Dose Escalation Study of MLN4924 in Adults With Melanoma

Clinical Trial ID NCT01011530

PubWeight™ 6.78‹?›

🔗 Visit the ClinicalTrials.gov page for NCT01011530

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Pro-senescence therapy for cancer treatment. Nat Rev Cancer 2011 2.75
2 Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxid Redox Signal 2014 1.06
3 MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis. Br J Pharmacol 2015 0.82
4 The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis. Cell Death Discov 2015 0.81
5 Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. EBioMedicine 2016 0.76
6 A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma. Invest New Drugs 2016 0.76
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