Am J Pathol (2009) 1.08
Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation. EMBO J (2005) 1.08
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Breathing with phox2b. Philos Trans R Soc Lond B Biol Sci (2009) 1.05
lessen encodes a zebrafish trap100 required for enteric nervous system development. Development (2006) 1.03
Transcription factors define the neuroanatomical organization of the medullary reticular formation. Front Neuroanat (2013) 1.03
Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways. Proc Natl Acad Sci U S A (2011) 1.01
Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling. Dev Biol (2010) 0.98
Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab (2014) 0.95
Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons. Proc Natl Acad Sci U S A (2000) 0.95
Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend. BMC Genomics (2009) 0.94
The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂. Elife (2015) 0.93
Factors that regulate embryonic gustatory development. BMC Neurosci (2007) 0.93
Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Dev Biol (2010) 0.93
An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet (2007) 0.92
Expression of sympathetic nervous system genes in Lamprey suggests their recruitment for specification of a new vertebrate feature. PLoS One (2011) 0.90
PHOX2A regulation of oculomotor complex nucleogenesis. Development (2010) 0.90
Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction. Dev Biol (2014) 0.90
A Histone2BCerulean BAC transgene identifies differential expression of Phox2b in migrating enteric neural crest derivatives and enteric glia. Dev Dyn (2008) 0.89
Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression. J Clin Invest (2012) 0.89
Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models. PLoS Genet (2013) 0.88
MiR-326 regulates cell proliferation and migration in lung cancer by targeting phox2a and is regulated by HOTAIR. Am J Cancer Res (2016) 0.88
Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo. Dev Biol (2011) 0.88
Cyclic AMP signaling functions as a bimodal switch in sympathoadrenal cell development in cultured primary neural crest cells. Mol Cell Biol (2000) 0.87
Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion. Dev Biol (2012) 0.87
A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics. Genesis (2013) 0.86
The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells. Biochem J (2006) 0.86
Congenital innervation dysgenesis syndrome (CID)/congenital cranial dysinnervation disorders (CCDDs). Eye (Lond) (2011) 0.86
Cytokines inhibit norepinephrine transporter expression by decreasing Hand2. Mol Cell Neurosci (2011) 0.85
Congenital central hypoventilation syndrome and the PHOX2B gene: a model of respiratory and autonomic dysregulation. Respir Physiol Neurobiol (2010) 0.85
The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification. EMBO J (2013) 0.85
The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Dev Dyn (2005) 0.85
Congenital fibrosis syndrome associated with central nervous system abnormalities. Graefes Arch Clin Exp Ophthalmol (2003) 0.85
KIF21A mutations in two Chinese families with congenital fibrosis of the extraocular muscles (CFEOM). Mol Vis (2010) 0.85
The Hlx homeobox transcription factor is required early in enteric nervous system development. BMC Dev Biol (2006) 0.84
Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution. PLoS Genet (2015) 0.84
Lack of KIF21A mutations in congenital fibrosis of the extraocular muscles type I patients from consanguineous Saudi Arabian families. Mol Vis (2011) 0.84
Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation. PLoS One (2012) 0.84
Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7. Proc Natl Acad Sci U S A (2005) 0.83
Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep (2011) 0.83
Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy. J Physiol (2016) 0.83
Transcription factor GATA-3 regulates the transcriptional activity of dopamine beta-hydroxylase by interacting with Sp1 and AP4. Neurochem Res (2008) 0.83
Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish. Front Neurosci (2014) 0.82
Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis. Dev Dyn (2011) 0.81
Plasticity of neural crest-placode interaction in the developing visceral nervous system. Dev Dyn (2011) 0.81
Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2. Mol Cell Neurosci (2011) 0.81
Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease. Hum Genet (2005) 0.80
Phox2b expression in the aldosterone-sensitive HSD2 neurons of the NTS. Brain Res (2008) 0.80
Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine beta-hydroxylase in the locus coeruleus and adrenal glands of rats. J Neurochem (2005) 0.80
A novel de novo KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Möbius syndrome. Mol Vis (2014) 0.80
Congenital central hypoventilation syndrome: a bedside-to-bench success story for advancing early diagnosis and treatment and improved survival and quality of life. Pediatr Res (2016) 0.79
ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy. Br J Ophthalmol (2004) 0.79
Embryology and development of the enteric nervous system. Gut (2000) 0.79
Activated satellite cells in medial rectus muscles of patients with strabismus. Invest Ophthalmol Vis Sci (2008) 0.79
Sympathetic neurons and chromaffin cells share a common progenitor in the neural crest in vivo. Neural Dev (2013) 0.79
Hoxb1 controls anteroposterior identity of vestibular projection neurons. PLoS One (2012) 0.79
A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry. PLoS One (2015) 0.78
Transcription factor Phox2 upregulates expression of norepinephrine transporter and dopamine β-hydroxylase in adult rat brains. Neuroscience (2011) 0.78
Alanine Expansions Associated with Congenital Central Hypoventilation Syndrome Impair PHOX2B Homeodomain-mediated Dimerization and Nuclear Import. J Biol Chem (2016) 0.78
Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci (2016) 0.78
Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors. Mol Biol Evol (2015) 0.77
Phox2b influences the development of a caudal dopaminergic subset. PLoS One (2012) 0.77
Retinal Dysfunction in Patients with Congenital Fibrosis of the Extraocular Muscles Type 2. Ophthalmic Genet (2014) 0.77
The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice. Eur J Neurosci (2015) 0.76
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