Exploring protein homology with the Blocks server.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 9594665)

Published in Trends Genet on April 01, 1998

Authors

S Pietrokovski1, J G Henikoff, S Henikoff

Author Affiliations

1: Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. pietro@muller.fhcrc.org

Articles by these authors

Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci U S A (1992) 61.33

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. Gene (1984) 56.23

Predicting deleterious amino acid substitutions. Genome Res (2001) 28.95

Comparative genomics of the eukaryotes. Science (2000) 26.62

Position-based sequence weights. J Mol Biol (1994) 24.41

Using substitution probabilities to improve position-specific scoring matrices. Comput Appl Biosci (1996) 11.32

Embedding strategies for effective use of information from multiple sequence alignments. Protein Sci (1997) 11.25

Automated assembly of protein blocks for database searching. Nucleic Acids Res (1991) 10.84

Unidirectional digestion with exonuclease III in DNA sequence analysis. Methods Enzymol (1987) 10.31

Increased coverage of protein families with the blocks database servers. Nucleic Acids Res (2000) 9.18

Finding protein similarities with nucleotide sequence databases. Methods Enzymol (1990) 6.63

Automated construction and graphical presentation of protein blocks from unaligned sequences. Gene (1995) 6.11

Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences. Nucleic Acids Res (1998) 5.70

Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science (2001) 5.50

Localization of RNA from heat-induced polysomes at puff sites in Drosophila melanogaster. Proc Natl Acad Sci U S A (1975) 5.29

Protein family classification based on searching a database of blocks. Genomics (1994) 5.24

Targeted screening for induced mutations. Nat Biotechnol (2000) 4.89

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell (1994) 4.83

Targeting induced local lesions IN genomes (TILLING) for plant functional genomics. Plant Physiol (2000) 4.66

Performance evaluation of amino acid substitution matrices. Proteins (1993) 4.46

Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase. Nat Biotechnol (2000) 4.20

Chromatin profiling using targeted DNA adenine methyltransferase. Nat Genet (2001) 4.09

Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. Nature (1990) 3.88

The risk for and severity of bleeding complications in elderly patients treated with warfarin. The National Consortium of Anticoagulation Clinics. Ann Intern Med (1996) 3.79

High-throughput screening for induced point mutations. Plant Physiol (2001) 3.75

Blocks+: a non-redundant database of protein alignment blocks derived from multiple compilations. Bioinformatics (1999) 3.70

PHAT: a transmembrane-specific substitution matrix. Predicted hydrophobic and transmembrane. Bioinformatics (2000) 3.66

Something from nothing: the evolution and utility of satellite repeats. Trends Genet (1998) 3.43

Transcription terminates in yeast distal to a control sequence. Cell (1983) 3.40

National Science Foundation-Sponsored Workshop Report: "The 2010 Project" functional genomics and the virtual plant. A blueprint for understanding how plants are built and how to improve them. Plant Physiol (2000) 3.29

Genetic modification of heterochromatic association and nuclear organization in Drosophila. Nature (1996) 3.28

A histone-H3-like protein in C. elegans. Nature (1999) 3.14

Recent enhancements to the Blocks Database servers. Nucleic Acids Res (1997) 3.01

The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes. Mol Cell Biol (1988) 2.98

Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands. Cell (1986) 2.75

The HP1 chromo shadow domain binds a consensus peptide pentamer. Curr Biol (2000) 2.47

Adaptive evolution of Cid, a centromere-specific histone in Drosophila. Genetics (2001) 2.45

Modulation of a transcription factor counteracts heterochromatic gene silencing in Drosophila. Cell (2001) 2.37

Isolation of a gene from Drosophila by complementation in yeast. Nature (1981) 2.30

New features of the Blocks Database servers. Nucleic Acids Res (1999) 2.28

Sequences responsible for transcription termination on a gene segment in Saccharomyces cerevisiae. Mol Cell Biol (1984) 2.25

PATMAT: a searching and extraction program for sequence, pattern and block queries and databases. Comput Appl Biosci (1992) 2.22

Blocks-based methods for detecting protein homology. Electrophoresis (2000) 2.19

Poised for contagion: evolutionary origins of the infectious abilities of invertebrate retroviruses. Genome Res (2000) 2.01

Transcription at two heat shock loci in Drosophila. Cell (1977) 1.97

Centromeres are specialized replication domains in heterochromatin. J Cell Biol (2001) 1.97

The hinge and chromo shadow domain impart distinct targeting of HP1-like proteins. Mol Cell Biol (2001) 1.95

Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila. J Cell Biol (1998) 1.90

Exploring and explaining epigenetic effects. Trends Genet (1997) 1.87

rbcR [correction of rcbR], a gene coding for a member of the LysR family of transcriptional regulators, is located upstream of the expressed set of ribulose 1,5-bisphosphate carboxylase/oxygenase genes in the photosynthetic bacterium Chromatium vinosum. J Bacteriol (1991) 1.86

Copy number and orientation determine the susceptibility of a gene to silencing by nearby heterochromatin in Drosophila. Genetics (1996) 1.80

Superior performance in protein homology detection with the Blocks Database servers. Nucleic Acids Res (1998) 1.77

Trans-sensing effects from Drosophila to humans. Cell (1991) 1.75

Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans. Genetics (1997) 1.72

Modification of the Drosophila heterochromatic mutation brownDominant by linkage alterations. Genetics (1994) 1.68

A pairing-sensitive element that mediates trans-inactivation is associated with the Drosophila brown gene. Genes Dev (1991) 1.66

Large-scale chromosomal movements during interphase progression in Drosophila. J Cell Biol (1998) 1.60

Nucleotide sequence and initial functional characterization of the clcR gene encoding a LysR family activator of the clcABD chlorocatechol operon in Pseudomonas putida. J Bacteriol (1993) 1.57

Position-effect variegation and chromosome structure of a heat shock puff in Drosophila. Chromosoma (1981) 1.54

Blocks database and its applications. Methods Enzymol (1996) 1.47

So what's new? Nature (1991) 1.43

The Blocks database--a system for protein classification. Nucleic Acids Res (1996) 1.38

A Drosophila metabolic gene transcript is alternatively processed. Cell (1983) 1.37

Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila. Proc Natl Acad Sci U S A (1986) 1.30

The Saccharomyces cerevisiae ADE5,7 protein is homologous to overlapping Drosophila melanogaster Gart polypeptides. J Mol Biol (1986) 1.26

A reexamination of spreading of position-effect variegation in the white-roughest region of Drosophila melanogaster. Genetics (2000) 1.25

Heterochromatin protein 1 binds transgene arrays. Chromosoma (1998) 1.22

Use of oligonucleotides to generate large deletions. Nucleic Acids Res (1986) 1.21

A helix-turn-helix DNA-binding motif predicted for transposases of DNA transposons. Mol Gen Genet (1997) 1.21

A distal heterochromatic block displays centromeric activity when detached from a natural centromere. Mol Cell (1999) 1.21

A relationship between asparagine synthetase A and aspartyl tRNA synthetase. J Biol Chem (1992) 1.13

A computerized intervention to improve timing of outpatient follow-up: a multicenter randomized trial in patients treated with warfarin. National Consortium of Anticoagulation Clinics. J Gen Intern Med (1994) 1.12

Dual recognition-incision enzymes might be involved in mismatch repair and meiosis. Trends Biochem Sci (2000) 1.12

Cloning exons of mapping of transcription: characterization of the Drosophila melanogaster alcohol dehydrogenase gene. Nucleic Acids Res (1983) 1.11

Drosophila genomic sequence annotation using the BLOCKS+ database. Genome Res (2000) 1.04

Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers. Genetics (1998) 1.04

Multifunctional polypeptides for purine de novo synthesis. Bioessays (1987) 1.02

A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis. Biochemistry (1985) 1.02

Sequence of a Drosophila DNA segment that functions in Saccharomyces cerevisiae and its regulation by a yeast promoter. Nucleic Acids Res (1983) 1.01

Heterochromatic trans-inactivation of Drosophila white transgenes. Genetics (1997) 1.01

Applying whole-genome studies of epigenetic regulation to study human disease. Cytogenet Genome Res (2006) 1.01

Somatic instability of a Drosophila chromosome. Genetics (1992) 1.01

Introduction of a DNA methyltransferase into Drosophila to probe chromatin structure in vivo. Chromosoma (1996) 1.00

Two Drosophila melanogaster mutations block successive steps of de novo purine synthesis. Proc Natl Acad Sci U S A (1986) 0.93

Gene organization: nested genes take flight. Curr Biol (1993) 0.93

Genome maps 8. Building gene families. Wall chart. Science (1997) 0.91

Pairing-dependent mislocalization of a Drosophila brown gene reporter to a heterochromatic environment. Genetics (1999) 0.88

Amino acid substitution matrices. Adv Protein Chem (2000) 0.87

Characterization of sequences responsible for trans-inactivation of the Drosophila brown gene. Cold Spring Harb Symp Quant Biol (1993) 0.86

Ordered deletions using exonuclease III. Methods Mol Biol (1994) 0.83

Conservation of brown gene trans-inactivation in Drosophila. Genetics (1995) 0.83

Repetitive arrays containing a housekeeping gene have altered polytene chromosome morphology in Drosophila. Chromosoma (1998) 0.81

The House & Garden guide to chromatin remodelling. Nat Genet (1999) 0.80

You read it here first. Nature (1997) 0.79

Predicting in vivo protein peptide interactions with random phage display. Comb Chem High Throughput Screen (2001) 0.78

Ordered deletions using exonuclease III. Methods Mol Biol (1996) 0.78

A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species. Mol Cell Biol (1989) 0.77