Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions.

PubWeight™: 1.56‹?› | Rank: Top 4%

🔗 View Article (PMID 9927402)

Published in Circulation on February 02, 1999

Authors

M Gwechenberger1, L H Mendoza, K A Youker, N G Frangogiannis, C W Smith, L H Michael, M L Entman

Author Affiliations

1: Section of Cardiovascular Sciences, Department of Medicine, The DeBakey Heart Center, Houston, TX, USA.

Articles citing this

The immune system and cardiac repair. Pharmacol Res (2008) 3.42

Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol (2004) 2.61

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci U S A (2000) 2.25

IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. Cardiovasc Res (2004) 2.12

The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol (2014) 1.99

Apoptosis in myocardial ischaemia and infarction. J Clin Pathol (2002) 1.59

gp130 cytokines stimulate proteasomal degradation of tyrosine hydroxylase via extracellular signal regulated kinases 1 and 2. J Neurochem (2011) 1.56

p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6. Mol Biol Cell (2004) 1.44

Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients. Eur J Nucl Med Mol Imaging (2008) 1.39

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. Proc Natl Acad Sci U S A (1999) 1.32

The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. Circ Res (2016) 1.27

Role of innate and adaptive immune mechanisms in cardiac injury and repair. Nat Rev Immunol (2015) 1.22

From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream To Identify Novel Targets for Atheroprotection. Circ Res (2016) 1.22

Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia. Am J Pathol (2001) 1.11

The role of interleukin-6 in the failing heart. Heart Fail Rev (2001) 1.10

Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway. Acta Pharmacol Sin (2012) 1.04

New insights into insulin resistance in the diabetic heart. Trends Endocrinol Metab (2011) 1.03

Infarction-induced cytokines cause local depletion of tyrosine hydroxylase in cardiac sympathetic nerves. Exp Physiol (2009) 0.99

The varying faces of IL-6: From cardiac protection to cardiac failure. Cytokine (2015) 0.98

Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells. Circ Res (2012) 0.98

Insulin resistance and inflammation markers in myocardial infarction. J Inflamm Res (2013) 0.93

Absence of gp130 in dopamine beta-hydroxylase-expressing neurons leads to autonomic imbalance and increased reperfusion arrhythmias. Am J Physiol Heart Circ Physiol (2009) 0.90

Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury. Yonsei Med J (2010) 0.90

Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance. Int J Exp Pathol (2000) 0.89

The inflammatory response and cardiac repair after myocardial infarction. Korean Circ J (2009) 0.89

Toll-like receptor and its roles in myocardial ischemic/reperfusion injury. Med Sci Monit (2011) 0.88

Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Am J Pathol (2002) 0.87

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH). Semin Immunopathol (2013) 0.87

The lack of cardiotrophin-1 alters expression of interleukin-6 and leukemia inhibitory factor mRNA but does not impair cardiac injury response. Cytokine (2006) 0.85

MicroRNA involvement in immune activation during heart failure. Cardiovasc Drugs Ther (2011) 0.84

Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice. Lab Invest (2012) 0.84

Communication in the heart: the role of the innate immune system in coordinating cellular responses to ischemic injury. J Cardiovasc Transl Res (2012) 0.84

Role of tumour necrosis factor-alpha and other cytokines in ischemia-reperfusion-induced injury in the heart. Exp Clin Cardiol (2005) 0.83

Cardiac ischemia-reperfusion regulates sympathetic neuropeptide expression through gp130-dependent and independent mechanisms. Neuropeptides (2010) 0.83

Anti-inflammatory effect of protocatechuic aldehyde on myocardial ischemia/reperfusion injury in vivo and in vitro. Inflammation (2013) 0.83

STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration. Mol Cell Neurosci (2013) 0.83

Cardiac molecular-acclimation mechanisms in response to swimming-induced exercise in Atlantic salmon. PLoS One (2013) 0.81

Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors. World J Cardiol (2014) 0.81

Cardiac biomarkers: new tools for heart failure management. Cardiovasc Diagn Ther (2012) 0.81

Establishment and characterization of an experimental model of coronary thrombotic microembolism in rats. Am J Pathol (2010) 0.80

Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes. Int J Biochem Cell Biol (2012) 0.80

Voluntary exercise-induced changes in beta2-adrenoceptor signalling in rat ventricular myocytes. Exp Physiol (2008) 0.79

Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure. J Am Heart Assoc (2016) 0.76

Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. Drug Des Devel Ther (2015) 0.76

Noninvasive imaging of myocyte apoptosis following application of a stem cell-engineered delivery platform to acutely infarcted myocardium. J Nucl Med (2013) 0.76

Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-α-mediated cardiac inflammatory responses. Am J Physiol Heart Circ Physiol (2014) 0.76

Mechanical regulation of cardiac fibroblast pro-fibrotic phenotypes. Mol Biol Cell (2017) 0.75

Reduced acute myocardial ischemia-reperfusion injury in IL-6-deficient mice employing a closed-chest model. Inflamm Res (2016) 0.75

Microparticles in patients undergoing transcatheter aortic valve implantation (TAVI). Heart Vessels (2016) 0.75

Articles by these authors

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20

Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest (1997) 5.19

ELAM-1 is an adhesion molecule for skin-homing T cells. Nature (1991) 5.12

Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol (1999) 3.67

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1993) 3.57

Adhesion molecules and inflammatory injury. FASEB J (1994) 3.53

Myocardial ischemia and reperfusion: a murine model. Am J Physiol (1995) 3.38

Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium. Blood (1990) 3.02

Mechanisms of neutrophil-induced parenchymal cell injury. J Leukoc Biol (1997) 3.00

Motility and adhesiveness in human neutrophils. Effects of chemotactic factors. J Clin Invest (1979) 2.91

Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med (1998) 2.81

Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. Circulation (1998) 2.77

LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J Clin Invest (1997) 2.71

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clin Cancer Res (1999) 2.70

Host resistance factors in human milk. J Pediatr (1973) 2.69

Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial. Lancet (1977) 2.54

Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest (1991) 2.50

Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway. J Immunol (2000) 2.45

A chronic mouse model of myocardial ischemia-reperfusion: essential in cytokine studies. Am J Physiol Heart Circ Physiol (2000) 2.42

Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J (1990) 2.41

Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol (1993) 2.32

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med (2000) 2.29

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci U S A (2000) 2.25

Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J Immunol (1990) 2.24

Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation (2001) 2.23

Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon. RNA (1998) 2.18

Co-transcriptional commitment to alternative splice site selection. Nucleic Acids Res (1998) 2.07

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice. Genes Dev (1991) 2.07

A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J Clin Invest (1997) 2.04

Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutally exclusive exons. Mol Cell Biol (1999) 2.02

Further studies on the specificity of presumed immune associations of myasthenia gravis and consideration of possible pathogenic implications. Ann N Y Acad Sci (1966) 2.02

Specific cleavage of hyper-edited dsRNAs. EMBO J (2001) 1.98

Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB). RNA (2001) 1.98

P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells. Biophys J (1993) 1.95

Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion. Mol Biol Cell (2000) 1.95

Invited letter concerning: neutrophil activation during cardiopulmonary bypass. J Thorac Cardiovasc Surg (1991) 1.93

Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91

Inflammation in the course of early myocardial ischemia. FASEB J (1991) 1.90

E-selectin supports neutrophil rolling in vitro under conditions of flow. J Clin Invest (1993) 1.90

The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing. Mol Cell Biol (1988) 1.89

Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion. Circulation (1998) 1.88

RNAi is antagonized by A-->I hyper-editing. EMBO Rep (2001) 1.86

Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners. J Immunol (1997) 1.84

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc Natl Acad Sci U S A (2001) 1.83

Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action. Proc Natl Acad Sci U S A (1987) 1.82

Cytoplasmic Ca2+ does not inhibit the cardiac muscle sarcoplasmic reticulum ryanodine receptor Ca2+ channel, although Ca(2+)-induced Ca2+ inactivation of Ca2+ release is observed in native vesicles. J Membr Biol (1993) 1.78

A magnetic reconnection X-line extending more than 390 Earth radii in the solar wind. Nature (2006) 1.74

Beta 2-integrin and L-selectin are obligatory receptors in neutrophil aggregation. Blood (1993) 1.74

Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb). Cardiovasc Res (2000) 1.73

Monoclonal antibodies to leukocyte integrins CD11a/CD18 and CD11b/CD18 or intercellular adhesion molecule-1 inhibit chemoattractant-stimulated neutrophil transendothelial migration in vitro. Blood (1991) 1.72

Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood (1991) 1.69

Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1. Blood (2000) 1.69

Genetic mapping and QTL analysis of fiber-related traits in cotton ( Gossypium). Theor Appl Genet (2003) 1.66

IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury. J Immunol (2000) 1.66

Evaluation of a fiberoptic intracranial pressure monitor. J Neurosurg (1990) 1.63

Abnormal mobility of neonatal polymorphonuclear leukocytes. Relationship to impaired redistribution of surface adhesion sites by chemotactic factor or colchicine. J Clin Invest (1981) 1.62

Myocardial infarction and remodeling in mice: effect of reperfusion. Am J Physiol (1999) 1.62

Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest (1997) 1.62

Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures. Circulation (1992) 1.61

Complement C5a, TGF-beta 1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion. Circulation (1997) 1.60

The mechanism of Ca2+ regulation of vascular smooth muscle thin filaments by caldesmon and calmodulin. J Biol Chem (1987) 1.60

Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am J Physiol (1991) 1.59

The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties. Biochemistry (1994) 1.59

Multilocus interactions restrict gene introgression in interspecific populations of polyploid Gossypium (cotton). Evolution (2000) 1.58

The thin filaments of smooth muscles. J Muscle Res Cell Motil (1985) 1.57

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions. J Clin Invest (1994) 1.57

Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals. J Appl Physiol (1985) (1992) 1.56

Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion. J Clin Invest (1992) 1.55

The cells of human colostrum. I. In vitro studies of morphology and functions. Pediatr Res (1968) 1.54

Hemodynamic changes in apolipoprotein E-knockout mice. Am J Physiol Heart Circ Physiol (2000) 1.54

Molecular dynamics of the transition from L-selectin- to beta 2-integrin-dependent neutrophil adhesion under defined hydrodynamic shear. Biophys J (1996) 1.53

Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease? J Am Coll Cardiol (1996) 1.53

Neutrophil adherence to isolated adult canine myocytes. Evidence for a CD18-dependent mechanism. J Clin Invest (1990) 1.52

Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet (1977) 1.52

Clinical improvement of patients with emphysema after radiotherapy. Thorax (1977) 1.52

Neutrophil CD18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin. J Immunol (1997) 1.51

The pattern of binding of fluorescein-labeled concanavalin A to the motile lymphocyte. J Reticuloendothel Soc (1970) 1.51