PubRank

P R Young

Author PubWeight™ 184.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1995 11.89
2 SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995 9.62
3 Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 1998 3.88
4 Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication. Virology 1996 3.60
5 Malpractice claims against family physicians are the best doctors sued more? J Fam Pract 1999 2.87
6 A new nomenclature for IL-1-family genes. Trends Immunol 2001 2.57
7 Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J Biol Chem 1996 2.55
8 Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol 1993 2.40
9 Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 1994 2.37
10 Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 1998 2.32
11 Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem 2000 2.24
12 A statement on the generalist physician from the American Boards of Family Practice and Internal Medicine. JAMA 1994 2.16
13 Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci U S A 2000 2.16
14 5-lipoxygenase inhibitory activity of zileuton. J Pharmacol Exp Ther 1991 2.14
15 Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J Biol Chem 1998 2.12
16 Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J Leukoc Biol 1996 2.09
17 Diagnosis and initial management of blunt pancreatic trauma: guidelines from a multiinstitutional review. Ann Surg 1998 2.07
18 A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J Biol Chem 1997 2.00
19 Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun 1997 1.99
20 The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta. J Biol Chem 1988 1.95
21 Processing of precursor interleukin 1 beta and inflammatory disease. J Biol Chem 1990 1.94
22 Activation of the p38 mitogen-activated protein kinase by type I interferons. J Biol Chem 1999 1.94
23 Structural basis of inhibitor selectivity in MAP kinases. Structure 1998 1.89
24 Performances of family practice diplomates on successive mandatory recertification examinations. Acad Med 1993 1.75
25 Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. J Biol Chem 2001 1.72
26 Intragenic amplification and divergence in the mouse alpha-fetoprotein gene. Nature 1981 1.69
27 A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett 1996 1.68
28 Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J Biol Chem 1998 1.60
29 Iodine-131 in breast milk following therapy for thyroid carcinoma. J Nucl Med 1994 1.51
30 Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectors. J Virol 2000 1.49
31 The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J Biol Chem 2000 1.47
32 Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor. J Immunol 1996 1.45
33 The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. Gene 1994 1.43
34 Precise location of sequential dengue virus subcomplex and complex B cell epitopes on the nonstructural-1 glycoprotein. Arch Virol 1994 1.43
35 The interaction of intercalating drugs with nucleic acids. Annu Rev Biophys Bioeng 1981 1.42
36 Prenatal care--a serious national dilemma. J Am Board Fam Pract 1990 1.41
37 Construction and expression in vivo of an internally deleted mouse alpha-fetoprotein gene: presence of a transcribed Alu-like repeat within the first intervening sequence. Nucleic Acids Res 1982 1.40
38 Anomalies associated with myelodysplasia. Urology 1992 1.39
39 Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation. Mol Cell Biol 1984 1.39
40 Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist. Proc Natl Acad Sci U S A 1995 1.32
41 Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase. Bioorg Med Chem 1997 1.31
42 Immunoaffinity purification of native dimer forms of the flavivirus non-structural glycoprotein, NS1. J Virol Methods 1990 1.31
43 Production of dimer-specific and dengue virus group cross-reactive mouse monoclonal antibodies to the dengue 2 virus non-structural glycoprotein NS1. J Gen Virol 1991 1.30
44 Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein. Biochem J 2001 1.30
45 Interleukin-1 beta mRNA expression in ischemic rat cortex. Stroke 1993 1.30
46 A rapid and quantitative method for the determination of interleukin-1 alpha and -beta mRNA expression in human monocytes and macrophages. J Immunol Methods 1989 1.29
47 Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res Mol Brain Res 1996 1.28
48 Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. J Biol Chem 1995 1.27
49 Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1. FEBS Lett 1996 1.26
50 Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction. FASEB J 2000 1.22
51 Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor. J Gen Virol 1999 1.21
52 Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines. J Immunol 1998 1.18
53 West Nile Virus NS2B/NS3 protease as an antiviral target. Curr Med Chem 2008 1.18
54 Experimental brain injury induces expression of interleukin-1 beta mRNA in the rat brain. Brain Res Mol Brain Res 1995 1.17
55 Purification and characterization of human recombinant interleukin-1 beta. J Biol Chem 1987 1.16
56 Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli. Biochem Biophys Res Commun 1997 1.16
57 The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor. Int J Immunopharmacol 1992 1.16
58 ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1. J Biol Chem 1995 1.16
59 Structure-function mapping of interleukin 1 precursors. Cleavage leads to a conformational change in the mature protein. J Biol Chem 1991 1.12
60 Renal metastases from thyroid papillary carcinoma: study of sodium iodide symporter expression. Thyroid 2001 1.11
61 Fine structure analysis of Pichinde virus nucleocapsids. J Gen Virol 1983 1.10
62 Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase. J Biol Chem 1996 1.10
63 Improved membrane preservation of flavivirus-infected cells with cryosectioning. J Virol Methods 1996 1.09
64 Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways. Cardiovasc Res 2000 1.09
65 Analysis of the interaction between human interleukin-5 and the soluble domain of its receptor using a surface plasmon resonance biosensor. J Mol Recognit 1994 1.08
66 Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex. J Cereb Blood Flow Metab 1995 1.08
67 Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway. J Biol Chem 1997 1.07
68 Educational resource sharing and collaborative training in family practice and internal medicine. A statement from the American Boards of Internal Medicine and Family Practice. JAMA 1995 1.05
69 Prevalence of koala retrovirus in geographically diverse populations in Australia. Aust Vet J 2012 1.04
70 The influence of the normal microbial flora on the susceptibility of rats to experimental autoimmune thyroiditis. Clin Exp Immunol 1988 1.04
71 The isolation of recombinants between related orbiviruses. J Gen Virol 1978 1.03
72 Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs. Gene 1994 1.03
73 3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation. J Med Chem 1988 1.02
74 Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann N Y Acad Sci 1993 1.01
75 Systematic transperineal ultrasound guided template biopsy of the prostate in patients at high risk. J Urol 2001 1.01
76 Evolution of the albumin: alpha-fetoprotein ancestral gene from the amplification of a 27 nucleotide sequence. J Mol Biol 1984 0.97
77 Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast. J Biol Chem 1995 0.95
78 Maturation of the dengue-2 virus NS1 protein in insect cells: effects of downstream NS2A sequences on baculovirus-expressed gene constructs. J Gen Virol 1995 0.94
79 Enhancement of immunoblot staining using a mixed chromogenic substrate. J Immunol Methods 1989 0.94
80 The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors. J Immunol 1997 0.94
81 In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase. J Med Chem 1987 0.92
82 Secondary structure in polyuridylic acid. Non-classical hydrogen bonding and the function of the ribose 2'-hydroxyl group. J Mol Biol 1978 0.92
83 Secretion of N-glycosylated interleukin-1 beta in Saccharomyces cerevisiae using a leader peptide from Candida albicans. Effect of N-linked glycosylation on biological activity. J Biol Chem 1991 0.90
84 Colourimetric PCR-based detection of monodon baculovirus in whole Penaeus monodon postlarvae. J Virol Methods 1998 0.89
85 Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia. Neurosci Lett 1993 0.89
86 Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation. Biochem Biophys Res Commun 1999 0.88
87 Dengue: a continuing challenge for molecular biology. Curr Opin Infect Dis 1998 0.86
88 The effects of anti-inflammatory and other agents on the rat dermal arthus reaction. Res Commun Chem Pathol Pharmacol 1982 0.85
89 Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival. Blood 1999 0.84
90 The effects of female sex steroids on the development of autoimmune thyroiditis in thymectomized and irradiated rats. Clin Exp Immunol 1983 0.84
91 Mapping of neutralizing epitopes and the receptor binding site of human interleukin 1 beta. J Biol Chem 1993 0.83
92 Frameshift mutagenesis of 9-aminoacridine derivatives in Salmonella typhimurium. Mutat Res 1981 0.83
93 Evaluating energetics of erythropoietin ligand binding to homodimerized receptor extracellular domains. Methods Enzymol 2000 0.83
94 Patients don't present with five choices: an alternative to multiple-choice tests in assessing physicians' competence. Acad Med 1999 0.83
95 Characterization of Nugget virus, a serotype of the Kemerovo group of orbiviruses. Aust J Exp Biol Med Sci 1984 0.82
96 Identification of residues in West Nile virus pre-membrane protein that influence viral particle secretion and virulence. J Gen Virol 2012 0.82
97 Site exclusion and sequence specificity in binding of 9-aminoacridine to the deoxytetranucleotide dpApGpCpT. Proc Natl Acad Sci U S A 1980 0.82
98 Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates. Arch Biochem Biophys 2006 0.82
99 Structure-activity studies of human IL-1 beta with mature and truncated proteins expressed in Escherichia coli. J Immunol 1988 0.82
100 Pyruvamide semicarbazone formation. Kinetics, mechanism, and pertinence to pyruvamide-dependent histidine decarboxylase. J Am Chem Soc 1975 0.81
101 Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors. J Med Chem 1997 0.81
102 Hepatitis B surface antigen polypeptide micelles from antigen expressed in Saccharomyces cerevisiae. J Virol Methods 1986 0.81
103 Nurse-physician interaction in a family medical care center. Nurs Outlook 1974 0.81
104 Orally active hydroxamic acid inhibitors of leukotriene biosynthesis. J Med Chem 1988 0.81
105 Binding of 9-aminoacridine to deoxydinucleoside phosphates of defined sequence: preferences and stereochemistry. J Mol Biol 1981 0.80
106 Constitutive and PMA-induced interleukin-1 production by the human astrocytoma cell line T24. Cell Immunol 1989 0.80
107 Pyruvamide-promoted deamination and decarboxylation of amines and amino acids: a system modelling histidine decarboxylase. FEBS Lett 1974 0.79
108 Beneficial effect of testosterone in the treatment of chronic autoimmune thyroiditis in rats. J Immunol 1986 0.79
109 Further aspects of IL-1 beta secretion revealed by transfected monkey kidney cells. Cytokine 1992 0.79
110 Modified influenza virosomes: recent advances and potential in gene delivery. Curr Med Chem 2007 0.78
111 Inhibitors of the p38 mitogen-activated kinase modulate IL-4 induction of low affinity IgE receptor (CD23) in human monocytes. J Immunol 1998 0.78
112 Type I IL-1 receptor: ligand specific confirmation differences and the role of glycosylation in ligand binding. Cytokine 1996 0.78
113 Secretion of N-glycosylated human recombinant interleukin-1 alpha in Saccharomyces cerevisiae. Gene 1990 0.78
114 Localization of the human stress responsive MAP kinase-like CSAIDs binding protein (CSBP) gene to chromosome 6q21.3/21.2. Genomics 1995 0.78
115 Preliminary X-ray crystallography studies of recombinant human interleukin-1 alpha. Purification and structural characterization. J Biol Chem 1989 0.78
116 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones. J Med Chem 1996 0.78
117 Monodon baculovirus from Australia: ultrastructural observations. Dis Aquat Organ 2000 0.78
118 Expression of recombinant West Nile virus prM protein fused to an affinity tag for use as a diagnostic antigen. J Virol Methods 2011 0.78
119 GABA from putrescine is bound in macromolecular form in keratinocytes. Life Sci 1983 0.78
120 Mechanism of the interaction between myelin basic protein and the myelin membrane; the role of arginine methylation. Biochem Biophys Res Commun 1987 0.77
121 1991 certification-recertification examinations. J Am Board Fam Pract 1992 0.77
122 Evaluation of plaque size reduction as a method for the detection of Pichinde virus antibody. Arch Virol 1980 0.77
123 Structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle changes in conformation that affect protein-protein recognition. Biochemistry 1993 0.77
124 Mob-1 expression in IL-2-induced ARDS: regulation by TNF-alpha. Am J Physiol 1995 0.77
125 Non-protein thiols flux to S-nitrosothiols in endothelial cells: an LPS redox signal. Shock 2000 0.77
126 2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents. J Med Chem 1983 0.77
127 Secretion of interleukin-1 beta and Escherichia coli galactokinase by Streptomyces lividans. J Bacteriol 1988 0.77
128 Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis. J Med Chem 1988 0.77
129 Binding of mercury(II) to poly(dA-dT) studied by proton nuclear magnetic resonance. Biochemistry 1982 0.77
130 Low-molecular-weight TNF biosynthesis inhibitors: strategies and prospectives. Circ Shock 1994 0.76
131 Variation among New and Old World arenaviruses. Trans R Soc Trop Med Hyg 1984 0.76
132 Secretion of lactic acid by peritoneal macrophages during extracellular phagocytosis. The possible role of local hyperacidity in inflammatory demyelination. J Neuroimmunol 1987 0.76
133 Pharmacological studies in the rat with [2-(1,3-didecanoyloxy)-propyl]2-acetyloxybenzoate (A-45474): an aspirin pro-drug with negligible gastric irritation. Agents Actions 1980 0.76
134 Sequence of the dengue virus type 2 (strain PR-159) NS1 gene and comparison with its vaccine derivative. Nucleic Acids Res 1993 0.75
135 Fluctuational opening-closing reactions in DNA and mononucleosome cores of chromatin probed by h-exchange and ligand binding reactions. Biophys J 1980 0.75
136 Quality control of radiolabeled leukocytes with monoclonal antibodies. J Nucl Med 1994 0.75
137 Geriatrics. JAMA 1989 0.75
138 Expanding the family practice model. J Am Board Fam Pract 1990 0.75
139 Supervisors discuss need, methods for inservice education. Hosp Top 1966 0.75
140 Ribonucleoprotein complexes associated with virions of Pichinde virus and Pichinde virus-infected cells. Med Microbiol Immunol 1986 0.75
141 Optimization of PCR and automated sequencing of clinical isolates of respiratory syncytial virus. J Virol Methods 1994 0.75
142 Liberal education for family practice. J Am Board Fam Pract 1989 0.75
143 Measurement of inflammatory reactions by a dye dilution method. J Pharm Pharmacol 1982 0.75
144 Patient expectation: what is comprehensive health care? J Fam Pract 1979 0.75
145 Experimental antiinflammatory and analgesic studies with 3-trifluoromethyl-s-triazolo (3,4-a)-isoquinoline. Arch Int Pharmacodyn Ther 1974 0.75
146 Empiricism in family practice. J Am Board Fam Pract 1988 0.75
147 The properties of A-69412: a small hydrophilic 5-lipoxygenase inhibitor. Agents Actions 1993 0.75
148 Family practice curriculum: how well does it reflect family practice? Fam Med 1988 0.75
149 Quantitative structure-activity relationships of inhibitors of immune complex-induced inflammation: 1-phenyl-3-aminopyrazoline derivatives. J Pharm Sci 1990 0.75
150 Regulation of Pichinde virus replication in Vero and BHK-21 cells. Med Microbiol Immunol 1986 0.75
151 New azacannabinoids highly active in the central nervous system. J Med Chem 1983 0.75
152 Pharmacologic studies with ABBOTT-30360, an analgesic-tranquilizer, and its analogues. Arch Int Pharmacodyn Ther 1971 0.75
153 Licensure versus certification. J Am Board Fam Pract 1989 0.75
154 Collaboration in family practice. J Am Board Fam Pract 1988 0.75
155 Pharmacologic studies with 4,5-dihydro-1,3-dimethyl-1H-pyrazolo-(3,4-b) (1,4)-benzoxazepine hydrochloride. Arch Int Pharmacodyn Ther 1973 0.75
156 A-78773: a selective, potent 5-lipoxygenase inhibitor. J Lipid Mediat 1993 0.75
157 Radiographic imaging of the artificial urinary sphincter pressure regulating balloon. J Urol 2001 0.75
158 Species differences in the toxicity of the schistosomicide ABBOTT-16612. Toxicol Appl Pharmacol 1966 0.75
159 Determination of the likelihood of repetitive sequences in the alpha-fetoprotein gene. J Mol Biol 1984 0.75
160 Prevention of antiinflammatory drug-induced gastric lesions in rats by Abbott-29590. Am J Dig Dis 1974 0.75
161 Hepatic copper overload--is it Wilson's disease? Aust N Z J Med 1994 0.75
162 Time dependence of the methylation of myelin basic protein from bovine brain; evidence for protein-methylarginine demethylation. Biochem Biophys Res Commun 1987 0.75
163 Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives. J Med Chem 1977 0.75
164 Inhibitors of immune complex-induced inflammation: 5-substituted 3-[1-(2-benzoxazolyl)hydrazino]propanenitrile derivatives. J Pharm Sci 1990 0.75
165 Anti-inflammatory and other properties of 2,3-dihydrol-1-H-pyridino-(2,3- b) (1,4)-thiazine-2-one; ABBott-29590. Arch Int Pharmacodyn Ther 1972 0.75
166 A case for refereed journals. J Am Board Fam Pract 1989 0.75
167 Anxiety. J Am Board Fam Pract 1989 0.75