Published in Clin Diagn Virol on July 15, 1998
Effect of alpha interferon on the hepatitis C virus replicon. J Virol (2001) 6.18
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13
Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells. J Virol (2004) 2.76
Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles. J Virol (2008) 2.74
Translational control of viral gene expression in eukaryotes. Microbiol Mol Biol Rev (2000) 2.63
Protein-protein interactions between hepatitis C virus nonstructural proteins. J Virol (2003) 2.23
Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J Virol (1999) 1.96
Viral determinants of resistance to treatment in patients with hepatitis C. Clin Microbiol Rev (2007) 1.65
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol (2002) 1.44
Cytopathic and noncytopathic interferon responses in cells expressing hepatitis C virus subgenomic replicons. J Virol (2003) 1.41
High-resolution functional profiling of hepatitis C virus genome. PLoS Pathog (2008) 1.30
Acute hepatitis C virus infection: a chronic problem. Hepatology (2008) 1.15
The cell biology of the unfolded protein response. Gastroenterology (2011) 1.11
Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A. J Virol (2012) 1.03
Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway. J Biol Chem (2008) 0.95
Impact of hepatitis C virus heterogeneity on interferon sensitivity: an overview. World J Gastroenterol (2014) 0.94
Full-length sequences of 11 hepatitis C virus genotype 2 isolates representing five subtypes and six unclassified lineages with unique geographical distributions and genetic variation patterns. J Gen Virol (2012) 0.92
Characterization of full-length hepatitis C virus sequences for subtypes 1e, 1h and 1l, and a novel variant revealed Cameroon as an area in origin for genotype 1. J Gen Virol (2013) 0.90
Response of hepatitis C virus to long-term passage in the presence of alpha interferon: multiple mutations and a common phenotype. J Virol (2013) 0.88
Pegylated interferon and ribavirin promote early evolution of nonstructural 5A protein in individuals with hepatitis C who demonstrate a response to treatment. J Infect Dis (2009) 0.85
The impact of self-identified race on epidemiologic studies of gene expression. Genet Epidemiol (2011) 0.84
Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy. World J Gastroenterol (2007) 0.84
Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. Cell Mol Immunol (2015) 0.83
Glances in Immunology of HIV and HCV Infection. Adv Virol (2012) 0.82
Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin. PLoS One (2008) 0.81
The hepatitis C virus NS5A protein and response to interferon alpha: mutational analyses in patients with chronic HCV genotype 3a infection from India. Med Microbiol Immunol (2006) 0.81
Mutations around interferon sensitivity-determining region: a pilot resistance report of hepatitis C virus 1b in a Hong Kong population. World J Gastroenterol (2011) 0.79
Replicative homeostasis III: implications for antiviral therapy and mechanisms of response and non-response. Virol J (2007) 0.79
The role of HCV proteins on treatment outcomes. Virol J (2015) 0.78
Viral infection: an evolving insight into the signal transduction pathways responsible for the innate immune response. Adv Virol (2012) 0.77
Andes virus nucleocapsid protein interrupts protein kinase R dimerization to counteract host interference in viral protein synthesis. J Virol (2014) 0.77
Oxidative stress-associated protein tyrosine kinases and phosphatases in Fanconi anemia. Antioxid Redox Signal (2014) 0.76
High-dose interferon-alpha2b induction therapy in combination with ribavirin for treatment of chronic hepatitis C in patients with non-response or relapse after interferon-alpha monotherapy. World J Gastroenterol (2005) 0.75
Analysis of mutations in the core and NS5A genes of hepatitis C virus in non-responder and relapser patients after treatment with Peg-IFN-α and ribavirin. Virusdisease (2016) 0.75
dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication. Front Cell Infect Microbiol (2017) 0.75
HCV viremia associates with NK cell activation and dysfunction in anti retroviral HIV/HCV co-infected subjects. J Viral Hepat (2017) 0.75
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology (1997) 5.26
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol (1998) 4.52
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Virology (1995) 4.43
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42
Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase. Pharmacol Ther (1998) 3.64
Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase. Proc Natl Acad Sci U S A (1993) 3.62
Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology (2000) 2.92
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A (1993) 2.90
Translational control of viral gene expression in eukaryotes. Microbiol Mol Biol Rev (2000) 2.63
A comprehensive view of regulation of gene expression by double-stranded RNA-mediated cell signaling. J Biol Chem (2001) 2.58
The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase. Eur J Biochem (1989) 2.42
How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A. Virology (2001) 2.39
Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase. J Interferon Cytokine Res (1998) 2.32
Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain. Mol Cell Biol (1998) 2.21
The three influenza virus polymerase (P) proteins not associated with viral nucleocapsids in the infected cell are in the form of a complex. J Virol (1987) 2.20
Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity. EMBO J (1987) 2.17
Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events. J Virol (2001) 2.13
Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells. Proc Natl Acad Sci U S A (1990) 2.05
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. Proc Natl Acad Sci U S A (1999) 2.03
The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. Mol Cell Biol (1994) 2.03
Infection of Macaca nemestrina by human immunodeficiency virus type-1. Science (1992) 2.01
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells. Mol Cell Biol (1984) 1.97
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation. J Virol (1989) 1.96
Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J Virol (1999) 1.96
Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product. Science (1990) 1.93
Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA. J Virol (1993) 1.67
Translational control by influenza virus. Identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation. J Biol Chem (1995) 1.66
Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics. J Virol (2006) 1.63
Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. Mol Cell Biol (1986) 1.61
An adenovirus glycoprotein binds heavy chains of class I transplantation antigens from man and mouse. Nature (1982) 1.60
Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirus. J Virol (1986) 1.59
Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase. J Biol Chem (1992) 1.57
The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties. Proc Natl Acad Sci U S A (1994) 1.57
Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells. Cell (1984) 1.57
Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase. Proc Natl Acad Sci U S A (1993) 1.56
Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation. Mol Cell Biol (1995) 1.53
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. J Biol Chem (1999) 1.43
Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor. Mol Cell Biol (1998) 1.39
Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation. Mol Cell Biol (1996) 1.37
Purification of a native membrane-associated adenovirus tumor antigen. J Virol (1982) 1.35
Molecular mechanisms responsible for malignant transformation by regulatory and catalytic domain variants of the interferon-induced enzyme RNA-dependent protein kinase. J Biol Chem (1995) 1.34
The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR. Proc Natl Acad Sci U S A (1997) 1.29
Translational control by influenza virus. Selective translation is mediated by sequences within the viral mRNA 5'-untranslated region. J Biol Chem (1993) 1.29
Induction of neutralizing antibodies by the coxsackievirus B3 virion polypeptide, VP2. Virology (1980) 1.25
The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death? J Interferon Cytokine Res (1999) 1.24
Translational control by influenza virus. Selective and cap-dependent translation of viral mRNAs in infected cells. J Biol Chem (1992) 1.20
Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1. Proc Natl Acad Sci U S A (1999) 1.19
Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli. Biochemistry (1991) 1.17
Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. Mol Cell Biol (1998) 1.17
Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. J Virol (2007) 1.17
Detection of protein kinase homologues and viral RNA-binding domains utilizing polyclonal antiserum prepared against a baculovirus-expressed ds RNA-activated 68,000-Da protein kinase. Virology (1992) 1.16
Efficient transcription, not translation, is dependent on adenovirus tripartite leader sequences at late times of infection. J Virol (1988) 1.15
Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A. J Virol (2001) 1.14
Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function. Proc Natl Acad Sci U S A (1991) 1.13
What happens inside lentivirus or influenza virus infected cells: insights into regulation of cellular and viral protein synthesis. Methods (1997) 1.12
A novel mRNA and a low molecular weight polypeptide encoded in the transforming region of adenovirus DNA. EMBO J (1982) 1.10
Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase. Gene (1996) 1.10
The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. J Biol Chem (1996) 1.08
Immunological studies of the group B coxsackieviruses by the sandwich enzyme-linked immunosorbent assay (ELISA) and immunoprecipitation. J Gen Virol (1980) 1.07
Indirect enzyme-linked immunosorbent assay (ELISA) for the detection of Coxsackievirus group B antibodies. J Gen Virol (1980) 1.02
Resources for genetic management and genomics research on non-human primates at the National Primate Research Centers (NPRCs). J Med Primatol (2009) 1.01
Control of adenovirus early gene expression: accumulation of viral mRNA after infection of transformed cells. J Virol (1981) 1.00
Control of adenovirus gene expression: cellular gene products restrict expression of adenovirus host range mutants in nonpermissive cells. J Virol (1983) 0.99
The 58-kDa cellular inhibitor of the double stranded RNA-dependent protein kinase requires the tetratricopeptide repeat 6 and DnaJ motifs to stimulate protein synthesis in vivo. J Biol Chem (1996) 0.98
Acute infection of Macaca nemestrina by human immunodeficiency virus type 1. Virology (1993) 0.96
PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon. J Interferon Res (1993) 0.95
Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus. Arch Virol (2010) 0.94
How does influenza virus regulate gene expression at the level of mRNA translation? Let us count the ways. Gene Expr (1993) 0.93
An adenovirus agnogene. Nucleic Acids Res (1982) 0.93
Serial in vivo passage of HIV-1 infection in Macaca nemestrina. Virology (1997) 0.90
Transmission of the simian immunodeficiency virus SIVmne in macaques and baboons. J Med Primatol (1989) 0.90
Interferon treatment inhibits the replication of simian immunodeficiency virus at an early stage: evidence for a block between attachment and reverse transcription. Virology (1998) 0.90
Inhibition of double-stranded RNA- and tumor necrosis factor alpha-mediated apoptosis by tetratricopeptide repeat protein and cochaperone P58(IPK). Mol Cell Biol (1999) 0.89
Evading the interferon response: hepatitis C virus and the interferon-induced protein kinase, PKR. Curr Top Microbiol Immunol (2000) 0.88
P58IPK, a novel cochaperone containing tetratricopeptide repeats and a J-domain with oncogenic potential. Cell Mol Life Sci (2000) 0.87
Chromosomal assignment of the interferon-inducible double-stranded RNA-dependent protein kinase (PRKR) to human chromosome 2p21-p22 and mouse chromosome 17 E2. Genomics (1993) 0.87
Viral and cellular gene expression in CD4+ human lymphoid cell lines infected by the simian immunodeficiency virus, SIV/Mne. Virology (1991) 0.86
Mechanism of viroid pathogenesis: differential activation of the interferon-induced, double-stranded RNA-activated, M(r) 68,000 protein kinase by viroid strains of varying pathogenicity. Biochimie (1993) 0.86
Chromosomal assignment of the gene encoding the human 58-kDa inhibitor (PRKRI) of the interferon-induced dsRNA-activated protein kinase to chromosome 13q32. Genomics (1996) 0.85
Interferon inhibits the replication of HIV-1, SIV, and SHIV chimeric viruses by distinct mechanisms. Virology (1998) 0.85
Cellular inhibitors of the interferon-induced, dsRNA-activated protein kinase. Prog Mol Subcell Biol (1994) 0.84
Intrarectal inoculation of macaques by the simian immunodeficiency virus, SIVmne E11S: CD4+ depletion and AIDS. J Med Primatol (1994) 0.84
Development of an in vitro mRNA degradation assay utilizing extracts from HIV-1- and SIV-infected cells. Virology (1996) 0.80
Differential sensitivity to 5-fluoro-orotic acid as a screen for bait RNA-independent false positives in a yeast three-hybrid system. Biotechniques (1999) 0.80
Using genetic means to dissect homologous and heterologous protein-protein interactions of PKR, the interferon-induced protein kinase. Methods (1998) 0.80
Cryopreserved yeast cells suitable for routine, small-scale transformations. Biotechniques (1998) 0.79
Inoculation of Macaca fascicularis with simian immunodeficiency virus, SIVmne immunologic, serologic, and pathologic changes. J Med Primatol (1990) 0.77
HSV.com: maneuvering the internetworks of viral neuropathogenesis and evasion of the host defense. Proc Natl Acad Sci U S A (2000) 0.77
HIV-1 infection of animals: the search for a pathogenesis model continues. AIDS (1993) 0.75