Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity.

PubWeight™: 0.92‹?›

🔗 View Article (PMID 9380029)

Published in Mol Pharmacol on October 01, 1997

Authors

S Patel1, A U Sprung, B A Keller, V J Heaton, L M Fisher

Author Affiliations

1: Molecular Genetics Group, Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, University of London, London SW17 0RE, UK.

Articles by these authors

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob Agents Chemother (1996) 7.10

Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones. Antimicrob Agents Chemother (1989) 5.80

DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. J Bacteriol (1990) 5.13

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction. Antimicrob Agents Chemother (1991) 4.35

Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J Bacteriol (1996) 4.34

DNA gyrase: purification and catalytic properties of a fragment of gyrase B protein. Proc Natl Acad Sci U S A (1979) 4.34

Nucleotide sequence of the Staphylococcus aureus gyrB-gyrA locus encoding the DNA gyrase A and B proteins. J Bacteriol (1992) 3.95

DNA gyrase action involves the introduction of transient double-strand breaks into DNA. Proc Natl Acad Sci U S A (1980) 3.87

Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. Antimicrob Agents Chemother (1997) 3.83

DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother (1998) 3.12

DNA cloning and organization of the Staphylococcus aureus gyrA and gyrB genes: close homology among gyrase proteins and implications for 4-quinolone action and resistance. J Bacteriol (1990) 2.96

Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother (1991) 2.80

Site-specific interaction of DNA gyrase with DNA. Proc Natl Acad Sci U S A (1981) 2.75

Interaction of bleomycin A2 with deoxyribonucleic acid: DNA unwinding and inhibition of bleomycin-induced DNA breakage by cationic thiazole amides related to bleomycin A2. Biochemistry (1985) 1.94

DNase I hypersensitive sites in the chromatin of human mu immunoglobulin heavy-chain genes. Nature (1984) 1.94

Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones. Antimicrob Agents Chemother (1999) 1.73

gyrA mutations in ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus from Indiana, Minnesota, and Tennessee. J Infect Dis (1991) 1.54

DNA gyrase complex with DNA: determinants for site-specific DNA breakage. EMBO J (1986) 1.52

Effect of lacto-N-neotetraose, asialoganglioside-GM1 and neuraminidase on adherence of otitis media-associated serotypes of Streptococcus pneumoniae to chinchilla tracheal epithelium. Microb Pathog (1999) 1.46

Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro. Antimicrob Agents Chemother (2000) 1.45

DNA supercoiling and gene expression. Nature (1984) 1.35

Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins. Antimicrob Agents Chemother (2001) 1.27

Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase. Antimicrob Agents Chemother (2000) 1.25

Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells. FEBS Lett (1990) 1.24

Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases. Biochim Biophys Acta (1993) 1.24

Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast. Cancer Res (1993) 1.23

Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives. Biochem J (1992) 1.19

Aging and speed of behavior: possible consequences for psychological functioning. Annu Rev Psychol (1995) 1.17

DNA gyrase: site-specific interactions and transient double-strand breakage of DNA. Cold Spring Harb Symp Quant Biol (1981) 1.16

Quantitative evaluation of dizziness characteristics and impact on quality of life. Am J Otol (1996) 1.14

Effect of adenovirus type 1 and influenza A virus on Streptococcus pneumoniae nasopharyngeal colonization and otitis media in the chinchilla. Ann Otol Rhinol Laryngol (2000) 1.12

Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta. J Biol Chem (1995) 1.09

Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms. Antimicrob Agents Chemother (1999) 1.06

Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIalpha (p170) and IIbeta (p180). Mol Pharmacol (1996) 0.99

Impact of rapid weight loss on cognitive function in collegiate wrestlers. Med Sci Sports Exerc (1998) 0.98

Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2 beta construct allows the study of topoisomerase II beta inhibitors in yeast. Cancer Chemother Pharmacol (1997) 0.95

Energetics of proline racemase: tracer perturbation experiments using [14C]proline that measure the interconversion rate of the two forms of free enzyme. Biochemistry (1986) 0.95

Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha. Mol Pharmacol (2000) 0.94

Analysis of a chimeric class-I patatin-GUS gene in transgenic potato plants: High-level expression in tubers and sucrose-inducible expression in cultured leaf and stem explants. Plant Mol Biol (1989) 0.93

Nucleotide sequence of the recF gene cluster from Staphylococcus aureus and complementation analysis in Bacillus subtilis recF mutants. Mol Gen Genet (1995) 0.92

Regulation of DNA supercoiling in Escherichia coli: genetic basis of a compensatory mutation in DNA gyrase. FEBS Lett (1989) 0.91

An Escherichia coli DNA topoisomerase I mutant has a compensatory mutation that alters two residues between functional domains of the DNA gyrase A protein. J Bacteriol (1992) 0.90

Treatment of acute hepatic coma by ex vivo baboon and human liver perfusions. Surgery (1972) 0.89

Energetics of proline racemase: racemization of unlabeled proline in the unsaturated, saturated, and oversaturated regimes. Biochemistry (1986) 0.88

Water running with and without a flotation vest in competitive and recreational runners. Med Sci Sports Exerc (1997) 0.88

Deinduction of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesis in Reuber H-35 cells. J Biol Chem (1975) 0.86

DNA supercoiling by DNA gyrase. Nature (1981) 0.86

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta. Biochem Pharmacol (1996) 0.84

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line. Br J Cancer (1993) 0.83

Nuclear distribution of human DNA topoisomerase IIbeta: a nuclear targeting signal resides in the 116-residue C-terminal tail. Exp Cell Res (1998) 0.83

Identification of a factor IX point mutation using SSCP analysis and direct sequencing. Nucleic Acids Res (1990) 0.83

Recovery of Chlamydia trachomatis from patients of southeastern venereal disease clinic. Am J Clin Pathol (1980) 0.83

Experience in the treatment of hepatic failure by intermittent liver hemoperfusions. Surg Gynecol Obstet (1973) 0.82

DNA topoisomerases: enzymes that change the shape of DNA. Sci Prog (1990) 0.82

Aging and slowing of behavior: consequences for cognition and survival. Nebr Symp Motiv (1991) 0.82

Molecular cloning and expression of the Candida albicans TOP2 gene allows study of fungal DNA topoisomerase II inhibitors in yeast. Biochem J (1997) 0.82

Effect of tumor necrosis factor alpha and interleukin 1-alpha on the adherence of Streptococcus pneumoniae to chinchilla tracheal epithelium. Acta Otolaryngol (1999) 0.81

Structure and partial amino acid sequence of calf thymus DNA topoisomerase II: comparison with other type II enzymes. Biochem Biophys Res Commun (1990) 0.81

DNA binding and intercalation by novel porphyrins: role of charge and substituents probed by DNase I footprinting and topoisomerase I unwinding. FEBS Lett (1990) 0.81

Gatifloxacin derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase. Bioorg Med Chem Lett (2006) 0.81

NorA plasmid resistance to fluoroquinolones: role of copy number and norA frameshift mutations. Antimicrob Agents Chemother (1996) 0.81

Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase. Antimicrob Agents Chemother (1996) 0.80

Development and properties of an etoposide-resistant human leukaemic CCRF-CEM cell line. Anticancer Drug Des (1990) 0.80

Systemic lymphangiomatosis: a combined diagnostic approach of lymphangiography and computed tomography. J Comput Tomogr (1986) 0.80

Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. Biochem J (1995) 0.80

Effects of meal form and composition on plasma testosterone, cortisol, and insulin following resistance exercise. Int J Sport Nutr Exerc Metab (2000) 0.79

Noninvasive estimation of the maximal lactate steady state in trained cyclists. Med Sci Sports Exerc (1999) 0.79

Quantification of 9-carboxy-11-nor-delta 9-tetrahydrocannabinol in urine using brominated 9-carboxy-11-nor-delta 9-tetrahydrocannabinol as the internal standard and high-performance liquid chromatography with electrochemical detection. Biomed Chromatogr (1997) 0.79

Escherichia coli DNA gyrase: genetic analysis of gyrA and gyrB mutations responsible for thermosensitive enzyme activity. FEBS Lett (1992) 0.79

Human DNA topoisomerase IIalpha-dependent DNA cleavage and yeast cell killing by anthracycline analogues. Cancer Res (1998) 0.78

Fibrinolytic effects of intracoronary streptokinase administration in patients with acute myocardial infarction and coronary insufficiency. Circulation (1983) 0.78

Acute hepatic coma successfully treated by extracorporeal baboon liver perfusions. Br Med J (1972) 0.78

Statistical quality control of rabbit brain thromboplastin for clinical use in the prothrombin time determination. Am J Clin Pathol (1966) 0.78

Clinical utilization of the international normalized ratio (INR). J Clin Lab Anal (2000) 0.77

Energetics of proline racemase: rates, fractionation factors, and buffer catalysis in the oversaturated region. Nature of the interconversion of the two forms of free enzyme. Biochemistry (1986) 0.77

Partial isolation and translation in vitro of messenger ribonucleic acid for phosphoenolpyruvate carboxykinase (guanosine triphosphate). Biochem J (1976) 0.77

Energetics of triosephosphate isomerase: the nature of the proton transfer between the catalytic base and solvent water. Biochemistry (1976) 0.77

Relationship of major histocompatibility complex class II genes to inhibitor antibody formation in hemophilia A. Thromb Haemost (1990) 0.76

Mutations at arg486 and glu571 in human topoisomerase IIalpha confer resistance to amsacrine: relevance for antitumor drug resistance in human cells. Mol Pharmacol (2000) 0.76

Energetics of proline racemase: transition-state fractionation factors for the two protons involved in the catalytic steps. Biochemistry (1986) 0.76

DNA unwinding in transcription and recombination. Nature (1982) 0.76

Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication. Biochim Biophys Acta (1999) 0.76

Globular protein stability: aspects of interest in protein turnover. Acta Biol Med Ger (1981) 0.76

Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord. Eur J Neurol (2013) 0.76

Shellfish Report from the Standpoint of the Sanitary Engineer. Am J Public Health Nations Health (1936) 0.75

A study of the psychology of agoraphobia. Behav Res Ther (1985) 0.75

Plasmid DNA supercoiling by DNA gyrase. Methods Mol Biol (2001) 0.75

Report of the Committee on Shellfish : Engineering Section. Am J Public Health Nations Health (1947) 0.75

Report of the Committee on Shellfish : Engineering Section. Am J Public Health Nations Health (1945) 0.75

Ocular complications of factor XIII deficiency. Trans Pac Coast Otoophthalmol Soc Annu Meet (1969) 0.75

Endomyocardial biopsy in pediatric oncology: implications for nursing. J Assoc Pediatr Oncol Nurses (1985) 0.75

Modification in movement accuracy in the triphasic pattern during a rapid forearm-flexion task. Percept Mot Skills (1988) 0.75

Ocular complications of factor XIII deficiency. Am J Ophthalmol (1969) 0.75

Characteristics of telephone applicants to a residential rehabilitation program for homeless veterans. J Consult Clin Psychol (1990) 0.75

DNA breakage by Escherichia coli DNA gyrase in vitro and in vivo. Biochem Soc Trans (1986) 0.75

Expression in Escherichia coli and purification of human eosinophil-derived neurotoxin with ribonuclease activity. Protein Expr Purif (1995) 0.75

Report of the Committee on Shellfish (Wartime Shellfish Problems) : Engineering Section. Am J Public Health Nations Health (1944) 0.75

Nucleotide sequence of the recF gene cluster from Staphylococcus aureus and complementation analysis in Bacillus subtilis recF mutants. Mol Gen Genet (1995) 0.75