Why are two different cross-linkers necessary for actin bundle formation in vivo and what does each cross-link contribute?

PubWeight™: 1.84‹?› | Rank: Top 3%

🔗 View Article (PMC 2132811)

Published in J Cell Biol on October 05, 1998

Authors

L G Tilney1, P S Connelly, K A Vranich, M K Shaw, G M Guild

Author Affiliations

1: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Articles citing this

The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins. Cell (2000) 2.82

Parallel actin bundles and their multiple actin-bundling proteins. Curr Opin Cell Biol (2000) 2.48

Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo. J Cell Biol (2003) 2.31

F-actin bundles are derivatives of microvilli: What does this tell us about how bundles might form? J Cell Biol (2000) 1.79

The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase. Genetics (2000) 1.65

Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis. Mol Biol Cell (2001) 1.55

Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. Br J Cancer (2003) 1.55

Dynamic length regulation of sensory stereocilia. Semin Cell Dev Biol (2008) 1.54

Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42. J Cell Biol (2000) 1.53

Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells. J Neurosci (2004) 1.48

Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles. Mol Biol Cell (2003) 1.46

Helical twist controls the thickness of F-actin bundles. Proc Natl Acad Sci U S A (2008) 1.40

Regulation of actin filament cross-linking and bundle shape in Drosophila bristles. J Cell Biol (2000) 1.39

Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover. Plant Cell (2010) 1.31

Microtubule-dependent organization of vaccinia virus core-derived early mRNAs into distinct cytoplasmic structures. Mol Biol Cell (2001) 1.24

Assembly of filopodia by the formin FRL2 (FMNL3). Cytoskeleton (Hoboken) (2010) 1.20

Cytoskeletal dynamics and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.19

How to make a curved Drosophila bristle using straight actin bundles. Proc Natl Acad Sci U S A (2005) 1.17

A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics (2010) 1.17

Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice. PLoS Genet (2011) 1.17

Structural polymorphism of the cytoskeleton: a model of linker-assisted filament aggregation. Proc Natl Acad Sci U S A (2005) 1.14

Actin filament bundles in Drosophila wing hairs: hairs and bristles use different strategies for assembly. Mol Biol Cell (2005) 1.13

Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly. Cytoskeleton (Hoboken) (2011) 1.12

Twinfilin is required for actin-dependent developmental processes in Drosophila. J Cell Biol (2001) 1.09

Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma. Br J Cancer (2007) 1.04

Long continuous actin bundles in Drosophila bristles are constructed by overlapping short filaments. J Cell Biol (2003) 1.04

A balance of capping protein and profilin functions is required to regulate actin polymerization in Drosophila bristle. Mol Biol Cell (2003) 1.03

Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells. J Cell Sci (2006) 1.01

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol Biol Cell (2011) 1.00

Arabidopsis VILLIN2 and VILLIN3 are required for the generation of thick actin filament bundles and for directional organ growth. Plant Physiol (2011) 0.99

Molecular mechanism of fascin function in filopodial formation. J Biol Chem (2012) 0.99

Filopodial initiation and a novel filament-organizing center, the focal ring. Mol Biol Cell (2001) 0.98

The role of actin bundling proteins in the assembly of filopodia in epithelial cells. Cell Adh Migr (2011) 0.94

The role actin filaments play in providing the characteristic curved form of Drosophila bristles. Mol Biol Cell (2004) 0.91

Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines. Diagn Pathol (2010) 0.90

Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle. Mol Cell Biol (2009) 0.90

Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espin. J Cell Sci (2014) 0.85

Inner ear tissue preservation by rapid freezing: improving fixation by high-pressure freezing and hybrid methods. Hear Res (2014) 0.82

Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. Nat Commun (2015) 0.81

Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesis. Genetics (2005) 0.78

Fascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia. J Biol Chem (2016) 0.78

The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle. Mol Cell Biol (2011) 0.76

Fascin- and α-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting. Curr Biol (2016) 0.76

IKKε inhibits PKC to promote Fascin-dependent actin bundling. Development (2016) 0.75

Articles cited by this

Staging the metamorphosis of Drosophila melanogaster. J Embryol Exp Morphol (1981) 3.45

Drosophila singed, a fascin homolog, is required for actin bundle formation during oogenesis and bristle extension. J Cell Biol (1994) 2.32

How actin filaments pack into bundles. Cold Spring Harb Symp Quant Biol (1982) 2.10

Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli. J Cell Biol (1998) 2.06

F actin bundles in Drosophila bristles. I. Two filament cross-links are involved in bundling. J Cell Biol (1995) 1.97

Actin filaments, stereocilia, and hair cells of the bird cochlea. II. Packing of actin filaments in the stereocilia and in the cuticular plate and what happens to the organization when the stereocilia are bent. J Cell Biol (1983) 1.97

Preliminary biochemical characterization of the stereocilia and cuticular plate of hair cells of the chick cochlea. J Cell Biol (1989) 1.74

forked proteins are components of fiber bundles present in developing bristles of Drosophila melanogaster. Genetics (1994) 1.73

FlyBase: a Drosophila database. Nucleic Acids Res (1998) 1.65

F-actin bundles in Drosophila bristles are assembled from modules composed of short filaments. J Cell Biol (1996) 1.64

Actin filaments, stereocilia, and hair cells of the bird cochlea. IV. How the actin filaments become organized in developing stereocilia and in the cuticular plate. Dev Biol (1986) 1.64

The villin-like protein encoded by the Drosophila quail gene is required for actin bundle assembly during oogenesis. Cell (1994) 1.58

Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations. J Cell Sci (1996) 1.52

Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev Dyn (1998) 1.51

Structure of F-actin needles from extracts of sea urchin oocytes. J Mol Biol (1981) 1.50

Assembly of the intestinal brush border: appearance and redistribution of microvillar core proteins in developing chick enterocytes. J Cell Biol (1987) 1.48

Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Development (1989) 1.47

Three-dimensional structure of a single filament in the Limulus acrosomal bundle: scruin binds to homologous helix-loop-beta motifs in actin. J Cell Biol (1994) 1.47

Actin filament cables in Drosophila nurse cells are composed of modules that slide passively past one another during dumping. J Cell Biol (1997) 1.39

Changes in the organization of actin filaments in the stereocilia of noise-damaged lizard cochleae. Hear Res (1982) 1.26

Growth conditions control the size and order of actin bundles in vitro. Biophys J (1991) 1.21

Changes in the F-actin cytoskeleton during neurosensory bristle development in Drosophila: the role of singed and forked proteins. Cell Motil Cytoskeleton (1998) 1.18

Single amino acid mutations in Drosophila fascin disrupt actin bundling function in vivo. Genetics (1996) 1.16

Three-dimensional reconstruction of an actin bundle. J Cell Biol (1988) 1.10

Development of the structural components of the brush border in absorptive cells of the chick intestine. Cell Tissue Res (1979) 1.10

Methods to visualize actin polymerization associated with bacterial invasion. Methods Enzymol (1994) 1.05

Articles by these authors

A new high-capacity cosmid vector and its use. Gene (1980) 4.72

The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers. Genetics (1991) 2.97

How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J Cell Sci (2001) 2.83

Actin filament nucleation by the bacterial pathogen, Listeria monocytogenes. J Cell Biol (1990) 2.54

Effect of abrupt temperature shift on the growth of mesophilic and psychrophilic yeasts. J Bacteriol (1967) 2.49

A plastid segregation defect in the protozoan parasite Toxoplasma gondii. EMBO J (2001) 2.37

F actin bundles in Drosophila bristles. I. Two filament cross-links are involved in bundling. J Cell Biol (1995) 1.97

The plastid of Toxoplasma gondii is divided by association with the centrosomes. J Cell Biol (2000) 1.95

Determination of the minimal temperature for growth of Escherichia coli. J Bacteriol (1971) 1.72

F-actin bundles in Drosophila bristles are assembled from modules composed of short filaments. J Cell Biol (1996) 1.64

The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis. Development (1993) 1.58

Differential expression of Broad-Complex transcription factors may forecast tissue-specific developmental fates during Drosophila metamorphosis. Development (1994) 1.54

Defective interfering particles of Sindbis virus. V. Sequence relationships between SVSTD 42 S RNA and intracellular defective viral RNAs. Virology (1977) 1.53

Formation of actin filament bundles in the ring canals of developing Drosophila follicles. J Cell Biol (1996) 1.41

Actin filament cables in Drosophila nurse cells are composed of modules that slide passively past one another during dumping. J Cell Biol (1997) 1.39

Regulation of actin filament cross-linking and bundle shape in Drosophila bristles. J Cell Biol (2000) 1.39

The roles of temperature, pH and mosquito factors as triggers of male and female gametogenesis of Plasmodium berghei in vitro. Parasitology (1997) 1.37

Actin filaments and microtubules play different roles during bristle elongation in Drosophila. J Cell Sci (2000) 1.33

Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene. Int J Obes (Lond) (2007) 1.30

Molecular analysis of the ecdysterone-inducible 2B5 "early' puff in Drosophila melanogaster. EMBO J (1986) 1.30

Synthesis of macromolecules by Escherichia coli near the minimal temperature for growth. J Bacteriol (1967) 1.29

The ecdysone-induced puffing cascade in Drosophila salivary glands: a Broad-Complex early gene regulates intermolt and late gene transcription. Genetics (1991) 1.29

The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis. EMBO J (1994) 1.25

Sindbis virus messenger RNA: the 5'-termini and methylated residues of 26 and 42 S RNA. Virology (1977) 1.15

Formation of filaments and synthesis of macromolecules at temperatures below the minimum for growth of Escherichia coli. J Bacteriol (1968) 1.12

The Drosophila Broad-Complex early gene directly regulates late gene transcription during the ecdysone-induced puffing cascade. Dev Biol (1996) 1.11

Hydrogen sulfide production by bacteria and sulfmyoglobin formation in prepacked chilled beef. Appl Microbiol (1970) 1.09

Poly(A) shortening of coregulated transcripts in Drosophila. Dev Biol (1986) 1.06

Closely linked DNA elements control the expression of the Sgs-5 glue protein gene in Drosophila. Genes Dev (1987) 1.04

Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel. Parasitology (1987) 1.01

Molecular analysis of a developmentally regulated gene which is expressed in the larval salivary gland of Drosophila. Dev Biol (1984) 0.99

Endocytosed transferrin in African trypanosomes is delivered to lysosomes and may not be recycled. Eur J Cell Biol (1992) 0.99

The structure of plasmodesmata as revealed by plasmolysis, detergent extraction, and protease digestion. J Cell Biol (1991) 0.97

Larval salivary gland secretion proteins in Drosophila. Identification and characterization of the Sgs-5 structural gene. J Mol Biol (1984) 0.96

An ecdysterone-responsive puff site in Drosophila contains a cluster of seven differentially regulated genes. J Mol Biol (1986) 0.95

Defective interfering particles of Sindbis virus. III. Intracellular viral RNA species in chick embryo cell cultures. Virology (1975) 0.92

Defective interfering particles of Sindbis virus. IV. Virion RNA species and molecular weight determination of defective double-stranded RNA. Virology (1977) 0.92

The distribution of plasmodesmata and its relationship to morphogenesis in fern gametophytes. Development (1990) 0.90

Larval salivary gland secretion proteins in Drosophila structural analysis of the Sgs-5 gene. J Mol Biol (1986) 0.89

The transferrin receptor in African trypanosomes: identification, partial characterization and subcellular localization. Eur J Cell Biol (1993) 0.88

Differential expression of the oligomycin-sensitive ATPase in bloodstream forms of Trypanosoma brucei brucei. Mol Biochem Parasitol (1991) 0.87

Local delivery of TNF by retrovirus-transduced T lymphocytes exacerbates experimental autoimmune encephalomyelitis. Clin Immunol (1999) 0.86

Molecular characterization of the 71E late puff in Drosophila melanogaster reveals a family of novel genes. J Mol Biol (1996) 0.85

Identification and characterization of the antigen-specific subpopulation of alloreactive CD4+ T cells in vitro and in vivo. Transplantation (2000) 0.84

Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors. J Med Chem (1991) 0.83

Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis (2013) 0.82

Hormonal induction of Dopa decarboxylase in the epidermis of Drosophila is mediated by the Broad-Complex. Development (1995) 0.82

Theileria parva: reappearance of schizonts in infected lymphoblastoid cells treated with parvaquone is dependent on interleukin 2-like growth factors. Exp Parasitol (1989) 0.82

Ultrastructural studies on the replication and morphogenesis of Nairobi sheep disease virus, a Nairovirus. Arch Virol (1996) 0.81

Directional movement of variable surface glycoprotein-antibody complexes in Trypanosoma brucei. Eur J Cell Biol (1993) 0.81

Schistosoma mansoni: dose-related tegumental surface changes after in vivo treatment with praziquantel. Z Parasitenkd (1983) 0.81

Schistosoma mansoni: the effects of a subcurative dose of praziquantel on the ultrastructure of worms in vivo. Z Parasitenkd (1983) 0.80

Schistosoma mansoni: changes in elemental composition in relation to the age and sexual status of the worms. Parasitology (1983) 0.80

Trypanosoma brucei brucei: in vitro production of metacyclic forms. J Protozool (1992) 0.80

Rickettsial infections of midgut cells are not associated with susceptibility of Glossina morsitans centralis to Trypanosoma congolense infection. Acta Trop (1989) 0.79

Schistosoma mansoni: the presence and ultrastructure of vitelline cells in adult males. J Helminthol (1982) 0.78

Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones. J Med Chem (1992) 0.77

A light and electron microscopic study of changes in blood and bone marrow in acute hemorrhagic Trypanosoma vivax infection in calves. Vet Pathol (1992) 0.77

Trypanosoma congolense in the microvasculature of the pituitary gland of experimentally infected Boran cattle (Bos indicus). Vet Pathol (1993) 0.77

Isolation and preliminary characterisation of a previously unidentified Theileria parasite of cattle in Kenya. Res Vet Sci (1994) 0.77

The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome. Cell Death Dis (2012) 0.76

The fine structure of the brain of Gastrocotyle trachuri (Monogena: Platyhelminthes). Cell Tissue Res (1982) 0.75

Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents. J Med Chem (1993) 0.75

The significance and nature of defective interfering viruses. Bull Schweiz Akad Med Wiss (1977) 0.75

Input synapses on to a locust sensory neurone revealed by cobalt-electron microscopy. Brain Res (1980) 0.75

Schistosoma mansoni: effects of praziquantel on the ultrastructure of worms in vivo. Trans R Soc Trop Med Hyg (1982) 0.75

Schistosoma mansoni: electron probe X-ray microanalysis of the elemental composition of the tegument and subtegumental tissues of adult worms. Exp Parasitol (1984) 0.75

Effect of aerosolized lactic acid on the survival of airborne microorganisms. Appl Microbiol (1967) 0.75

The demonstration of calcium in the axonal granules of the peripheral nervous system of male Schistosoma mansoni by X-ray microanalysis. Cell Tissue Res (1982) 0.75

5-Fluorouracil, doxorubicin, and mitomycin-C in the treatment of adenocarcinoma and large cell carcinoma of the lung. Cancer (1987) 0.75

Characterization of Theileria parva which infects waterbuck (Kobus defassa). Parasitology (1994) 0.75

The ultrastructure of synapses in the brain of Gastrocotyle trachuri (Monogenea, Platyhelminthes). Cell Tissue Res (1981) 0.75

Visualization of synapses of physiologically identified cobalt-filled neurones in the locust [proceedings]. J Physiol (1979) 0.75