Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors.

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Published in Nat Med on December 01, 1997

Authors

D W Laske1, R J Youle, E H Oldfield

Author Affiliations

1: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA.

Associated clinical trials:

A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients (AADC) | NCT02852213

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Hybridoma cells containing intracellular anti-ricin antibodies show ricin meets secretory antibody before entering the cytosol. J Biol Chem (1987) 1.06

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Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1. Cancer Res (1991) 1.06

Spinal cord swelling preceding syrinx development. Case report. J Neurosurg (2000) 1.06

Usefulness of inferior petrosal sinus venous endocrine markers in Cushing's disease. J Neurosurg (1988) 1.06