PubRank

T P Sakmar

Author PubWeight™ 85.51‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat Med 1998 4.77
2 A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5. Proc Natl Acad Sci U S A 2000 3.10
3 Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin. Proc Natl Acad Sci U S A 1988 3.01
4 Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 1996 2.55
5 Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry. J Virol 1998 2.38
6 A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin. J Biol Chem 1988 2.37
7 Rhodopsin: structural basis of molecular physiology. Physiol Rev 2001 2.16
8 Rhodopsin mutants that bind but fail to activate transducin. Science 1990 2.16
9 Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120. Proc Natl Acad Sci U S A 2000 2.16
10 Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants. Proc Natl Acad Sci U S A 1993 1.97
11 How color visual pigments are tuned. Trends Biochem Sci 1999 1.82
12 Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. J Biol Chem 1992 1.82
13 Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state. Biochemistry 1996 1.66
14 A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. J Biol Chem 1994 1.63
15 Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits. J Biol Chem 2000 1.60
16 Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group. Biochemistry 1993 1.51
17 The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction. J Biol Chem 2000 1.42
18 Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6. Biochemistry 1998 1.41
19 Identification of glutamic acid 113 as the Schiff base proton acceptor in the metarhodopsin II photointermediate of rhodopsin. Biochemistry 1994 1.32
20 Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants. J Biol Chem 1998 1.32
21 The effects of amino acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin. J Biol Chem 1996 1.31
22 Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation. J Biol Chem 1993 1.29
23 Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments. Mol Pharmacol 1999 1.29
24 Functional interaction of transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant. J Biol Chem 1996 1.21
25 Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells. EMBO J 1995 1.18
26 Mutation of a conserved cysteine in the X-linked cone opsins causes color vision deficiencies by disrupting protein folding and stability. Invest Ophthalmol Vis Sci 1997 1.17
27 Introduction of hydroxyl-bearing amino acids causes bathochromic spectral shifts in rhodopsin. Amino acid substitutions responsible for red-green color pigment spectral tuning. J Biol Chem 1992 1.15
28 Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins. J Biol Chem 2001 1.15
29 Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 2001 1.14
30 The C9 methyl group of retinal interacts with glycine-121 in rhodopsin. Proc Natl Acad Sci U S A 1997 1.14
31 Light-dependent transducin activation by an ultraviolet-absorbing rhodopsin mutant. Biochemistry 1993 1.12
32 Transducin-dependent protonation of glutamic acid 134 in rhodopsin. Biochemistry 2000 1.10
33 Resonance Raman microprobe spectroscopy of rhodopsin mutants: effect of substitutions in the third transmembrane helix. Biochemistry 1992 1.09
34 Spectroscopic evidence for interaction between transmembrane helices 3 and 5 in rhodopsin. Biochemistry 1998 1.08
35 The steric trigger in rhodopsin activation. J Mol Biol 1997 1.05
36 Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding. J Biol Chem 1995 1.04
37 Characterization of the mutant visual pigment responsible for congenital night blindness: a biochemical and Fourier-transform infrared spectroscopy study. Biochemistry 1996 0.99
38 Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays. J Biol Chem 1995 0.96
39 The function of interdomain interactions in controlling nucleotide exchange rates in transducin. J Biol Chem 2001 0.94
40 Photoactivated state of rhodopsin and how it can form. Biophys Chem 1995 0.93
41 Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium. J Biol Chem 1999 0.93
42 pH dependence of photolysis intermediates in the photoactivation of rhodopsin mutant E113Q. Biochemistry 2000 0.91
43 Partial agonist activity of 11-cis-retinal in rhodopsin mutants. J Biol Chem 1997 0.91
44 Reconstitution of the vertebrate visual cascade using recombinant heterotrimeric transducin purified from Sf9 cells. Protein Expr Purif 2000 0.90
45 Evidence for the specific interaction of a lipid molecule with rhodopsin which is altered in the transition to the active state metarhodopsin II. FEBS Lett 1998 0.90
46 Assays for activation of recombinant expressed opsins by all-trans-retinals. Methods Enzymol 2000 0.89
47 Role of the C9 methyl group in rhodopsin activation: characterization of mutant opsins with the artificial chromophore 11-cis-9-demethylretinal. Biochemistry 1998 0.89
48 Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding. J Biol Chem 1994 0.88
49 Movement of the retinylidene Schiff base counterion in rhodopsin by one helix turn reverses the pH dependence of the metarhodopsin I to metarhodopsin II transition. J Biol Chem 1993 0.88
50 Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Proc Natl Acad Sci U S A 1996 0.88
51 Characterization of rhodopsin-transducin interaction: a mutant rhodopsin photoproduct with a protonated Schiff base activates transducin. Biochemistry 1994 0.88
52 A mutant rhodopsin photoproduct with a protonated Schiff base displays an active-state conformation: a Fourier-transform infrared spectroscopy study. Biochemistry 1994 0.87
53 Rhodopsin activation affects the environment of specific neighboring phospholipids: an FTIR spectroscopic study. Biophys J 2000 0.86
54 Studies on Limulus lysate coagulating system. Prog Clin Biol Res 1979 0.86
55 Chromophore structural changes in rhodopsin from nanoseconds to microseconds following pigment photolysis. Proc Natl Acad Sci U S A 1997 0.86
56 Time-resolved spectroscopy of the early photolysis intermediates of rhodopsin Schiff base counterion mutants. Biochemistry 1997 0.85
57 Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes. Biochemistry 2000 0.85
58 Colour tuning mechanisms of visual pigments. Novartis Found Symp 1999 0.83
59 A differential labelling model for determining the number of catalytically essential carboxyl groups in fumarase. Biochim Biophys Acta 1981 0.83
60 Spectroscopic evidence for altered chromophore--protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness. Biochemistry 1996 0.82
61 Selective stabilization of the high affinity binding conformation of glucagon receptor by the long splice variant of Galpha(s). J Biol Chem 2000 0.81
62 Properties of early photolysis intermediates of rhodopsin are affected by glycine 121 and phenylalanine 261. Biochemistry 1997 0.80
63 Structural determinants of active state conformation of rhodopsin: molecular biophysics approaches. Methods Enzymol 2000 0.78
64 Analysis of functional microdomains of rhodopsin. Methods Enzymol 2000 0.78
65 Studies on Limulus amoebocyte lysate. III. Purification of an endotoxin-binding protein from Limulus amoebocyte membranes. J Biol Chem 1980 0.76
66 Restoration of compact discs. Nat Genet 2000 0.75