PubRank

J Wess

Author PubWeight™ 79.59‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 1991 2.55
2 Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor. J Neurosci 2001 2.54
3 Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 2001 2.39
4 Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 1999 2.16
5 Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 1999 1.93
6 Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. J Biol Chem 1995 1.92
7 Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci U S A 2001 1.87
8 Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proc Natl Acad Sci U S A 1993 1.75
9 Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition. Mol Pharmacol 1996 1.54
10 Prevalence and predictors of depressive, anxiety and substance use disorders in HIV-infected and uninfected men: a longitudinal evaluation. Psychol Med 1997 1.52
11 Identification and molecular characterization of m3 muscarinic receptor dimers. J Biol Chem 1999 1.51
12 M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro. J Pharmacol Exp Ther 2000 1.40
13 Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor. J Biol Chem 1995 1.33
14 Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition. Mol Pharmacol 1996 1.33
15 Elucidating the role of muscarinic receptors in psychosis. Life Sci 2001 1.29
16 Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality. Am J Physiol Heart Circ Physiol 2008 1.28
17 Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proc Natl Acad Sci U S A 1995 1.25
18 Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 1998 1.21
19 Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast. J Neurochem 2001 1.18
20 Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. J Clin Invest 2000 1.15
21 Antimuscarinic action of methoctramine, a new cardioselective M-2 muscarinic receptor antagonist, alone and in combination with atropine and gallamine. Eur J Pharmacol 1987 1.13
22 Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis. Diabetes Obes Metab 2007 1.11
23 Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide. EMBO J 1996 1.10
24 Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice. Proc Natl Acad Sci U S A 1999 1.10
25 Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor. J Biol Chem 1995 1.08
26 M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices. Mol Cell Neurosci 2001 1.08
27 Functional role in ligand binding and receptor activation of an asparagine residue present in the sixth transmembrane domain of all muscarinic acetylcholine receptors. J Biol Chem 1994 1.07
28 Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication. J Clin Invest 1997 1.03
29 Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 2003 1.03
30 Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits. Biochemistry 1997 1.02
31 Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice. Life Sci 2001 1.01
32 Reconstitution of functional muscarinic receptors by co-expression of amino- and carboxyl-terminal receptor fragments. FEBS Lett 1993 1.01
33 Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons. Life Sci 2001 0.99
34 Use of a disulfide cross-linking strategy to study muscarinic receptor structure and mechanisms of activation. J Biol Chem 1999 0.99
35 Functional characterization of five V2 vasopressin receptor gene mutations. Mol Cell Endocrinol 1996 0.97
36 Muscarinic receptor-operated Ca2+ influx in transfected fibroblast cells is independent of inositol phosphates and release of intracellular Ca2+. Proc Natl Acad Sci U S A 1992 0.97
37 Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type. Eur J Pharmacol 1988 0.96
38 Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice. Br J Pharmacol 2006 0.95
39 The N-terminal extension of Galphaq is critical for constraining the selectivity of receptor coupling. J Biol Chem 1997 0.92
40 Different single receptor domains determine the distinct G protein coupling profiles of members of the vasopressin receptor family. J Biol Chem 1996 0.92
41 Functional characterization of a series of mutant G protein alphaq subunits displaying promiscuous receptor coupling properties. J Biol Chem 1998 0.91
42 Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. Eur Respir J 2009 0.91
43 Use of knockout mice reveals involvement of M2-muscarinic receptors in control of the kinetics of acetylcholine release. J Neurophysiol 2003 0.91
44 Depolarization initiates phasic acetylcholine release by relief of a tonic block imposed by presynaptic M2 muscarinic receptors. J Neurophysiol 2005 0.90
45 Neuropsychiatric correlates of cerebral white-matter radiolucencies in probable Alzheimer's disease. Arch Neurol 1992 0.90
46 A comparison of the antimuscarinic effects of pirenzepine and N-methylatropine on ganglionic and vascular muscarinic receptors in the rat. Life Sci 1984 0.89
47 Molecular basis of V2 vasopressin receptor/Gs coupling selectivity. J Biol Chem 1998 0.89
48 Functional role of a cytoplasmic aromatic amino acid in muscarinic receptor-mediated activation of phospholipase C. J Biol Chem 1994 0.87
49 Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling. J Neurochem 1999 0.87
50 Mutational analysis of the relative orientation of transmembrane helices I and VII in G protein-coupled receptors. J Biol Chem 1995 0.87
51 Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice. Life Sci 2001 0.87
52 Molecular aspects of vasopressin receptor function. Adv Exp Med Biol 1998 0.86
53 Neurological characteristics of HIV-infected men and women seeking primary medical care. Eur J Neurol 1999 0.86
54 Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Neuropharmacology 2003 0.85
55 Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis. J Biol Chem 2001 0.84
56 Genetic analysis of receptor-Galphaq coupling selectivity. J Biol Chem 1997 0.83
57 Structure-function analysis of muscarinic receptors and their associated G proteins. Life Sci 1999 0.83
58 Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis. J Biol Chem 1996 0.82
59 Identification of an intracellular tyrosine residue critical for muscarinic receptor-mediated stimulation of phosphatidylinositol hydrolysis. J Biol Chem 1994 0.82
60 Molecular aspects of muscarinic receptor dimerization. Neuropsychopharmacology 2000 0.82
61 Use of a sandwich enzyme-linked immunosorbent assay strategy to study mechanisms of G protein-coupled receptor assembly. J Biol Chem 1999 0.82
62 Neurobehavioral correlates of perceived mental and motor slowness in HIV infection and AIDS. J Neuropsychiatry Clin Neurosci 1998 0.81
63 Muscarinic ganglionic stimulants: conformationally restrained analogues related to [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride. J Med Chem 1986 0.81
64 Stimulation of ganglionic muscarinic M1 receptors by a series of tertiary arecaidine and isoarecaidine esters in the pithed rat. Eur J Pharmacol 1987 0.81
65 Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes. Br J Pharmacol 1989 0.80
66 Material-specific memory loss in probable Alzheimer's disease. J Neurol Neurosurg Psychiatry 1992 0.79
67 Intramolecular interactions in muscarinic acetylcholine receptors studied with chimeric m2/m5 receptors. Mol Pharmacol 1994 0.78
68 Muscarinic receptor subtypes--pharmacological, molecular biological and therapeutical aspects. Pharm Acta Helv 1995 0.77
69 The third intracellular domain of the m3 muscarinic receptor determines coupling to calcium influx in transfected Chinese hamster ovary cells. FEBS Lett 1996 0.76
70 Structure-function analysis of muscarinic acetylcholine receptors. J Physiol Paris 1999 0.76
71 Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling. Proc Natl Acad Sci U S A 1994 0.76
72 Influence of monovalent cations on the binding of a charged and an uncharged ('carbo'-)muscarinic antagonist to muscarinic receptors. Br J Pharmacol 1996 0.75
73 Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. Arzneimittelforschung 1989 0.75
74 Use of temporal context information in Alzheimer's disease. Neuropsychologia 1993 0.75
75 Determination of muscarinic agonist potencies at M1 and M2 muscarinic receptors in a modified pithed rat preparation. Naunyn Schmiedebergs Arch Pharmacol 1990 0.75
76 Antiarrhythmic activity of the local anaesthetic fomocaine and some of its analogues. Arzneimittelforschung 1989 0.75
77 Molecular genetics of signal transduction by muscarinic acetylcholine receptors. Soc Gen Physiol Ser 1990 0.75
78 Etiology and management of gastrointestinal gas. G E N 1979 0.75
79 Muscarinic agonist-mediated increases in serum corticosterone levels are abolished in m(2) muscarinic acetylcholine receptor knockout mice. J Pharmacol Exp Ther 2002 0.75