The next frontier of molecular medicine: delivery of therapeutics.

PubWeight™: 2.59‹?› | Rank: Top 1%

🔗 View Article (PMID 9623964)

Published in Nat Med on June 01, 1998

Authors

R K Jain1

Author Affiliations

1: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.

Articles citing this

Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol (2000) 5.94

Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol (2002) 5.04

Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54

Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev (2013) 3.44

Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations. Biophys J (1999) 3.26

Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J (2002) 3.25

Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy. IEEE Trans Magn (2010) 3.07

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A (2001) 2.96

Engineering the perfect (bacterial) cancer therapy. Nat Rev Cancer (2010) 2.70

Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer (2003) 2.40

Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv Drug Deliv Rev (2011) 2.23

Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma. Cancer Res (2008) 2.13

Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc Natl Acad Sci U S A (1999) 1.82

Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue. Antimicrob Agents Chemother (2004) 1.64

Vascular permeability in a human tumour xenograft: molecular charge dependence. Br J Cancer (2000) 1.60

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A (2008) 1.60

Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors. ACS Nano (2012) 1.56

TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A (2012) 1.51

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci Transl Med (2016) 1.47

Screening phage display libraries for organ-specific vascular immunotargeting in vivo. Proc Natl Acad Sci U S A (2005) 1.46

Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating. J Control Release (2014) 1.45

Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery. Proc Natl Acad Sci U S A (2002) 1.43

A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab Chip (2008) 1.30

Enabling individualized therapy through nanotechnology. Pharmacol Res (2010) 1.28

Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model. Neoplasia (2006) 1.24

Can engineered bacteria help control cancer? Proc Natl Acad Sci U S A (2001) 1.22

Spatially resolved fluorescence correlation spectroscopy using a spinning disk confocal microscope. Biophys J (2006) 1.16

Stable RNA nanoparticles as potential new generation drugs for cancer therapy. Adv Drug Deliv Rev (2013) 1.15

In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6. Neoplasia (2008) 1.15

Hypoxic stress and cancer: imaging the axis of evil in tumor metastasis. NMR Biomed (2011) 1.06

Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy. Clin Cancer Res (2009) 1.05

Imaging intratumoral convection: pressure-dependent enhancement in chemotherapeutic delivery to solid tumors. Clin Cancer Res (2009) 1.02

Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope. J Cell Mol Med (2007) 1.00

Bacterial therapies: completing the cancer treatment toolbox. Curr Opin Biotechnol (2008) 0.99

Imaging transgene activity in vivo. Cancer Res (2008) 0.97

Single-cell analysis demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumor cylindroids. Biotechnol Bioeng (2008) 0.94

Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model. Neoplasia (2009) 0.94

Diffusion of flexible random-coil dextran polymers measured in anisotropic brain extracellular space by integrative optical imaging. Biophys J (2008) 0.94

Exploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunities. Adv Drug Deliv Rev (2013) 0.92

Interaction between shock wave and single inertial bubbles near an elastic boundary. Phys Rev E Stat Nonlin Soft Matter Phys (2006) 0.92

Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment. Trends Biotechnol (2009) 0.90

Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion. Ann Biomed Eng (2007) 0.89

Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. Biomed Res Int (2014) 0.87

Developmental and pathological angiogenesis in the central nervous system. Cell Mol Life Sci (2014) 0.86

Potent and tumor specific: arming bacteria with therapeutic proteins. Ther Deliv (2015) 0.86

Phage display peptide probes for imaging early response to bevacizumab treatment. Amino Acids (2010) 0.86

Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia (2002) 0.85

Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging. Br J Cancer (2001) 0.85

Mechanistic modelling of dynamic MRI data predicts that tumour heterogeneity decreases therapeutic response. Br J Cancer (2010) 0.82

Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS. Biotechnol Prog (2010) 0.82

ONCOLYTIC HERPES SIMPLEX VIRUS 1 (HSV-1) VECTORS: INCREASING TREATMENT EFFICACY AND RANGE THROUGH STRATEGIC VIRUS DESIGN. Drugs Future (2010) 0.82

Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil. Integr Biol (Camb) (2013) 0.81

Vascular endothelial growth factor C-induced lymphangiogenesis decreases tumor interstitial fluid pressure and tumor. Transl Oncol (2013) 0.81

Prognostic significance of VEGF expression in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy. BMC Cancer (2008) 0.81

Antibody library-based tumor endothelial cells surface proteomic functional screen reveals migration-stimulating factor as an anti-angiogenic target. Mol Cell Proteomics (2008) 0.81

Targets and mechanisms of photodynamic therapy in lung cancer cells: a brief overview. Cancers (Basel) (2011) 0.80

Nanocarrier-mediated targeting of tumor and tumor vascular cells improves uptake and penetration of drugs into neuroblastoma. Front Oncol (2013) 0.80

Quorum-sensing Salmonella selectively trigger protein expression within tumors. Proc Natl Acad Sci U S A (2015) 0.80

Pediatric primary intramedullary spinal cord glioblastoma. Rare Tumors (2010) 0.79

Mathematical Model of Oxygen Transport in Tuberculosis Granulomas. Ann Biomed Eng (2015) 0.79

Applications of glycosyltransferases in the site-specific conjugation of biomolecules and the development of a targeted drug delivery system and contrast agents for MRI. Expert Opin Drug Deliv (2008) 0.79

A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors. Biotechnol Bioeng (2011) 0.79

Effect of hydration on interstitial distribution of charged albumin in rat dermis in vitro. J Physiol (2005) 0.79

Improved micro-distribution of antibody-photon absorber conjugates after initial near infrared photoimmunotherapy (NIR-PIT). J Control Release (2016) 0.78

Preparation and biocompatibility study of in situ forming polymer implants in rat brains. J Mater Sci Mater Med (2011) 0.78

Magnetic Nanoparticles: Material Engineering and Emerging Applications in Lithography and Biomedicine. J Mater Sci (2015) 0.78

Recombinant mutated human TNF in combination with chemotherapy for stage IIIB/IV non-small cell lung cancer: a randomized, phase III study. Sci Rep (2015) 0.77

High acute myeloid leukemia derived VEGFA levels are associated with a specific vascular morphology in the leukemic bone marrow. Cell Oncol (Dordr) (2011) 0.77

Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts. Br J Cancer (2003) 0.76

A Novel Methodology for Applying Multivoxel MR Spectroscopy to Evaluate Convection-Enhanced Drug Delivery in Diffuse Intrinsic Pontine Gliomas. AJNR Am J Neuroradiol (2016) 0.75

Development of a diffusion-based mathematical model for predicting chemotherapy effects. Conf Proc IEEE Eng Med Biol Soc (2014) 0.75

Development of a novel small antibody that retains specificity for tumor targeting. J Exp Clin Cancer Res (2009) 0.75