PubRank

P A Halban

Author PubWeight™ 107.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992 5.45
2 Proliferation of sorted human and rat beta cells. Diabetologia 2007 3.56
3 Regulation of immunoreactive-insulin release from a rat cell line (RINm5F). Biochem J 1983 1.85
4 Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin. Diabetes 2000 1.71
5 Insulin resistance in HIV protease inhibitor-associated diabetes. J Acquir Immune Defic Syndr 1999 1.61
6 Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells. Biochem J 2001 1.56
7 The possible importance of contact between pancreatic islet cells for the control of insulin release. Endocrinology 1982 1.55
8 A new, rapid, method for preparation of dispersed pancreatic acini. Biochem J 1985 1.53
9 SNAP-25 is expressed in islets of Langerhans and is involved in insulin release. J Cell Biol 1995 1.48
10 Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway. J Cell Biol 1987 1.43
11 Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content. J Biol Chem 1980 1.40
12 The preparation of a semisynthetic tritiated insulin with a specific radioactivity of up to 20 Curies per millimole. Biochem J 1975 1.37
13 Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the beta cell. Biochem Pharmacol 1980 1.35
14 Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 1997 1.34
15 Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation. J Cell Sci 1994 1.31
16 Uvomorulin mediates calcium-dependent aggregation of islet cells, whereas calcium-independent cell adhesion molecules distinguish between islet cell types. Dev Biol 1991 1.31
17 Functional differences between rat islets of ventral and dorsal pancreatic origin. J Clin Invest 1982 1.27
18 Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. Diabetologia 1979 1.22
19 SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion. J Biol Chem 1997 1.17
20 Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis. EMBO J 1996 1.15
21 Trafficking of non-regulated secretory proteins in insulin secreting (INS-1) cells. Diabetologia 2000 1.11
22 Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes 1987 1.11
23 Isolation of pancreatic islets and primary culture of the intact microorgans or of dispersed islet cells. Methods Enzymol 1990 1.08
24 Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types. Exp Cell Res 1990 1.08
25 Inhibition of proinsulin to insulin conversion in rat islets using arginine and lysine analogs. Lack of effect on rate of release of modified products. J Biol Chem 1982 1.06
26 Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells. Proc Natl Acad Sci U S A 1989 1.05
27 The degradation of semisynthetic tritiated insulin by perfused mouse livers. Biochem J 1976 1.05
28 Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription. Diabetologia 2003 1.04
29 Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. Diabetologia 2005 1.03
30 In vivo modulation of gap junctions and dye coupling between B-cells of the intact pancreatic islet. Diabetes 1983 1.03
31 Differential rates of release of newly synthesized and of stored insulin from pancreatic islets. Endocrinology 1982 1.03
32 Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor. J Neurochem 2002 1.02
33 Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells. J Cell Sci 2000 1.01
34 Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1. J Biol Chem 1997 1.01
35 The effect of aprotinin on the absorption of subcutaneously injected regular insulin in normal subjects. Diabetes 1980 1.00
36 Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. J Biol Chem 1987 1.00
37 Sorting human beta-cells consequent to targeted expression of green fluorescent protein. Diabetes 1998 1.00
38 Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet beta cells and non-beta cells. Biochem J 1994 0.99
39 Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia. Diabetologia 1997 0.99
40 Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro. Diabetologia 2002 0.99
41 Increased clearance and degradation of [3H]insulin in streptozotocin diabetic rats. J Clin Invest 1981 0.98
42 Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F). Biochem J 1983 0.98
43 The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide. Biochem J 1988 0.98
44 SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion. Biochem J 1999 0.96
45 Kinetics of proinsulin conversion in human islets. Diabetes 1993 0.96
46 Identification and characterization of alpha 3 beta 1 integrin on primary and transformed rat islet cells. Exp Cell Res 1997 0.96
47 Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon. FEBS Lett 1997 0.95
48 Dispersed adult rat pancreatic islet cells in culture: A, B, and D cell function. Metabolism 1984 0.94
49 Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PC1/3 in transformed beta cells. J Biol Chem 1993 0.94
50 Novel, non-crinophagic, degradation of connecting peptide in transformed pancreatic beta cells. J Biol Chem 1993 0.93
51 Proinsulin targeting to the regulated pathway is not impaired in carboxypeptidase E-deficient Cpefat/Cpefat mice. J Biol Chem 1997 0.93
52 Storage of tissue-type plasminogen activator in Weibel-Palade bodies of human endothelial cells. Arterioscler Thromb Vasc Biol 1999 0.92
53 Resistance of the insulin crystal to lysosomal proteases: implications for pancreatic B-cell crinophagy. Diabetologia 1987 0.92
54 Mobilization of subcutaneously injected tritiated insulin in rats: effects of muscular exercise. Diabetologia 1978 0.92
55 Trafficking/sorting and granule biogenesis in the beta-cell. Semin Cell Dev Biol 2000 0.92
56 Intracellular pathways of insulin transport across vascular endothelial cells. Am J Physiol 1988 0.91
57 Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT20 cells. J Biol Chem 1994 0.91
58 Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. J Clin Endocrinol Metab 2004 0.91
59 High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin. Diabetologia 1986 0.91
60 Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells. J Biol Chem 1989 0.90
61 Insulin degradation by hepatocytes in primary culture. Endocrinology 1981 0.90
62 Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II. Biochem J 1991 0.88
63 Distribution and metabolism of intravenously injected tritiated insulin in rats. Metabolism 1979 0.88
64 Tumor necrosis factor-alpha modifies adhesion properties of rat islet B cells. J Clin Invest 1993 0.87
65 Vascularization of purified pancreatic islet-like cell aggregates (pseudoislets) after syngeneic transplantation. Diabetes 1998 0.86
66 Des-(27-31)C-peptide. A novel secretory product of the rat pancreatic beta cell produced by truncation of proinsulin connecting peptide in secretory granules. J Biol Chem 1996 0.85
67 Proinsulin modified by analogues of arginine and lysine is degraded rapidly in pancreatic B-cells. Biochem J 1984 0.85
68 Inositol 1,4,5-trisphosphate receptor subtype 3 in pancreatic islet cell secretory granules revisited. Proc Natl Acad Sci U S A 1996 0.85
69 Influence of glucose on insulin handling by rat islets in culture. A reflection of integrated changes in insulin biosynthesis, release, and intracellular degradation. Diabetes 1983 0.85
70 Processing of proinsulin by transfected hepatoma (FAO) cells. J Biol Chem 1992 0.84
71 Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix. Diabetes 2001 0.84
72 Isolation of pancreatic islets of Langerhans by filtration on nylon mesh. Biochem Biophys Res Commun 1978 0.84
73 High-performance liquid chromatography analysis of circulating insulins distinguishes between endogenous insulin production (a potential pitfall with streptozotocin diabetic rats) and islet xenograft function. Diabetologia 1990 0.84
74 Biologic activity and pharmacokinetics of biosynthetic human insulin in the rat. Diabetes Care 1981 0.83
75 Elevated proinsulin biosynthesis in vitro from a rat model of non-insulin-dependent diabetes mellitus. Diabetes 1983 0.83
76 Heterogeneity of expression and secretion of native and mutant [AspB10]insulin in AtT20 cells. Mol Endocrinol 1991 0.83
77 Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets. FEBS Lett 1987 0.82
78 Role of clathrin in the regulated secretory pathway of pancreatic beta-cells. J Cell Sci 2001 0.82
79 Effects of aging on insulin synthesis and secretion. Differential effects on preproinsulin messenger RNA levels, proinsulin biosynthesis, and secretion of newly made and preformed insulin in the rat. J Clin Invest 1988 0.81
80 Relative hypersecretion of proinsulin in rat model of NIDDM. Diabetes 1991 0.81
81 Binding and degradation of semisynthetic tritiated insulin by IM-9 cultured human lymphocytes. Diabetes 1980 0.81
82 Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model. Diabetologia 2013 0.80
83 Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat. Diabetologia 2011 0.80
84 Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion. Diabetologia 2013 0.80
85 The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs. Mol Cell Endocrinol 1992 0.80
86 Islet B-cell dysfunction and the time course of recovery following chronic overinsulinisation of normal rats. Diabetologia 1988 0.79
87 SNAP-25 can self-associate to form a disulfide-linked complex. Biol Chem 1997 0.79
88 Pharmacokinetics of subcutaneously injected tritiated insulin: effects of exercise. Diabetes 1979 0.79
89 Hypoglycaemia caused by atypical insulin antibodies in a patient with benign monoclonal gammopathy. J Intern Med 1993 0.79
90 Truncated (des-[27-31]) C-peptide is not a major secretory product of human islets. Diabetologia 2002 0.79
91 Establishment and culture of insulin-secreting beta cell lines. Methods Enzymol 1990 0.78
92 Tris(hydroxymethyl)aminomethane inhibits the synthesis and processing of proinsulin in isolated rat pancreatic islets without affecting release of insulin stores. Diabetes 1986 0.78
93 Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells. Diabetologia 1993 0.78
94 Resistance against subcutaneous insulin successfully managed with aprotinin. Lancet 1980 0.78
95 Sequence requirements for proinsulin processing at the B-chain/C-peptide junction. Biochem J 1995 0.77
96 Processing of proinsulin by furin, PC2, and PC3 in (co) transfected COS (monkey kidney) cells. Diabetes 1995 0.77
97 Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats. Diabetologia 1990 0.77
98 Insulin production: from gene to granule. Diabetologia 1997 0.76
99 The GM2-1 ganglioside islet autoantigen in insulin-dependent diabetes mellitus is expressed in secretory granules and is not beta-cell specific. Endocrinology 1998 0.76
100 Proinsulin conversion in GH3 cells after coexpression of human proinsulin with the endoproteases PC2 and/or PC3. Diabetes 1997 0.76
101 Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease. Diabetes Obes Metab 2012 0.76
102 Proinsulin conversion intermediates: a possible source of confusion. Diabetologia 1991 0.75
103 Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor. Biochem J 1979 0.75
104 Degradation of pork insulin and biosynthetic human insulin in vitro and in vivo: a comparative study. Endocr Res Commun 1981 0.75
105 Internalization of 125I-insulin by IM-9 cultured human lymphocytes: a comparison between A14-monoiodo-pork and biosynthetic human insulin. Diabetes Care 1981 0.75
106 Sponsor, leader and lobbyist: the European Foundation for the Study of Diabetes (EFSD) and the future of diabetes research in Europe. Diabetologia 2000 0.75
107 Production of insulin antibodies by mice rejecting insulin transfected cells. J Autoimmun 1989 0.75
108 Perturbation of hormone storage and release induced by cyproheptadine in rat pancreatic islets in vitro. Endocrinology 1979 0.75
109 Modulation by sodium butyrate of the differentiated status of a clonal pancreatic B-cell line (RIN). Diabetes Res 1989 0.75