Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.

PubWeight™: 1.33‹?› | Rank: Top 10%

🔗 View Article (PMC 2230889)

Published in J Physiol on April 15, 1998

Authors

C J Mathews1, J A Tabcharani, X B Chang, T J Jensen, J R Riordan, J W Hanrahan

Author Affiliations

1: Department of Physiology, McGill University, Montréal, Québec, Canada.

Articles citing this

Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating scheme. J Gen Physiol (1999) 1.92

Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains. J Gen Physiol (2000) 1.81

Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains. J Physiol (2002) 1.62

Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels. J Physiol (2000) 1.39

A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution. Proc Natl Acad Sci U S A (2000) 1.32

The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics. J Gen Physiol (2006) 1.28

Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle. J Gen Physiol (2006) 1.24

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA. J Gen Physiol (2005) 1.22

Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA. J Physiol (2003) 1.19

ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc Natl Acad Sci U S A (2010) 1.19

Phosphorylation of CFTR by PKA promotes binding of the regulatory domain. EMBO J (2005) 1.14

Regulation of murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary cells. J Physiol (1998) 1.13

NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR. EMBO J (2009) 1.12

A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter. J Biol Chem (2011) 1.03

The CFTR ion channel: gating, regulation, and anion permeation. Cold Spring Harb Perspect Med (2013) 1.00

Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR. J Physiol (2014) 1.00

Distinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel. J Gen Physiol (2002) 0.98

Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J Biol Chem (2009) 0.93

A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle. Proc Natl Acad Sci U S A (2001) 0.91

A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gating. J Physiol (2001) 0.89

An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening. J Biol Chem (2014) 0.87

Time-dependent interactions of glibenclamide with CFTR: kinetically complex block of macroscopic currents. J Membr Biol (2004) 0.86

Regulation of ABC transporter function via phosphorylation by protein kinases. Curr Pharm Biotechnol (2011) 0.86

Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation. FASEB J (2015) 0.84

Steady-state interactions of glibenclamide with CFTR: evidence for multiple sites in the pore. J Membr Biol (2004) 0.84

Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations. J Biol Chem (2013) 0.82

Novel adenoviral vectors coding for GFP-tagged wtCFTR and deltaF508-CFTR: characterization of expression and electrophysiological properties in A549 cells. Pflugers Arch (2004) 0.81

Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators. PLoS One (2016) 0.77

How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). J Biol Chem (2016) 0.75

Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels. FASEB J (2015) 0.75

Articles cited by this

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem (1991) 8.03

Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Nature (1992) 5.45

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell (1991) 3.75

Phosphorylation-regulated Cl- channel in CHO cells stably expressing the cystic fibrosis gene. Nature (1991) 3.61

Nucleoside triphosphates are required to open the CFTR chloride channel. Cell (1991) 3.21

The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity. J Biol Chem (1995) 2.88

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites. J Biol Chem (1993) 2.85

Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis. Proc Natl Acad Sci U S A (1994) 2.84

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein. J Biol Chem (1990) 2.77

Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland. Nat Genet (1992) 2.64

ATPase activity of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (1996) 2.33

Phosphorylation of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (1992) 2.28

Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating. J Biol Chem (1994) 2.23

Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle. Neuron (1994) 2.20

Effect of ATP concentration on CFTR Cl- channels: a kinetic analysis of channel regulation. Biophys J (1994) 1.99

Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells. J Membr Biol (1988) 1.92

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases. J Biol Chem (1993) 1.77

The cystic fibrosis mutation (delta F508) does not influence the chloride channel activity of CFTR. Nat Genet (1993) 1.72

The CFTR chloride channel of mammalian heart. Annu Rev Physiol (1995) 1.66

ATP alters current fluctuations of cystic fibrosis transmembrane conductance regulator: evidence for a three-state activation mechanism. J Gen Physiol (1994) 1.53

CFTR displays voltage dependence and two gating modes during stimulation. J Gen Physiol (1994) 1.50

CFTR channels in immortalized human airway cells. Am J Physiol (1992) 1.48

Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A. J Biol Chem (1997) 1.46

CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance. Am J Physiol (1994) 1.43

Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature (1996) 1.35

Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc Natl Acad Sci U S A (1994) 1.34

cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation. J Biol Chem (1995) 1.22

Beta-adrenergic and muscarinic regulation of the chloride current in guinea-pig ventricular cells. J Physiol (1991) 1.21

Regulation of CFTR Cl- channel gating by ADP and ATP analogues. J Gen Physiol (1995) 1.21

Inhibition of an outwardly rectifying anion channel by HEPES and related buffers. J Membr Biol (1990) 1.20

Sequence homologies between nucleotide binding regions of CFTR and G-proteins suggest structural and functional similarities. FEBS Lett (1995) 1.05

Structural and functional similarities between the nucleotide-binding domains of CFTR and GTP-binding proteins. Biophys J (1995) 1.04

Identification of protein kinase A phosphorylation sites on NBD1 and R domains of CFTR using electrospray mass spectrometry with selective phosphate ion monitoring. Protein Sci (1996) 0.98

Phosphate stimulates CFTR Cl- channels. Biophys J (1994) 0.92

A recombinant polypeptide model of the second predicted nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator is a GTP-binding protein. FEBS Lett (1996) 0.88

Articles by these authors

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell (1995) 5.61

Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene. Proc Natl Acad Sci U S A (1990) 4.74

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR). Cell (1992) 4.71

Mutation analysis for heterozygote detection and the prenatal diagnosis of cystic fibrosis. N Engl J Med (1990) 4.60

Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Genomics (1991) 4.27

Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science (1983) 3.88

Phosphorylation-regulated Cl- channel in CHO cells stably expressing the cystic fibrosis gene. Nature (1991) 3.61

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature (1985) 3.59

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance. Cell (1991) 3.56

Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders. Science (1985) 3.43

Multi-ion pore behaviour in the CFTR chloride channel. Nature (1993) 3.14

Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP. EMBO J (1994) 2.93

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites. J Biol Chem (1993) 2.85

The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells. J Biol Chem (1993) 2.65

Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland. Nat Genet (1992) 2.64

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome. EMBO J (1998) 2.55

CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli. Am J Physiol (1997) 2.35

Comparison of filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation. Mol Cell Biol (1989) 2.30

Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (1994) 2.27

Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions. J Gen Physiol (1997) 2.26

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression. Mol Cell Biol (1982) 2.03

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability. J Biol Chem (1979) 1.98

Genetic and biochemical characterization of multidrug resistance. Pharmacol Ther (1985) 1.92

Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene. J Biol Chem (1991) 1.86

MSP RFLP for X-linked proteolipid protein gene (PLP) identified with either rat or human PLP cDNA clone. Nucleic Acids Res (1987) 1.80

Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP. Science (1996) 1.78

Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. J Gen Physiol (1993) 1.74

Multidrug-resistance phenotype in Chinese hamster ovary cells. Cancer Treat Rep (1983) 1.72

The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun (1986) 1.71

Disease-associated mutations in the fourth cytoplasmic loop of cystic fibrosis transmembrane conductance regulator compromise biosynthetic processing and chloride channel activity. J Biol Chem (1996) 1.66

Dual effects of ADP and adenylylimidodiphosphate on CFTR channel kinetics show binding to two different nucleotide binding sites. J Gen Physiol (1999) 1.61

Disulphonic stilbene block of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in a mammalian cell line and its regulation by a critical pore residue. J Physiol (1996) 1.61

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein. Cancer Res (1983) 1.53

Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels. J Gen Physiol (1997) 1.51

Glutathione permeability of CFTR. Am J Physiol (1998) 1.48

[Recommendations for clinical-chemical departments: lipid-lipoprotein analysis]. Ugeskr Laeger (1990) 1.47

Multi-Ion mechanism for ion permeation and block in the cystic fibrosis transmembrane conductance regulator chloride channel. J Gen Physiol (1997) 1.47

Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel. J Gen Physiol (1998) 1.46

Regulation of CFTR ion channel gating by MgATP. FEBS Lett (1998) 1.46

Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A. J Biol Chem (1997) 1.46

Low-conductance chloride channel activated by cAMP in the epithelial cell line T84. FEBS Lett (1990) 1.45

Removal of multiple arginine-framed trafficking signals overcomes misprocessing of delta F508 CFTR present in most patients with cystic fibrosis. Mol Cell (1999) 1.45

Flickery block of single CFTR chloride channels by intracellular anions and osmolytes. Am J Physiol (1996) 1.42

Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion. J Biol Chem (1994) 1.42

[Hyperlipidemia in children]. Ugeskr Laeger (1993) 1.40

Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (2001) 1.39

The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH. J Biol Chem (1992) 1.38

The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating. J Physiol (2000) 1.38

CFTR is a monomer: biochemical and functional evidence. J Membr Biol (2002) 1.38

Human fetal liver contains both zinc- and copper-rich forms of metallothionein. J Biol Chem (1980) 1.35

Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc Natl Acad Sci U S A (1994) 1.34

The CFTR chloride channel: nucleotide interactions and temperature-dependent gating. J Membr Biol (1998) 1.33

Direct action of genistein on CFTR. Pflugers Arch (1997) 1.32

Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator. Biochemistry (1994) 1.32

Modification of DNA ends can decrease end joining relative to homologous recombination in mammalian cells. Proc Natl Acad Sci U S A (1987) 1.29

ATPase activity of purified multidrug resistance-associated protein. J Biol Chem (1997) 1.29

Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1. J Biol Chem (2000) 1.27

CFTR channels expressed in CHO cells do not have detectable ATP conductance. J Membr Biol (1996) 1.26

Disease-associated mutations in cytoplasmic loops 1 and 2 of cystic fibrosis transmembrane conductance regulator impede processing or opening of the channel. Biochemistry (1997) 1.25

Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator. FEBS Lett (1997) 1.24

cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A (1991) 1.23

cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation. J Biol Chem (1995) 1.22

Cytoplasmic loop three of cystic fibrosis transmembrane conductance regulator contributes to regulation of chloride channel activity. J Biol Chem (1996) 1.21

Inhibition of an outwardly rectifying anion channel by HEPES and related buffers. J Membr Biol (1990) 1.20

Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA. J Physiol (2003) 1.19