Published in BMJ on August 08, 1998
CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ (2010) 28.70
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ (2008) 5.71
How to randomise. BMJ (1999) 5.24
Cardiovascular effects of tumour necrosis factor α antagonism in patients with acute myocardial infarction: a first in human study. Heart (2013) 3.94
Modifying dyspepsia management in primary care: a cluster randomised controlled trial of educational outreach compared with passive guideline dissemination. Br J Gen Pract (2003) 3.88
Treatment allocation by minimisation. BMJ (2005) 3.55
Behavioural counselling to increase consumption of fruit and vegetables in low income adults: randomised trial. BMJ (2003) 3.37
Prognostic factors in ALS: A critical review. Amyotroph Lateral Scler (2009) 2.63
Issues in outcomes research: an overview of randomization techniques for clinical trials. J Athl Train (2008) 2.18
A randomised controlled trial of self-help interventions in patients with a primary care diagnosis of irritable bowel syndrome. Gut (2005) 2.11
Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med (2012) 1.85
Lack of radiological and clinical benefit over two years of low dose prednisolone for rheumatoid arthritis: results of a randomised controlled trial. Ann Rheum Dis (2004) 1.69
Effects of algorithm for diagnosis of active labour: cluster randomised trial. BMJ (2008) 1.62
Improving teenagers' knowledge of emergency contraception: cluster randomised controlled trial of a teacher led intervention. BMJ (2002) 1.57
Allocation techniques for balance at baseline in cluster randomized trials: a methodological review. Trials (2012) 1.55
Progressive coronary calcification despite intensive lipid-lowering treatment: a randomised controlled trial. Heart (2006) 1.55
Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients. Crit Care (2008) 1.34
Hydrodilatation, corticosteroids and adhesive capsulitis: a randomized controlled trial. BMC Musculoskelet Disord (2008) 1.17
Randomised block design is more powerful than minimisation. BMJ (1999) 1.02
Effect of supervised aerobic exercise rehabilitation on physical fitness and quality-of-life in survivors of critical illness: an exploratory minimized controlled trial (PIX study). Br J Anaesth (2014) 0.93
Cost effectiveness of brace, physiotherapy, or both for treatment of tennis elbow. Br J Sports Med (2006) 0.92
Minimisation is much better than the randomised block design in certain cases. BMJ (1999) 0.92
A randomized trial of the addition of home-based exercise to specialist heart failure nurse care: the Birmingham Rehabilitation Uptake Maximisation study for patients with Congestive Heart Failure (BRUM-CHF) study. Eur J Heart Fail (2009) 0.91
The Study Centre of the German Surgical Society--rationale and current status. Langenbecks Arch Surg (2005) 0.90
Imagery in the aftermath of viewing a traumatic film: using cognitive tasks to modulate the development of involuntary memory. J Behav Ther Exp Psychiatry (2011) 0.86
Randomization Does Not Help Much, Comparability Does. PLoS One (2015) 0.85
Effects of tailored neck-shoulder pain treatment based on a decision model guided by clinical assessments and standardized functional tests. A study protocol of a randomized controlled trial. BMC Musculoskelet Disord (2012) 0.84
Audiovisual biofeedback breathing guidance for lung cancer patients receiving radiotherapy: a multi-institutional phase II randomised clinical trial. BMC Cancer (2015) 0.81
A randomised controlled trial of hospital-based case management to improve colorectal cancer patients' health-related quality of life and evaluations of care. BMJ Open (2012) 0.81
Statistical issues in the use of dynamic allocation methods for balancing baseline covariates. Br J Cancer (2011) 0.81
Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trial. Eur J Nutr (2012) 0.80
Feed the ICU patient 'gastric' first, and go post-pyloric only in case of failure. Crit Care (2010) 0.79
Investigating the relationship between predictability and imbalance in minimisation: a simulation study. Trials (2013) 0.79
Communication interventions to improve adherence to infection control precautions: a randomised crossover trial. BMC Infect Dis (2013) 0.78
Randomised controlled trial of a supervised exercise rehabilitation program for colorectal cancer survivors immediately after chemotherapy: study protocol. BMC Cancer (2007) 0.78
The view of European experts regarding health economics for medical nutrition in disease-related malnutrition. Eur J Clin Nutr (2015) 0.77
Randomization in clinical trials: stratification or minimization? The HERMES free simulation software. Clin Oral Investig (2013) 0.77
Challenges and ideas from a research program on high-quality, evidence-based practice in school mental health. J Clin Child Adolesc Psychol (2013) 0.77
Decreased morbidity following long saphenous vein harvesting using a minimally invasive technique: a randomised controlled trial comparing two techniques for long saphenous vein harvest. J Cardiothorac Surg (2006) 0.76
A cluster randomized controlled trial of the Promoting Alternative Thinking Strategies (PATHS) curriculum. J Sch Psychol (2016) 0.75
Development of a minimization instrument for allocation of a hospital-level performance improvement intervention to reduce waiting times in Ontario emergency departments. Implement Sci (2009) 0.75
Optimized design and analysis of preclinical intervention studies in vivo. Sci Rep (2016) 0.75
Is tailored treatment superior to non-tailored treatment for pain and disability in women with non-specific neck pain? A randomized controlled trial. BMC Musculoskelet Disord (2016) 0.75
Spiritual healing in the treatment of rheumatoid arthritis: an exploratory single centre, parallel-group, double-blind, three-arm, randomised, sham-controlled trial. Evid Based Complement Alternat Med (2014) 0.75
Internet-based treatment for Romanian adults with panic disorder: protocol of a randomized controlled trial comparing a Skype-guided with an unguided self-help intervention (the PAXPD study). BMC Psychiatry (2016) 0.75
Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics (1975) 18.25
Minimization: a new method of assigning patients to treatment and control groups. Clin Pharmacol Ther (1974) 7.08
Allocation of patients to treatment groups in a controlled clinical study. Br J Cancer (1978) 5.25
On the use of Pocock and Simon's method for balancing treatment numbers over prognostic factors in the controlled clinical trial. Biometrics (1976) 3.82
Pre-operative aspirin decreases platelet aggregation and increases post-operative blood loss--a prospective, randomised, placebo controlled, double-blind clinical trial in 100 patients with chronic stable angina. Eur J Cardiothorac Surg (1994) 2.28
Lessons from the Bristol case. More openness--on risks and on individual surgeons' performance. BMJ (1998) 7.52
Monitoring the results of cardiac surgery by variable life-adjusted display. Lancet (1997) 6.58
Randomised trial of endoscopic versus percutaneous stent insertion in malignant obstructive jaundice. Lancet (1987) 3.84
The increased risk of venous thromboembolism and the use of third generation progestagens: role of bias in observational research. The Transnational Research Group on Oral Contraceptives and the Health of Young Women. Contraception (1996) 3.23
A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis. Lancet (1986) 2.52
A colposcopic case-control study of cervical squamous intraepithelial lesions in women with anogenital warts. Genitourin Med (1992) 2.49
Pre-operative aspirin decreases platelet aggregation and increases post-operative blood loss--a prospective, randomised, placebo controlled, double-blind clinical trial in 100 patients with chronic stable angina. Eur J Cardiothorac Surg (1994) 2.28
The impact of microemboli during cardiopulmonary bypass on neuropsychological functioning. Stroke (1994) 2.25
Comparison of two strategies for myocardial management during coronary artery operations. Ann Thorac Surg (1994) 2.21
EuroSCORE: a systematic review of international performance. Eur J Cardiothorac Surg (2004) 2.10
Redefining leadership in health care. BMJ (2001) 2.08
Human immunodeficiency virus infection, hepatitis B virus infection, and sexual behaviour of women attending a genitourinary medicine clinic. Br Med J (Clin Res Ed) (1988) 2.06
Cardiac surgery in older people. Br J Hosp Med (1993) 2.04
Trends in sexual behaviour and risk factors for HIV infection among homosexual men, 1984-7. BMJ (1989) 1.97
Alcohol consumption, pregnancy, and low birthweight. Lancet (1983) 1.96
Quality of life, employment status, and anginal symptoms after coronary angioplasty or bypass surgery. 3-year follow-up in the Randomized Intervention Treatment of Angina (RITA) Trial. Circulation (1996) 1.86
Monitoring surgical performance using risk-adjusted cumulative sum charts. Biostatistics (2000) 1.85
A comparison of the risks of venous thromboembolic disease in association with different combined oral contraceptives. Br J Clin Pharmacol (2000) 1.84
A meta-analysis of reported correlations between prognostic factors in breast cancer: does axillary lymph node metastasis represent biology or chronology? Eur J Cancer (1991) 1.78
The differential risk of oral contraceptives: the impact of full exposure history. Hum Reprod (1999) 1.78
The culprit coronary artery lesion. Lancet (1991) 1.75
False aneurysm of the left ventricle. Heart (1998) 1.69
Quick-fix technique? J Am Dent Assoc (1998) 1.60
'Get some research under your belt!'--good advice? A personal view. J R Soc Med (1995) 1.60
Resternotomy for bleeding after cardiac operation: a marker for increased morbidity and mortality. Ann Thorac Surg (1995) 1.58
Trends in female sexual behaviour and sexually transmitted diseases in London, 1982-1992. Genitourin Med (1995) 1.57
Likely variations in perioperative mortality associated with cardiac surgery: when does high mortality reflect bad practice? Heart (2000) 1.53
Endoscopic management of malignant biliary obstruction: stents of 10 French gauge are preferable to stents of 8 French gauge. Gastrointest Endosc (1988) 1.52
Heterosexual relationships and condom-use in the spread of sexually transmitted diseases to women. Genitourin Med (1995) 1.47
What sort of letters do GPs want to receive from hospital specialists? Br J Hosp Med (1989) 1.46
Management of patients with Björk-Shiley prosthetic valves. Br Heart J (1991) 1.46
Comparison of 5-day, 1-day, and 2-day cyclical combination chemotherapy in advanced breast cancer. Lancet (1975) 1.45
Training surgeons and safeguarding patients. Ann R Coll Surg Engl (1996) 1.44
Which patients will not benefit from further intensive care after cardiac surgery? Lancet (1994) 1.43
Correlation of angiographic and surgical findings in distal coronary branches. Br Heart J (1984) 1.41
What is the place of the clinical case report in medical publishing? J R Soc Med (1995) 1.39
A controlled trial of substrate-enhanced, warm reperfusion ("hot shot") versus simple reperfusion. Ann Thorac Surg (2000) 1.38
Multimodal therapy from stage-II breast cancer. Lancet (1978) 1.38
Pragmatic versus explanatory trials. Int J Technol Assess Health Care (1989) 1.37
Flying after heart surgery. Heart (1999) 1.37
Square pegs in round holes: has psychometric testing a place in choosing a surgical career? A preliminary report of work in progress. Ann R Coll Surg Engl (1999) 1.32
The use of oral contraceptives and the occurrence of acute myocardial infarction in young women. Results from the Transnational Study on Oral Contraceptives and the Health of Young Women. Contraception (1997) 1.30
Imaging the dissected aorta. Br Heart J (1993) 1.25
Elective replacement of the aortic root in Marfan's syndrome. Br Heart J (1993) 1.23
The language of breathlessness. Use of verbal descriptors by patients with cardiopulmonary disease. Am Rev Respir Dis (1991) 1.21
Meta-analysis of the association of enteroviruses with human heart disease. Heart (1997) 1.20
Cerebral consequences of cardiopulmonary bypass. Lancet (1986) 1.20
Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease. J Neurol Neurosurg Psychiatry (1987) 1.20
Risk profiles for genital infection in women. Genitourin Med (1993) 1.18
Trends in sexual behaviour and HIV testing among women presenting at a genitourinary medicine clinic during the advent of AIDS. Genitourin Med (1991) 1.18
Imaging the thoracic aorta in the injured patient. Heart (1997) 1.16
Whose lung is it anyway? Thorax (2002) 1.15
Doxorubicin-induced hair loss and possible modification by scalp cooling. Lancet (1977) 1.15
Selective or truncal vagotomy? Five-year results of a double-blind, randomized, controlled trial. Br J Surg (1973) 1.14
Cardiovascular manifestations of Marfan's syndrome: improved evaluation by transoesophageal echocardiography. Br Heart J (1993) 1.13
Contamination of blood during cardiopulmonary bypass: the effect of antibiotic prophylaxis. J Hosp Infect (1988) 1.12
A prospective randomized controlled trial of suction versus non-suction to the under-water seal drains following lung resection. Eur J Cardiothorac Surg (2005) 1.11
Reference values and prediction equations for normal lung function in a non-smoking white urban population. Thorax (1991) 1.10
Racial origin, sexual lifestyle, and genital infection among women attending a genitourinary medicine clinic in London (1992). Sex Transm Infect (1998) 1.10
The effect of hypothermic circulatory arrest time on cerebral function, morphology, and biochemistry. An experimental study. J Thorac Cardiovasc Surg (1983) 1.06
Demonstration of the ascending aorta in infective endocarditis by intravenous digital subtraction angiography. Br Heart J (1988) 1.06
Quality of life measurements in eating disorders, angina, and transplant candidates: are they comparable? J R Soc Med (1994) 1.04
Oxygen supplementation before or after submaximal exercise in patients with chronic obstructive pulmonary disease. Thorax (2003) 1.04
Racial origin and primary renal diagnosis in 771 patients with end-stage renal disease. Nephrol Dial Transplant (1991) 1.02
Racial origin, sexual behaviour, and genital infection among heterosexual men attending a genitourinary medicine clinic in London (1993-4). Sex Transm Infect (1998) 1.02
QT interval in anorexia nervosa. Br Heart J (1994) 1.01
Sexual behaviour and sexually transmitted infection among African and Caribbean men in London. Int J STD AIDS (1999) 1.00
A defence of the small clinical trial: evaluation of three gastroenterological studies. Br Med J (Clin Res Ed) (1986) 0.98
Clinical reports of pulmonary metastasectomy for colorectal cancer: a citation network analysis. Br J Cancer (2011) 0.97
Oral contraceptives and the decline in mortality from circulatory disease. Fertil Steril (1981) 0.96
Demographic characteristics of patients undergoing aortic valve replacement for stenosis: relation to valve morphology. Heart (1996) 0.96
Traumatic rupture of the thoracic aorta: computed tomography may be a dangerous waste of time. Ann R Coll Surg Engl (1994) 0.96
Exocrine pancreatic function in mediastinal teratomata: an aid to preoperative diagnosis? Ann Thorac Surg (1992) 0.96
Parsonnet score is a good predictor of the duration of intensive care unit stay following cardiac surgery. Heart (2000) 0.95
The effects of age, body mass index, smoking and general health on the risk of venous thromboembolism in users of combined oral contraceptives. Eur J Contracept Reprod Health Care (2000) 0.95
Replacement of the aortic root in Marfan's syndrome. N Engl J Med (1999) 0.95
Insertion of a chest drain: how to do it. Br J Hosp Med (1998) 0.94
False aneurysm of the right internal mammary artery. Ann Thorac Surg (1991) 0.93
Evaluation and expression of bronchial provocation tests. Bull Eur Physiopathol Respir (1981) 0.93
Predictors of seropositivity to herpes simplex virus type 2 in women. Int J STD AIDS (2003) 0.92
Antibiotic prophylaxis in cardiac surgery: serum and tissue levels of teicoplanin, flucloxacillin and tobramycin. J Antimicrob Chemother (1988) 0.92
The use of a new glycopeptide antibiotic, teicoplanin, in the treatment of bacterial endocarditis. Postgrad Med J (1987) 0.92
An unusual cause of dysphagia: a vascular ring. Postgrad Med J (1994) 0.92
Subjective reports of cognition in relation to assessed cognitive performance following coronary artery bypass surgery. J Psychosom Res (1989) 0.92
Reducing the risk of major elective surgery. BMJ (1999) 0.92
The safe duration of total circulatory arrest with profound hypothermia. Ann R Coll Surg Engl (1984) 0.92
Monophasic action potentials at discontinuation of cardiopulmonary bypass: evidence for contraction-excitation feedback in man. Circulation (1988) 0.92
Minimisation is much better than the randomised block design in certain cases. BMJ (1999) 0.92
An ion selective electrode for the determination of potassium [proceedings]. J Physiol (1977) 0.91
Need all young surgeons be Masters? Br J Hosp Med (1986) 0.91
Living with a univentricular heart. Heart (2001) 0.91
Incidence and patterns of depression following coronary artery bypass graft surgery. J Psychosom Res (1997) 0.90
Reciprocal inhibition of nitric oxide and prostacyclin synthesis in human saphenous vein. Br J Pharmacol (1996) 0.90
Left recurrent laryngeal nerve palsy as the presenting feature of sarcoidosis. Sarcoidosis (1986) 0.90
Factors predisposing to wound infection in cardiac surgery. A prospective study of 517 patients. Eur J Cardiothorac Surg (1987) 0.89
Use of monophasic action potential recordings during routine coronary-artery bypass surgery as an index of localised myocardial ischaemia. Lancet (1986) 0.89
Aortic root complications of infective endocarditis--influence on surgical outcome. Eur Heart J (1991) 0.89