Genetics and the pathobiology of ageing.

Epigenetic drift in aging identical twins. Proc Natl Acad Sci U S A (2005) 1.42

Werner protein recruits DNA polymerase delta to the nucleolus. Proc Natl Acad Sci U S A (2000) 1.23

Stem cells from birth to death: The history and the future. J Am Aging Assoc (2002) 0.77

Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics. DNA Repair (Amst) (2012) 0.75

Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal. Nucleic Acids Res (2014) 0.75

Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science (1993) 33.32

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature (1991) 16.77

Positional cloning of the Werner's syndrome gene. Science (1996) 10.98

Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science (1995) 8.31

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest (1970) 6.44

Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) (1966) 6.15

Evolution of senescence: late survival sacrificed for reproduction. Philos Trans R Soc Lond B Biol Sci (1991) 5.93

Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci U S A (1973) 4.72

Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci (1997) 4.57

Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci U S A (1989) 3.55

Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat Genet (1996) 3.19

Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol Biomarkers Prev (1996) 2.76

Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst (1997) 2.74

Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res (1997) 2.18

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res (1992) 1.98

Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet (1996) 1.90

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet (1981) 1.85

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet (1997) 1.52

Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet Cell Genet (1975) 1.45

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet (1996) 1.43

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. Am J Pathol (1991) 1.37

Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature (1992) 1.37

Progeria: a human-disease model of accelerated aging. Am J Clin Nutr (1992) 1.29

Genetic aspects of familial amyloidosis with corneal lattice dystrophy and cranial neuropathy. Clin Genet (1973) 1.24

Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J Clin Endocrinol Metab (1996) 1.22

Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum Mol Genet (1996) 1.19

Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts. Exp Gerontol (1982) 1.18

Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet (1997) 1.17

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum Genet (1990) 1.16

Scanning the genome with 1772 microsatellite markers in search of a bipolar disorder susceptibility gene. Mol Psychiatry (1996) 1.15

Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature. Clin Genet (1981) 1.13

Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis. Ann N Y Acad Sci (1996) 1.11

Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J Invest Dermatol (1994) 1.05

Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. Am J Hum Genet (1996) 1.03

Homozygosity mapping and Werner's syndrome. Lancet (1992) 1.02

Dietary restriction. Exp Gerontol (1995) 1.00

Dopamine and serotonin systems in human and rodent brain: effects of age and neurodegenerative disease. J Am Geriatr Soc (1987) 0.99

Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol (1995) 0.97

Syndromes of accelerated aging. Natl Cancer Inst Monogr (1982) 0.91

Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the 'oldest old'. Brain Res (1985) 0.87

Finnish type of familial amyloidosis: cosegregation of Asp187----Asn mutation of gelsolin with the disease in three large families. Am J Hum Genet (1991) 0.87

Characteristics of familial Alzheimer's disease in nine kindreds of Volga German ancestry. Prog Clin Biol Res (1989) 0.85

No detectable mutations at Werner helicase locus in progeria. Lancet (1996) 0.85

Interactions of aging and environmental agents: the gerontological perspective. Prog Clin Biol Res (1987) 0.84

Alzheimer's disease. Missense on the membrane. Nature (1995) 0.82

The significance of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Ciba Found Symp (1987) 0.77

Neuronal plasticity in normal aging and deficient plasticity in Alzheimer's disease: a proposed intercellular signal cascade. Prog Brain Res (1990) 0.77

Osteosclerosis of the phalanges in Werner syndrome. Radiology (1989) 0.77

Looking into the black box: new directions in neuroimaging. Neuron (1996) 0.76

Lessons from human progeroid syndromes. Nature (2000) 1.70

Somatic mutations are frequent and increase with age in human kidney epithelial cells. Hum Mol Genet (1996) 1.50

Somatic mutagenesis and antimutagenesis in aging research. Mutat Res (1996) 0.80