Published in J Physiol on March 15, 1998
Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J Physiol (2002) 1.41
Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications. Mol Aspects Med (2013) 1.33
Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine. Mol Pharm (2009) 1.28
PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J Clin Invest (2001) 1.27
H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol (2007) 1.22
Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice. Drug Metab Dispos (2010) 1.14
H(+)/solute-induced intracellular acidification leads to selective activation of apical Na(+)/H(+) exchange in human intestinal epithelial cells. J Clin Invest (1999) 1.03
Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant. AAPS PharmSci (2001) 0.94
Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice. Drug Metab Dispos (2011) 0.90
Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1. Am J Physiol Gastrointest Liver Physiol (2011) 0.90
Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2). Br J Pharmacol (2005) 0.89
Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption. Histochem Cell Biol (2002) 0.89
Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine. J Pharmacol Exp Ther (2009) 0.88
Ca2+ and cAMP-activated Cl- conductances mediate Cl- secretion in a mouse renal inner medullary collecting duct cell line. J Physiol (2000) 0.87
Transcriptional and functional regulation of the intestinal peptide transporter PEPT1. J Physiol (2013) 0.86
Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells. AAPS PharmSci (1999) 0.84
Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat. J Neurochem (2014) 0.83
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3). Biochim Biophys Acta (2007) 0.83
Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. Pflugers Arch (2005) 0.83
Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1 receptor in a human enterocyte-like cell line (Caco-2). Br J Pharmacol (2003) 0.83
PEPT1-mediated cefixime uptake into human intestinal epithelial cells is increased by Ca2+ channel blockers. Antimicrob Agents Chemother (2002) 0.82
Epithelial transport in inflammatory bowel diseases. Inflamm Bowel Dis (2014) 0.82
Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null mice. J Pharm Sci (2010) 0.81
Small bowel review: normal physiology part 1. Dig Dis Sci (2001) 0.81
Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1. Drug Metab Dispos (2012) 0.81
Development and characterization of a novel mouse line humanized for the intestinal peptide transporter PEPT1. Mol Pharm (2014) 0.79
Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice. Biochem Pharmacol (2016) 0.79
In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug at PEPT1. Drug Metab Dispos (2016) 0.75
Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium. Antimicrob Agents Chemother (2005) 0.75
Regulation of intracellular pH during H+-coupled oligopeptide absorption in enterocytes from guinea-pig ileum. J Physiol (1998) 0.75
Di- and tripeptide transport in vertebrates: the contribution of teleost fish models. J Comp Physiol B (2016) 0.75
High-efficiency cloning of full-length cDNA. Mol Cell Biol (1982) 22.81
Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol (1993) 5.24
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology (1989) 5.24
Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature (1994) 3.54
Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem (1995) 2.32
Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes. J Biol Chem (1993) 1.58
Effect of dietary carbohydrate on monosaccharide uptake by mouse small intestine in vitro. J Physiol (1984) 1.55
Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther (1995) 1.53
Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors. Pflugers Arch (1994) 1.43
Regulation of the mRNA-binding protein AUF1 by activation of the beta-adrenergic receptor signal transduction pathway. J Biol Chem (1996) 1.42
Regulation of the ovine intestinal Na+/glucose co-transporter (SGLT1) is dissociated from mRNA abundance. Biochem J (1993) 1.23
Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase, and assignment of the gene locus to chromosome 3. Gene (1987) 1.20
Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line. Biochem J (1994) 1.14
Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs. Biochem Biophys Res Commun (1995) 1.10
Nutrient regulation of human intestinal sugar transporter (SGLT1) expression. Gut (1997) 1.08
Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol (1993) 1.03
H(+)-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics. Biochim Biophys Acta (1993) 0.99
Effect of diet on glucose transporter site density along the intestinal crypt-villus axis. Am J Physiol (1992) 0.97
Adaptation of glucose transport across rat enterocyte basolateral membrane in response to altered dietary carbohydrate intake. J Physiol (1991) 0.95
Lactase and sucrase-isomaltase gene expression during Caco-2 cell differentiation. Biochem J (1995) 0.92
Rapid enhancement of brush border glucose uptake after exposure of rat jejunal mucosa to glucose. Gut (1996) 0.90
Dietary regulation of intestinal transport of the dipeptide carnosine. Am J Physiol (1988) 0.89
Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic. Pflugers Arch (1993) 0.89
The mRNA-binding protein COLBP is glutamate dehydrogenase. FEBS Lett (1995) 0.89
Characteristics and mechanism of glutamine-dipeptide absorption in human intestine. Gastroenterology (1992) 0.88
Polarized distribution of neutral endopeptidase 24.11 at the cell surface of cultured human intestinal epithelial Caco-2 cells. Biochem J (1992) 0.88
Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP. Biochem Biophys Res Commun (1996) 0.86
Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription. Proc Natl Acad Sci U S A (1994) 0.85
Post-transcriptional regulation of Na+/glucose cotransporter (SGTL1) gene expression in LLC-PK1 cells. Increased message stability after cyclic AMP elevation or differentiation inducer treatment. J Biol Chem (1995) 0.83
Glucose, glutamine, and ketone-body metabolism in human enterocytes. Metabolism (1988) 0.80
Noncompetitive inhibition of cephradine uptake by enalapril in rabbit intestinal brush-border membrane vesicles: an enalapril specific inhibitory binding site on the peptide carrier. J Pharmacol Exp Ther (1994) 0.78
Peptides in human nutrition. Nutr Res Rev (1989) 0.78
Effect of 25-hydroxycholesterol on cholesteryl ester formation in Caco-2 cells. Lipids (1992) 0.77
Xylanase B and an arabinofuranosidase from Pseudomonas fluorescens subsp. cellulosa contain identical cellulose-binding domains and are encoded by adjacent genes. Biochem J (1990) 2.80
Identification of two strains of MDCK cells which resemble separate nephron tubule segments. Biochim Biophys Acta (1981) 2.78
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells. Res Microbiol (1994) 2.37
M-cell surface beta1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer's patch M cells. Infect Immun (1998) 2.34
Conserved reiterated domains in Clostridium thermocellum endoglucanases are not essential for catalytic activity. Gene (1988) 2.25
Conserved serine-rich sequences in xylanase and cellulase from Pseudomonas fluorescens subspecies cellulosa: internal signal sequence and unusual protein processing. Mol Microbiol (1989) 2.20
Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity. Biochem J (1998) 2.05
Demonstration of protein asymmetries in the plasma membrane of cultured renal (MDCK) epithelial cells by lactoperoxidase-mediated iodination. FEBS Lett (1979) 2.05
The nucleotide sequence of a carboxymethylcellulase gene from Pseudomonas fluorescens subsp. cellulosa. Mol Gen Genet (1988) 2.03
Spatial separation of protein domains is not necessary for catalytic activity or substrate binding in a xylanase. Biochem J (1990) 1.93
The X6 "thermostabilizing" domains of xylanases are carbohydrate-binding modules: structure and biochemistry of the Clostridium thermocellum X6b domain. Biochemistry (2000) 1.84
A modular esterase from Pseudomonas fluorescens subsp. cellulosa contains a non-catalytic cellulose-binding domain. Biochem J (1993) 1.80
Identification of the cellulose-binding domain of the cellulosome subunit S1 from Clostridium thermocellum YS. FEMS Microbiol Lett (1992) 1.73
The non-catalytic cellulose-binding domain of a novel cellulase from Pseudomonas fluorescens subsp. cellulosa is important for the efficient hydrolysis of Avicel. Biochem J (1995) 1.66
Evidence for a general role for non-catalytic thermostabilizing domains in xylanases from thermophilic bacteria. Biochem J (1995) 1.64
Differential expression of lectin-binding sites defines mouse intestinal M-cells. J Histochem Cytochem (1993) 1.61
Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes. J Biol Chem (1993) 1.58
Characterization of human purified epithelial and stromal cells from endometrium and endometriosis in tissue culture. Fertil Steril (1992) 1.58
Evidence for a general role for high-affinity non-catalytic cellulose binding domains in microbial plant cell wall hydrolases. Mol Microbiol (1994) 1.53
A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity. Structure (1999) 1.52
A modular xylanase containing a novel non-catalytic xylan-specific binding domain. Biochem J (1995) 1.48
The location of the ligand-binding site of carbohydrate-binding modules that have evolved from a common sequence is not conserved. J Biol Chem (2001) 1.45
Transepithelial chemotaxis of rat peritoneal exudate cells. Br J Exp Pathol (1983) 1.40
Arabinanase A from Pseudomonas fluorescens subsp. cellulosa exhibits both an endo- and an exo- mode of action. Biochem J (1997) 1.40
The role of conserved tryptophan residues in the interaction of a bacterial cellulose binding domain with its ligand. FEMS Microbiol Lett (1993) 1.34
The structural basis for the ligand specificity of family 2 carbohydrate-binding modules. J Biol Chem (2000) 1.33
Actin accumulation at sites of attachment of indigenous apathogenic segmented filamentous bacteria to mouse ileal epithelial cells. Infect Immun (1993) 1.32
Evidence for synergy between family 2b carbohydrate binding modules in Cellulomonas fimi xylanase 11A. Biochemistry (2001) 1.31
Characterization of the gene celD and its encoded product 1,4-beta-D-glucan glucohydrolase D from Pseudomonas fluorescens subsp. cellulosa. Biochem J (1992) 1.31
The Pseudomonas cellulosa glycoside hydrolase family 51 arabinofuranosidase exhibits wide substrate specificity. Biochem J (2001) 1.31
Nucleotide sequence of the Erwinia chrysanthemi NCPPB 1066 L-asparaginase gene. Gene (1986) 1.31
Rapid disruption of epithelial barrier function by Salmonella typhimurium is associated with structural modification of intercellular junctions. Infect Immun (1995) 1.31
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J Biol Chem (1993) 1.30
Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia. Eur J Cell Biol (1998) 1.29
Gene transfer in the gastrointestinal tract. Appl Environ Microbiol (1999) 1.29
The conserved noncatalytic 40-residue sequence in cellulases and hemicellulases from anaerobic fungi functions as a protein docking domain. J Biol Chem (1995) 1.28
Structure of a family 15 carbohydrate-binding module in complex with xylopentaose. Evidence that xylan binds in an approximate 3-fold helical conformation. J Biol Chem (2001) 1.27
Crystal structure of mannanase 26A from Pseudomonas cellulosa and analysis of residues involved in substrate binding. J Biol Chem (2001) 1.27
Novel cellulose-binding domains, NodB homologues and conserved modular architecture in xylanases from the aerobic soil bacteria Pseudomonas fluorescens subsp. cellulosa and Cellvibrio mixtus. Biochem J (1995) 1.27
The starch-binding domain from glucoamylase disrupts the structure of starch. FEBS Lett (1999) 1.26
Carbohydrate-binding modules from a thermostable Rhodothermus marinus xylanase: cloning, expression and binding studies. Biochem J (2000) 1.26
Selective binding and transcytosis of latex microspheres by rabbit intestinal M cells. Cell Tissue Res (1993) 1.24
Complete nucleotide sequence of the Rhodosporidium toruloides gene coding for phenylalanine ammonia-lyase. Gene (1987) 1.24
Cloning and sequencing of the celA gene encoding endoglucanase A of Butyrivibrio fibrisolvens strain A46. J Gen Microbiol (1990) 1.23
The cellodextrinase from Pseudomonas fluorescens subsp. cellulosa consists of multiple functional domains. Biochem J (1991) 1.22
Solution structure of the CBM10 cellulose binding module from Pseudomonas xylanase A. Biochemistry (2000) 1.20
Homologous xylanases from Clostridium thermocellum: evidence for bi-functional activity, synergism between xylanase catalytic modules and the presence of xylan-binding domains in enzyme complexes. Biochem J (1999) 1.20
All three surface tryptophans in Type IIa cellulose binding domains play a pivotal role in binding both soluble and insoluble ligands. FEBS Lett (1998) 1.20
Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: the role of conserved amino acids in ligand binding. Biochemistry (2001) 1.19
A novel carbohydrate-binding protein is a component of the plant cell wall-degrading complex of Piromyces equi. J Biol Chem (2001) 1.18
Endoglucanase E, produced at high level in Escherichia coli as a lacZ' fusion protein, is part of the Clostridium thermocellum cellulosome. Enzyme Microb Technol (1990) 1.18
Inosine 5'-monophosphate dehydrogenase of Escherichia coli. Purification by affinity chromatography, subunit structure and inhibition by guanosine 5'-monophosphate. Biochem J (1979) 1.18
Characterization of a cryptic plasmid from Lactobacillus plantarum. Gene (1989) 1.17
Cellulase Ss (CelS) is synonymous with the major cellobiohydrolase (subunit S8) from the cellulosome of Clostridium thermocellum. Appl Biochem Biotechnol (1993) 1.17
Ion transport in 'tight' epithelial monolayers of MDCK cells. J Membr Biol (1981) 1.17
A non-modular endo-beta-1,4-mannanase from Pseudomonas fluorescens subspecies cellulosa. Biochem J (1995) 1.17
Mannanase A from Pseudomonas fluorescens ssp. cellulosa is a retaining glycosyl hydrolase in which E212 and E320 are the putative catalytic residues. Biochemistry (1996) 1.16
Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway? J Pharmacol Exp Ther (1994) 1.16
A family 26 mannanase produced by Clostridium thermocellum as a component of the cellulosome contains a domain which is conserved in mannanases from anaerobic fungi. Microbiology (1999) 1.16
Evidence that linker sequences and cellulose-binding domains enhance the activity of hemicellulases against complex substrates. Biochem J (1996) 1.16
The type II and X cellulose-binding domains of Pseudomonas xylanase A potentiate catalytic activity against complex substrates by a common mechanism. Biochem J (1999) 1.15
Active secretion of the fluoroquinolone ciprofloxacin by human intestinal epithelial Caco-2 cell layers. Br J Pharmacol (1993) 1.14
The rat mucosal mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin. Eur J Cell Biol (1998) 1.14
H(+)-coupled (Na(+)-independent) proline transport in human intestinal (Caco-2) epithelial cell monolayers. FEBS Lett (1993) 1.14
Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells. Br J Pharmacol (1997) 1.13
Probiotics shown to change bacterial community structure in the avian gastrointestinal tract. Appl Environ Microbiol (1999) 1.13
Transformation of Rhodosporidium toruloides. Gene (1985) 1.12
Identification of two strains of cultured canine renal epithelial cells (MDCK cells) which display entirely different physiological properties. Q J Exp Physiol (1981) 1.12
Autoradiographic localisation of [3H]ouabain bound to cultured epithelial cell monolayers of MDCK cells. Biochim Biophys Acta (1981) 1.11
Nucleotide sequence of the Ruminococcus albus SY3 endoglucanase genes celA and celB. Mol Gen Genet (1990) 1.10
Paracellular barrier and junctional protein distribution depend on basolateral extracellular Ca2+ in cultured epithelia. Biochim Biophys Acta (1994) 1.10
The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers. J Membr Biol (1995) 1.10
The non-catalytic C-terminal region of endoglucanase E from Clostridium thermocellum contains a cellulose-binding domain. Biochem J (1991) 1.09
Key residues in subsite F play a critical role in the activity of Pseudomonas fluorescens subspecies cellulosa xylanase A against xylooligosaccharides but not against highly polymeric substrates such as xylan. J Biol Chem (1997) 1.09
Functional organization of the bovine rumen epithelium. Am J Physiol Regul Integr Comp Physiol (2004) 1.08
Xylanase B from Neocallimastix patriciarum contains a non-catalytic 455-residue linker sequence comprised of 57 repeats of an octapeptide. Biochem J (1994) 1.08
Exploiting M cells for drug and vaccine delivery. Adv Drug Deliv Rev (2001) 1.08
A new family of rhamnogalacturonan lyases contains an enzyme that binds to cellulose. Biochem J (2001) 1.08
Inoculum composition and Salmonella pathogenicity island 1 regulate M-cell invasion and epithelial destruction by Salmonella typhimurium. Infect Immun (1998) 1.08
Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells. Infect Immun (1996) 1.06
Structure of the catalytic core of the family F xylanase from Pseudomonas fluorescens and identification of the xylopentaose-binding sites. Structure (1994) 1.06
Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches. Histochem J (1994) 1.06
The topology of the substrate binding clefts of glycosyl hydrolase family 10 xylanases are not conserved. J Biol Chem (1998) 1.06
Structure and function analysis of Pseudomonas plant cell wall hydrolases. Prog Nucleic Acid Res Mol Biol (1998) 1.05
Na(+)-independent, H(+)-coupled transepithelial beta-alanine absorption by human intestinal Caco-2 cell monolayers. J Biol Chem (1993) 1.05