FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR) (FLAT-SUGAR)

Clinical Trial ID NCT01524705

PubWeight™ 0.75‹?›

🔗 Visit the ClinicalTrials.gov page for NCT01524705

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008 47.90
2 Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008 38.76
3 Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003 35.39
4 Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2008 25.70
5 Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med 2008 17.19
6 Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006 11.78
7 Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 2001 8.80
8 KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J Kidney Dis 2007 8.79
9 Adiponectin and adiponectin receptors. Endocr Rev 2005 8.46
10 Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000 7.37
11 Mean amplitude of glycemic excursions, a measure of diabetic instability. Diabetes 1970 6.68
12 Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL. J Clin Invest 2007 5.38
13 The effect of continuous glucose monitoring in well-controlled type 1 diabetes. Diabetes Care 2009 4.93
14 Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 2008 4.05
15 Quantifying temporal glucose variability in diabetes via continuous glucose monitoring: mathematical methods and clinical application. Diabetes Technol Ther 2005 3.84
16 Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring. Diabetes Care 2003 3.08
17 In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 1999 2.90
18 The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview of the literature. Arch Intern Med 1997 2.88
19 A novel approach to continuous glucose analysis utilizing glycemic variation. Diabetes Technol Ther 2005 2.74
20 Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death. Diabetes 2002 2.73
21 1,5-anhydroglucitol and postprandial hyperglycemia as measured by continuous glucose monitoring system in moderately controlled patients with diabetes. Diabetes Care 2006 2.44
22 The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci U S A 2004 2.39
23 Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus. Circulation 2004 2.22
24 Statistical tools to analyze continuous glucose monitor data. Diabetes Technol Ther 2009 2.12
25 Comment on: American Diabetes Association. Standards of medical care in diabetes--2011. Diabetes Care 2011;34(Suppl. 1):S11-S61. Diabetes Care 2011 1.95
26 New and improved methods to characterize glycemic variability using continuous glucose monitoring. Diabetes Technol Ther 2009 1.95
27 Beyond hemoglobin A1c--need for additional markers of risk for diabetic microvascular complications. JAMA 2010 1.69
28 Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes--the 'dead in bed' syndrome revisited. Diabetologia 2008 1.57
29 Time to abandon microalbuminuria? Kidney Int 2006 1.56
30 Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia. Diabetes 2003 1.50
31 Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes. J Clin Endocrinol Metab 2008 1.49
32 Insulin as an anti-inflammatory and antiatherogenic modulator. J Am Coll Cardiol 2009 1.43
33 Blood glucose monitoring technology: translating data into practice. Endocr Pract 2004 1.40
34 Combined statin and niacin therapy remodels the high-density lipoprotein proteome. Circulation 2008 1.38
35 Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. J Biol Chem 2010 1.19
36 Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects. Circulation 2005 1.16
37 Inhibition of the lytic action of cell-bound terminal complement components by human high density lipoproteins and apoproteins. J Clin Invest 1983 1.12
38 Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis. Trends Pharmacol Sci 2005 1.09
39 Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging. Mol Cell Biol 2002 1.09
40 Usefulness of a highly sensitive urinary and serum IL-6 assay in patients with diabetic nephropathy. Nephron 2000 1.03
41 Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arterioscler Thromb Vasc Biol 2010 0.96
42 Sustained astrocytic clusterin expression improves remodeling after brain ischemia. Neurobiol Dis 2006 0.95
43 Glycaemic variability and inflammation in subjects with metabolic syndrome. Acta Diabetol 2008 0.85
44 Intermittent high glucose exacerbates the aberrant production of adiponectin and resistin through mitochondrial superoxide overproduction in adipocytes. J Mol Endocrinol 2010 0.84
45 Design of FLAT-SUGAR: Randomized Trial of Prandial Insulin Versus Prandial GLP-1 Receptor Agonist Together With Basal Insulin and Metformin for High-Risk Type 2 Diabetes. Diabetes Care 2015 0.75
Next 100