PubRank

J W Akkerman

Author PubWeight™ 85.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Rapid Ca2+-mediated activation of Rap1 in human platelets. EMBO J 1997 3.23
2 Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. Nature 1986 2.31
3 Relation between energy production and adenine nucleotide metabolism in human blood platelets. Biochim Biophys Acta 1980 1.59
4 Activation of the small GTPase Ral in platelets. Mol Cell Biol 1998 1.58
5 Activation of sodium-proton exchange is a prerequisite for Ca2+ mobilization in human platelets. Nature 1987 1.39
6 Dual regulation of platelet protein kinase B. J Biol Chem 2000 1.37
7 Sequential regulation of the small GTPase Rap1 in human platelets. Mol Cell Biol 2000 1.32
8 Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients. Blood 1987 1.18
9 Interrelationships among platelet responses: studies on the burst in proton liberation, lactate production, and oxygen uptake during platelet aggregation and Ca2+ secretion. Blood 1981 1.14
10 Use of leukocyte-depleted platelet concentrates for the prevention of refractoriness and primary HLA alloimmunization: a prospective, randomized trial. Blood 1991 1.05
11 Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit. Biochem J 1996 0.99
12 Protein kinase C enhances Ca2+ mobilization in human platelets by activating Na+/H+ exchange. J Biol Chem 1988 0.97
13 Metabolic energy is required in human platelets at any stage during optical aggregation and secretion. Biochim Biophys Acta 1984 0.96
14 A novel technique for rapid determination of energy consumption in platelets. Demonstration of different energy consumption associated with three secretory responses. Biochem J 1983 0.95
15 Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. Biochem J 1991 0.95
16 Reactome - a curated knowledgebase of biological pathways: megakaryocytes and platelets. J Thromb Haemost 2012 0.94
17 Quantification of energy consumption in platelets during thrombin-induced aggregation and secretion. Tight coupling between platelet responses and the increment in energy consumption. Biochem J 1984 0.94
18 Determination of levels of glycolytic intermediates and nucleotides in platelets by pulse-labeling with [32P]orthophosphate. Anal Biochem 1983 0.94
19 Low-density lipoprotein enhances platelet secretion via integrin-alphaIIbbeta3-mediated signaling. Arterioscler Thromb Vasc Biol 1999 0.94
20 Rapid separation of cytosol and particle fraction of human platelets by digitonin-induced cell damage. Br J Haematol 1980 0.93
21 Expression of transient receptor potential mRNA isoforms and Ca(2+) influx in differentiating human stem cells and platelets. Biochim Biophys Acta 2001 0.93
22 Inhibition of platelet integrin alpha(IIb)beta(3) by peptides that interfere with protein kinases and the beta(3) tail. Arterioscler Thromb Vasc Biol 2000 0.92
23 Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. Biochem J 1984 0.92
24 LDLs increase the exposure of fibrinogen binding sites on platelets and secretion of dense granules. Arterioscler Thromb 1994 0.91
25 Signal transduction through trimeric G proteins in megakaryoblastic cell lines. Arterioscler Thromb Vasc Biol 1997 0.89
26 Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. J Biol Chem 1986 0.89
27 Human platelets secrete chemotactic activity for eosinophils. Blood 1993 0.88
28 Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure. Arterioscler Thromb Vasc Biol 1998 0.88
29 Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia. Blood 1983 0.88
30 Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes. Biochim Biophys Acta 1982 0.87
31 Platelet aggregation and Ca2+ secretion are independent of simultaneous ATP production. FEBS Lett 1979 0.87
32 Relation between membrane fluidity and signal transduction in the human megakaryoblastic cell line MEG-01. Biochim Biophys Acta 1995 0.86
33 Regulation of carbohydrate metabolism in platelets. A review. Thromb Haemost 1978 0.86
34 Na+/H+ exchange modulates Ca2+ mobilization in human platelets stimulated by ADP and the thromboxane mimetic U 46619. J Biol Chem 1990 0.86
35 Regulation of glycoprotein IIB/IIIA exposure on platelets stimulated with alpha-thrombin. Blood 1992 0.85
36 Early platelet activation by low density lipoprotein via p38MAP kinase. Thromb Haemost 1999 0.85
37 Maturation of megakaryoblastic cells is accompanied by upregulation of G(s)alpha-L subtype and increased cAMP accumulation. Thromb Haemost 1998 0.85
38 Identification of alpha-subunits of trimeric GTP-binding proteins in human platelets by RT-PCR. Biochem Biophys Res Commun 1995 0.84
39 Enhancement of platelet functions by low density lipoproteins. Biochim Biophys Acta 1992 0.84
40 Platelet Na(+)-H+ exchanger activity in normotensive and hypertensive subjects: effect of enalapril therapy upon antiport activity. J Hypertens 1992 0.84
41 Balanced contribution of glycolytic and adenylate pool in supply of metabolic energy in platelets. J Biol Chem 1985 0.84
42 The energetics of early platelet responses. Energy consumption during shape change and aggregation with special reference to protein phosphorylation and the polyphosphoinositide cycle. Biochem J 1985 0.83
43 UVB radiation exposes fibrinogen binding sites on platelets by activating protein kinase C via reactive oxygen species. Br J Haematol 1993 0.83
44 Na+/H+ exchange as a modulator of platelet activation. Trends Biochem Sci 1988 0.83
45 Effects of low-dose EPA-E on glycemic control, lipid profile, lipoprotein(a), platelet aggregation, viscosity, and platelet and vessel wall interaction in NIDDM. Diabetes Care 1993 0.83
46 Kinetic analysis of alpha-granule secretion by platelets. A methodological report. Thromb Res 1982 0.83
47 Thrombopoietin increases platelet sensitivity to alpha-thrombin via activation of the ERK2-cPLA2 pathway. Thromb Haemost 2000 0.83
48 Properties of PAF-acether-induced platelet aggregation and secretion. Studies in gel-filtered human platelets. Thromb Res 1983 0.83
49 Evaluation of platelet tests for measurement of cell integrity. Thromb Haemost 1978 0.83
50 Regulation of glycolytic flux in human platelets: relation between energy production by glyco(geno)lysis and energy consumption. Biochim Biophys Acta 1978 0.82
51 Activation of Na+/H+ exchange and Ca2+ mobilization start simultaneously in thrombin-stimulated platelets. Evidence that platelet shape change disturbs early rises of BCECF fluorescence which causes an underestimation of actual cytosolic alkalinization. Biochem J 1989 0.82
52 A patient with purine nucleoside phosphorylase deficiency: enzymological and metabolic aspects. Clin Chim Acta 1977 0.82
53 Biogenesis of G-protein mediated calcium signaling in human megakaryocytes. Thromb Haemost 2001 0.82
54 Simultaneous measurement of aggregation, secretion, oxygen uptake, proton production, and intracellular metabolites in the same platelet suspension. Anal Biochem 1979 0.82
55 Cytosolic calcium ions regulate lipid mobility in the plasma membrane of the human megakaryoblastic cell line MEG-01. Eur J Biochem 1994 0.82
56 The Hermansky-Pudlak syndrome. Evidence for a lowered 5-hydroxytryptamine content in platelets of heterozygotes. Scand J Haematol 1977 0.81
57 Low density lipoprotein phosphorylates the focal adhesion-associated kinase p125(FAK) in human platelets independent of integrin alphaIIb beta3. J Biol Chem 1999 0.81
58 Inhibition of Na+/H+ exchange reduces Ca2+ mobilization without affecting the initial cleavage of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. FEBS Lett 1987 0.81
59 Close correlation between platelet responses and adenylate energy charge during transient substrate depletion. Biochim Biophys Acta 1983 0.81
60 Alpha 2A-adrenergic receptors activate protein kinase C in human platelets via a pertussis toxin-sensitive G-protein. FEBS Lett 1994 0.80
61 Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets. Biochem J 2000 0.80
62 ATP-ADP compartmentation in storage pool deficient platelets: correlation between granule-bound ADP and the bleeding time. Br J Haematol 1983 0.80
63 Sodium fluoride prevents receptor- and protein kinase C-mediated activation of the human platelet Na+/H+ exchanger without inhibiting its basic pHi-regulating activity. J Biol Chem 1990 0.80
64 Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. Biochem J 1986 0.80
65 PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. Biochem J 1986 0.80
66 Different pathways for control of Na+/H+ exchange via activation of the thrombin receptor. Biochem J 1994 0.80
67 Comparative studies on the energetics of platelet responses induced by different agonists. Biochem J 1986 0.80
68 Phosphorylation reactions and the affinity state of platelet integrin alphaIIbbeta3. Platelets 1997 0.80
69 Development of the Baylor/NASA axial flow ventricular assist device: in vitro performance and systematic hemolysis test results. Artif Organs 1994 0.79
70 Identification of granular heterogeneity in blood platelets by controlled digitonin-induced cell lysis. Thromb Res 1980 0.79
71 Stimulus-response coupling in human platelets. Evidence against a role of PAF-acether in the "third pathway'. Thromb Res 1983 0.79
72 Impaired energy metabolism in platelets from patients with Wiskott-Aldrich syndrome. Thromb Haemost 1989 0.79
73 Correction of the bleeding time in patients with storage pool deficiency by infusion of cryoprecipitate. Br J Haematol 1978 0.79
74 Blood platelet plasminogen activator inhibitor: two different pools of endothelial cell type plasminogen activator inhibitor in human blood. Thromb Haemost 1986 0.79
75 Extreme deficiency of L-type pyruvate kinase with moderate clinical expression. Clin Chim Acta 1982 0.79
76 Arachidonate transfer between platelets and lipoproteins. Thromb Haemost 1992 0.78
77 Regulation of platelet glycoprotein IIb/IIIa (integrin alpha IIB beta 3) function via the thrombin receptor. Biochem J 1995 0.78
78 Stimulus-aggregation coupling in platelets activated with PAF-acether. Biochim Biophys Acta 1986 0.78
79 Na+/H+ exchange and Ca2+ influx. FEBS Lett 1989 0.78
80 The influence of lipoproteins on blood platelets. Am Heart J 1993 0.78
81 Regulation of the receptor for platelet-activating factor on human platelets. Biochem J 1993 0.78
82 A new variant of glucosephosphate isomerase deficiency: GPI-Kortrijk. Clin Chim Acta 1977 0.78
83 The Wiskott-Aldrich syndrome: studies on a possible defect in mitochondrial ATP resynthesis in platelets. Br J Haematol 1982 0.77
84 Lateral mobility of integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) in the plasma membrane of a human megakaryocyte. Thromb Haemost 1997 0.77
85 Influence of Mg2. Biochim Biophys Acta 1974 0.77
86 Stimulation of human platelets by collagen occurs by a Na+/H+ exchanger independent mechanism. Biochim Biophys Acta 1990 0.77
87 Human platelet 6-phosphofructokinase. Purification, kinetic parameters and the influence of sulphate ions on enzyme activity. Biochim Biophys Acta 1974 0.77
88 Abnormal platelet functions in a patient with abetalipoproteinemia. Thromb Haemost 1991 0.76
89 Alterations in 32P-labelled intermediates during flux activation of human platelet glycolysis. Biochim Biophys Acta 1984 0.76
90 Kinetics of energy consumption in human platelets with blocked ATP regeneration. Int J Biochem 1986 0.76
91 Subcellular localization of alpha-subunits of trimeric G-proteins in human platelets. Biochem Biophys Res Commun 1997 0.76
92 Targeting of porcine pancreatic phospholipase A2 to human platelets. Introduction of an RGD sequence and acyl-group by chemical modification. Eur J Biochem 1996 0.76
93 Trypanosoma brucei and Trypanosoma vivax: antigen-antibody complexes as a cause of platelet serotonin release in vitro and in vivo. Exp Parasitol 1977 0.76
94 4,4'-Di-isothiocyanatostilbene-2,2'-disulphonic acid ('DIDS') activates protein kinase C and Na+/H+ exchange in human platelets via alpha 2A-adrenergic receptors. Biochem J 1993 0.75
95 Measurement of platelet-activating factor in biological specimens. J Lipid Mediat 1992 0.75
96 Clinical experience with transfusion of leukocyte-poor platelet concentrates prepared by filtration with prostacyclin. Blood 1987 0.75
97 Targeting of porcine pancreatic phospholipase A2 to human platelets: introduction of an RGD sequence by genetic engineering. Thromb Haemost 1995 0.75
98 Differences in the susceptibility of platelets to freezing damage in relation to size. Transfusion 1989 0.75
99 Preparation of concentrated platelet suspensions by dehydration against polyethyleneglycol 20,000. Scand J Haematol 1976 0.75
100 Improved survival rates in dogs after extracorporeal circulation by improved control of heparin levels. J Thorac Cardiovasc Surg 1974 0.75
101 Cryopreservation disturbs stimulus-response coupling in a platelet subpopulation. Br J Haematol 1987 0.75
102 Three variants of glucose-phosphate isomerase deficiency. Monogr Hum Genet 1978 0.75
103 Irradiation of platelets with UV-B light exposes fibrinogen binding sites via an intracellular mechanism. Br J Haematol 1990 0.75
104 The influence of cyclandelate on Ca++ translocation in human platelets. Drugs 1987 0.75
105 Effect of epinephrine on the regulation of Na+/H+ exchange in human platelets. Biochim Biophys Acta 1993 0.75
106 Filtration. A method to prepare white cell-poor platelet concentrates with optimal preservation of platelet viability. Transfusion 1990 0.75
107 Rapid alterations in lateral mobility of lipids in the plasma membrane of activated human megakaryocytes. Eur J Biochem 1994 0.75
108 Platelet integrin alphaIIbbeta3: target and generator of signalling. Platelets 2000 0.75
109 Negative regulation of the platelet Na+/H+ exchanger by trimeric G-proteins. Eur J Biochem 2000 0.75
110 [Pre-stained slides for differential blood counts (author's transl)]. Dtsch Med Wochenschr 1977 0.75
111 Pilot trial of the effects of low-dose acetylsalicylic acid on platelet thromboxane B2 production. Eur J Clin Nutr 1995 0.75
112 Effect of platelet agonists on the binding of platelet-activating factor to human platelets. J Lipid Mediat 1992 0.75
113 Dilution with normal plasma in a heparin assay. Thromb Haemost 1977 0.75
114 Control of heparin therapy with an activated partial thromboplastin time. Neth J Med 1973 0.75
115 Interference of deoxyadenosine with transmembrane signaling events in human T lymphocytes. Int J Immunopharmacol 1990 0.75
116 Cytosolic alkalinization alone is not sufficient for Ca2+ mobilization, phosphatidic acid formation, and protein phosphorylation in human platelets. Biochem Biophys Res Commun 1989 0.75
117 Human platelet 6-phosphofructokinase. Relation between inhibition by Mg-ATP2-and cooperativity towards fructose 6-phosphate and investigations on the formation of a ternary complex. Biochim Biophys Acta 1975 0.75
118 Acquired secretion defect in platelets after cryopreservation in dimethyl sulfoxide. Transfusion 1986 0.75
119 PAF-acetylhydrolase, predominantly present in LDL in healthy subjects, is associated with HDL in a patient with LDL deficiency. J Lipid Mediat 1992 0.75
120 Occupancy of platelet receptors for platelet-activating factor in asthmatic patients during an allergen-induced bronchoconstrictive reaction. J Lipid Mediat 1993 0.75
121 Variations in levels of glycolytic intermediates in human platelets during platelet-collagen interaction. Biochim Biophys Acta 1976 0.75
122 Lysophosphatidic acid-independent platelet activation by low-density lipoprotein. FEBS Lett 2001 0.75
123 Platelet functions and energy metabolism in a patient with hexokinase deficiency. Blood 1984 0.75
124 Evaluation of a new UVB source for irradiation of platelet concentrates. Br J Haematol 1990 0.75
125 Ultraviolet-B irradiation of platelets induces a dose-dependent increase in the expression of platelet activation markers with storage. Br J Haematol 1993 0.75
126 Use of Iloprost for leukocyte depletion of platelet concentrates by filtration. Vox Sang 1989 0.75
127 Biochemical studies in Hermansky-Pudlak syndrome. Scand J Haematol 1979 0.75
128 Intracellular localization of fibrinogen in human blood platelets. Bibl Haematol 1977 0.75