Published in Cytokine Growth Factor Rev on September 01, 1997
Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res (2005) 4.24
WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A (1998) 3.73
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev (2006) 3.16
The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. Nature (2000) 2.82
The CCN family of proteins: structure-function relationships. Trends Biochem Sci (2008) 2.82
Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol (1999) 2.67
Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther (2002) 2.63
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest (2011) 2.54
Transforming growth factor-beta and fibrosis. World J Gastroenterol (2007) 2.35
Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology (2006) 2.26
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease? J Cell Commun Signal (2009) 2.00
Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J Invest Dermatol (2009) 1.93
Lower urinary connective tissue growth factor levels and incident CKD stage 3 in the general population. Am J Kidney Dis (2011) 1.88
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells. Biochem J (2006) 1.72
The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy. PLoS One (2008) 1.68
Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol (2003) 1.64
Enhanced myofibroblastic differentiation and survival in Thy-1(-) lung fibroblasts. Am J Respir Cell Mol Biol (2006) 1.54
Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair. Proc Natl Acad Sci U S A (2001) 1.47
Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload. PLoS One (2009) 1.43
Regulatory mechanisms of TGF-β1-induced fibrogenesis of human alveolar epithelial cells. J Cell Mol Med (2016) 1.40
Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts. PLoS One (2017) 1.39
Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. Fibrogenesis Tissue Repair (2010) 1.37
The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol (2006) 1.36
Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it? J Cell Commun Signal (2009) 1.33
Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol (2001) 1.32
Interstitial fibrosis and growth factors. Environ Health Perspect (2000) 1.32
Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem J (2001) 1.32
Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. Am J Pathol (2001) 1.31
Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression. J Am Soc Nephrol (2015) 1.30
Median nerve trauma in a rat model of work-related musculoskeletal disorder. J Neurotrauma (2003) 1.28
The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts. Mol Pathol (2001) 1.24
TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis. J Oncol (2015) 1.23
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol (2009) 1.22
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation. FASEB J (2013) 1.18
Mammalian twisted gastrulation is essential for skeleto-lymphogenesis. Mol Cell Biol (2003) 1.17
Advances in antifibrotic therapy. Expert Rev Gastroenterol Hepatol (2008) 1.17
Determinants of initiation and progression of idiopathic pulmonary fibrosis. Respirology (2009) 1.16
Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression. J Mammary Gland Biol Neoplasia (2009) 1.15
Conditional overexpression of connective tissue growth factor disrupts postnatal lung development. Am J Respir Cell Mol Biol (2009) 1.11
Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci (2008) 1.11
Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring. Am J Pathol (2003) 1.11
Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis Rheum (2010) 1.11
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice. J Histochem Cytochem (2007) 1.10
Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal (2009) 1.09
CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network. PLoS One (2011) 1.09
Cellular and molecular mechanisms of intestinal fibrosis. World J Gastroenterol (2012) 1.07
Molecular targets for treatment of kidney fibrosis. J Mol Med (Berl) (2012) 1.06
Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's-derived fibroblasts. BMC Musculoskelet Disord (2011) 1.06
Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. Br J Ophthalmol (2004) 1.05
Scar wars: is TGFbeta the phantom menace in scleroderma? Arthritis Res Ther (2006) 1.05
The mechanism of TGF-β signaling during palate development. Oral Dis (2011) 1.04
Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor-β1-connective tissue growth factor signalling cascade. Clin Exp Pharmacol Physiol (2011) 1.03
Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo. J Invest Dermatol (2012) 1.03
New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses. Am J Respir Crit Care Med (2014) 1.02
Molecular mechanisms and in vivo mouse models of skin aging associated with dermal matrix alterations. Lab Anim Res (2011) 1.02
Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF). Respir Res (2010) 1.01
Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther (2009) 1.01
Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). Br J Pharmacol (2001) 1.00
Angiotensin II increases connective tissue growth factor in the kidney. Am J Pathol (2003) 1.00
Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness. Exp Cell Res (2007) 0.99
Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts. Bone (2008) 0.99
Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. BMC Complement Altern Med (2012) 0.98
CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2011) 0.97
Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. J Cell Commun Signal (2009) 0.97
Myofibroblasts: paracrine cells important in health and disease. Trans Am Clin Climatol Assoc (2000) 0.97
Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review). Int J Oncol (2015) 0.96
Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol (2011) 0.96
Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN Rheumatol (2013) 0.95
Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms. Mol Pathol (2001) 0.95
Attenuation of fibrosis in vitro and in vivo with SPARC siRNA. Arthritis Res Ther (2010) 0.95
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice. J Histochem Cytochem (2008) 0.95
Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma. RNA (2012) 0.95
Extracellular matrix-mediated differentiation of periodontal progenitor cells. Differentiation (2009) 0.94
Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation. Am J Pathol (2014) 0.93
Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor. Endocrinology (2008) 0.93
A connective tissue growth factor signaling receptor in corneal fibroblasts. Invest Ophthalmol Vis Sci (2012) 0.92
Site-specific keloid fibroblasts alter the behaviour of normal skin and normal scar fibroblasts through paracrine signalling. PLoS One (2013) 0.92
Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose. Clin Exp Nephrol (2005) 0.91
TGF-β-stimulated CTGF production enhanced by collagen and associated with biogenesis of a novel 31-kDa CTGF form in human corneal fibroblasts. Invest Ophthalmol Vis Sci (2010) 0.90
Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin. J Biol Chem (2009) 0.90
Fibrogenesis in kidney transplantation: potential targets for prevention and therapy. Transplantation (2009) 0.90
Integrins as Modulators of Transforming Growth Factor Beta Signaling in Dermal Fibroblasts During Skin Regeneration After Injury. Adv Wound Care (New Rochelle) (2013) 0.89
Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation. Mol Cell Biol (2008) 0.89
Possible strategies for anti-fibrotic drug intervention in scleroderma. J Cell Commun Signal (2011) 0.89
TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels. Respir Res (2005) 0.89
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). Int J Mol Med (2015) 0.88
Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFβ2 and its receptor TGFβRII. Invest Ophthalmol Vis Sci (2011) 0.87
Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro. Jpn J Ophthalmol (2008) 0.86
Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro. Mol Vis (2011) 0.86
Aldosterone upregulates connective tissue growth factor gene expression via p38 MAPK pathway and mineralocorticoid receptor in ventricular myocytes. J Korean Med Sci (2004) 0.86
Matricellular proteins and biomaterials. Matrix Biol (2014) 0.86
Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now? Drugs (2016) 0.85
Conditional knockout of CTGF affects corneal wound healing. Invest Ophthalmol Vis Sci (2014) 0.85