PubRank

P Fraser

Author PubWeight™ 151.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003 19.77
2 Mortality of employees of the United Kingdom Atomic Energy Authority, 1946-1979. Br Med J (Clin Res Ed) 1985 5.48
3 Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 2000 4.68
4 Transcription complex stability and chromatin dynamics in vivo. Nature 1995 4.51
5 Intergenic transcription and transinduction of the human beta-globin locus. Genes Dev 1997 4.30
6 Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997 4.10
7 Detailed analysis of the site 3 region of the human beta-globin dominant control region. EMBO J 1990 4.05
8 Mortality of employees of the Atomic Weapons Establishment, 1951-82. BMJ 1988 3.82
9 Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus. Mol Cell 2000 3.75
10 The beta-globin dominant control region: hypersensitive site 2. EMBO J 1990 3.75
11 Case-control study of prostatic cancer in employees of the United Kingdom Atomic Energy Authority. BMJ 1993 2.85
12 Importance of globin gene order for correct developmental expression. Genes Dev 1991 2.85
13 Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell 1996 2.77
14 The role of EKLF in human beta-globin gene competition. Genes Dev 1996 2.72
15 The epidemiology of systemic lupus erythematosus in populations of African ancestry: a critical review of the "prevalence gradient hypothesis". Arthritis Rheum 1998 2.47
16 On the estimation of relative risk from vital statistical data. J Epidemiol Community Health 1979 2.34
17 Does pregnancy protect against ovarian cancer? Lancet 1978 2.28
18 Discriminant functions in differential diagnosis of hypercalcaemia. Lancet 1971 2.16
19 Collection and validation of data in the United Kingdom Atomic Energy Authority mortality study. Br Med J (Clin Res Ed) 1985 2.13
20 A transgenic mouse model of sickle cell disorder. Nature 1990 2.05
21 Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J Cell Biol 1999 2.03
22 Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Genes Dev 1999 1.98
23 Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis 1997 1.92
24 The effect of distance on long-range chromatin interactions. Mol Cell 1997 1.90
25 Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J Biol Chem 1997 1.81
26 An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron 1994 1.77
27 Chromatin interaction mechanism of transcriptional control in vivo. EMBO J 1998 1.72
28 Radiation dose and second cancer risk in patients treated for cancer of the cervix. Radiat Res 1988 1.66
29 Developmental regulation of DNA replication timing at the human beta globin locus. EMBO J 2001 1.45
30 Combined analysis of mortality in three United Kingdom nuclear industry workforces, 1946-1988. Radiat Res 1994 1.34
31 The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol Med 1996 1.32
32 Radiation dose and leukemia risk in patients treated for cancer of the cervix. J Natl Cancer Inst 1987 1.28
33 Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations. J Biol Chem 2001 1.21
34 Alcohol and oesophageal cancer: an assessment of the evidence from routinely collected data. J Epidemiol Community Health 1979 1.21
35 Census-based mortality study of fertiliser manufactures. Br J Ind Med 1982 1.19
36 Position effects and genetic disease. Trends Genet 1996 1.19
37 Atmospheric trends in methylchloroform and the global average for the hydroxyl radical. Science 1987 1.16
38 Health related selection and death rates in the United Kingdom Atomic Energy Authority workforce. Br J Ind Med 1990 1.14
39 A survey of dietary nitrate in well-water users. Int J Epidemiol 1984 1.11
40 Further assessment of the effects of occupational radiation exposure in the United Kingdom Atomic Energy Authority mortality study. Br J Ind Med 1987 1.10
41 Discrimination between iron-deficiency and heterozygous-thalassaemia syndromes in differential diagnosis of microcytosis. Lancet 1979 1.09
42 Nitrate and human cancer: a review of the evidence. Int J Epidemiol 1980 1.08
43 Activation of the beta globin locus by transcription factors and chromatin modifiers. EMBO J 2000 1.08
44 Methods for age-adjustment of rates. Stat Med 1984 1.06
45 Chronic microsporidian infection of the nasal mucosae, sinuses and conjunctivae in HIV disease. Genitourin Med 1992 1.06
46 Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A 1997 1.04
47 Sequence comparison of human and murine erythrocyte alpha-spectrin cDNA. Gene 1985 0.99
48 Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry 2012 0.99
49 Transcription factories and nuclear organization of the genome. Cold Spring Harb Symp Quant Biol 2011 0.99
50 Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes. Neurobiol Aging 2000 0.98
51 Maintaining updated DNA-based HLA assignments in the National Marrow Donor Program Bone Marrow Registry. Rev Immunogenet 2000 0.98
52 Cancer mortality in relation to monitoring for radionuclide exposure in three UK nuclear industry workforces. Br J Cancer 1998 0.98
53 The regulation of human globin gene switching. Philos Trans R Soc Lond B Biol Sci 1993 0.98
54 New clothes for amyloid enhancing factor (AEF): silk as AEF. Amyloid 1999 0.98
55 HLA gene frequencies in children and adults with systemic onset juvenile rheumatoid arthritis. Arthritis Rheum 1985 0.96
56 Geographical variations in the epidemic of asthma deaths. Br J Prev Soc Med 1971 0.95
57 Evaluation of beta-globin gene therapy constructs in single copy transgenic mice. Nucleic Acids Res 1997 0.94
58 Hydrocortisone suppression test and discriminant analysis in differential diagnosis of hypercalcaemia. Lancet 1980 0.90
59 High-level regulated expression of the human G6PD gene in transgenic mice. Gene 1996 0.88
60 The chicken beta/epsilon-globin enhancer directs autonomously regulated, high-level expression of the chicken epsilon-globin gene in transgenic mice. Proc Natl Acad Sci U S A 1994 0.88
61 Thrombotic thrombocytopenic purpura and systemic lupus erythematosus. Ann Rheum Dis 1986 0.87
62 Regulation of human globin gene switching. Cold Spring Harb Symp Quant Biol 1993 0.86
63 Second primary malignancy after Hodgkin's disease, ovarian cancer and cancer of the testis: a population-based cohort study. Br J Cancer 1987 0.86
64 Radiation dose and breast cancer risk in patients treated for cancer of the cervix. Int J Cancer 1989 0.85
65 Health aspects of nitrate in drinking water. Sci Total Environ 1981 0.84
66 Further experience with discriminant functions in differential diagnosis of hypercalcaemia. Postgrad Med J 1976 0.84
67 Establishment of a smoking cessation programme in primary and secondary care in Canterbury. N Z Med J 2000 0.83
68 Single-dose dexamethasone paclitaxel premedication. Gynecol Oncol 1998 0.82
69 The pattern of disease in hospital, 1968-1978. Health Trends 1983 0.82
70 Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy. Arthritis Rheum 1989 0.81
71 Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice. Clin Exp Immunol 2006 0.80
72 The dynamics of globin gene expression and gene therapy vectors. Semin Hematol 1998 0.80
73 The dominant control region of the human beta-globin domain. Ann N Y Acad Sci 1990 0.79
74 Nitrates: epidemiological evidence. IARC Sci Publ 1985 0.79
75 Clonally expanded Valpha12+ (AV12S1),CD8+ T cells from a patient with rheumatoid arthritis are autoreactive. Arthritis Rheum 1998 0.79
76 The glycosylation of human myelin basic protein at threonines 95 and 98 occurs sequentially. Biochim Biophys Acta 1988 0.79
77 Thy-1 tk transgenic mice with a conditional lymphocyte deficiency. Int Immunol 1993 0.79
78 Designing an intervention for women with systemic lupus erythematosus from medically underserved areas to improve care: a qualitative study. Lupus 2012 0.78
79 A differentiation stage-specific factor interacts with mouse carbonic anhydrase form I gene and a conserved sequence in mammalian beta-globin genes. Differentiation 1991 0.78
80 I-123 iofetamine SPECT scan in systemic lupus erythematosus patients with cognitive and other minor neuropsychiatric symptoms: a pilot study. Lupus 1992 0.77
81 The dynamics of globin gene expression and position effects. Novartis Found Symp 1998 0.77
82 Functional analysis of the human neurofilament light chain gene promoter. Nucleic Acids Res 1993 0.76
83 Proteoglycans and amyloid fibrillogenesis. Ciba Found Symp 1996 0.76
84 Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice. Nucleic Acids Res 1993 0.75
85 Human relevance: epidemiology and occupational exposure. Oncology 1980 0.75
86 What to do with the offending bird. Aust Fam Physician 2001 0.75
87 Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. Acta Neurol Scand Suppl 2000 0.75
88 Epidemiological monitoring: methods for analysing routinely-collected data. Sci Total Environ 1984 0.75
89 Hazards of medical computing. Lancet 1972 0.75
90 Prevalence of idiopathic vertebral sclerosis, Zöetermeer, Rotterdam, 1975-1978. Spine (Phila Pa 1976) 1991 0.75
91 An Aß concatemer with altered aggregation propensities. Biochim Biophys Acta 2010 0.75
92 Cervical cancer and husband's occupation. Lancet 1984 0.75
93 The dynamics of globin gene expression and gene therapy vectors. Ann N Y Acad Sci 1998 0.75
94 Effect of cyclosporine on urinary kallikrein excretion in patients with rheumatoid arthritis. J Lab Clin Med 1988 0.75
95 Colorectal cancer. Recent trends. Recent Results Cancer Res 1982 0.75