Published in Blood on May 01, 1998
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci U S A (2000) 3.68
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A (2003) 3.46
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood (2005) 3.32
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol (1998) 3.13
ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol (1998) 3.06
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci U S A (2001) 2.84
Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol Cell Biol (2002) 1.89
CBFbeta is critical for AML1-ETO and TEL-AML1 activity. Blood (2009) 1.74
AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J Exp Med (2002) 1.65
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development. Proc Natl Acad Sci U S A (2004) 1.60
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood (2006) 1.48
Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol Cell Biol (2001) 1.46
A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. Mol Cell Biol (1999) 1.44
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep (2000) 1.44
Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood (2012) 1.42
RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed) (2012) 1.37
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding. Leukemia (2012) 1.35
Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol (2008) 1.29
Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts. Blood (2007) 1.29
Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice. Proc Natl Acad Sci U S A (2004) 1.28
The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor. Proc Natl Acad Sci U S A (1999) 1.24
The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates. Mol Cell Biol (1998) 1.24
Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood (2009) 1.23
The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO. Blood (2012) 1.23
Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood (2012) 1.20
p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death. Blood (2007) 1.18
The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO. Blood (2007) 1.17
AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets. PLoS Genet (2008) 1.17
The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor. Proc Natl Acad Sci U S A (1999) 1.16
C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest (2012) 1.14
AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion. Proc Natl Acad Sci U S A (2005) 1.14
Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML. Proc Natl Acad Sci U S A (2000) 1.14
Epigenetic consequences of AML1-ETO action at the human c-FMS locus. EMBO J (2003) 1.14
ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia. Blood (2012) 1.12
Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins. Proc Natl Acad Sci U S A (2002) 1.08
The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc Natl Acad Sci U S A (1998) 1.07
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Blood (2012) 1.07
Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling. Leukemia (2014) 1.04
Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood (2010) 1.02
RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis. Blood (2008) 1.02
Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity. BMC Cell Biol (2006) 1.01
Core binding factor at the crossroads: determining the fate of the HSC. J Cell Physiol (2010) 0.98
Identification of AML1-ETO modulators by chemical genomics. Blood (2009) 0.97
Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein. Mol Cell Biol (2002) 0.96
The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1. Mol Cell Biol (2001) 0.94
Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy. Mol Cell Biol (2000) 0.94
Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia. Blood (2011) 0.93
Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML. Blood (2012) 0.92
A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO. Proc Natl Acad Sci U S A (2009) 0.92
N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene. Blood (2011) 0.91
The evolution of cancer modeling: the shadow of stem cells. Dis Model Mech (2010) 0.91
RUNX1: A microRNA hub in normal and malignant hematopoiesis. Int J Mol Sci (2013) 0.91
Mouse chromosome engineering for modeling human disease. Annu Rev Genomics Hum Genet (2006) 0.90
AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway. Blood (2013) 0.90
Prognostic value of AML 1/ETO fusion transcripts in patients with acute myelogenous leukemia. Korean J Intern Med (2003) 0.87
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood (2014) 0.87
HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Mol Cell Biol (1999) 0.87
A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy. Blood (2006) 0.87
MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice. Blood (2005) 0.86
JAK inhibitors suppress t(8;21) fusion protein-induced leukemia. Leukemia (2013) 0.86
Creating a transloxation. Engineering interchromosomal translocations in the mouse. EMBO Rep (2000) 0.86
Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group. Br J Cancer (2004) 0.85
Animal models of leukemia: any closer to the real thing? Cancer Metastasis Rev (2013) 0.84
Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO. Blood Cells Mol Dis (2007) 0.82
Maternal health conditions during pregnancy and acute leukemia in children with Down syndrome: A Children's Oncology Group study. Pediatr Blood Cancer (2009) 0.81
RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1). J Cell Biochem (2010) 0.80
Perturbation-expression analysis identifies RUNX1 as a regulator of human mammary stem cell differentiation. PLoS Comput Biol (2015) 0.79
Directing oncogenic fusion genes into stem cells via an SCL enhancer. Proc Natl Acad Sci U S A (2005) 0.78
Fusion-protein truncation provides new insights into leukemogenesis. Proc Natl Acad Sci U S A (2004) 0.77
Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8. Br J Cancer (1999) 0.77
Zebrafish as a model for leukemia and other hematopoietic disorders. J Hematol Oncol (2015) 0.77
Developmental-stage-dependent transcriptional response to leukaemic oncogene expression. Nat Commun (2015) 0.76
In vivo chemical screening for modulators of hematopoiesis and hematological diseases. Adv Hematol (2012) 0.76
Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity. Leukemia (2016) 0.76
New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins. Front Biol (Beijing) (2016) 0.75
Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis. Br J Haematol (2015) 0.75
Mouse models for core binding factor leukemia. Leukemia (2015) 0.75
Transcriptional Auto-Regulation of RUNX1 P1 Promoter. PLoS One (2016) 0.75
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell (1997) 12.41
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell (1996) 10.83
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell (1996) 9.74
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature (1986) 9.63
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell (1988) 9.04
Acute myeloid leukemia. N Engl J Med (1999) 7.04
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 6.96
Effect of some (2-chloroethyl) trimethylammonium chloride analogs and other growth retardants on gibberellin biosynthesis in Fusarium moniliforme. Plant Physiol (1965) 6.08
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell (1998) 5.92
Jak2 is essential for signaling through a variety of cytokine receptors. Cell (1998) 5.92
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature (1996) 5.45
Crystal structure of an IHF-DNA complex: a protein-induced DNA U-turn. Cell (1996) 5.38
Genetic diversity and disease control in rice. Nature (2000) 5.34
Gene splicing by overlap extension. Methods Enzymol (1993) 4.59
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science (1994) 4.50
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem (2001) 4.45
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia (2003) 4.17
Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell (1987) 4.10
Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J Cell Biol (1993) 4.03
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell (1994) 3.56
Regulation of the T-independent humoral response by TACI. Immunity (2001) 3.43
Tissue pressure measurements as a determinant for the need of fasciotomy. Clin Orthop Relat Res (1976) 3.32
Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron (2001) 3.30
Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol (1993) 3.17
Impact of a computer-based patient record system on data collection, knowledge organization, and reasoning. J Am Med Inform Assoc (2000) 3.16
Direct analysis and identification of proteins in mixtures by LC/MS/MS and database searching at the low-femtomole level. Anal Chem (1997) 3.09
FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun (2000) 3.08
Defective lymphoid development in mice lacking Jak3. Science (1995) 3.04
High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J (2006) 2.94
Isozyme frequency patterns in Drosophila pavani associated with geographical and seasonal variables. Genetics (1972) 2.90
CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol (1999) 2.82
Increased incidence of bone metastases in hepatocellular carcinoma. Eur J Gastroenterol Hepatol (2001) 2.75
TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. Science (1999) 2.70
The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol (1995) 2.70
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol (2001) 2.60
TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia (1995) 2.54
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res (1993) 2.43
RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains. J Cell Biol (1999) 2.42
Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax (2008) 2.37
Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes. EMBO J (1992) 2.34
Fluorescence in situ hybridization using 16S rRNA-targeted oligonucleotides reveals localization of methanogens and selected uncultured bacteria in mesophilic and thermophilic sludge granules. Appl Environ Microbiol (1999) 2.33
Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science (1994) 2.28
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia (2009) 2.24
BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity. J Biol Chem (1997) 2.23
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet (1997) 2.20
Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science (1993) 2.17
Phylogenetic diversity of mesophilic and thermophilic granular sludges determined by 16S rRNA gene analysis. Microbiology (1998) 2.14
A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential. Cell (1988) 2.14
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J Biol Chem (1999) 2.13
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis. Gene (1990) 2.12
Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. Hepatology (2000) 2.10
Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies. N Engl J Med (1995) 2.05
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias. Leukemia (2007) 2.04
A population-based estimate of the burden of diarrhoeal illness in the United States: FoodNet, 1996-7. Epidemiol Infect (2002) 2.03
Severe diffuse non-scarring hair loss in systemic lupus erythematosus - clinical and histopathological analysis of four cases. J Eur Acad Dermatol Venereol (2011) 1.99
A myosin missense mutation, not a null allele, causes familial hypertrophic cardiomyopathy. Circulation (1995) 1.98
The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol (1998) 1.98
Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location. Phys Med Biol (2011) 1.98
Biliary Excretion of Cyclosporine in Liver Transplant Patients. Transplant Proc (1985) 1.98
Surface water pollution in three urban territories of Nepal, India, and Bangladesh. Environ Manage (2001) 1.97
Cigarette smoking is associated with augmented progression of renal insufficiency in severe essential hypertension. Am J Kidney Dis (2000) 1.96
Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J Biol Chem (1999) 1.94
Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis. Leukemia (2009) 1.92
Intrafamilial transmission of hepatitis C virus. Lancet (1989) 1.90
T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells. J Exp Med (2000) 1.88
Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies. Genes Cells (1996) 1.86
The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. J Biol Chem (2001) 1.84
Lack of acrosome formation in Hrb-deficient mice. Science (2001) 1.84
Non-Hodgkin's lymphoma in childhood. N Engl J Med (1996) 1.83
Acute lymphoblastic leukemia in a developing country: preliminary results of a nonrandomized clinical trial in El Salvador. J Pediatr Hematol Oncol (2000) 1.83
Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J Cell Biol (1999) 1.79
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene (2000) 1.76
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol (1996) 1.75
Hydraulic Conductivity Recovery versus Water Pressure in Xylem of Acer saccharum. Plant Physiol (1992) 1.72
Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase. EMBO J (1990) 1.72
Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry (2006) 1.71
Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions. Leukemia (2009) 1.70
Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol (2001) 1.64
Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders. Arch Dermatol (1997) 1.62
Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function. Proc Natl Acad Sci U S A (2001) 1.62
An SNP in protamine 1: a possible genetic cause of male infertility? J Med Genet (2005) 1.61
Allelotype study of primary hepatocellular carcinoma. Cancer Res (1991) 1.61
Efficacy of antibiotic therapy for infection with Shiga-like toxin-producing Escherichia coli O157:H7 in mice with protein-calorie malnutrition. Eur J Clin Microbiol Infect Dis (1999) 1.60
Partial rescue of the Vif-negative phenotype of mutant human immunodeficiency virus type 1 strains from nonpermissive cells by intravirion reverse transcription. J Virol (2000) 1.60
Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proc Natl Acad Sci U S A (1998) 1.60
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes. Proc Natl Acad Sci U S A (1990) 1.58
Endothelin(A) (ET(A)) and ET(B) receptor-mediated regulation of nitric oxide synthase 1 (NOS1) and NOS3 isoforms in the renal inner medulla. Acta Physiol (Oxf) (2007) 1.57
The refined crystal structure of hexon, the major coat protein of adenovirus type 2, at 2.9 A resolution. J Mol Biol (1994) 1.57
Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. Ann Hematol (2004) 1.57
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature (1995) 1.54
Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol Cell Biol (1999) 1.53
A comparison of the BURP and conventional and modified jaw thrust manoeuvres for orotracheal intubation using the Clarus Video System. Anaesthesia (2013) 1.53
Auxin-controlled glycoprotein release into the medium of embryogenic carrot cells. Plant Physiol (1986) 1.52