T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin (T-IR)

Clinical Trial ID NCT01686828

PubWeight™ 0.75‹?›

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003 41.22
2 Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010 11.77
3 Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006 7.19
4 Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 2007 6.91
5 Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 2008 4.56
6 The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 1996 4.10
7 Insulin sensitivity during combined androgen blockade for prostate cancer. J Clin Endocrinol Metab 2006 2.98
8 Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab 2005 2.89
9 Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 2004 2.73
10 Differential effects of androgens and estrogens on bone turnover in normal men. J Clin Endocrinol Metab 2003 2.54
11 Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab 2004 2.47
12 Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab 2008 2.24
13 Preventive therapy for breast cancer: a consensus statement. Lancet Oncol 2011 1.69
14 Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. J Clin Invest 2009 1.62
15 Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2007 1.56
16 Adipocytokines, obesity, and insulin resistance during combined androgen blockade for prostate cancer. Urology 2008 1.53
17 Acute testosterone deprivation reduces insulin sensitivity in men. Clin Endocrinol (Oxf) 2012 1.53
18 Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A 2011 1.52
19 Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity. J Clin Endocrinol Metab 1998 1.51
20 Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians. Diabetes 2008 1.29
21 Estrogen receptors in immunity and autoimmunity. Clin Rev Allergy Immunol 2011 1.25
22 Testosterone administration suppresses adiponectin levels in men. J Androl 2004 1.24
23 Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod 2007 1.18
24 A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men. J Clin Endocrinol Metab 2004 1.13
25 Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care 2010 1.12
26 Novel pathway of adipogenesis through cross-talk between adipose tissue macrophages, adipose stem cells and adipocytes: evidence of cell plasticity. PLoS One 2011 1.12
27 Insulin resistance, inflammation, and obesity: role of monocyte chemoattractant protein-1 (or CCL2) in the regulation of metabolism. Mediators Inflamm 2010 1.09
28 Sex steroids as inflammatory regulators. J Steroid Biochem Mol Biol 2010 1.08
29 Macrophage gene expression is related to obesity and the metabolic syndrome in human subcutaneous fat as well as in visceral fat. Diabetologia 2011 1.03
30 The effects of supraphysiological doses of testosterone on angry behavior in healthy eugonadal men--a clinical research center study. J Clin Endocrinol Metab 1996 0.96
31 Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist. J Clin Endocrinol Metab 2002 0.91
32 Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development. Endocrinology 2010 0.90
33 Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study. Eur J Endocrinol 2009 0.89
34 A pilot study of sampling subcutaneous adipose tissue to examine biomarkers of cancer risk. Cancer Prev Res (Phila) 2009 0.88
35 Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage. Cytokine 2007 0.86
36 The immune response during the luteal phase of the ovarian cycle: increasing sensitivity of human monocytes to endotoxin. Fertil Steril 2001 0.83
37 Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy. J Clin Endocrinol Metab 2007 0.83
38 Genetic and clinical spectrum of aromatase deficiency in infancy, childhood and adolescence. Horm Res 2009 0.83
39 Excess deaths associated with obesity: cause and effect. Int J Obes (Lond) 2006 0.82
40 Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men. J Clin Endocrinol Metab 2016 0.78
41 [Diagnosis and treatment of osteopathic parathyroid adenoma]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2003 0.75
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