Obesity is associated with macrophage accumulation in adipose tissue.

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Published in J Clin Invest on December 01, 2003


Stuart P Weisberg1, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante

Author Affiliations

1: Division of Moleuclar Genetics, Department of Pediatrics, Columbia University, New York, New York 10032, USA.

Associated clinical trials:

T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin (T-IR) | NCT01686828

Adiposity and Airway Inflammation in HIV-Associated Airway Disease (SHOP) | NCT02975258

Impact of Ageing on Adipose, Muscle and Systemic Inflammation | NCT02777138

Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL) (EIFFEL) | NCT01745471

Comparison of Hematopoietic Stem Cell Activity in Adipose Tissue From Type 2 Diabetic Patients and Healthy Volunteers (WAT2DO) | NCT03260452

Serum Insulin Response After Acute and Chronic Sucralose Ingestion in Healthy Volunteers With Variable Body Mass Index | NCT03703141

Effectiveness of Dapagliflozin for Weight Loss | NCT03968224

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Randomized study of paclitaxel and tamoxifen deposition into human brain tumors: implications for the treatment of metastatic brain tumors. Clin Cancer Res (2006) 1.12

Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet (2008) 1.10

Obesity, inflammation, and macrophages. Nestle Nutr Workshop Ser Pediatr Program (2009) 1.08

Effectiveness of academic detailing on breast cancer screening among primary care physicians in an underserved community. J Am Board Fam Med (2006) 1.07

Prevalence and predictors of antioxidant supplement use during breast cancer treatment: the Long Island Breast Cancer Study Project. Cancer (2009) 1.07

Periodontal infection, systemic inflammation, and insulin resistance: results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2004. Diabetes Care (2012) 1.05

Breast cancer treatment across health care systems: linking electronic medical records and state registry data to enable outcomes research. Cancer (2013) 1.05

Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance. Int J Body Compos Res (2009) 1.03

Implementing academic detailing for breast cancer screening in underserved communities. Implement Sci (2007) 1.03

Natural history and clinical outcome of sporadic renal cortical tumors diagnosed in the young adult. Urology (2004) 1.01

Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice. Am J Physiol Regul Integr Comp Physiol (2012) 1.01

Barriers to adherence to cystic fibrosis infection control guidelines. Pediatr Pulmonol (2008) 1.01

Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol (2004) 1.00

Considerations regarding the genetics of obesity. Obesity (Silver Spring) (2008) 1.00

Influence of donor and recipient sex mismatch on heart transplant outcomes: analysis of the International Society for Heart and Lung Transplantation Registry. J Heart Lung Transplant (2012) 0.99

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest (2002) 0.97

Effects of weight loss and leptin on skeletal muscle in human subjects. Am J Physiol Regul Integr Comp Physiol (2011) 0.97

Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96

In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J (2009) 0.96

Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring) (2008) 0.96

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny. Obesity (Silver Spring) (2010) 0.96

Is Hispanic race an important predictor of treatment failure following radical prostatectomy for prostate cancer? J Urol (2004) 0.95

Piecewise exponential models to assess the influence of job-specific experience on the hazard of acute injury for hourly factory workers. BMC Med Res Methodol (2013) 0.95

Kidney function and long-term medication adherence after myocardial infarction in the elderly. Clin J Am Soc Nephrol (2011) 0.95

Inhibition of BCL2 expression and activity increases H460 sensitivity to the growth inhibitory effects of polyphenon E. J Exp Ther Oncol (2009) 0.94

The role of vitamin D and SLCO1B1*5 gene polymorphism in statin-associated myalgias. Dermatoendocrinol (2010) 0.94