Published in Protein Sci on November 01, 1997
Permissive secondary mutations enable the evolution of influenza oseltamivir resistance. Science (2010) 5.94
Thermodynamic prediction of protein neutrality. Proc Natl Acad Sci U S A (2005) 3.30
Prevalence of epistasis in the evolution of influenza A surface proteins. PLoS Genet (2011) 2.41
A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase. PLoS One (2011) 1.16
Chemical chaperone rescue of mutant human cystathionine beta-synthase. Mol Genet Metab (2007) 1.14
Interaction energy based protein structure networks. Biophys J (2010) 0.96
Compensatory evolution of a WW domain variant lacking the strictly conserved Trp residue. J Mol Evol (2007) 0.90
Systematic study of the genetic response of a variable virus to the introduction of deleterious mutations in a functional capsid region. J Virol (2009) 0.82
Rescue of deleterious mutations by the compensatory Y30F mutation in ketosteroid isomerase. Mol Cells (2013) 0.80
Consensus protein design. Protein Eng Des Sel (2016) 0.80
Delineation of an evolutionary salvage pathway by compensatory mutations of a defective lysozyme. Protein Sci (1998) 0.79
Promoters largely determine the efficiency of repressor action. Proc Natl Acad Sci U S A (1988) 4.18
Turns in peptides and proteins. Adv Protein Chem (1985) 4.05
Sequence determinants of promoter activity. Cell (1982) 4.00
Systematic mutation of bacteriophage T4 lysozyme. J Mol Biol (1991) 3.96
A mutant T4 lysozyme displays five different crystal conformations. Nature (1990) 3.07
Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution. J Mol Biol (1987) 3.02
Control of enzyme activity by an engineered disulfide bond. Science (1989) 2.70
Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J Mol Biol (1993) 2.50
Studies on protein stability with T4 lysozyme. Adv Protein Chem (1995) 2.16
Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein. Biochemistry (1987) 2.12
Genetic analysis of staphylococcal nuclease: identification of three intragenic "global" suppressors of nuclease-minus mutations. Genetics (1985) 2.08
Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft. Biochemistry (1991) 2.03
Construction of Escherichia coli amber suppressor tRNA genes. II. Synthesis of additional tRNA genes and improvement of suppressor efficiency. J Mol Biol (1990) 2.02
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J Mol Biol (1994) 1.95
Structure-based design of a lysozyme with altered catalytic activity. Nat Struct Biol (1995) 1.73
A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme. Science (1993) 1.50
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants. Proc Natl Acad Sci U S A (1989) 1.50
Relation between hen egg white lysozyme and bacteriophage T4 lysozyme: evolutionary implications. J Mol Biol (1981) 1.46
Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J Mol Biol (1991) 1.29
Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme. J Mol Biol (1996) 1.23
Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme. J Mol Biol (1991) 1.21
Crystallographic determination of the mode of binding of oligosaccharides to T4 bacteriophage lysozyme: implications for the mechanism of catalysis. J Mol Biol (1981) 1.15
Reexamination of the role of Asp20 in catalysis by bacteriophage T4 lysozyme. Biochemistry (1991) 1.12
Development of an in vivo method to identify mutants of phage T4 lysozyme of enhanced thermostability. Protein Sci (1993) 1.02
Structural analysis of the temperature-sensitive mutant of bacteriophage T4 lysozyme, glycine 156----aspartic acid. J Biol Chem (1987) 0.95
Genetic analysis of bacteriophage T4 lysozyme structure and function. J Bacteriol (1994) 0.83
Second-site reversion of a structural defect in bacteriophage T4 lysozyme. FASEB J (1996) 0.83
Genetic analysis of bacteriophage P22 lysozyme structure. Genetics (1989) 0.82
Mutation of active site residues in synthetic T4-lysozyme gene and their effect on lytic activity. Biochem Biophys Res Commun (1988) 0.82
Structures of randomly generated mutants of T4 lysozyme show that protein stability can be enhanced by relaxation of strain and by improved hydrogen bonding via bound solvent. Protein Sci (1993) 0.81
Systematic mutation of bacteriophage T4 lysozyme. J Mol Biol (1991) 3.96
Atomic structure of thymidylate synthase: target for rational drug design. Science (1987) 2.48
Phage P22 lysis genes: nucleotide sequences and functional relationships with T4 and lambda genes. Virology (1985) 1.71
Milk allergy: clinical picture and familial incidence. Can Med Assoc J (1967) 1.66
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. J Biol Chem (1997) 1.42
Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis. Biochemistry (1987) 1.36
Structure and function of a membrane anchor-less form of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus. J Biol Chem (1993) 1.33
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. Nat Struct Biol (2001) 1.27
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity. Parasitology (1997) 1.24
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug. Biochemistry (1999) 1.02
Roles of Cys148 and Asp179 in catalysis by deoxycytidylate hydroxymethylase from bacteriophage T4 examined by site-directed mutagenesis. Biochemistry (1992) 1.02
Structure of phage P22 gene 19 lysozyme inferred from its homology with phage T4 lysozyme. Implications for lysozyme evolution. J Mol Biol (1985) 0.95
Functional significance of conserved amino acid residues. Proteins (1992) 0.93
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence. Biochemistry (1998) 0.92
Parameters affecting the restoration of activity to inactive mutants of thymidylate synthase via subunit exchange: further evidence that thymidylate synthase is a half-of-the-sites activity enzyme. Biochemistry (2001) 0.91
Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1). Acta Crystallogr D Biol Crystallogr (1999) 0.87
Genetic analysis of bacteriophage T4 lysozyme structure and function. J Bacteriol (1994) 0.83
Kinetic and equilibrium alpha-secondary tritium isotope effects on reactions catalyzed by dCMP hydroxymethylase from bacteriophage T4. Biochemistry (1994) 0.81
Mutations in an upstream regulatory sequence that increase expression of the bacteriophage T4 lysozyme gene. J Bacteriol (1987) 0.80
Residues in the longitudinal, hydrophobic strip-of-helix relate to terminations and crossings of alpha-helices. J Biol Chem (1992) 0.78
Evidence from 18O exchange studies for an exocyclic methylene intermediate in the reaction catalyzed by T4 deoxycytidylate hydroxymethylase. Biochemistry (1994) 0.78
Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery. Mol Divers (2005) 0.77
Evidence that the Australian sylvatic strain of Echinococcus granulosus is infective to humans. Med J Aust (1987) 0.76
Disodium cromoglycate in treatment of asthmatic children. Can Fam Physician (1973) 0.75
The management of medical and surgical problems complicated by allergic reactions. Univ Mich Med Cent J (1968) 0.75