Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy.

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Published in Antioxid Redox Signal on February 20, 2014

Authors

Yongchao Zhao1, Meredith A Morgan, Yi Sun

Author Affiliations

1: Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan , Ann Arbor, Michigan.

Associated clinical trials:

MLN4924 for the Treatment of Acute Myelogenous Leukemia, Myelodysplastic Syndrome, and Acute Lymphoblastic Leukemia | NCT00911066

Study of MLN4924 in Adult Patients With Nonhematologic Malignancies | NCT00677170

Study of MLN4924, a Novel Inhibitor of Nedd8 Activating Enzyme, in Adult Patients With Lymphoma or Multiple Myeloma | NCT00722488

Study of MLN4924 Plus Azacitidine in Treatment-Naïve Patients With Acute Myelogenous Leukemia (AML) Who Are 60 Years or Older | NCT01814826

Dose Escalation Study of MLN4924 in Adults With Melanoma | NCT01011530

Dose Escalation, Multi-arm Study of MLN4924 Plus Docetaxel, Gemcitabine, or Combination of Carboplatin and Paclitaxel in Patients With Solid Tumors | NCT01862328

MLN4924 Compared With MLN4924 Plus Chemotherapy for Large B-cell Lymphoma | NCT01415765

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The ubiquitin system. Annu Rev Biochem (1998) 43.36

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics (2002) 30.58

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (2001) 23.83

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06

Methods in mammalian autophagy research. Cell (2010) 20.08

RING domain E3 ubiquitin ligases. Annu Rev Biochem (2009) 12.55

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol (2007) 12.48

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature (2009) 8.44

Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol (2004) 6.93

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev (1999) 6.56

The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J (1998) 6.37

Functional and quantitative proteomics using SILAC. Nat Rev Mol Cell Biol (2006) 6.25

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem (1991) 6.16

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell (2008) 6.07

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97

Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44

A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC). Nat Protoc (2006) 5.21

Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21

Redox redux: revisiting PTPs and the control of cell signaling. Cell (2005) 5.10

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science (2001) 4.82

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol (2003) 4.61

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci (2009) 4.50

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell (2004) 4.46

COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell (2003) 4.25

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell (2008) 4.09

Global protein stability profiling in mammalian cells. Science (2008) 3.91

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84

Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol (2004) 3.72

Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun (1992) 3.66

Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature (2006) 3.60

Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res (2008) 3.58

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev (2008) 3.49

A novel protein modification pathway related to the ubiquitin system. EMBO J (1998) 3.36

Nedd8 on cullin: building an expressway to protein destruction. Oncogene (2004) 3.29

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci U S A (1998) 3.26

The COP9 signalosome. Annu Rev Cell Dev Biol (2003) 3.25

Quantitative, high-resolution proteomics for data-driven systems biology. Annu Rev Biochem (2011) 3.19

Global identification of modular cullin-RING ligase substrates. Cell (2011) 3.13

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell (2004) 3.07

NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer (2012) 3.04

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CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol Cell (2002) 2.92

The COP9 signalosome: more than a protease. Trends Biochem Sci (2008) 2.81

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev (1999) 2.78

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev (2008) 2.71

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J Biol Chem (1997) 2.64

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol Cell (2010) 2.64

Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev (2002) 2.55

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. Blood (2010) 2.49

The ubiquitin-related protein RUB1 and auxin response in Arabidopsis. Science (1998) 2.42

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem (2003) 2.36

Free radicals, antioxidant enzymes, and carcinogenesis. Free Radic Biol Med (1990) 2.35

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. EMBO J (1997) 2.29

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J (2000) 2.27

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J Cell Biol (2001) 2.26

Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 2.19

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol (2011) 2.08

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell (2011) 2.03

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature (2005) 2.01

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell (2009) 1.98

Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proc Natl Acad Sci U S A (2008) 1.92

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. Blood (2010) 1.89

NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells. Cancer Res (2010) 1.87

Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J (2007) 1.86

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell (2011) 1.85

Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal (2010) 1.85

Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep (2008) 1.84

The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1. Cell (1992) 1.83

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy. Genes Cancer (2010) 1.80

Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science (2002) 1.79

N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science (2011) 1.78

Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Mol Cell (2008) 1.78

The bacterial fermentation product butyrate influences epithelial signaling via reactive oxygen species-mediated changes in cullin-1 neddylation. J Immunol (2009) 1.78

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR. Mol Cell (2011) 1.78

Discovery of the negative regulator of Nrf2, Keap1: a historical overview. Antioxid Redox Signal (2010) 1.76

DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem (2003) 1.72

Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J Biol Chem (2003) 1.68

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology (2012) 1.66

Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer. Clin Cancer Res (2009) 1.65

NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem (2003) 1.64

Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription. Nat Cell Biol (2006) 1.62

Identification and characterization of DEN1, a deneddylase of the ULP family. J Biol Chem (2003) 1.62

Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues. Biochemistry (1996) 1.61

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene (2012) 1.57

Cloning of a cDNA which encodes a novel ubiquitin-like protein. Biochem Biophys Res Commun (1993) 1.56

Control of cell growth by the SCF and APC/C ubiquitin ligases. Curr Opin Cell Biol (2009) 1.55

Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover. Cancer Res (2011) 1.51

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis. EMBO J (2003) 1.50

Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep (2009) 1.48

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J (2005) 1.48

SCF E3 ubiquitin ligases as anticancer targets. Curr Cancer Drug Targets (2011) 1.46

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol (2004) 1.45

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