Two distinct protein-protein interactions between the NIT2 and NMR regulatory proteins are required to establish nitrogen metabolite repression in Neurospora crassa.

PubWeight™: 0.92‹?›

🔗 View Article (PMID 9427402)

Published in Mol Microbiol on November 01, 1997

Authors

H Pan1, B Feng, G A Marzluf

Author Affiliations

1: Department of Biochemistry, The Ohio State University, Columbus 43210, USA.

Articles citing this

Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67

Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in Aspergillus nidulans and a member of the "streetwise" GATA family of transcription factors. Microbiol Mol Biol Rev (1998) 1.29

Recent advances in nitrogen regulation: a comparison between Saccharomyces cerevisiae and filamentous fungi. Eukaryot Cell (2008) 1.14

Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans. Genetics (2011) 1.00

Cross-species hybridization with Fusarium verticillioides microarrays reveals new insights into Fusarium fujikuroi nitrogen regulation and the role of AreA and NMR. Eukaryot Cell (2008) 0.98

Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis. Protein Sci (2004) 0.98

Nitrogen regulation of fungal secondary metabolism in fungi. Front Microbiol (2014) 0.97

GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans. Fungal Genet Biol (2007) 0.91

Deletion of the 389 N-terminal residues of the transcriptional activator AREA does not result in nitrogen metabolite derepression in Aspergillus nidulans. J Bacteriol (1998) 0.87

The TamA protein fused to a DNA-binding domain can recruit AreA, the major nitrogen regulatory protein, to activate gene expression in Aspergillus nidulans. Genetics (1999) 0.86

Characterization of pco-1, a newly identified gene which regulates purine catabolism in Neurospora. Curr Genet (2004) 0.83

Characterization of an Nmr homolog that modulates GATA factor-mediated nitrogen metabolite repression in Cryptococcus neoformans. PLoS One (2012) 0.80

The Ustilago maydis Nit2 homolog regulates nitrogen utilization and is required for efficient induction of filamentous growth. Eukaryot Cell (2012) 0.78

Cooperative action of the NIT2 and NIT4 transcription factors upon gene expression in Neurospora crassa. Curr Genet (2003) 0.77

Ure2 is involved in nitrogen catabolite repression and salt tolerance via Ca2+ homeostasis and calcineurin activation in the yeast Hansenula polymorpha. J Biol Chem (2010) 0.77

Articles by these authors

Positive control by the cys-3 locus in regulation of sulfur metabolism in Neurospora. J Mol Biol (1968) 3.24

Regulation of nitrogen metabolism and gene expression in fungi. Microbiol Rev (1981) 2.71

nit-2, the major nitrogen regulatory gene of Neurospora crassa, encodes a protein with a putative zinc finger DNA-binding domain. Mol Cell Biol (1990) 2.25

nit-2, the major positive-acting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. Proc Natl Acad Sci U S A (1990) 2.24

Control of the synthesis of a single enzyme by multiple regulatory circuits in Neurospora crassa. Proc Natl Acad Sci U S A (1975) 1.92

Genetic and metabolic control of the purine catabolic enzymes of Neurospora crasse. Mol Gen Genet (1975) 1.87

Characterization of the sequence complexity and organization of the Neurospora crassa genome. Biochemistry (1979) 1.86

Genome organization and characterization of the repetitive and inverted repeat DNA sequences in Neurospora crassa. J Biol Chem (1980) 1.73

Characterization of nit-2, the major nitrogen regulatory gene of Neurospora crassa. Mol Cell Biol (1987) 1.73

Genetic and biochemical studies of distinct sulfate permease species in different developmental stages of Neurospora crassa. Arch Biochem Biophys (1970) 1.58

nit-4, a pathway-specific regulatory gene of Neurospora crassa, encodes a protein with a putative binuclear zinc DNA-binding domain. Mol Cell Biol (1991) 1.50

Nitrogen regulation of amino acid catabolism in Neurospora crassa. Biochem Genet (1978) 1.50

Transformation of Neurospora crassa with circular and linear DNA and analysis of the fate of the transforming DNA. Curr Genet (1985) 1.50

Molecular cloning and analysis of the regulation of nit-3, the structural gene for nitrate reductase in Neurospora crassa. Proc Natl Acad Sci U S A (1987) 1.45

Regulation of a sulfur-controlled protease in Neurospora crassa. J Bacteriol (1973) 1.44

Amber nonsense mutations in regulatory and structural genes of the nitrogen control circuit of Neurospora crassa. Curr Genet (1986) 1.43

Gene disruption by transformation in Neurospora crassa. Mol Cell Biol (1985) 1.43

cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a protein with a putative leucine zipper DNA-binding element. Mol Cell Biol (1989) 1.36

Metabolic control and autogenous regulation of nit-3, the nitrate reductase structural gene of Neurospora crassa. J Bacteriol (1988) 1.35

Molecular cloning and characterization of the cys-3 regulatory gene of Neurospora crassa. Mol Cell Biol (1987) 1.31

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions. Pharmacol Ther (1993) 1.29

The negative-acting NMR regulatory protein of Neurospora crassa binds to and inhibits the DNA-binding activity of the positive-acting nitrogen regulatory protein NIT2. Biochemistry (1995) 1.27

Identification of the product of the major regulatory gene of the nitrogen control circuit of Neurospora crassa as a nuclear DNA-binding protein. J Biol Chem (1981) 1.26

Genetic and metabolic controls for sulfate metabolism in Neurospora crassa: isolation and study of chromate-resistant and sulfate transport-negative mutants. J Bacteriol (1970) 1.25

Specificity and regulation of peptide transport on Neurospora crassa. Arch Biochem Biophys (1975) 1.20

Regulation of the purine catabolic enzymes in Neurospora crassa. Arch Biochem Biophys (1975) 1.20

Isolation, characterization and disruption of the areA nitrogen regulatory gene of Gibberella fujikuroi. Mol Gen Genet (1999) 1.19

Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position. Clin Pharmacol Ther (2013) 1.19

Regulation of L-amino acid oxidase and of D-amino acid oxidase in Neurospora crassa. Mol Gen Genet (1982) 1.18

Isolation of nit-4, the minor nitrogen regulatory gene which mediates nitrate induction in Neurospora crassa. J Bacteriol (1989) 1.17

Nit-3, the structural gene of nitrate reductase in Neurospora crassa: nucleotide sequence and regulation of mRNA synthesis and turnover. Mol Gen Genet (1991) 1.15

Genetic and metabolic regulation of purine base transport in Neurospora crassa. Mol Gen Genet (1976) 1.15

Plasmid recovery from transformants and the isolation of chromosomal DNA segments improving plasmid replication in Neurospora crassa. Curr Genet (1985) 1.14

Transformation of Neurospora crassa with the trp-1 gene and the effect of host strain upon the fate of the transforming DNA. Curr Genet (1988) 1.14

Regulation of L-phenylalanine ammonia-lyase by L-phenylalanine and nitrogen in Neurospora crassa. J Bacteriol (1982) 1.13

Molecular cloning and analysis of the regulation of cys-14+, a structural gene of the sulfur regulatory circuit of Neurospora crassa. Mol Cell Biol (1988) 1.13

Isolation and characterization of a new gene, sre, which encodes a GATA-type regulatory protein that controls iron transport in Neurospora crassa. Mol Gen Genet (1998) 1.12

Immunohistoselective sequencing (IHSS) of p53 tumor suppressor gene in human oesophageal precancerous lesions. Carcinogenesis (1996) 1.11

Enzymatic studies with the suppressor of vermilion of Drosophila melanogaster. Genetics (1965) 1.11

Role of p53 gene mutations in human esophageal carcinogenesis: results from immunohistochemical and mutation analyses of carcinomas and nearby non-cancerous lesions. Carcinogenesis (1999) 1.11

Small proteins that modulate calmodulin-dependent signal transduction: effects of PEP-19, neuromodulin, and neurogranin on enzyme activation and cellular homeostasis. Mol Neurobiol (2001) 1.11

Control of the synthesis, activity, and turnover of enzymes of sulfur metabolism in Neurospora crassa. Arch Biochem Biophys (1972) 1.10

Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation. Mol Psychiatry (2013) 1.08

Molecular cloning and analysis of nre, the major nitrogen regulatory gene of Penicillium chrysogenum. Curr Genet (1995) 1.08

Uptake and efflux of sulfate in Neurospora crassa. Biochim Biophys Acta (1974) 1.08

Nucleotide sequence, messenger RNA stability, and DNA recognition elements of cys-14, the structural gene for sulfate permease II in Neurospora crassa. Biochemistry (1991) 1.07

Ocular components measured by keratometry, phakometry, and ultrasonography in emmetropic and myopic optometry students. Optom Vis Sci (1997) 1.06

Preventing renal ischemia-reperfusion injury using small interfering RNA by targeting complement 3 gene. Am J Transplant (2006) 1.06

Sequence complexity and abundance classes of nuclear and polysomal polyadenylated RNA in Neurospora crassa. Biochim Biophys Acta (1980) 1.06

Nucleotide sequence and analysis of NMR, a negative-acting regulatory gene in the nitrogen circuit of Neurospora crassa. Mol Gen Genet (1990) 1.05

Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. J Pharmacol Exp Ther (2001) 1.05

Sequencing and preliminary characterization of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio harveyi. Biochemistry (1999) 1.05

The specific interaction of chromate with the dual sulfate permease systems of Neurospora crassa. Arch Biochem Biophys (1971) 1.04

Size restriction on utilization of peptides by amino acid auxotrophs of Neurospora crassa. J Bacteriol (1975) 1.03

Genetic and metabolic control of sulfate metabolism in Neurospora crassa: a specific permease for choline-O-sulfate. Biochem Genet (1972) 1.03

Common and contrasting genomic profiles among the major human lung cancer subtypes. Cold Spring Harb Symp Quant Biol (2005) 1.00

Peptide utilization by amino acid auxotrophs of Neurospora crassa. J Bacteriol (1974) 1.00

Interaction between major nitrogen regulatory protein NIT2 and pathway-specific regulatory factor NIT4 is required for their synergistic activation of gene expression in Neurospora crassa. Mol Cell Biol (1998) 0.99

Nitrogen regulation of uricase synthesis in Neurospora crassa. Mol Gen Genet (1979) 0.99

DNA recognition by the NIT2 nitrogen regulatory protein: importance of the number, spacing, and orientation of GATA core elements and their flanking sequences upon NIT2 binding. Biochemistry (1994) 0.99

cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. J Biol Chem (1990) 0.98

Statins for primary prevention of cardiovascular and cerebrovascular events in diabetic patients without established cardiovascular diseases: a meta-analysis. Exp Clin Endocrinol Diabetes (2011) 0.98

ASD4, a new GATA factor of Neurospora crassa, displays sequence-specific DNA binding and functions in ascus and ascospore development. Biochemistry (2000) 0.97

Molecular cloning and characterization of a negative-acting nitrogen regulatory gene of Neurospora crassa. Mol Gen Genet (1988) 0.97

Functional analysis of the two zinc fingers of SRE, a GATA-type factor that negatively regulates siderophore synthesis in Neurospora crassa. Biochemistry (1999) 0.96

Perception of foreign cigarettes and their advertising in China: a study of college students from 12 universities. Tob Control (1998) 0.96

Sequence-specific DNA binding by NIT4, the pathway-specific regulatory protein that mediates nitrate induction in Neurospora. Mol Microbiol (1995) 0.95

Regulation of sulfate transport in neurospora by transinhibition and by inositol depletion. Arch Biochem Biophys (1973) 0.93

Transporter studies in drug development: experience to date and follow-up on decision trees from the International Transporter Consortium. Clin Pharmacol Ther (2013) 0.91

Induction and de novo synthesis of uricase, a nitrogen-regulated enzyme in Neurospora crassa. J Bacteriol (1987) 0.91

Major extracellular protease of Neurospora crassa. J Bacteriol (1984) 0.91

NRE, the major nitrogen regulatory protein of Penicillium chrysogenum, binds specifically to elements in the intergenic promoter regions of nitrate assimilation and penicillin biosynthetic gene clusters. Curr Genet (1995) 0.91

Recognition of specific nucleotide bases and cooperative DNA binding by the trans-acting nitrogen regulatory protein NIT2 of Neurospora crassa. Nucleic Acids Res (1993) 0.91

A color-selectable and site-specific integrative transformation system for gene expression studies in the dematiaceous fungus Wangiella (Exophiala) dermatitidis. Curr Genet (1999) 0.90

Nitrogen regulation of acid phosphatase in Neurospora crassa. J Bacteriol (1980) 0.90

Vascular endothelial growth factors C and D represent novel prognostic markers in colorectal carcinoma using quantitative image analysis. Eur Surg Res (2007) 0.90

A reporter gene analysis of penicillin biosynthesis gene expression in Penicillium chrysogenum and its regulation by nitrogen and glucose catabolite repression. Appl Environ Microbiol (1994) 0.90

Analysis of conventional and in vitro generated mutants of nmr, the negatively acting nitrogen regulatory gene of Neurospora crassa. Mol Gen Genet (1990) 0.89

Mutational analysis of the DNA-binding domain of the CYS3 regulatory protein of Neurospora crassa. Mol Cell Biol (1991) 0.89

Molecular comparison of the negative-acting nitrogen control gene, nmr, in Neurospora crassa and other Neurospora and fungal species. Biochem Genet (1991) 0.88

Multiple intracellular peptidases in Neurospora crassa. J Bacteriol (1979) 0.88

Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents. Am J Physiol Gastrointest Liver Physiol (2010) 0.88

Newer antifungal agents for fungal infection prevention during hematopoietic cell transplantation: a meta-analysis. Transplant Proc (2013) 0.88

Binding affinity and functional significance of NIT2 and NIT4 binding sites in the promoter of the highly regulated nit-3 gene, which encodes nitrate reductase in Neurospora crassa. J Bacteriol (1995) 0.87

NIT2, the nitrogen regulatory protein of Neurospora crassa, binds upstream of nia, the tomato nitrate reductase gene, in vitro. Curr Genet (1992) 0.86

Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats. Neuroscience (2007) 0.86

Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes. Curr Genet (1995) 0.86

The regulatory protein NIT4 that mediates nitrate induction in Neurospora crassa contains a complex tripartite activation domain with a novel leucine-rich, acidic motif. Curr Genet (1996) 0.85

DNA binding site specificity of the Neurospora global nitrogen regulatory protein NIT2: analysis with mutated binding sites. Mol Gen Genet (1994) 0.84

The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia (2009) 0.84

Amino-acid substitutions in the zinc finger of NIT2, the nitrogen regulatory protein of Neurospora crassa, alter promoter element recognition. Curr Genet (1993) 0.84

Electrospray ionization Fourier transform ion cyclotron resonance analysis of large polymerase chain reaction products. J Am Soc Mass Spectrom (2000) 0.84

Isolation and characterization of cadmium-resistant mutants of Neurospora crassa. Can J Microbiol (1989) 0.84

The NIT2 nitrogen regulatory protein of Neurospora: expression and stability of nit-2 mRNA and protein. Curr Genet (1999) 0.84

Characterization of pco-1, a newly identified gene which regulates purine catabolism in Neurospora. Curr Genet (2004) 0.83

The positive-acting sulfur regulatory protein CYS3 of Neurospora crassa: nuclear localization, autogenous control, and regions required for transcriptional activation. Mol Gen Genet (1993) 0.83

Determination of the Neurospora crassa CYS 3 sulfur regulatory protein consensus DNA-binding site: amino-acid substitutions in the CYS3 bZIP domain that alter DNA-binding specificity. Curr Genet (1996) 0.83

Nucleotide sequence and DNA recognition elements of alc, the structural gene which encodes allantoicase, a purine catabolic enzyme of Neurospora crassa. Biochemistry (1990) 0.83