| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.
|
Nature
|
1997
|
15.75
|
|
2
|
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.
|
EMBO J
|
1998
|
10.01
|
|
3
|
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
|
Science
|
1997
|
9.53
|
|
4
|
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
|
Nature
|
1997
|
7.69
|
|
5
|
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.
|
EMBO J
|
1997
|
4.48
|
|
6
|
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.
|
Proc Natl Acad Sci U S A
|
2000
|
4.08
|
|
7
|
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
|
Cell
|
1993
|
3.57
|
|
8
|
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
|
J Cell Sci
|
1999
|
3.43
|
|
9
|
Apoptosis in podocytes induced by TGF-beta and Smad7.
|
J Clin Invest
|
2001
|
3.40
|
|
10
|
Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice.
|
EMBO J
|
2001
|
3.24
|
|
11
|
Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.
|
J Biol Chem
|
1998
|
3.23
|
|
12
|
The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation.
|
FEBS Lett
|
1998
|
3.00
|
|
13
|
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis.
|
J Cell Sci
|
2007
|
2.95
|
|
14
|
TGF-beta signaling by Smad proteins.
|
Adv Immunol
|
2000
|
2.47
|
|
15
|
Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells.
|
FEBS Lett
|
2001
|
2.46
|
|
16
|
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.
|
J Biol Chem
|
1997
|
2.39
|
|
17
|
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
|
J Cell Biol
|
1995
|
2.36
|
|
18
|
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.
|
J Biol Chem
|
2000
|
2.31
|
|
19
|
Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs.
|
Mol Cell
|
2000
|
2.23
|
|
20
|
Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
|
Proc Natl Acad Sci U S A
|
1995
|
2.19
|
|
21
|
Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development.
|
Development
|
2000
|
1.89
|
|
22
|
Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms.
|
J Biol Chem
|
1990
|
1.86
|
|
23
|
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
|
Biochem Biophys Res Commun
|
1998
|
1.85
|
|
24
|
DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells.
|
Oncogene
|
1997
|
1.77
|
|
25
|
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway.
|
J Biol Chem
|
1997
|
1.66
|
|
26
|
Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.
|
J Biol Chem
|
1994
|
1.61
|
|
27
|
Transforming growth factor beta1 induces nuclear export of inhibitory Smad7.
|
J Biol Chem
|
1998
|
1.61
|
|
28
|
Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia.
|
J Immunol
|
1992
|
1.47
|
|
29
|
Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells.
|
J Biol Chem
|
1999
|
1.41
|
|
30
|
Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.
|
J Biol Chem
|
1994
|
1.39
|
|
31
|
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.
|
EMBO J
|
2001
|
1.34
|
|
32
|
Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter.
|
J Biol Chem
|
2000
|
1.33
|
|
33
|
SMAD3 represses androgen receptor-mediated transcription.
|
Cancer Res
|
2001
|
1.32
|
|
34
|
Genomic characterization of the human DNA excision repair gene ERCC-1.
|
Nucleic Acids Res
|
1987
|
1.31
|
|
35
|
Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats.
|
Bone
|
1998
|
1.27
|
|
36
|
Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation.
|
Am J Respir Cell Mol Biol
|
2001
|
1.24
|
|
37
|
Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.
|
J Biol Chem
|
1994
|
1.24
|
|
38
|
Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.
|
J Biol Chem
|
2000
|
1.23
|
|
39
|
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.
|
Nucleic Acids Res
|
2000
|
1.23
|
|
40
|
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.
|
J Biol Chem
|
1998
|
1.23
|
|
41
|
Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells.
|
Curr Biol
|
2000
|
1.23
|
|
42
|
Expression of Smad proteins in human colorectal cancer.
|
Int J Cancer
|
1999
|
1.21
|
|
43
|
Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis.
|
J Bone Miner Res
|
1998
|
1.20
|
|
44
|
Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.
|
Kidney Int
|
2007
|
1.18
|
|
45
|
Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration.
|
Cancer Res
|
1999
|
1.18
|
|
46
|
Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads.
|
J Biol Chem
|
2001
|
1.18
|
|
47
|
A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system.
|
J Biol Chem
|
1996
|
1.17
|
|
48
|
Human mast cell migration in response to members of the transforming growth factor-beta family.
|
J Leukoc Biol
|
2000
|
1.14
|
|
49
|
Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells.
|
J Biol Chem
|
1998
|
1.12
|
|
50
|
Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum.
|
Bone
|
1997
|
1.12
|
|
51
|
Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line.
|
Genes Cells
|
1998
|
1.11
|
|
52
|
Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis.
|
Mech Dev
|
1995
|
1.10
|
|
53
|
Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes.
|
Dev Biol
|
1999
|
1.09
|
|
54
|
Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases.
|
Biochem Biophys Res Commun
|
1998
|
1.09
|
|
55
|
Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway.
|
Biochem Soc Trans
|
2006
|
1.09
|
|
56
|
Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis.
|
Lab Invest
|
1994
|
1.08
|
|
57
|
Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation.
|
J Bone Miner Res
|
1995
|
1.08
|
|
58
|
The prognostic role of TGF-β signaling pathway in breast cancer patients.
|
Ann Oncol
|
2012
|
1.04
|
|
59
|
Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.
|
Dev Cell
|
2001
|
1.01
|
|
60
|
Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix.
|
J Biol Chem
|
1995
|
1.00
|
|
61
|
Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors.
|
Mol Cell Endocrinol
|
1996
|
0.99
|
|
62
|
Intracellular signaling of osteogenic protein-1 through Smad5 activation.
|
J Cell Physiol
|
1998
|
0.99
|
|
63
|
Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.
|
EMBO J
|
1996
|
0.99
|
|
64
|
Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity.
|
Cell Signal
|
2001
|
0.96
|
|
65
|
Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament.
|
Am J Pathol
|
1997
|
0.95
|
|
66
|
Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis.
|
Dev Dyn
|
2000
|
0.95
|
|
67
|
ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells.
|
Oncogene
|
2006
|
0.95
|
|
68
|
Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells.
|
J Cell Physiol
|
1999
|
0.94
|
|
69
|
The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line.
|
J Biol Chem
|
2000
|
0.93
|
|
70
|
Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma.
|
Oncogene
|
2010
|
0.93
|
|
71
|
Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments.
|
Growth Factors
|
2000
|
0.92
|
|
72
|
Immunohistochemical detection of activin A, follistatin, and activin receptors during fracture healing in the rat.
|
J Orthop Res
|
1998
|
0.91
|
|
73
|
Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.
|
Br J Cancer
|
1996
|
0.90
|
|
74
|
Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide.
|
Mol Endocrinol
|
1992
|
0.87
|
|
75
|
Expression of TGF-beta related Smad proteins in human epithelial skin tumors.
|
Int J Oncol
|
1999
|
0.87
|
|
76
|
Signal transduction via serine/threonine kinase receptors.
|
Semin Cell Biol
|
1994
|
0.86
|
|
77
|
Expression of transforming growth factor-beta1, activin A, and their receptors in thyroid follicle cells: negative regulation of thyrocyte growth and function.
|
Endocrinology
|
1999
|
0.86
|
|
78
|
Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer.
|
Genes Chromosomes Cancer
|
1999
|
0.86
|
|
79
|
IL-1 beta and IL-6 selectively induce transforming growth factor-beta isoforms in human articular chondrocytes.
|
J Immunol
|
1993
|
0.84
|
|
80
|
Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.
|
Mamm Genome
|
1999
|
0.83
|
|
81
|
SMAD destruction turns off signalling.
|
Nat Cell Biol
|
1999
|
0.83
|
|
82
|
Regulation of the levels of three transforming growth factor beta mRNAs by estrogen and their effects on the proliferation of human breast cancer cells.
|
Mol Cell Endocrinol
|
1993
|
0.82
|
|
83
|
Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor.
|
J Biol Chem
|
1997
|
0.82
|
|
84
|
Ectopic expression of Smad7 inhibits transforming growth factor-beta responses in vascular smooth muscle cells.
|
Life Sci
|
2001
|
0.81
|
|
85
|
A rat pituitary tumor cell line (GH3) expresses type I and type II receptors and other cell surface binding protein(s) for transforming growth factor-beta.
|
J Biol Chem
|
1995
|
0.81
|
|
86
|
Role of TGF-beta in the tumor stroma.
|
Curr Cancer Drug Targets
|
2008
|
0.81
|
|
87
|
Bone morphogenetic protein signalling in NGF-stimulated PC12 cells.
|
Biochem Biophys Res Commun
|
2003
|
0.81
|
|
88
|
Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding.
|
J Cell Physiol
|
1997
|
0.80
|
|
89
|
Characterization of in vivo phosphorylation of activin type II receptor.
|
Biochem Biophys Res Commun
|
1993
|
0.79
|
|
90
|
Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases.
|
Methods Mol Biol
|
2001
|
0.79
|
|
91
|
Orthotopic ossification of the spinal ligaments of Zucker fatty rats: a possible animal model for ossification of the human posterior longitudinal ligament.
|
J Orthop Res
|
1997
|
0.79
|
|
92
|
Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by fluorescence in situ hybridization.
|
Cytogenet Cell Genet
|
1998
|
0.79
|
|
93
|
Signal transduction. An anchor for activation.
|
Nature
|
1999
|
0.78
|
|
94
|
TGF-β in aging and disease.
|
Cell Tissue Res
|
2011
|
0.78
|
|
95
|
The effects of transforming growth factor beta 3 on the growth of highly enriched hematopoietic progenitor cells derived from normal human bone marrow and peripheral blood.
|
Cancer Res
|
1991
|
0.78
|
|
96
|
Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors.
|
Mamm Genome
|
1998
|
0.77
|
|
97
|
Lack of responsiveness to TGF-beta1 in a thyroid carcinoma cell line with functional type I and type II TGF-beta receptors and Smad proteins, suggests a novel mechanism for TGF-beta insensitivity in carcinoma cells.
|
Mol Cell Endocrinol
|
1999
|
0.75
|