Published in Blood on May 15, 1998
The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J (2001) 1.67
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J (2002) 1.55
The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocrinol (2010) 1.44
Core erythropoietin receptor signals for late erythroblast development. Blood (2005) 1.26
Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal (2012) 1.11
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood (2006) 1.07
Lyn kinase promotes erythroblast expansion and late-stage development. Blood (2006) 1.06
Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase. EMBO J (2001) 0.96
A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp Hematol (2008) 0.94
Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia. Front Immunol (2014) 0.92
DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β. PLoS One (2011) 0.88
Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis. Br J Haematol (2011) 0.86
JAK2 activation by growth hormone and other cytokines. Biochem J (2015) 0.85
Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells. Exp Hematol (2008) 0.85
Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects. PLoS One (2012) 0.85
Erythropoietin receptor signaling is membrane raft dependent. PLoS One (2012) 0.83
Advances in understanding the pathogenesis of primary familial and congenital polycythaemia. Br J Haematol (2010) 0.83
Erythropoietin down-regulates stem cell factor receptor (Kit) expression in the leukemic proerythroblast: role of Lyn kinase. PLoS One (2009) 0.81
The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7. Immunol Lett (2010) 0.81
Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis. PLoS Pathog (2016) 0.81
PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells. Int J Oncol (2012) 0.78
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. PLoS One (2015) 0.75
Origins of the Vertebrate Erythro/Megakaryocytic System. Biomed Res Int (2015) 0.75
Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL. Oncotarget (2016) 0.75
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell (1993) 6.04
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol (1988) 4.20
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature (1994) 3.36
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J (1994) 3.32
Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J (1995) 2.90
Disruption of the Bcl6 gene results in an impaired germinal center formation. J Exp Med (1997) 2.17
Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis (2008) 2.11
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J (1999) 2.10
Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: RRR (remission induction by Remicade in RA) study. Ann Rheum Dis (2010) 2.04
Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J (1996) 2.02
Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J (1995) 2.00
Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis. Nat Med (1999) 1.95
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J (1995) 1.87
Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest (1995) 1.85
Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus. Clin Immunol Immunopathol (1984) 1.81
Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis. J Clin Gastroenterol (1999) 1.59
Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci (2000) 1.58
Decreased autologous mixed lymphocyte reaction in Sjögren's syndrome. J Clin Invest (1980) 1.52
Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J Biol Chem (1994) 1.50
Possible involvement of Epstein-Barr virus in polyclonal B cell activation in Sjögren's syndrome. Arthritis Rheum (1988) 1.45
Abundant expression of common cytokine receptor gamma chain (CD132) in rheumatoid joints. J Rheumatol (2001) 1.44
Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol (2001) 1.43
Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture. J Clin Invest (1987) 1.42
Induction of anti-DNA antibodies by immunization with anti-DNA antibodies: mechanism and characterization. Lupus (2000) 1.39
Reliability of recalled self-report on headache intensity: investigation using ecological momentary assessment technique. Cephalalgia (2006) 1.38
The first isolation of enantiomeric and meso-zeaxanthin in nature. Comp Biochem Physiol B (1986) 1.31
Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res (1990) 1.30
Overexpression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma by bone marrow cells from patients with myelodysplastic syndromes. Leukemia (1997) 1.27
Spectroscopic determination of cytochrome c oxidase content in tissues containing myoglobin or hemoglobin. Anal Biochem (1996) 1.27
Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node. Cardiovasc Res (1995) 1.27
Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc Natl Acad Sci U S A (1991) 1.25
Estimated prevalence and incidence of adult Still's disease: findings by a nationwide epidemiological survey in Japan. J Epidemiol (1997) 1.23
Proteolysis of spectrin by calpain accompanies theta-burst stimulation in cultured hippocampal slices. Brain Res Mol Brain Res (1995) 1.20
Interleukin 2 enhances natural killing of normal lymphocytes. Cell Immunol (1984) 1.17
Glycogen synthase kinase-3beta and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells. Oncogene (2007) 1.17
Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5. J Leukoc Biol (1995) 1.12
Beta 1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients. J Exp Med (1993) 1.11
Arthritis in patients infected with human T lymphotropic virus type I. Clinical and immunopathologic features. Arthritis Rheum (1991) 1.11
Effects of cytokines and periodontopathic bacteria on the leukocyte function-associated antigen 1/intercellular adhesion molecule 1 pathway in gingival fibroblasts in adult periodontitis. Infect Immun (1994) 1.11
p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide. Apoptosis (2005) 1.10
Ceramide induces apoptosis via CPP32 activation. FEBS Lett (1996) 1.09
Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. J Clin Invest (1990) 1.08
An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells. J Biol Chem (1996) 1.07
Actinomycosis of urachal remnants. J Urol (1988) 1.07
Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome. J Clin Lab Anal (1993) 1.07
Reactive lymphoid hyperplasia of the liver characterized by an angiofollicular pattern mimicking Castleman's disease. Pathol Int (1996) 1.06
Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats. J Immunol (2000) 1.03
IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A. J Hum Genet (2001) 1.01
Mucoepidermoid carcinoma of the thymic region. Acta Pathol Jpn (1982) 1.01
Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat 5. J Biol Chem (1995) 1.01
CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3. J Biol Chem (1999) 1.01
CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G. Blood (1999) 1.00
Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion. J Biol Chem (2000) 0.99
Age-related hypermethylation of the hMLH1 promoter in gastric cancers. Int J Cancer (2001) 0.99
The proto-oncogene Bc16 inhibits apoptotic cell death in differentiation-induced mouse myogenic cells. Oncogene (1999) 0.98
Identification of negative regulatory regions within the first exon and intron of the BCL6 gene. Oncogene (2000) 0.98
Oral manifestations of acute promyelocytic leukemia. J Oral Surg (1978) 0.97
Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. Blood (1996) 0.97
Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis. Am J Gastroenterol (1999) 0.96
Upregulated expression of chemokines in herniated nucleus pulposus resorption. Spine (Phila Pa 1976) (1996) 0.96
beta-adrenergic modulation of L-type Ca2+-channel currents in early-stage embryonic mouse heart. Am J Physiol (1999) 0.96
Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice. J Immunol (2000) 0.96
Prolactin enhances CCAAT enhancer-binding protein-beta (C/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells. Mol Endocrinol (2000) 0.95
Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region. DNA Res (1999) 0.95
Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. Blood (1994) 0.95
Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line. Mol Cell Biol (1998) 0.95
Expressions of cytokine genes during development of autoimmune sialadenitis in MRL/lpr mice. Eur J Immunol (1993) 0.95
Adult T cell leukemia presenting with proliferative synovitis. Arthritis Rheum (1988) 0.95
Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells. Oncogene (1999) 0.94
Gastrointestinal autonomic nerve tumor with giant abscess. A case report and literature review. J Clin Gastroenterol (1997) 0.94
Stimulation of NMDA receptors activates calpain in cultured hippocampal slices. Neurosci Lett (1994) 0.94
An increase in peripheral blood Ia-positive T cells in Sjögren's syndrome correlates with a decrease in the autologous mixed lymphocyte response. Clin Exp Immunol (1982) 0.94
[A case of so-called Lennert's lymphoma, suspected of sarcoidosis due to uveitis occurring first and elevation of serum angiotensin-converting enzyme (ACE)]. Nihon Kyobu Shikkan Gakkai Zasshi (1984) 0.93
Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line. J Biol Chem (2000) 0.93
Characteristic changes in T(2)-value, apparent diffusion coefficient, and ultrastructure of substantia nigra evolving exofocal postischemic neuronal death in rats. Brain Res (2001) 0.93
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J (1995) 0.92
Detection of inflammatory cytokines in psoriatic skin. Arch Dermatol Res (1995) 0.92
Differential regulation of immediate early gene expression in preadipocyte cells through multiple signaling pathways. Biochem Biophys Res Commun (1999) 0.92
Different apparent diffusion coefficient: water content correlations of gray and white matter during early ischemia. Stroke (1998) 0.92
Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. Arthritis Rheum (1983) 0.91
p53 expression in myeloid cells of myelodysplastic syndromes. Association with evolution of overt leukemia. Am J Pathol (1994) 0.91
Solitary neurofibroma of the esophagus. Acta Pathol Jpn (1985) 0.91
Anticoagulant effects of 1alpha,25-dihydroxyvitamin D3 on human myelogenous leukemia cells and monocytes. Blood (1998) 0.91
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta. Oncogene (2006) 0.91
Molecular characterization of the genomic breakpoint junction in the t(11;18) (q21;q21) translocation of a gastric MALT lymphoma. Biochem Biophys Res Commun (2001) 0.91
Slow-fast form of atrioventricular nodal reentrant tachycardia with eccentric retrograde left-sided activation. Jpn Heart J (1999) 0.91
Immunomodulation by isoprinosine: effects on in vitro immune functions of lymphocytes from humans with autoimmune diseases. Clin Exp Immunol (1983) 0.90