The effects of age on the overall population and on sub-populations of myenteric neurons in the rat small intestine.

PubWeight™: 1.03‹?› | Rank: Top 15%

🔗 View Article (PMC 1467802)

Published in J Anat on May 01, 1998

Authors

R J Johnson1, M Schemann, R M Santer, T Cowen

Author Affiliations

1: Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London, UK.

Articles citing this

5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci (2009) 2.21

Innervation of the gastrointestinal tract: patterns of aging. Auton Neurosci (2007) 1.61

Effect of age on the enteric nervous system of the human colon. Neurogastroenterol Motil (2009) 1.29

Changes in chemical coding of myenteric neurones in ulcerative colitis. Gut (2003) 1.25

Restricted diet rescues rat enteric motor neurones from age related cell death. Gut (2000) 1.14

Effect of chronic, extrinsic denervation on functional NANC innervation with vasoactive intestinal polypeptide and substance P in longitudinal muscle of rat jejunum. Neurogastroenterol Motil (2007) 0.89

Aging of the mammalian gastrointestinal tract: a complex organ system. Age (Dordr) (2013) 0.86

Age-associated plasticity in the intrinsic innervation of the ovine rumen. J Anat (2003) 0.84

Age-related changes in functional NANC innervation with VIP and substance P in the jejunum of Lewis rats. Auton Neurosci (2009) 0.83

Myenteric nitrergic neurons along the rat esophagus: evidence for regional and strain differences in age-related changes. Histochem Cell Biol (2003) 0.82

Evaluation of the effect of Ginkgo biloba extract (EGb 761) on the myenteric plexus of the small intestine of Wistar rats. J Gastroenterol (2007) 0.78

Ginkgo biloba (EGb 761) extract: effects on the myenteric plexus of the large intestine in Wistar rats. Dig Dis Sci (2008) 0.78

Effects of the neonatal treatment with monosodium glutamate on myenteric neurons and the intestine wall in the ileum of rats. J Gastroenterol (2006) 0.77

Chromatographic analysis of age-related changes in mucosal serotonin transmission in the murine distal ileum. Chem Cent J (2012) 0.77

Enteric nervous system in the small intestine: pathophysiology and clinical implications. Curr Gastroenterol Rep (2010) 0.77

Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders? Neurogastroenterol Motil (2013) 0.77

Effects of insulin treatment on HuC/HuD, NADH diaphorase, and nNOS-positive myoenteric neurons of the duodenum of adult rats with acute diabetes. Dig Dis Sci (2008) 0.76

Aqueous Extract of Agaricus blazei Murrill Prevents Age-Related Changes in the Myenteric Plexus of the Jejunum in Rats. Evid Based Complement Alternat Med (2015) 0.75

Experimental Cancer Cachexia Changes Neuron Numbers and Peptide Levels in the Intestine: Partial Protective Effects after Dietary Supplementation with L-Glutamine. PLoS One (2016) 0.75

Heparin-binding EGF like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res (2017) 0.75

Articles cited by this

PGP 9.5--a new marker for vertebrate neurons and neuroendocrine cells. Brain Res (1983) 2.41

Colocalization of nitric oxide synthase and NADPH-diaphorase in the myenteric plexus of the rat gut. Neurosci Lett (1992) 1.40

Pontamine sky blue: a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Histochemistry (1985) 1.24

Identification of cholinergic neurons in enteric nervous system by antibodies against choline acetyltransferase. Am J Physiol (1993) 1.23

Enteric neuron numbers and sizes in Auerbach's plexus in the small and large intestine of adult and aged rats. J Auton Nerv Syst (1988) 1.22

Neuron size and number in the myenteric plexus of the newborn and adult rat. J Anat (1971) 1.21

Detection of nerve cells by a histochemical technic. Experientia (1969) 1.15

Fall in the number of myenteric neurons in aging guinea pigs. Gastroenterology (1989) 1.15

Choline acetyltransferase immunoreactivity in the human small and large intestine. Gastroenterology (1996) 1.12

Immunohistochemical identification of cholinergic neurons in the myenteric plexus of guinea-pig small intestine. Neuroscience (1991) 1.11

Changes in gastric emptying rates with age. Clin Sci (Lond) (1984) 1.10

Regional differences in the number of neurons in the myenteric plexus of the guinea pig small intestine and colon: an evaluation of markers used to count neurons. Anat Rec (1996) 1.09

The number of neurons in the small intestine of mice, guinea-pigs and sheep. Neuroscience (1987) 1.00

Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description. Cell Tissue Res (1994) 0.99

Effect of age on NADPH-diaphorase-containing myenteric neurones of rat ileum and proximal colon. Cell Tissue Res (1995) 0.99

Age-induced nerve cell loss in the myenteric plexus of the small intestine in man. Gerontology (1993) 0.98

Neuronal nitric oxide in the gut. J Gastroenterol Hepatol (1994) 0.96

Survival of the population of NADPH-diaphorase stained myenteric neurons in the small intestine of aged rats. J Auton Nerv Syst (1994) 0.95

Nerve cell loss in the myenteric plexus of the human esophagus in relation to age: a preliminary investigation. Gerontology (1995) 0.91

The distribution of novel intermediate filament proteins defines subpopulations of myenteric neurons in rat intestine. Gastroenterology (1994) 0.91

Immunohistochemical visualization of the enteric nervous system using antibodies against protein gene product (PGP) 9.5. Ann Anat (1993) 0.90

Biochemical markers of aging. Exp Gerontol (1988) 0.88

Density of substance P, vasoactive intestinal polypeptide and somatostatin-containing nerve fibers in the ageing small intestine of the rats. Gerontology (1987) 0.87

Total numbers of neurons in myenteric ganglia of the guinea-pig small intestine. Cell Tissue Res (1993) 0.86

Extrinsic denervation increases NADPH diaphorase staining in myenteric nerves of guinea pig ileum. Neurosci Lett (1994) 0.85

Evidence for a decrease in sympathetic control of intestinal function in the aged rat. Neurobiol Aging (1992) 0.83

Ageing in the autonomic nervous system: a result of nerve-target interactions? A review. Mech Ageing Dev (1993) 0.82

Age-related changes in enteric neuromuscular transmission. J Pharmacol Exp Ther (1990) 0.81

The pelvic innervation in the rat: different spinal origin and projections in Sprague-Dawley and Wistar rats. Brain Res (1989) 0.81

Age-related changes in the gastrointestinal tract. Nutr Rev (1992) 0.80

Articles by these authors

(truncated to the top 100)

Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil (2007) 1.71

Mast cell population density, blood vessel density and histamine content in normal human skin. Br J Dermatol (1979) 1.53

Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedebergs Arch Pharmacol (1997) 1.47

[Irritable bowel syndrome: German consensus guidelines on definition, pathophysiology and management]. Z Gastroenterol (2011) 1.46

Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil (2013) 1.45

Postprandial patterns of canine jejunal motility and transit of luminal content. Gastroenterology (1986) 1.33

Changes in chemical coding of myenteric neurones in ulcerative colitis. Gut (2003) 1.25

Pontamine sky blue: a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Histochemistry (1985) 1.24

Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease. Neurogastroenterol Motil (2001) 1.22

Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons. Aging Cell (2006) 1.15

Restricted diet rescues rat enteric motor neurones from age related cell death. Gut (2000) 1.14

Choline acetyltransferase immunoreactivity in the human small and large intestine. Gastroenterology (1996) 1.12

Distribution of mast cells in human dermis: development of a mapping technique. Br J Dermatol (1979) 1.11

Effects of the probiotic yeast Saccharomyces boulardii on the neurochemistry of myenteric neurones in pig jejunum. Neurogastroenterol Motil (2004) 1.10

Morphology and innervation of the fish heart. Adv Anat Embryol Cell Biol (1985) 1.09

Neurodegeneration: a key factor in the ageing gut. Neurogastroenterol Motil (2004) 1.06

Enteric neurodegeneration in ageing. Neurogastroenterol Motil (2008) 1.06

Characteristics of mucosally projecting myenteric neurones in the guinea-pig proximal colon. J Physiol (1999) 1.05

Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity. Osteoarthritis Cartilage (2005) 1.04

Multisite optical recording of excitability in the enteric nervous system. Neurogastroenterol Motil (1999) 1.03

Age and sex do not affect the volume, cell numbers, or cell size of the suprachiasmatic nucleus of the rat: an unbiased stereological study. J Comp Neurol (1995) 1.02

Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide. Neurogastroenterol Motil (2010) 1.00

Galanin mimics slow synaptic inhibition in myenteric neurons. Eur J Pharmacol (1986) 0.99

Fast calcium and voltage-sensitive dye imaging in enteric neurones reveal calcium peaks associated with single action potential discharge. J Physiol (2011) 0.99

Subpopulations of gastric myenteric neurons are differentially activated via distinct serotonin receptors: projection, neurochemical coding, and functional implications. J Neurosci (1997) 0.95

Neural components of distension-evoked secretory responses in the guinea-pig distal colon. J Physiol (2001) 0.95

Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors. Cell Tissue Res (1999) 0.93

Mucosal projections of enteric neurons in the porcine small intestine. J Comp Neurol (2000) 0.93

Projections and neurochemical coding of myenteric neurons innervating the mucosa of the guinea pig proximal colon. Cell Tissue Res (1997) 0.93

Actions of nitric oxide-generating sodium nitroprusside in myenteric plexus of guinea pig small intestine. Am J Physiol (1993) 0.92

Neuropeptides in the skin of patients with atopic dermatitis. Clin Exp Dermatol (1995) 0.92

Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1beta-dependent pathway. Am J Physiol Gastrointest Liver Physiol (2003) 0.92

NGF can induce a 'young' pattern of reinnervation in transplanted cerebral blood vessels from ageing rats. J Comp Neurol (1993) 0.92

Changes in fibre populations of the rat hairy skin following selective chemodenervation by capsaicin. Cell Tissue Res (1999) 0.92

Nitric oxide synthase, choline acetyltransferase, catecholamine enzymes and neuropeptides and their colocalization in the anterior pelvic ganglion, the inferior mesenteric ganglion and the hypogastric nerve of the male guinea pig. J Chem Neuroanat (1997) 0.92

Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome. Neurogastroenterol Motil (2014) 0.91

Motor patterns of small intestine determined by closely spaced extraluminal transducers and videofluoroscopy. Am J Physiol (1987) 0.91

The nerves to blood vessels supplying blood to nerves: the innervation of vasa nervorum. Brain Res (1984) 0.90

Immunocytochemical analysis of potential neurotransmitters present in the myenteric plexus and muscular layers of the corpus of the guinea pig stomach. Anat Rec (1989) 0.90

Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients. Neurogastroenterol Motil (2012) 0.90

Anatomy and blood supply of the coeliac-superior mesenteric ganglion complex of the rat. Anat Embryol (Berl) (1981) 0.90

Different subpopulations of cholinergic and nitrergic myenteric neurones project to mucosa and circular muscle of the guinea-pig gastric fundus. Cell Tissue Res (1998) 0.90

Development and ageing of perivascular adrenergic nerves in the rabbit. A quantitative fluorescence histochemical study using image analysis. J Auton Nerv Syst (1982) 0.90

Identification of motor neurons to the circular muscle of the guinea pig gastric corpus. J Comp Neurol (1998) 0.89

A study of the distribution of chromaffin-positive (CH+) and small intensely fluorescent (SIF) cells in sympathetic ganglia of the rat at various ages. J Anat (1975) 0.89

The organization of the sarcoplasmic reticulum in teleost ventricular myocardial cells. Cell Tissue Res (1974) 0.89

Adipose tissue at entheses: the innervation and cell composition of the retromalleolar fat pad associated with the rat Achilles tendon. J Anat (2007) 0.88

Capsaicin-sensitive extrinsic afferents are involved in acid-induced activation of distinct myenteric neurons in the rat stomach. Neurogastroenterol Motil (2003) 0.87

Distribution and changes with age of calcitonin gene-related peptide- and substance P-immunoreactive nerves of the rat urinary bladder and lumbosacral sensory neurons. Eur J Morphol (2002) 0.87

Different tachykinin receptors mediate chloride secretion in the distal colon through activation of submucosal neurones. Naunyn Schmiedebergs Arch Pharmacol (1999) 0.87

Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon. Am J Physiol (1994) 0.87

Calcitonin gene-related peptide excites myenteric neurons. Eur J Pharmacol (1986) 0.86

5-HT receptors on interstitial cells of Cajal, smooth muscle and enteric nerves. Neurogastroenterol Motil (2007) 0.86

Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons. J Cell Biol (2001) 0.86

Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine. Neurogastroenterol Motil (2013) 0.85

Differential regulation of survival and growth in adult sympathetic neurons: an in vitro study of neurotrophin responsiveness. J Neurobiol (2001) 0.85

Neurochemical coding of myenteric neurons in the guinea-pig antrum. Cell Tissue Res (1999) 0.85

A quantitative study of the effects of age on the noradrenergic innervation of Auerbach's plexus in the rat. Mech Ageing Dev (1988) 0.85

Substance P and other neuropeptides do not induce mediator release in isolated human intestinal mast cells. Neurogastroenterol Motil (2004) 0.85

Effects of prenatal undernutrition on prevertebral sympathetic neurons in the rat: a morphological and fluorescence histochemical study. J Anat (1987) 0.84

Immunohistochemical evidence for the presence of calbindin containing neurones in the myenteric plexus of the guinea-pig stomach. Neurosci Lett (1999) 0.84

Leptin excites enteric neurons of guinea-pig submucous and myenteric plexus. Neurogastroenterol Motil (2011) 0.84

Identification of neural profiles containing vasoactive intestinal polypeptide, acetylcholinesterase and catecholamines in the rat thymus. J Anat (1991) 0.84

Can the neurotrophic hypothesis explain degeneration and loss of plasticity in mature and ageing autonomic nerves? J Auton Nerv Syst (1996) 0.84

Serum-free culture of dissociated, purified adult and aged sympathetic neurons and quantitative assays of growth and survival. J Neurosci Methods (2001) 0.84

Perivascular noradrenergic and peptide-containing nerves show different patterns of changes during development and ageing in the guinea-pig. J Auton Nerv Syst (1986) 0.84

Projections and neurochemical coding of motor neurones to the circular and longitudinal muscle of the guinea pig gastric corpus. Pflugers Arch (2000) 0.84

The fine structure of the heart of the teleost, Pleuronectes platessa L. Z Zellforsch Mikrosk Anat (1972) 0.83

The multi-herbal drug STW 5 (Iberogast) has prosecretory action in the human intestine. Neurogastroenterol Motil (2009) 0.83

Mechanical characteristics of phase II and phase III of the interdigestive migrating motor complex in dogs. Gastroenterology (1986) 0.83

Immunohistochemical, morphological and functional changes in the peripheral sudomotor neuro-effector system in elderly people. J Auton Nerv Syst (1992) 0.83

Projections of excitatory and inhibitory motor neurones to the circular and longitudinal muscle of the guinea pig colon. Cell Tissue Res (2001) 0.83

Total neuronal numbers of rat lumbosacral primary afferent neurons do not change with age. Neurosci Lett (2001) 0.83

Evidence for a decrease in sympathetic control of intestinal function in the aged rat. Neurobiol Aging (1992) 0.83

Development of the human Achilles tendon enthesis organ. J Anat (2008) 0.83

Target-specific differences in the dendritic morphology and neuropeptide content of neurons in the rat SCG during development and aging. J Comp Neurol (1996) 0.82

Sympathetic and sensory innervation of the urinary tract in young adult and aged rats: a semi-quantitative histochemical and immunohistochemical study. Histochem J (1994) 0.82

Enkephalin-immunoreactive subpopulations in the myenteric plexus of the guinea-pig fundus project primarily to the muscle and not to the mucosa. Cell Tissue Res (1998) 0.82

Distribution and changes with age of nitric oxide synthase-immunoreactive nerves of the rat urinary bladder, ureter and in lumbosacral sensory neurons. Eur J Morphol (2001) 0.82

Preservation of the cervical vagus nerve in aged rats: morphometric and enzyme histochemical evidence. J Auton Nerv Syst (1996) 0.82

Choline acetyltransferase-immunoreactive neurones in a prevertebral sympathetic ganglion, the inferior mesenteric ganglion. J Auton Nerv Syst (1995) 0.82

The effect of surgical procedures on blood vessel innervation. A fluorescence histochemical study of degeneration and regrowth of perivascular adrenergic nerves. Blood Vessels (1982) 0.82

Glycine activates myenteric neurones in adult guinea-pigs. J Physiol (2001) 0.82

Enteric neurodegeneration in ageing. Neurogastroenterol Motil (2008) 0.81

Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. Naunyn Schmiedebergs Arch Pharmacol (1997) 0.81

Perivascular nerves of the human basal cerebral arteries: II. Changes in aging and Alzheimer's disease. J Cereb Blood Flow Metab (1996) 0.81

Ultrastructural and histochemical studies on the innervation of the heart of a teleost, Pleuronectes platessa L. Z Zellforsch Mikrosk Anat (1972) 0.81

In vitro motility disorders associated with displaced abomasum in dairy cows. Neurogastroenterol Motil (1998) 0.81

Differential effects of inflammatory mediators on ion secretion in the guinea-pig colon. Comp Biochem Physiol A Physiol (1997) 0.81

Proceedings: Pseudopyogenic granuloma: the histopathogenesis in the light of ultrastructural studies. Br J Dermatol (1976) 0.81

Mechanical factors regulating gastric emptying of viscous nutrient meals in dogs. Q J Exp Physiol (1984) 0.81

Electron probe x-ray microanalysis of small granulated cells in rat sympathetic ganglia after sequential aldehyde and dichromate treatment. J Histochem Cytochem (1977) 0.80

Quantitative analysis of the density and pattern of adrenergic innervation of blood vessels. A new method. Histochemistry (1980) 0.80

Excitatory and inhibitory innervation of the heart of the plaice (Pleuronectes platessa): anatomical and electrophysiological studies. J Physiol (1972) 0.80

Reduced laminin immunoreactivity in the blood vessel wall of ageing rats correlates with reduced innervation in vivo and following transplantation. Cell Tissue Res (1995) 0.80

The role of NGF in pregnancy-induced degeneration and regeneration of sympathetic nerves in the guinea pig uterus. J Auton Nerv Syst (2000) 0.80

Perivascular nerves of the human basal cerebral arteries: I. Topographical distribution. J Cereb Blood Flow Metab (1996) 0.80

Innervation pattern of guinea pig pulmonary vasculature depends on vascular diameter. J Appl Physiol (1985) (1997) 0.80

Polarized enteric submucosal circuits involved in secretory responses of the guinea-pig proximal colon. J Physiol (1998) 0.80

The herbal preparation STW5 (lberogast) has potent and region-specific effects on gastric motility. Neurogastroenterol Motil (2004) 0.80