Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 9989476)

Published in J Appl Toxicol on April 29, 1999

Authors

J Ashby1, H Tinwell, W Pennie, A N Brooks, P A Lefevre, N Beresford, J P Sumpter

Author Affiliations

1: Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.

Articles citing this

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife (2014) 1.07

Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br J Pharmacol (2008) 1.06

Phytoestrogens and breast cancer prevention: possible mechanisms of action. Environ Health Perspect (2008) 1.02

Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans. Oxid Med Cell Longev (2015) 0.97

Significance of wine and resveratrol in cardiovascular disease: French paradox revisited. Exp Clin Cardiol (2006) 0.90

Effects of p-nonylphenol and resveratrol on body and organ weight and in vivo fertility of outbred CD-1 mice. Reprod Biol Endocrinol (2003) 0.89

Increasing the sensitivity of the rodent uterotrophic assay to estrogens, with particular reference to bisphenol A. Environ Health Perspect (2001) 0.83

PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations. Biomed Res Int (2014) 0.82

Phytoestrogens: food or drug? Clin Cases Miner Bone Metab (2007) 0.82

Roles of Dietary Phytoestrogens on the Regulation of Epithelial-Mesenchymal Transition in Diverse Cancer Metastasis. Toxins (Basel) (2016) 0.82

Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat. Environ Health Perspect (2002) 0.82

Structural insights into Resveratrol's antagonist and partial agonist actions on estrogen receptor alpha. BMC Struct Biol (2013) 0.80

Wine and bone health: a review. J Bone Miner Metab (2015) 0.77

Articles by these authors

Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology (1994) 4.10

Interval between decision and delivery by caesarean section-are current standards achievable? Observational case series. BMJ (2001) 3.72

Evaluation of the potential carcinogenicity and genetic toxicity to humans of the herbicide acetochlor. Hum Exp Toxicol (1996) 3.53

A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect (1995) 3.47

Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ Health Perspect (1995) 2.48

Endocrine disruption in wildlife: a critical review of the evidence. Crit Rev Toxicol (1998) 2.41

Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol Reprod (2002) 2.26

Several environmental oestrogens are also anti-androgens. J Endocrinol (1998) 2.17

Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use. Nature (1976) 2.00

The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Regul Toxicol Pharmacol (1997) 1.99

The estrogenic activity of phthalate esters in vitro. Environ Health Perspect (1997) 1.94

Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic. Toxicol Appl Pharmacol (1998) 1.89

Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero. Regul Toxicol Pharmacol (1999) 1.85

Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas). Environ Toxicol Chem (2001) 1.73

Uterotrophic activity of bisphenol A in the immature rat. Environ Health Perspect (1998) 1.72

Wild intersex roach (Rutilus rutilus) have reduced fertility. Biol Reprod (2002) 1.69

Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning. Toxicol Sci (2002) 1.57

Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. J Biol Chem (2000) 1.54

Structural features of alkylphenolic chemicals associated with estrogenic activity. J Biol Chem (1997) 1.49

Stress reduces the quality of gametes produced by rainbow trout. Biol Reprod (1992) 1.47

Infection of patients by bloodborne viruses. Br J Surg (2004) 1.46

An evaluation of 6 short-term tests for detecting organic chemical carcinogens. Br J Cancer (1978) 1.44

The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine. Mutat Res (1991) 1.41

A sequential approach to testing with the rodent bone marrow micronucleus assay--obviation of the need for statistical analyses of data. Mutat Res (1995) 1.39

Assessing the biological potency of binary mixtures of environmental estrogens using vitellogenin induction in juvenile rainbow trout (Oncorhynchus mykiss). Environ Sci Technol (2001) 1.26

Characterization of the human trophoblast-leukocyte antigenic molecules defined by a monoclonal antibody. J Immunol (1986) 1.19

Exposure of juvenile roach (Rutilus rutilus) to treated sewage effluent induces dose-dependent and persistent disruption in gonadal duct development. Environ Sci Technol (2001) 1.18

The effects of undernutrition, in utero, on reproductive function in adult male and female sheep. Anim Reprod Sci (2002) 1.15

Maturation and activation of hypothalamic-pituitary adrenal function in fetal sheep. Endocr Rev (1989) 1.13

Synergy between synthetic oestrogens? Nature (1997) 1.12

Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Regul Toxicol Pharmacol (1997) 1.12

Transcriptional state of the mouse mammary tumor virus promoter can affect topological domain size in vivo. J Biol Chem (1999) 1.11

Reproductive effects of long-term exposure to Bisphenol A in the fathead minnow (Pimephales promelas). Environ Sci Technol (2001) 1.11

Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals. J Steroid Biochem Mol Biol (1993) 1.10

Lack of activity of estradiol in rodent bone marrow micronucleus assays. Mutat Res (1997) 1.09

The deleterious effects of cortisol implantation on reproductive function in two species of trout, Salmo trutta L. and Salmo gairdneri Richardson. Gen Comp Endocrinol (1989) 1.09

Vitellogenin levels in male and female rainbow trout (Salmo gairdneri Richardson) at various stages of the reproductive cycle. Comp Biochem Physiol B (1986) 1.08

The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97. Toxicol Sci (2003) 1.08

Sexual disruption in a second species of wild cyprinid fish (the gudgeon, Gobio gobio) in United Kingdom freshwaters. Environ Toxicol Chem (2001) 1.07

Issues arising when interpreting results from an in vitro assay for estrogenic activity. Toxicol Appl Pharmacol (2000) 1.04

Removal of endocrine-disrupting chemicals in activated sludge treatment works. Environ Sci Technol (2001) 1.03

Programming of adult cardiovascular function after early maternal undernutrition in sheep. Am J Physiol Regul Integr Comp Physiol (2004) 1.02

The metabolism of methoxyethylmercury salts. Biochem J (1971) 1.01

Effects of nutrition and environmental factors on the fetal programming of the reproductive axis. Reproduction (2001) 1.01

Estrogenic induction of spermatogenesis in the hypogonadal mouse. Endocrinology (2000) 1.00

The effects of atrazine on the sexual maturation of female rats. Regul Toxicol Pharmacol (2002) 1.00

Endocrine disruptors and testis development. Environ Health Perspect (1998) 0.99

Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay. Environ Health Perspect (2001) 0.98

The single cell gel electrophoresis assay for induced DNA damage (comet assay): measurement of tail length and moment. Mutagenesis (1995) 0.98

Differential activation by xenoestrogens of ER alpha and ER beta when linked to different response elements. J Endocrinol (1998) 0.98

The role of the maturation-inducing steroid, 17,20beta-dihydroxypregn-4-en-3-one, in male fishes: a review. J Fish Biol (2010) 0.97

Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A. Toxicol Sci (2002) 0.96

Oestrogenic activity of an environmentally persistent alkylphenol in the reproductive tract but not the brain of rodents. J Steroid Biochem Mol Biol (1995) 0.96

Effect of rodent diets on the sexual development of the rat. Toxicol Sci (2001) 0.95

Effects of flavonoids on aromatase activity, an in vitro study. J Steroid Biochem Mol Biol (1996) 0.95

Involvement of gonadotropin in the uptake of vitellogenin into vitellogenic oocytes of the rainbow trout, Oncorhynchus mykiss. Gen Comp Endocrinol (1991) 0.95

Synchrotron X-ray studies of biological preparations at low temperatures with optical monitoring of sample integrity. Anal Biochem (1982) 0.94

Validation of radioimmunoassays for two salmon gonadotropins (GTH I and GTH II) and their plasma concentrations throughout the reproductivecycle in male and female rainbow trout (Oncorhynchus mykiss). Biol Reprod (1996) 0.93

Effect of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses. Reproduction (2001) 0.93

Plasma vitellogenin levels during the annual reproductive cycle of the female rainbow trout (Oncorhynchus mykiss): establishment and validation of an ELISA. Comp Biochem Physiol B Biochem Mol Biol (1997) 0.93

Effects of acute and chronic stress on the levels of circulating growth hormone in the rainbow trout, Oncorhynchus mykiss. Gen Comp Endocrinol (1991) 0.92

Seasonal variations in testicular germ cell stages and in plasma concentrations of sex steroids in male rainbow trout (Salmo gairdneri) maturing at 2 years old. Gen Comp Endocrinol (1989) 0.92

Changes in the affinity of estrogen and androgen receptors accompany changes in receptor abundance in brown and rainbow trout. Gen Comp Endocrinol (1994) 0.91

Steroids modulate corticotropin-releasing hormone production in human fetal membranes and placenta. J Clin Endocrinol Metab (1989) 0.91

Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. Food Chem Toxicol (1999) 0.90

Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep. J Endocrinol (2007) 0.90

A comparison of the female reproductive cycles of autumn-spawning and winter-spawning strains of rainbow trout (Salmo gairdneri Richardson). Gen Comp Endocrinol (1983) 0.90

Effect of maternal undernutrition on fetal testicular steroidogenesis during the CNS androgen-responsive period in male sheep fetuses. Reproduction (2002) 0.90

The effects of acute and chronic stress on the levels of reproductive hormones in the plasma of mature male brown trout, Salmo trutta L. Gen Comp Endocrinol (1987) 0.89

Molecular characterization and expression of two ovarian lipoprotein receptors in the rainbow trout, Oncorhynchus mykiss. Biol Reprod (1998) 0.89

Thalidomide: lack of mutagenic activity across phyla and genetic endpoints. Mutat Res (1997) 0.89

O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow. Blood (1997) 0.89

Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3, 4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays. Toxicol Lett (2000) 0.87

Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney. Reproduction (2005) 0.87

The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators. J Appl Toxicol (2000) 0.87

Male sexual development in "a sea of oestrogen". Lancet (1993) 0.87

Alternatives to the 2-species bioassay for the identification of potential human carcinogens. Hum Exp Toxicol (1996) 0.87

Is thalidomide mutagenic? Nature (1995) 0.86

The genetic toxicity of time: importance of DNA-unwinding time to the outcome of single-cell gel electrophoresis assays. Mutat Res (1997) 0.85

Mutation studies with dimethyl nitrosamine in young and old lac I transgenic mice. Mutat Res (1994) 0.84

The effect of cortisol on the secretion of sex steroids from cultured ovarian follicles of rainbow trout. Gen Comp Endocrinol (1990) 0.83

Cloning and gene expression of P450 17alpha-hydroxylase,17,20-lyase cDNA in the gonads and brain of the fathead minnow Pimephales promelas. Gen Comp Endocrinol (2003) 0.83

Uterotrophic activity of a "phytoestrogen-free" rat diet. Environ Health Perspect (2000) 0.83

The effects of stress on plasma ACTH, alpha-MSH, and cortisol levels in salmonid fishes. Gen Comp Endocrinol (1986) 0.83

Transformation of a non-oestrogenic steroid metabolite to an oestrogenically active substance by minimal bacterial activity. Chemosphere (1999) 0.83