Published in J Med Chem on October 22, 1998
A new modified thrombin binding aptamer containing a 5'-5' inversion of polarity site. Nucleic Acids Res (2006) 1.04
Sugar-modified G-quadruplexes: effects of LNA-, 2'F-RNA- and 2'F-ANA-guanosine chemistries on G-quadruplex structure and stability. Nucleic Acids Res (2013) 0.78
Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity. Nucleic Acids Res (2015) 0.76
Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule. Chembiochem (2017) 0.75
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science (1995) 9.48
Structural genomics: beyond the human genome project. Nat Genet (1999) 5.58
Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection. J Virol (1997) 3.79
Conformational and helicoidal analysis of 30 PS of molecular dynamics on the d(CGCGAATTCGCG) double helix: "curves", dials and windows. J Biomol Struct Dyn (1989) 3.78
PHASES-95: a program package for processing and analyzing diffraction data from macromolecules. Methods Enzymol (1997) 3.74
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc (1997) 3.69
A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys (1995) 3.53
Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection. J Infect Dis (2001) 3.47
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol (2001) 3.40
United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol (2001) 3.24
Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob Agents Chemother (1998) 3.01
Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int (2007) 2.98
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans. Proc Natl Acad Sci U S A (2001) 2.96
The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways. Mol Biol Cell (2000) 2.94
Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells. Nucleic Acids Res (1993) 2.72
Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J Exp Med (1996) 2.67
A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol Cell Biol (1993) 2.61
Improved thin-layer chromatographic method for the separation of major phospholipids and glycolipids from plant lipid extracts and phosphatidyl glycerol and bis(monoacylglyceryl) phosphate from animal lipid extracts. J Chromatogr (1977) 2.55
Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob Agents Chemother (1998) 2.44
Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques. Nat Med (2000) 2.33
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment. J Virol (2000) 2.24
9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob Agents Chemother (1996) 2.15
Engineering salt-tolerant Brassica plants: characterization of yield and seed oil quality in transgenic plants with increased vacuolar sodium accumulation. Proc Natl Acad Sci U S A (2001) 2.13
Effects of (R)-9-(2-phosphonylmethoxypropyl)adenine monotherapy on chronic SIV infection in macaques. AIDS Res Hum Retroviruses (1997) 2.12
Low Temperature Development Induces a Specific Decrease in trans-Delta-Hexadecenoic Acid Content which Influences LHCII Organization. Plant Physiol (1987) 2.07
A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA. Biochemistry (1993) 2.07
In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome. EMBO J (1997) 2.03
Vancomycin-associated drug reaction with eosinophilia and systemic symptoms syndrome. Intern Med J (2014) 2.00
The effect of weight loss in overweight, lactating women on the growth of their infants. N Engl J Med (2000) 2.00
Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease. Heart (1997) 1.99
Conversion of thrombin into an anticoagulant by protein engineering. Nature (1995) 1.98
Primary alcohol sulfatase in a Pseudomonas species. Appl Microbiol (1965) 1.97
Metabolism of linear alcohols with various chain lengths by a Pseudomonas species. Appl Microbiol (1966) 1.94
Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution. J Mol Biol (1996) 1.74
Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother (1998) 1.72
Dielectrophoretic assembly of electrically functional microwires from nanoparticle suspensions. Science (2001) 1.65
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology (2010) 1.63
Domain communication in the dynamical structure of human immunodeficiency virus 1 protease. Proc Natl Acad Sci U S A (1990) 1.61
Transrectal prostatic biopsy. Br Med J (1971) 1.60
Development at Cold-Hardening Temperatures : The Structure and Composition of Purified Rye Light Harvesting Complex II. Plant Physiol (1987) 1.59
Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection. AIDS (1998) 1.58
The removal of water and nonlipid contaminants from lipid extracts. Lipids (1970) 1.58
Process analysis in outpatient knee surgery: effects of regional and general anesthesia on anesthesia-controlled time. Anesthesiology (2000) 1.57
How stigmatizing is stigma in the life of people living with HIV: a study on HIV positive individuals from Chennai, South India. AIDS Care (2005) 1.57
HL7 document patient record architecture: an XML document architecture based on a shared information model. Proc AMIA Symp (1999) 1.55
Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res (1996) 1.55
Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi. EMBO J (2001) 1.54
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates. Antimicrob Agents Chemother (1993) 1.54
Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications. Colorectal Dis (2015) 1.53
Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res (1997) 1.52
Cellular and molecular mechanisms of radiation inhibition of restenosis. Part I: role of the macrophage and platelet-derived growth factor. Int J Radiat Oncol Biol Phys (1998) 1.50
Cutaneous epithelioid schwannomas: a rare variant of a benign peripheral nerve sheath tumor. J Cutan Pathol (1998) 1.49
Time dependence of atomic fluctuations in proteins: analysis of local and collective motions in bovine pancreatic trypsin inhibitor. Biochemistry (1982) 1.48
The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression. Proc Natl Acad Sci U S A (1998) 1.47
Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques. AIDS Res Hum Retroviruses (1998) 1.46
Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge. J Med Primatol (2003) 1.45
Contact screening and chemoprophylaxis in India's Revised Tuberculosis Control Programme: a situational analysis. Int J Tuberc Lung Dis (2009) 1.44
The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Mol Cell Biol (1995) 1.43
Role of envelope glycoprotein carbohydrate in human immunodeficiency virus (HIV) infectivity and virus-induced cell fusion. J Exp Med (1986) 1.43
Morphologic and body composition changes are different in men and women on generic combination antiretroviral therapy--an observational study. J Assoc Physicians India (2010) 1.43
Structural genomics of protein phosphatases. J Struct Funct Genomics (2007) 1.40
Evaluation of radiotherapy and/or surgicopathological staging after chemotherapy in the management of metastatic germ cell tumours. Br J Urol (1983) 1.40
Antibody-targeted chemotherapy for the treatment of relapsed acute myeloid leukemia. Am J Manag Care (2000) 1.40
From small acorns--developing a laparoscopic colorectal surgical service. Ann R Coll Surg Engl (2008) 1.38
p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter. J Biol Chem (1999) 1.34
Global aspects of tuberculosis in children. Paediatr Respir Rev (2001) 1.33
Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates. Nucleic Acids Res (1990) 1.32
Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies. J Acquir Immune Defic Syndr Hum Retrovirol (1999) 1.31
Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment. Mol Psychiatry (2013) 1.30
Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors. J Mol Biol (2008) 1.30
Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression. J Virol (1999) 1.28
The tertiary structure of a DNA aptamer which binds to and inhibits thrombin determines activity. Biochemistry (1993) 1.27
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice. Antimicrob Agents Chemother (1998) 1.26
Prevalence of respiratory diseases and their association with growth rate and space in randomly selected swine herds. Can J Vet Res (1986) 1.25
Biosynthesis of digalactosyl diglyceride in Vicia faba leaves. J Lipid Res (1975) 1.25
Polyamines and their biosynthetic decarboxylases in various tissues of the young rat during recovery from undernutrition. Biochem J (1977) 1.25
The human herpesvirus 8 homolog of Epstein-Barr virus SM protein (KS-SM) is a posttranscriptional activator of gene expression. J Virol (2000) 1.24
Disarming flu viruses. Sci Am (1999) 1.23
Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. J Mol Biol (2010) 1.23
Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution. Biochemistry (1993) 1.21
The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations. Antivir Ther (2006) 1.21
Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein. EMBO J (1997) 1.20
Lymphography and pelvic lymphadenectomy in carcinoma of the prostate. Br J Urol (1976) 1.20
Alcohol use and HIV sexual risk among MSM in Chennai, India. Int J STD AIDS (2011) 1.19
Neurofibromatosis 2: clinical and DNA linkage studies of a large kindred. N Engl J Med (1988) 1.18
Epstein-Barr virus SM protein interacts with mRNA in vivo and mediates a gene-specific increase in cytoplasmic mRNA. J Virol (2001) 1.18
Effects of Substituted Pyridazinones (San 6706, San 9774, San 9785) on Glycerolipids and Their Associated Fatty Acids in the Leaves of Vicia faba and Hordeum vulgare. Plant Physiol (1979) 1.18
The clinical spectrum of cardiac fibroma with diagnostic and surgical considerations: noninvasive imaging enhances management. Ann Thorac Surg (1988) 1.18
Galactolipid synthesis in Vicia faba leaves. V. Redistribution of 14C-labelling in the polar moieties and the 14C-labelling kinetics of the fatty acids of the molecular species of mono- and digalactosyl diacylglycerols. Biochim Biophys Acta (1980) 1.17
Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo. Biochemistry (1996) 1.17
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT. AIDS (2005) 1.17
Molecular genetic analysis of Epstein-Barr virus Cp promoter function. J Virol (1996) 1.16