A Dose Ranging Study of CHF 1531 in Asthmatic Subjects (FLASH)

Clinical Trial ID NCT03086460

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 56.72
2 Standardisation of spirometry. Eur Respir J 2005 48.20
3 Interpretative strategies for lung function tests. Eur Respir J 2005 21.50
4 Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993 20.55
5 An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009 9.38
6 Development and validation of a questionnaire to measure asthma control. Eur Respir J 1999 9.35
7 The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006 8.43
8 Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 2007 5.51
9 Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD. N Engl J Med 2016 4.51
10 Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone. N Engl J Med 2016 3.93
11 Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control Questionnaire. Respir Med 2005 3.48
12 COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest 2002 3.34
13 Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD. Thorax 2010 2.79
14 Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma. N Engl J Med 2016 2.65
15 Performance of American Thoracic Society-recommended spirometry reference values in a multiethnic sample of adults: the multi-ethnic study of atherosclerosis (MESA) lung study. Chest 2009 2.65
16 Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies. Thorax 2011 2.59
17 Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2014 2.41
18 Inhaled formoterol dry powder versus ipratropium bromide in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001 2.32
19 Tiotropium versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012 2.21
20 Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study. Chest 2009 2.20
21 Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial. Lancet 2016 2.19
22 Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results. Eur Respir J 2009 2.11
23 The FDA and safe use of long-acting beta-agonists in the treatment of asthma. N Engl J Med 2010 2.02
24 The efficiency of simulation-based multiple comparisons. Biometrics 1987 1.91
25 Assessing the safety of adding LABAs to inhaled corticosteroids for treating asthma. N Engl J Med 2011 1.91
26 Risks of long-acting beta-agonists in achieving asthma control. N Engl J Med 2009 1.89
27 Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 2005 1.83
28 The local side effects of inhaled corticosteroids: current understanding and review of the literature. Chest 2004 1.76
29 Impact of inhaled corticosteroid-induced oropharyngeal adverse events: results from a meta-analysis. Ann Allergy Asthma Immunol 2007 1.74
30 Comparison of the efficacy, tolerability, and safety of formoterol dry powder and oral, slow-release theophylline in the treatment of COPD. Chest 2002 1.73
31 Inhaled corticosteroids and the risks of diabetes onset and progression. Am J Med 2010 1.66
32 Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study, a randomised controlled trial. Thorax 2015 1.55
33 Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis. Thorax 2012 1.48
34 Superiority of "triple" therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax 2008 1.47
35 A randomized, 12-week, double-blind, placebo-controlled study comparing formoterol dry powder inhaler with albuterol metered-dose inhaler. Ann Allergy Asthma Immunol 2001 1.45
36 Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012 1.38
37 Use of inhaled and oral corticosteroids and the long-term risk of cataract. Ophthalmology 2009 1.13
38 Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Respir Res 2013 1.13
39 Smoking cessation and COPD. Eur Respir Rev 2013 1.09
40 Tiotropium bromide inhalation powder: a review of its use in the management of chronic obstructive pulmonary disease. Drugs 2012 1.09
41 Long-acting beta2-agonists for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2013 1.07
42 Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD. Respir Med 2011 1.05
43 Acceptability and reproducibility criteria of the American Thoracic Society as observed in a sample of the general population. Am Rev Respir Dis 1991 1.02
44 Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients. Int J Chron Obstruct Pulmon Dis 2008 1.01
45 Inhaled corticosteroid use in patients with chronic obstructive pulmonary disease and the risk of pneumonia: a retrospective claims data analysis. Int J Chron Obstruct Pulmon Dis 2013 1.01
46 Efficacy and safety of formoterol fumarate delivered by nebulization to COPD patients. Respir Med 2008 0.92
47 Skin manifestations of inhaled corticosteroids in COPD patients: results from Lung Health Study II. Chest 2004 0.89
48 Bone mineral density in patients with chronic obstructive pulmonary disease treated with budesonide Turbuhaler. Eur Respir J 2002 0.87
49 Risk of mortality associated with formoterol: a systematic review and meta-analysis. Eur Respir J 2009 0.87
50 One-Year Safety of Olodaterol Once Daily via Respimat® in Patients with GOLD 2-4 Chronic Obstructive Pulmonary Disease: Results of a Pre-Specified Pooled Analysis. COPD 2015 0.87
51 Pneumonia risk with inhaled fluticasone furoate and vilanterol compared with vilanterol alone in patients with COPD. Ann Am Thorac Soc 2015 0.85
52 A novel model-based approach for dose determination of glycopyrronium bromide in COPD. BMC Pulm Med 2012 0.85
53 Long-term use of fluticasone propionate/salmeterol fixed-dose combination and incidence of cataracts and glaucoma among chronic obstructive pulmonary disease patients in the UK General Practice Research Database. Int J Chron Obstruct Pulmon Dis 2011 0.81
54 Efficacy and Safety of Umeclidinium Added to Fluticasone Propionate/Salmeterol in Patients with COPD: Results of Two Randomized, Double-Blind Studies. COPD 2015 0.81
55 Nebulized formoterol fumarate: Dose selection and pharmacokinetics. Pulm Pharmacol Ther 2008 0.80
56 Comparison of bronchoprotective and bronchodilator effects of a single dose of formoterol delivered by hydrofluoroalkane and chlorofluorocarbon aerosols and dry powder in a double blind, placebo-controlled, crossover study. Br J Clin Pharmacol 2004 0.78
57 Formoterol delivered via the dry powder Aerolizer inhaler versus albuterol MDI and placebo in mild-to-moderate asthma: a randomized, double-blind, double-dummy trial. J Asthma 2003 0.78
58 A randomized, double-blind, double-dummy, single-dose, efficacy crossover trial comparing formoterol-HFA (pMDI) versus formoterol-DPI (Aerolizer) and placebo (pMDI or Aerolizer) in asthmatic patients. Respiration 2005 0.78
59 A randomized, double-blind, double-dummy, single-dose, crossover trial evaluating the efficacy and safety profiles of two dose levels (12 and 24 microg) of formoterol-HFA (pMDI) vs. those of a dose level (24 microg) of formoterol-DPI (Foradil/Aerolizer) and of placebo (pMDI or Aerolizer) in moderate to severe asthmatic patients. Respiration 2005 0.77
60 Blood eosinophil count and pneumonia risk in patients with chronic obstructive pulmonary disease: a patient-level meta-analysis. Lancet Respir Med 2016 0.76
61 Smoking cessation for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2016 0.76
62 Defining moderate asthma exacerbations in clinical trials based on ATS/ERS joint statement. Respir Med 2015 0.75
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