PubRank

R Jakes

Author PubWeight™ 145.90‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Alpha-synuclein in Lewy bodies. Nature 1997 20.83
2 alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 1998 8.41
3 Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1989 8.04
4 Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A 1988 4.45
5 Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature 1996 4.12
6 Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc Natl Acad Sci U S A 2000 3.86
7 Cingulin, a new peripheral component of tight junctions. Nature 1988 3.81
8 Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 1993 3.45
9 Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 1990 3.36
10 Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 1998 3.26
11 Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett 1995 3.15
12 Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J Biol Chem 1998 2.32
13 Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J 1997 2.24
14 Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases. Biochemistry 1975 2.18
15 The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. Biochem J 2001 2.16
16 The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc Natl Acad Sci U S A 1993 1.99
17 A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J Neurosci Res 2000 1.97
18 Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol 2000 1.92
19 Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. Biochem J 1994 1.85
20 Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 1994 1.84
21 Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS Lett 1998 1.79
22 Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J 1995 1.77
23 The primary structure of alamethicin. Biochem J 1970 1.77
24 Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc Natl Acad Sci U S A 1994 1.74
25 Villin sequence and peptide map identify six homologous domains. Proc Natl Acad Sci U S A 1988 1.71
26 Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau. J Biol Chem 1995 1.70
27 alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem 1999 1.57
28 Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Lett 1998 1.55
29 Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments. FEBS Lett 1999 1.53
30 p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]. FEBS Lett 1992 1.48
31 Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment. Eur J Biochem 1982 1.43
32 Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease. Proc Natl Acad Sci U S A 1990 1.42
33 Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. Proc Natl Acad Sci U S A 1991 1.41
34 The amino acid sequence of profilin from calf spleen. FEBS Lett 1979 1.39
35 Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase. J Neurochem 1995 1.36
36 Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases. FEBS Lett 1997 1.36
37 Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease. FEBS Lett 1998 1.35
38 Phosphorylation site sequence of smooth muscle myosin light chain (Mr = 20 000). FEBS Lett 1984 1.31
39 Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation. J Biol Chem 1997 1.30
40 Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. Am J Pathol 2000 1.28
41 Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique. Biochemistry 1975 1.26
42 Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease. Proc Natl Acad Sci U S A 1990 1.22
43 The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease. FEBS Lett 1992 1.21
44 Short-course adjuvant chemotherapy in high-risk stage I nonseminomatous germ cell tumors of the testis: a Medical Research Council report. J Clin Oncol 1996 1.18
45 Assembly of Alzheimer-like filaments from full-length tau protein. FEBS Lett 1994 1.18
46 Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein. FEBS Lett 1996 1.16
47 PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans. J Cell Sci 1996 1.16
48 Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and half-of-the-sites reactivity in aminoacylation. Biochemistry 1975 1.13
49 Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau. Neurosci Lett 1991 1.11
50 Mapping the cysteine residues and actin-binding regions of villin by using antisera to the amino and carboxyl termini of the molecule. Proc Natl Acad Sci U S A 1985 1.09
51 Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC. Biochem J 1997 1.09
52 From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases. Philos Trans R Soc Lond B Biol Sci 2001 1.05
53 Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356. Biochem J 1996 1.04
54 Tau gene mutation K257T causes a tauopathy similar to Pick's disease. J Neuropathol Exp Neurol 2000 1.04
55 A gelsolin-like Ca2+-dependent actin-binding domain in villin. Nature 1985 1.04
56 Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations. J Neurochem 2000 1.00
57 AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease. Brain Res Mol Brain Res 1996 1.00
58 Amino acid sequence of myosin essential light chain from the scallop Aquipecten irradians. Biochemistry 1986 0.95
59 Repeated sequences in methionyl-tRNA synthetase from E. coli. FEBS Lett 1974 0.94
60 Regulatory and essential light-chain-binding sites in myosin heavy chain subfragment-1 mapped by site-directed mutagenesis. J Mol Biol 1989 0.92
61 Calcium binding regions of myosin 'regulatory' light chains. FEBS Lett 1976 0.91
62 Localisation of light chain and actin binding sites on myosin. Eur J Biochem 1986 0.89
63 Molecular dissection of the paired helical filament. Neurobiol Aging 1995 0.86
64 Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neurosci Lett 1994 0.86
65 Genetic dissection of familial Parkinson's disease. Mol Med Today 1998 0.85
66 Alpha-synuclein inclusions in Alzheimer and Lewy body diseases. J Neuropathol Exp Neurol 2000 0.85
67 Phosphorylation of tau by cyclic-AMP-dependent protein kinase. Dementia 1994 0.83
68 Two-dimensional characterization of paired helical filament-tau from Alzheimer's disease: demonstration of an additional 74-kDa component and age-related biochemical modifications. J Neurochem 1997 0.83
69 Gram-scale purification of methionyl-tRNA and tyrosyl-tRNA synthetases from Escherichia coli. Eur J Biochem 1975 0.83
70 Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases. Biochem Soc Trans 1998 0.82
71 Role of the myosin light chains in the regulation of contractile activity. Soc Gen Physiol Ser 1982 0.82
72 Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies. Methods Mol Med 2001 0.82
73 Molecular dissection of the neurofibrillary lesions of Alzheimer's disease. Cold Spring Harb Symp Quant Biol 1996 0.81
74 Tau protein in Alzheimer's disease. Biochem Soc Trans 1995 0.80
75 Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6). Biochem Soc Trans 1997 0.79
76 Pituitary fibroblast growth factors: immunocharacterization of an acid component and N-terminal sequence analysis of a truncated basic component. Biochem Int 1988 0.75