Published in Invest New Drugs on January 01, 1997
Discovery and preclinical antitumor efficacy evaluations of LY32262 and LY33169. Invest New Drugs (2003) 1.49
A new paradigm for the development of anticancer agents from natural products. J Exp Ther Oncol (2006) 1.27
Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin. Invest New Drugs (1999) 0.94
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Mol Pharmacol (2012) 0.94
Synthesis of fluorinated benzophenones, xanthones, acridones, and thioxanthones by iterative nucleophilic aromatic substitution. J Org Chem (2011) 0.90
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter. Cancer Chemother Pharmacol (2013) 0.86
Antineoplastic potency of arylchloroethylurea derivatives in murine colon carcinoma. Invest New Drugs (2004) 0.84
Cloning and characterization of a novel beta-transaminase from Mesorhizobium sp. strain LUK: a new biocatalyst for the synthesis of enantiomerically pure beta-amino acids. Appl Environ Microbiol (2007) 0.83
Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors. Invest New Drugs (2005) 0.83
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. J Med Chem (2015) 0.81
Phase I dose-escalation study of the thioxanthone SR271425 administered intravenously once every 3 weeks in patients with advanced malignancies. Invest New Drugs (2008) 0.78
Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates. Mol Pharmacol (2016) 0.77
Cryptophycin 1 cellular levels and effects in vitro using L1210 cells. Invest New Drugs (1999) 0.75
Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice. Cancer Res (1984) 2.74
Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res (1975) 2.54
Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas. Cancer (1977) 1.06
Is the P388 murine tumor no longer adequate as a drug discovery model? Invest New Drugs (1987) 0.99
Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03. J Med Chem (1994) 0.81
Preclinical anticancer activity of cryptophycin-8. J Exp Ther Oncol (1996) 0.78
High-resolution global maps of 21st-century forest cover change. Science (2013) 17.90
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00
The fate of certain organic acids and amides in the rabbit. 10. The application of paper chromatography to metabolic studies of hydroxybenzoic acids and amides. Biochem J (1950) 7.25
Digital tomosynthesis in breast imaging. Radiology (1997) 5.82
The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev (1995) 5.68
Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo. J Natl Cancer Inst (1966) 5.06
Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA (1997) 4.49
Complete nucleotide sequence of a milk-transmitted mouse mammary tumor virus: two frameshift suppression events are required for translation of gag and pol. J Virol (1987) 4.37
Programmed cell death during Drosophila embryogenesis. Development (1993) 4.24
Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus. EMBO J (1986) 4.08
A new method for active surveillance of adverse events from diphtheria/tetanus/pertussis and measles/mumps/rubella vaccines. Lancet (1995) 3.93
Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis (2000) 3.71
Enhancing the effectiveness of tobacco package warning labels: a social psychological perspective. Tob Control (2002) 3.28
A pilot study of medical student 'abuse'. Student perceptions of mistreatment and misconduct in medical school. JAMA (1990) 3.16
Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J Neurobiol (1991) 3.12
Risk of aseptic meningitis after measles, mumps, and rubella vaccine in UK children. Lancet (1993) 3.08
The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs. Science (1988) 3.03
Complete structure and expression in transfected cells of high affinity IgE receptor. Nature (1989) 2.97
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol (1999) 2.93
Metabolism of derivatives of toluene. 4. Cresols. Biochem J (1950) 2.82
Growth characteristics of a mouse plasma cell tumor. Cancer Res (1968) 2.80
Practice parameters for the treatment of sigmoid diverticulitis--supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum (2000) 2.77
Ras promotes cell survival in Drosophila by downregulating hid expression. Cell (1998) 2.75
Risk factors for homelessness. Epidemiol Rev (1993) 2.55
Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine. J Neurosci (1996) 2.50
Hypocritical tosh. Br Dent J (2010) 2.48
The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages. Dev Biol (1988) 2.45
Lifetime and five-year prevalence of homelessness in the United States: new evidence on an old debate. Am J Orthopsychiatry (1995) 2.42
Mumps meningitis and measles, mumps, and rubella vaccine. Lancet (1992) 2.30
Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila. Science (1999) 2.29
Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE). Eur Heart J (2003) 2.20
A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration. Am J Hum Genet (2000) 2.18
Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction. Am J Physiol (1987) 2.14
Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients. CHIB 201 International Study Group. Lancet (1997) 2.12
Mutant alleles at the locus elav in Drosophila melanogaster lead to nervous system defects. A developmental-genetic analysis. J Neurogenet (1985) 2.12
Prevention of relapse in residual depression by cognitive therapy: a controlled trial. Arch Gen Psychiatry (1999) 2.12
Prophylactic treatment of postperfusion bleeding using EACA. Chest (1989) 2.09
Molecular cloning and nucleotide sequence of a complete human uroporphyrinogen decarboxylase cDNA. J Biol Chem (1986) 2.05
IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene (2001) 2.03
Mutations in the VMD2 gene are associated with juvenile-onset vitelliform macular dystrophy (Best disease) and adult vitelliform macular dystrophy but not age-related macular degeneration. Eur J Hum Genet (2000) 2.02
Strand displacement amplification and homogeneous real-time detection incorporated in a second-generation DNA probe system, BDProbeTecET. Clin Chem (1999) 2.01
Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine. J Infect Dis (1998) 2.00
Xanthine oxidase as a source of free radical damage in myocardial ischemia. J Mol Cell Cardiol (1985) 2.00
cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics (2000) 1.99
How roots respond to gravity. Sci Am (1986) 1.95
Genetic structure, function and regulation of the transposable element IS21. Mol Gen Genet (1989) 1.93
Saccades in presymptomatic and early stages of Huntington disease. Neurology (2006) 1.92
The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J Neurosci (1999) 1.90
An in vitro assay for growth-inhibiting activity of vinblastine. J Natl Cancer Inst (1965) 1.88
Hereditary spastic paraparesis: a review of new developments. J Neurol Neurosurg Psychiatry (2000) 1.87
Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase. Proc Natl Acad Sci U S A (1986) 1.87
Complications of smallpox vaccination. I. National survey in the United States, 1963. N Engl J Med (1967) 1.86
Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics (2000) 1.83
Childhood non-Hodgkin's lymphoma. The results of a randomized therapeutic trial comparing a 4-drug regimen (COMP) with a 10-drug regimen (LSA2-L2). N Engl J Med (1983) 1.82
Temperature-sensitive DNA synthesis mutants of Bacillus subtilis--appendix: theory of density transfer for symmetric chromosome replication. Genetics (1973) 1.80
Amantadine small-particle aerosol: generation and delivery to man. Proc Soc Exp Biol Med (1979) 1.76
Neural specificity of elav expression: defining a Drosophila promoter for directing expression to the nervous system. J Neurochem (1994) 1.76
Laparoscopic complications in markedly obese urologic patients (a multi-institutional review) Urology (1996) 1.75
Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res (1997) 1.74
Patterns of cell division and cell movement in the formation of the imaginal nervous system in Drosophila melanogaster. Dev Biol (1978) 1.71
Public knowledge, attitudes, and beliefs about homeless people: evidence for compassion fatigue. Am J Community Psychol (1995) 1.69
Gadolinium is not the only trigger for nephrogenic systemic fibrosis: insights from two cases and review of the recent literature. Am J Transplant (2007) 1.68
Metastatic patterns in soft-tissue sarcomas. Arch Surg (1983) 1.66
Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr Biol (1999) 1.65
Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron (1992) 1.64
Thermodynamic and kinetic characterization of the dissociation and assembly of quadruplex nucleic acids. Biopolymers (2001) 1.64
Cryptosporidium parvum infection of Caco-2 cell monolayers induces an apical monolayer defect, selectively increases transmonolayer permeability, and causes epithelial cell death. Infect Immun (1994) 1.61
Cohort study of the treatment of severe HIV-associated nephropathy with corticosteroids. Kidney Int (2000) 1.60
Signs of an olive branch: confronting the environmental health consequences of the Midwestern floods. Environ Health Perspect (1993) 1.59
The pendent view: an additional projection to confirm the diagnosis of milk of calcium. AJR Am J Roentgenol (2001) 1.58
ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform. Curr Biol (1996) 1.58
Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans. J Neurobiol (1993) 1.57
Aortic and mitral valve calcification in patients with end-stage renal disease. Lancet (1987) 1.54
Smoking after cardiac transplantation. Am J Transplant (2008) 1.54
Tension-free vaginal tape: outcomes among women with primary versus recurrent stress urinary incontinence. Obstet Gynecol (2002) 1.51
Predicting bacteremia in patients with sepsis syndrome. Academic Medical Center Consortium Sepsis Project Working Group. J Infect Dis (1997) 1.50
Measurement of risk for mental disorders and competence in a psychiatric epidemiologic community survey: the National Institute of Mental Health Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study. Soc Psychiatry Psychiatr Epidemiol (1998) 1.50
The infrequency of "pure culture" diagnoses among the anxiety disorders. J Clin Psychiatry (1996) 1.49
Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol Pharmacol (1998) 1.49
A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. Proc Natl Acad Sci U S A (1989) 1.48
Pharmacokinetics and toxicity of continuous infusion amphotericin B in cancer patients. J Pharm Sci (1989) 1.48
Antiretroviral use and other risks for HIV-associated neuropathies in an international cohort. Neurology (2006) 1.47
Computerized mass detection for digital breast tomosynthesis directly from the projection images. Med Phys (2006) 1.46
The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol Cell Biol (2001) 1.46
Octopamine immunoreactivity in the fruit fly Drosophila melanogaster. J Comp Neurol (1995) 1.42
Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. Invest New Drugs (1986) 1.41
Research note: Estimating maternal deaths averted: A field-based methodology. Int J Gynaecol Obstet (2005) 1.41
Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae. Infect Immun (1997) 1.41
Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi). Phys Rev Lett (2006) 1.40
Appraisal of a new rapid enzyme strip. Med J Aust (1980) 1.40
Detection of alcoholism in hospitalized children and their families. Am J Dis Child (1991) 1.39
Similar symptoms and confounding conditions: benign prostatic hyperplasia versus hyperglycemia. Urol Nurs (2001) 1.39
Clonazepam in the treatment of obsessive compulsive disorder associated with panic disorder in one patient. J Clin Psychiatry (1989) 1.39
Translocation of Shiga toxin across polarized intestinal cells in tissue culture. Infect Immun (1996) 1.39
Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression. Proc Natl Acad Sci U S A (1987) 1.38
Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor. J Neurosci (1990) 1.38
Defective neural development in Drosophila melanogaster embryos deficient for the tip of the X chromosome. Dev Biol (1980) 1.38
Survival in metastatic ocular melanoma. Cancer (1983) 1.37
Remission and relapse in subjects with panic disorder and panic with agoraphobia: a prospective short-interval naturalistic follow-up. J Nerv Ment Dis (1994) 1.36
Molecular cytogenetic characterization of a critical region in bands 7q35-q36 commonly deleted in malignant myeloid disorders. Blood (1998) 1.36