Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMID 9519742)

Published in Diabetes on March 01, 1998

Authors

E D Kennedy1, P Maechler, C B Wollheim

Author Affiliations

1: Department of Medicine, University Medical Centre, Geneva, Switzerland.

Articles citing this

Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta (2008) 2.56

The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal (2011) 2.05

Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.83

Regulation of insulin secretion: role of mitochondrial signalling. Diabetologia (2010) 1.70

Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metab (2007) 1.61

Reactive oxygen species in health and disease. J Biomed Biotechnol (2012) 1.52

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev (2008) 1.38

A role for von Hippel-Lindau protein in pancreatic beta-cell function. Diabetes (2008) 1.33

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line. EMBO J (1998) 1.26

Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25

The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS One (2011) 1.20

Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell. J Physiol (2000) 1.04

Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med (2008) 1.03

Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. J Biol Chem (2009) 0.98

The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes. Cell Calcium (2011) 0.95

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development. Diabetes (2013) 0.89

MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk. Diabetes (2016) 0.85

Glucose sensing in the pancreatic beta cell: a computational systems analysis. Theor Biol Med Model (2010) 0.85

Glucose stimulation induces dynamic change of mitochondrial morphology to promote insulin secretion in the insulinoma cell line INS-1E. PLoS One (2013) 0.85

Mitochondrial function is required for secretion of DAF-28/insulin in C. elegans. PLoS One (2011) 0.82

Age-related mitochondrial DNA depletion and the impact on pancreatic Beta cell function. PLoS One (2014) 0.81

Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. Endocrinology (2013) 0.81

Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. J Physiol (2002) 0.80

Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation. Sci Rep (2016) 0.79

High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells. BMC Gastroenterol (2012) 0.78

Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction. Islets (2012) 0.77

The effect of unhealthy β-cells on insulin secretion in pancreatic islets. BMC Med Genomics (2013) 0.75

Articles by these authors

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology (1992) 5.45

Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia (2005) 4.17

Is cytosolic ionized calcium regulating neutrophil activation? Science (1983) 3.97

Regulation of insulin release by calcium. Physiol Rev (1981) 3.91

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate. Nature (1984) 3.35

Mitochondrial function in normal and diabetic beta-cells. Nature (2001) 3.32

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature (1999) 2.99

Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem (1994) 2.46

Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials. Nature (1987) 2.37

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate. J Biol Chem (1984) 2.20

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils. J Cell Biol (1984) 2.15

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem (1999) 2.01

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells. J Biol Chem (1987) 1.99

Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells. J Biol Chem (1986) 1.91

Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion. J Biol Chem (1993) 1.86

Regulation of immunoreactive-insulin release from a rat cell line (RINm5F). Biochem J (1983) 1.85

The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins. J Biol Chem (1992) 1.84

Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion. EMBO J (1990) 1.84

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets. J Clin Invest (1988) 1.82

MAFA controls genes implicated in insulin biosynthesis and secretion. Diabetologia (2006) 1.80

Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells. J Biol Chem (1986) 1.68

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells. Biochem J (1984) 1.67

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells. Diabetologia (2008) 1.64

Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation. J Clin Invest (1985) 1.58

VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion. EMBO J (1995) 1.56

The possible importance of contact between pancreatic islet cells for the control of insulin release. Endocrinology (1982) 1.55

Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets. Proc Natl Acad Sci U S A (1986) 1.53

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia (2010) 1.52

SNAP-25 is expressed in islets of Langerhans and is involved in insulin release. J Cell Biol (1995) 1.48

Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest (1999) 1.45

Dynamic pacing of cell metabolism by intracellular Ca2+ transients. J Biol Chem (1994) 1.44

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J Biol Chem (2001) 1.42

Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine. J Biol Chem (1987) 1.41

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. J Biol Chem (2000) 1.41

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. J Clin Invest (2000) 1.41

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content. J Biol Chem (1980) 1.40

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line. J Biol Chem (1984) 1.39

Monolayer cell culture of neonatal rat pancreas: an ultrastructural and biochemical study of functioning endocrine cells. J Ultrastruct Res (1973) 1.38

Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the beta cell. Biochem Pharmacol (1980) 1.35

Glucagon release induced by pancreatic nerve stimulation in the dog. J Clin Invest (1973) 1.35

Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. EMBO J (1989) 1.35

Video imaging of cytosolic Ca2+ in pancreatic beta-cells stimulated by glucose, carbachol, and ATP. J Biol Chem (1992) 1.35

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets. Diabetologia (2012) 1.35

GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels. J Biol Chem (1988) 1.33

Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. J Cell Sci (1996) 1.33

Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1. J Biol Chem (1995) 1.33

Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets. Mol Biol Cell (1994) 1.32

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction. EMBO J (2000) 1.31

Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells. J Clin Invest (1996) 1.29

Functional differences between rat islets of ventral and dorsal pancreatic origin. J Clin Invest (1982) 1.27

Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells. Mol Endocrinol (1999) 1.27

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line. EMBO J (1998) 1.26

Inositol 1,4,5-trisphosphate and intracellular Ca2+ homeostasis in clonal pituitary cells (GH3). Translocation of Ca2+ into mitochondria from a functionally discrete portion of the nonmitochondrial store. J Biol Chem (1986) 1.24

Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance. J Clin Invest (2000) 1.23

Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists. Ann N Y Acad Sci (1986) 1.23

Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F. J Biol Chem (1986) 1.23

Calcium-induced insulin release in monolayer culture of the endocrine pancreas. Studies with ionophore A23187. J Biol Chem (1975) 1.21

The roles of intracellular and extracellular Ca++ in glucose-stimulated biphasic insulin release by rat islets. J Clin Invest (1978) 1.21

Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells. J Biol Chem (1987) 1.20

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. EMBO J (1997) 1.19

Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels. Mol Pharmacol (1992) 1.17

Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles. Experientia (1984) 1.16

Quinine inhibits Ca2+-independent K+ channels whereas tetraethylammonium inhibits Ca2+-activated K+ channels in insulin-secreting cells. FEBS Lett (1985) 1.16

Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis. EMBO J (1996) 1.15

Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits. EMBO J (1995) 1.15

Purine nucleotides induce regulated secretion of von Willebrand factor: involvement of cytosolic Ca2+ and cyclic adenosine monophosphate-dependent signaling in endothelial exocytosis. Blood (1998) 1.14

Regulated von Willebrand factor secretion is associated with agonist-specific patterns of cytoskeletal remodeling in cultured endothelial cells. Arterioscler Thromb Vasc Biol (2000) 1.13

Redistribution of ADP-ribosylation factor during stimulation of permeabilized cells with GTP analogues. Biochem J (1991) 1.13

Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells. Proc Natl Acad Sci U S A (1992) 1.13

The regulation of extramitochondrial steady state free Ca2+ concentration by rat insulinoma mitochondria. J Biol Chem (1983) 1.12

Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia (1992) 1.12

Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. J Clin Invest (1977) 1.11

Islet cyclic AMP levels are not lowered during alpha 2-adrenergic inhibition of insulin release. J Biol Chem (1984) 1.11

The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. EMBO J (1997) 1.11

Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes. J Biol Chem (1989) 1.10

Isolation of pancreatic islets and primary culture of the intact microorgans or of dispersed islet cells. Methods Enzymol (1990) 1.08

Spontaneous and chemoattractant-induced oscillations of cytosolic free calcium in single adherent human neutrophils. J Biol Chem (1988) 1.08

Studies on the dual effects of glucose on 45Ca++ efflux from isolated rat islets. Endocrinology (1978) 1.08

Stimulation of insulin release from permeabilized HIT-T15 cells by a synthetic peptide corresponding to the effector domain of the small GTP-binding protein rab3. FEBS Lett (1993) 1.08

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species. Diabetologia (2006) 1.07

Insulin and glucagon release from monolayer cell cultures of pancreas from newborn rats. Eur J Clin Invest (1973) 1.07

Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease. Diabetologia (1999) 1.06

Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells. J Biol Chem (1999) 1.06

Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells. Biochem J (1987) 1.06

Reactive oxygen intermediates induce regulated secretion of von Willebrand factor from cultured human vascular endothelial cells. Blood (1995) 1.06

A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion. Diabetes (2001) 1.06

Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell. J Physiol (2000) 1.04

Possible role for calmodulin in insulin release. Studies with trifluoperazine in rat pancreatic islets. J Clin Invest (1980) 1.04

Nonselective inhibition of neutrophil functions by sphinganine. J Biol Chem (1987) 1.03

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. Diabetologia (2005) 1.03

ATP-sensitive K+ channels in an insulin-secreting cell line are inhibited by D-glyceraldehyde and activated by membrane permeabilization. J Membr Biol (1986) 1.03

Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase. FEBS Lett (1998) 1.02

Soluble N-ethylmaleimide-sensitive-factor attachment protein and N-ethylmaleimide-insensitive factors are required for Ca2+-stimulated exocytosis of insulin. Biochem J (1996) 1.02

Free radical modulation of insulin release in INS-1 cells exposed to alloxan. Biochem Pharmacol (1999) 1.01

Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma). Arthritis Res (2001) 1.01