Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 103808)

Published in J Virol on January 01, 1999

Authors

K Weisshart1, C S Chow, D M Coen

Author Affiliations

1: Department of Biological Chemistry and Molecular Pharmacology and Committee on Virology, Harvard Medical School, Boston Massachusetts 02115, USA.

Articles citing this

A novel strategy to engineer DNA polymerases for enhanced processivity and improved performance in vitro. Nucleic Acids Res (2004) 1.91

The A20R protein is a stoichiometric component of the processive form of vaccinia virus DNA polymerase. J Virol (2001) 1.26

Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A (2008) 1.21

Characterization of human herpesvirus 8 ORF59 protein (PF-8) and mapping of the processivity and viral DNA polymerase-interacting domains. J Virol (2000) 1.21

Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis. J Virol (2005) 1.05

The human cytomegalovirus UL44 C clamp wraps around DNA. Structure (2008) 1.02

Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism. Nucleic Acids Res (2007) 0.99

Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches. J Virol (2001) 0.98

The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases. Proc Natl Acad Sci U S A (1999) 0.98

The positively charged surface of herpes simplex virus UL42 mediates DNA binding. J Biol Chem (2008) 0.97

Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication. J Virol (2007) 0.96

Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha. J Biol Chem (2008) 0.95

Evidence against a simple tethering model for enhancement of herpes simplex virus DNA polymerase processivity by accessory protein UL42. J Virol (2002) 0.93

Primer-dependent synthesis by poliovirus RNA-dependent RNA polymerase (3D(pol)). Nucleic Acids Res (2001) 0.93

Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approach. Antiviral Res (2008) 0.91

Binding of herpes simplex virus-1 US11 to specific RNA sequences. Nucleic Acids Res (2005) 0.91

Crystal structure of epstein-barr virus DNA polymerase processivity factor BMRF1. J Biol Chem (2009) 0.90

The Epstein-Barr virus BMRF1 gene is essential for lytic virus replication. J Virol (2006) 0.89

Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates. J Virol (2010) 0.88

Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis. J Virol (2007) 0.86

An artificial processivity clamp made with streptavidin facilitates oriented attachment of polymerase-DNA complexes to surfaces. Nucleic Acids Res (2008) 0.84

Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity. J Virol (2009) 0.82

The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. J Virol (2009) 0.80

Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated. Biochemistry (2015) 0.76

Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry (2017) 0.75

Articles cited by this

The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol (1988) 19.25

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell (1994) 6.54

Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp. Cell (1992) 5.77

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell (1996) 5.38

Replication factors required for SV40 DNA replication in vitro. I. DNA structure-specific recognition of a primer-template junction by eukaryotic DNA polymerases and their accessory proteins. J Biol Chem (1991) 4.32

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7. J Biol Chem (1987) 4.21

Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme. J Biol Chem (1991) 3.37

Bacteriophage T7 deoxyribonucleic acid replication invitro. Bacteriophage T7 DNA polymerase: an an emzyme composed of phage- and host-specific subunits. J Biol Chem (1975) 3.36

DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine. Annu Rev Biochem (1995) 3.27

Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement. Cell (1996) 2.96

The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. J Virol (1990) 2.79

The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1. J Virol (1987) 2.63

Properties of herpes simplex virus DNA polymerase and characterization of its associated exonuclease activity. Eur J Biochem (1979) 2.55

Mechanism of elongation of primed DNA by DNA polymerase delta, proliferating cell nuclear antigen, and activator 1. Proc Natl Acad Sci U S A (1990) 2.49

Functional interaction between the herpes simplex-1 DNA polymerase and UL42 protein. J Biol Chem (1990) 2.38

DNA-binding proteins of cells infected by herpes simplex virus type 1 and type 2. Intervirology (1976) 2.34

Studies of the binding of Escherichia coli RNA polymerase to DNA. II. The kinetics of the binding reaction. J Mol Biol (1972) 2.26

Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates. J Biol Chem (1987) 2.23

Smart machines at the DNA replication fork. Cell (1994) 2.22

Sliding clamps of DNA polymerases. J Mol Biol (1993) 2.11

Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases. Genes Cells (1996) 2.09

A transcriptional enhancer whose function imposes a requirement that proteins track along DNA. Science (1992) 1.94

Herpes simplex-1 DNA polymerase. Identification of an intrinsic 5'----3' exonuclease with ribonuclease H activity. J Biol Chem (1989) 1.93

The role of palindromic and non-palindromic sequences in arresting DNA synthesis in vitro and in vivo. J Mol Biol (1984) 1.90

Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10. J Virol (1997) 1.81

Rapid kinetic analysis of mechanochemical adenosinetriphosphatases. Methods Enzymol (1986) 1.72

Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures. J Virol (1994) 1.65

Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites. Virology (1997) 1.60

Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells. Nucleic Acids Res (1990) 1.49

Expression of herpes simplex virus type 1 DNA polymerase gene by in vitro translation and effects of gene deletions on activity. J Virol (1988) 1.47

The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication. J Virol (1993) 1.43

Processive replication of single-stranded DNA templates by the herpes simplex virus-induced DNA polymerase. J Biol Chem (1987) 1.43

Methods of analyzing processivity. Methods Enzymol (1995) 1.41

Functional interactions between SV40 T antigen and other replication proteins at the replication fork. J Biol Chem (1993) 1.28

On the processivity of polymerases. Ann N Y Acad Sci (1994) 1.26

Functional analysis of the herpes simplex virus UL42 protein. J Virol (1993) 1.25

Expression of herpes simplex virus type 1 DNA polymerase in Saccharomyces cerevisiae and detection of virus-specific enzyme activity in cell-free lysates. J Virol (1988) 1.25

Interaction of herpes simplex virus type 1 DNA polymerase and the UL42 accessory protein with a model primer template. J Virol (1994) 1.24

Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42. J Virol (1995) 1.19

The T4 DNA polymerase accessory proteins form an ATP-dependent complex on a primer-template junction. J Biol Chem (1991) 1.16

Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis. J Biol Chem (1994) 1.13

The catalytic subunit of the DNA polymerase of herpes simplex virus type 1 interacts specifically with the C terminus of the UL8 component of the viral helicase-primase complex. J Virol (1997) 1.13

On the processivity of DNA replication. J Biomol Struct Dyn (1983) 1.11

DNA polymerase III: running rings around the fork. Cell (1996) 1.01

Maturation of replicating simian virus 40 DNA molecules in isolated nuclei by continued bidirectional replication to the normal termination region. Biochim Biophys Acta (1979) 0.98

Sequence specificity of pausing by DNA polymerases. Biochem Biophys Res Commun (1989) 0.95

Replication of herpesvirus DNA. III. Rate of DNA elongation. J Virol (1977) 0.94

Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. J Biol Chem (1996) 0.90

The effect of the UL42 protein on the DNA polymerase activity of the catalytic subunit of the DNA polymerase encoded by herpes simplex virus type 1. FEBS Lett (1992) 0.89

Genetic analysis of the interaction between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin. Proc Natl Acad Sci U S A (1992) 0.89

Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding. Proc Natl Acad Sci U S A (1993) 0.88

On the structure of replication and transcription factories. J Cell Sci Suppl (1995) 0.83

Evidence that the nuclease activities associated with the herpes simplex type 1 DNA polymerase are due to the 3'-5' exonuclease. J Virol (1996) 0.76

Improved band shift assay for the simultaneous analysis of protein-DNA interactions and enzymatic functions of DNA polymerases. FEBS Lett (1992) 0.76

Articles by these authors

Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol (1989) 5.77

Maize plastid gene expressed during photoregulated development. Proc Natl Acad Sci U S A (1978) 5.02

A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J Virol (1989) 4.85

A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature (1992) 3.59

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain. Proc Natl Acad Sci U S A (1985) 3.47

The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency. J Virol (1993) 3.43

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1. Proc Natl Acad Sci U S A (1980) 3.32

Membrane proteins synthesized but not processed by isolated maize chloroplasts. J Cell Biol (1978) 3.31

Differential expression of the gene for the large subunit of ribulose bisphosphate carboxylase in maize leaf cell types. Cell (1978) 3.21

Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J Virol (1995) 3.18

Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science (1991) 3.14

Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants. J Virol (1990) 3.05

A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus. J Virol (1997) 2.83

The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity. J Virol (1990) 2.79

A genetic approach to promoter recognition during trans induction of viral gene expression. Science (1986) 2.77

Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment. Virology (1983) 2.66

A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency. J Virol (1999) 2.58

Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus. J Virol (1984) 2.51

Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc Natl Acad Sci U S A (1988) 2.27

Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Virology (1984) 2.19

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus. J Virol (1985) 2.18

A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob Agents Chemother (1993) 2.16

Location of the single gene for the large subunit of ribulosebisphosphate carboxylase on the maize chloroplast chromosome. J Biol Chem (1979) 2.12

A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells. Virology (1989) 2.10

The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase. Mol Cell (2000) 2.09

Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes. Mol Cell Biol (1985) 2.09

The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. J Virol (1997) 2.06

Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors. Virology (1985) 2.05

High-mobility-group 1 protein mediates DNA bending as determined by ring closures. Proc Natl Acad Sci U S A (1993) 2.03

Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons. J Virol (1993) 2.01

A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture. J Virol (1989) 1.95

Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine. J Virol (1982) 1.79

Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann Intern Med (1989) 1.78

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate. Proc Natl Acad Sci U S A (1986) 1.78

ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase. J Virol (1998) 1.75

Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities. J Virol (1981) 1.74

Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus. J Virol (1990) 1.67

Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin. Nucleic Acids Res (1983) 1.56

Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein. J Virol (1991) 1.55

A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein. J Biol Chem (1990) 1.54

Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. J Virol (1998) 1.52

Tissue-specific forms of actin in the developing chick. Cell (1976) 1.49

Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells. Nucleic Acids Res (1990) 1.49

Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. J Virol (1997) 1.46

Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis. Virology (1993) 1.46

Unique structural and stabilizing roles for the individual pseudouridine residues in the 1920 region of Escherichia coli 23S rRNA. Nucleic Acids Res (2000) 1.46

A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. J Virol (1992) 1.44

Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation. J Virol (1988) 1.43

The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication. J Virol (1993) 1.43

Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation. Virology (2000) 1.42

Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition. J Virol (1990) 1.41

Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice. Virology (1998) 1.40

Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir. Neurosurgery (1993) 1.39

Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein. Antimicrob Agents Chemother (1999) 1.38

Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene. J Virol (1991) 1.37

Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses. J Virol (1990) 1.35

Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability. Virology (1989) 1.35

Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs. J Infect Dis (1991) 1.29

Translational recoding induced by G-rich mRNA sequences that form unusual structures. Cell (1996) 1.29

A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant. Proc Natl Acad Sci U S A (1994) 1.26

Functional analysis of the herpes simplex virus UL42 protein. J Virol (1993) 1.25

Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. J Comp Neurol (1994) 1.21

Translational regulation of herpes simplex virus DNA polymerase. J Virol (1990) 1.21

Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42. J Virol (1995) 1.19

Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene. J Virol (1986) 1.17

A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature (1992) 1.16

Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia. J Virol (1993) 1.13

Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis? J Infect Dis (1998) 1.13

Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface. Proc Natl Acad Sci U S A (1995) 1.13

Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis. J Biol Chem (1994) 1.13

Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene. J Virol (1989) 1.11

Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site. Mol Cell Biol (1991) 1.09

Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments. J Virol (2001) 1.09

Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia. Antimicrob Agents Chemother (1990) 1.08

The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation. J Virol (1998) 1.05

Alternate utilization of two regulatory domains within the Moloney murine sarcoma virus long terminal repeat. Mol Cell Biol (1985) 1.04

Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant. J Virol (1998) 1.03

Molecular mechanisms of antiviral resistance. Antiviral Res (1995) 1.03

Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor. Mol Cell (2001) 1.00

Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches. J Virol (2001) 0.98

The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases. Proc Natl Acad Sci U S A (1999) 0.98

Structural and kinetic studies of a cisplatin-modified DNA icosamer binding to HMG1 domain B. J Biol Chem (1999) 0.96

Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation. Virology (1996) 0.96

Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1. Am J Med (1982) 0.96

Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene. Virology (1996) 0.96

Thermodynamics of RNA hairpins containing single internal mismatches. Nucleic Acids Res (1999) 0.96

Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922). Antimicrob Agents Chemother (1998) 0.93

Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase. J Biol Chem (2000) 0.93

A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology (1998) 0.92

CNS tumor therapy by attenuated herpes simplex viruses. Gene Ther (1994) 0.92

Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants. Antiviral Res (1998) 0.92

Histone stoichiometry and DNA circularization in archaeal nucleosomes. Nucleic Acids Res (1999) 0.89

General aspects of virus drug resistance with special reference to herpes simplex virus. J Antimicrob Chemother (1986) 0.88

Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding. Proc Natl Acad Sci U S A (1993) 0.88

Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Mol Biol (2001) 0.87

Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase. Virology (1995) 0.87

Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin. Antimicrob Agents Chemother (1984) 0.87

Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1. DNA (1986) 0.86