Published in Am J Pathol on October 01, 1998
Genomic imprinting: implications for human disease. Am J Pathol (1999) 2.26
Constitutional mismatch repair-deficiency syndrome: have we so far seen only the tip of an iceberg? Hum Genet (2008) 1.81
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol (2003) 1.24
Germline truncating mutations in both MSH2 and BRCA2 in a single kindred. Br J Cancer (2004) 1.17
Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae. Genetics (2007) 1.17
Inherited predisposition to glioma. Neuro Oncol (2009) 0.99
MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population. Am J Hum Genet (2004) 0.96
High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours. Br J Cancer (2002) 0.92
Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation. PLoS One (2011) 0.89
Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology Group. Pediatr Blood Cancer (2010) 0.88
Imprinted genes as potential genetic and epigenetic toxicologic targets. Environ Health Perspect (2000) 0.88
Alterations of p53, BCL-2, and hMSH2 protein expression in the normal brain tissues, gliosis, and gliomas. Int J Exp Pathol (2006) 0.87
p53, mdm2, EGFR, and msh2 expression in paired initial and recurrent glioblastoma multiforme. J Neurol Neurosurg Psychiatry (2003) 0.87
Type A microsatellite instability in pediatric gliomas as an indicator of Turcot syndrome. Eur J Hum Genet (2009) 0.87
Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: an analysis of ATP-induced ribonucleotide reductase R1 hexamerization data. Biol Direct (2009) 0.83
Missense mutations of MLH1 and MSH2 genes detected in patients with gastrointestinal cancer are associated with exonic splicing enhancers and silencers. Oncol Lett (2013) 0.81
Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade. Oncologist (2016) 0.78
Evaluation of microsatellite instability in tumors of central nervous system: A pilot study. Indian J Clin Biochem (2004) 0.75
Clues to the pathogenesis of familial colorectal cancer. Science (1993) 14.52
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54
Mutation of a mutL homolog in hereditary colon cancer. Science (1994) 9.04
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (1994) 8.04
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
The molecular basis of Turcot's syndrome. N Engl J Med (1995) 6.65
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (1994) 6.21
Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors. Annu Rev Biochem (1992) 5.64
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87
Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res (1997) 4.61
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (1995) 4.48
Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol (1996) 4.18
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet (1995) 4.01
Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology (1993) 3.76
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science (1995) 3.34
Mutations of GTBP in genetically unstable cells. Science (1995) 3.23
Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med (1995) 3.07
Instability of short tandem repeats (microsatellites) in human cancers. Nat Genet (1994) 2.45
hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res (1994) 2.39
Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A (1991) 2.27
Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet (1996) 2.19
Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases. Dis Colon Rectum (1960) 2.06
Risk of cancer revealed by follow-up of families with hereditary non-polyposis colorectal cancer: a population-based study. Int J Cancer (1993) 2.05
Microsatellite instability in inherited and sporadic neoplasms. Curr Opin Oncol (1995) 1.87
A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res (1995) 1.86
Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J Neurosurg (1994) 1.67
Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol (1993) 1.67
Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res (1997) 1.45
Microsatellite instability analysis: a multicenter study for reliability and quality control. Cancer Res (1997) 1.43
Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme. Brain Pathol (1997) 1.37
The risk of brain tumours in hereditary non-polyposis colorectal cancer (HNPCC). Int J Cancer (1996) 1.35
Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol (1997) 1.19
Drastic genetic instability of tumors and normal tissues in Turcot syndrome. Oncogene (1997) 1.13
Instability of microsatellites in human gliomas. Cancer Res (1995) 1.11
The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum. Cancer Res (1997) 1.09
The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma. Neurosci Lett (1988) 1.07
Colorectal carcinoma in Hong Kong: epidemiology and genetic mutations. Br J Cancer (1997) 1.05
Evidence of genetic progression in human gastric carcinomas with microsatellite instability. Oncogene (1997) 1.02
Statistical analysis of central nervous system tumors in China. J Neurosurg (1982) 0.98
The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas. Cancer Genet Cytogenet (1996) 0.89
Tumors of the central nervous system in Taiwan, Republic of China. Surg Neurol (1984) 0.88
Disease expression in Swiss hereditary non-polyposis colorectal cancer (HNPCC) kindreds. Int J Cancer (1997) 0.88
Microsatellite instability analysis of primary human brain tumors. Oncogene (1996) 0.85
Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas. Cancer Lett (1997) 0.85
Mismatch repair and cancer. Nature (1994) 0.85
Analysis of microsatellite repeats in pediatric brain tumors. Cancer Genet Cytogenet (1995) 0.83
Tumours of the central nervous system in Chinese in Hong Kong: a histological review. Aust N Z J Surg (1988) 0.77
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system. Biochem J (1985) 2.19
High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Cancer Res (2001) 2.07
Surgical lateral clearance in resected rectal carcinomas. A multivariate analysis of clinicopathologic features. Cancer (1993) 1.99
Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision. Am J Surg (2000) 1.97
Music training improves verbal memory. Nature (1998) 1.76
hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res (1999) 1.70
An autopsy study of pulmonary thromboembolism in Hong Kong Chinese. Pathology (1991) 1.66
Tumor necrosis factor mRNA localized to Paneth cells of normal murine intestinal epithelium by in situ hybridization. J Exp Med (1990) 1.52
Fine-needle aspiration biopsy of pilomatrixoma: still a diagnostic trap for the unwary. Diagn Cytopathol (1994) 1.51
Species heterogeneity in macrophage expression of the CD4 antigen. J Exp Med (1987) 1.49
Recurrent germline mutation in MSH2 arises frequently de novo. J Med Genet (2000) 1.49
Sensory ganglionectomy: theory, technical aspects, and clinical experience. J Neurosurg (2001) 1.47
Radiation recall with oxaliplatin: report of a case and a review of the literature. Clin Oncol (R Coll Radiol) (2001) 1.44
Esophagogastric anastomosis performed with a stapler: the occurrence of leakage and stricture. Surgery (1987) 1.41
An epithelial cyst in the cerebellopontine angle. Case report. J Neurosurg (1991) 1.39
Endoscopic cranionasal resection of anterior skull base tumor. Am J Otolaryngol (1998) 1.37
Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans. Am Ind Hyg Assoc J (1980) 1.36
Vascular endothelial growth factor is up-regulated in the early pre-malignant stage of colorectal tumour progression. Int J Cancer (1999) 1.35
Prospective evaluation of selective defunctioning stoma for low anterior resection with total mesorectal excision. World J Surg (1999) 1.34
In situ detection of Epstein-Barr virus in gastric and colorectal adenocarcinomas. Am J Surg Pathol (1994) 1.33
A multicentre randomized controlled trial of oral misoprostol and i.m. syntometrine in the management of the third stage of labour. Hum Reprod (2001) 1.32
Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas. Acta Neuropathol (1997) 1.26
Biochemical and ultrastructural properties of a mitochondrial inner membrane fraction deficient in outer membrane and matrix activities. J Cell Biol (1970) 1.26
Evidence for lytic infection by Epstein-Barr virus in mucosal lymphocytes instead of nasopharyngeal epithelial cells in normal individuals. J Med Virol (1995) 1.25
Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma. Cancer (1994) 1.23
The possible role of metabolites in therapeutic response to chlorpromazine treatment. Psychopharmacologia (1973) 1.22
Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3. Int J Cancer (2001) 1.20
The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells. Eur J Cancer (2003) 1.20
Self-expanding metallic stent in the treatment of colonic obstruction caused by advanced malignancies. Dis Colon Rectum (2000) 1.19
A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen. J Cell Biol (1995) 1.18
Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. Am J Surg Pathol (1998) 1.18
Trial of a community-based intervention to decrease infestation of Aedes aegypti mosquitoes in cement washbasins in El Progreso, Honduras. Acta Trop (1998) 1.18
BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs. J Clin Pathol (2005) 1.17
An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese. Aliment Pharmacol Ther (2001) 1.16
Pattern of cerebral atherosclerosis in Hong Kong Chinese. Severity in intracranial and extracranial vessels. Stroke (1993) 1.15
Cognitive function of patients with nasopharyngeal carcinoma with and without temporal lobe radionecrosis. Arch Neurol (2000) 1.14
Mononuclear phagocytes: tissue distribution and functional heterogeneity. Curr Opin Immunol (1989) 1.13
Extramedullary sites of involvement in hematologic malignancies: case 3. Hemorrhagic gastric plasmacytoma as the primary presentation in multiple myeloma. J Clin Oncol (2002) 1.13
Overexpression of p53 in hepatocellular carcinomas: a clinicopathological and prognostic correlation. J Gastroenterol Hepatol (1995) 1.11
Soluble E-cadherin is a valid prognostic marker in gastric carcinoma. Gut (2001) 1.11
Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon. Hum Pathol (1998) 1.09
Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer. J Natl Cancer Inst (1999) 1.09
Dopamine receptor D4 (DRD4) gene in Han Chinese children with attention-deficit/hyperactivity disorder (ADHD): increased prevalence of the 2-repeat allele. Am J Med Genet B Neuropsychiatr Genet (2005) 1.08
Seasonal variation in the necropsy incidence of pulmonary thromboembolism in Hong Kong. J Clin Pathol (1995) 1.06
Ewing sarcoma of the small intestine. J Pediatr Hematol Oncol (2001) 1.06
Comparison of the aesthetic facial proportions of southern Chinese and white women. Arch Facial Plast Surg (2000) 1.05
Colorectal carcinoma in Hong Kong: epidemiology and genetic mutations. Br J Cancer (1997) 1.05
The deterioration of semantic memory in Alzheimer's disease. Can J Exp Psychol (1999) 1.04
The superfamily of C3b/C4b-binding proteins. Fed Proc (1987) 1.04
Cutting edge: T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase. J Immunol (2001) 1.04
Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol (2000) 1.02
Prevalence of pulmonary arterial hypertension in an Australian scleroderma population: screening allows for earlier diagnosis. Intern Med J (2008) 1.02
Identifying barriers to hypertension guideline adherence using clinician feedback at the point of care. AMIA Annu Symp Proc (2006) 1.02
p53 overexpression is different in Epstein-Barr virus-associated and Epstein-Barr virus-negative carcinoma. Histopathology (1998) 1.01
Pre- and postoperative fMRI and clinical memory performance in temporal lobe epilepsy. J Neurol Neurosurg Psychiatry (2009) 1.01
Unusual ultrastructure of complement-component-C4b-binding protein of human complement by synchrotron X-ray scattering and hydrodynamic analysis. Biochem J (1986) 1.01
cDNA structure of murine C4b-binding protein, a regulatory component of the serum complement system. Biochemistry (1987) 1.01
Effect of exchange exocrine pancreatic insufficiency on small intestine in the mouse. Gastroenterology (1978) 1.01
High-frequency jet ventilation in the anesthetic management of a patient with tracheoesophageal fistula complicating carcinoma of the esophagus. Anesth Analg (1991) 1.00
A novel germline 1.8-kb deletion of hMLH1 mimicking alternative splicing: a founder mutation in the Chinese population. Oncogene (2001) 1.00
Signal to noise enhancement in dark field electron micrographs of vasopressin: filtering of arrays of images in reciprocal space. J Microsc (1977) 0.99
Long-term survival after gastrectomy for advanced bleeding or perforated gastric carcinoma. Eur J Surg (1996) 0.98
Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus. J Clin Pathol (1995) 0.98
Synchronous gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma in association with Helicobacter pylori infection: comparing reported cases between the East and West. Am J Gastroenterol (2001) 0.97
Primary B-cell lymphoma and lymphoma-like lesions of the uterine cervix. Am J Hematol (2003) 0.97
Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinomas in Hong Kong Chinese people. Cancer (1994) 0.97
Presence of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the middle ear. J Clin Pathol (1998) 0.97
Inhibition of proteasome function induced apoptosis in gastric cancer. Int J Cancer (2001) 0.97
Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes. Oncogene (2001) 0.96
Pulmonary retention of inhaled diesel particles after prolonged exposures to diesel exhaust. Fundam Appl Toxicol (1984) 0.96
The significance of skull fracture in acute traumatic intracranial hematomas in adolescents: a prospective study. J Neurosurg (1990) 0.96
Epstein-Barr virus is present in a wide histological spectrum of sinonasal carcinomas. Am J Surg Pathol (1995) 0.96
Sarcomatoid carcinoma of the small intestine. Aust N Z J Surg (1996) 0.95
Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. Br J Cancer (1999) 0.95