P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.

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Published in Mol Endocrinol on January 01, 1999

Authors

D H Geller1, R J Auchus, W L Miller

Author Affiliations

1: Department of Pediatrics, University of California, San Francisco 94143-0978, USA.

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