PubRank

S Younkin

Author PubWeight™ 63.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996 19.72
2 Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996 10.44
3 Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998 5.78
4 Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 1996 5.50
5 Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 1995 2.45
6 APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 2001 2.31
7 SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci 1999 2.21
8 Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci U S A 2000 1.66
9 A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease. Ann Clin Biochem 2009 1.66
10 An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron 1998 1.37
11 Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. J Neurosci 1997 1.33
12 Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion. Neurobiol Dis 1998 1.24
13 Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiol Aging 2003 1.19
14 Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury. J Comp Neurol 1998 1.05
15 Candida parapsilosis infection of a total hip-joint replacement: successful reimplantation after treatment with amphotericin B and 5-fluorocytosine. A case report. J Bone Joint Surg Am 1984 0.88
16 Increased Abeta42(43) from cell lines expressing presenilin 1 mutations. Ann Neurol 1998 0.87
17 Detection and quantitation of cellularly derived amyloid beta peptides by immunoprecipitation-HPLC-MS. FEBS Lett 1998 0.82
18 Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40. Neuroreport 1998 0.79
19 Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells. J Biol Chem 2000 0.79
20 Bone mineral density and L-thyroxine treatment in rapidly cycling bipolar disorder. Biol Psychiatry 1997 0.79
21 Mechanism of the hydrogen peroxide hemolysis test and its reversal with phenols. Am J Clin Nutr 1971 0.78
22 Analysis of in vivo-derived amyloid-beta polypeptides by on-line two-dimensional chromatography-mass spectrometry. Anal Biochem 2001 0.77
23 Molecular biology of Alzheimer's disease. Mol Genet Med 1993 0.75
24 A transient increase in junctional acetylcholine receptors after denervation. Brain Res 1981 0.75