Published in N Engl J Med on April 16, 2009
A Dose Ranging Study of CHF 1531 in Asthmatic Subjects (FLASH) | NCT03086460
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19
Asthma: clinical expression and molecular mechanisms. J Allergy Clin Immunol (2010) 1.84
Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA (2014) 1.67
Management of severe asthma in children. Lancet (2010) 1.60
The evidence on tiotropium bromide in asthma: from the rationale to the bedside. Multidiscip Respir Med (2017) 1.39
Long-acting beta-agonists in the management of chronic obstructive pulmonary disease: current and future agents. Respir Res (2010) 1.21
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest (2014) 1.00
Prevalence, incidence and persistence of anti-asthma medication use in 2- to 29-year-olds: a nationwide prescription study. Eur J Clin Pharmacol (2009) 0.88
Clinical implications of the intrinsic efficacy of beta-adrenoceptor drugs in asthma: full, partial and inverse agonism. Curr Opin Pulm Med (2010) 0.87
Safety of long-acting beta2-agonists in the management of asthma: a Primary Care Respiratory Alliance of Canada perspective. Can Fam Physician (2010) 0.84
Severe asthma in children. J Allergy Clin Immunol Pract (2014) 0.80
Clinical efficacy of tiotropium in children with asthma. Pak J Med Sci (2016) 0.76
Long-acting beta-agonists in asthma. N Engl J Med (2009) 0.75
Salmeterol use and risk of hospitalization among emergency department patients with acute asthma. Ann Allergy Asthma Immunol (2010) 0.75
Achieving symptom control in patients with moderate asthma. Clin Med Insights Circ Respir Pulm Med (2011) 0.75
Balancing the benefits and risks of inhaled long-acting beta-agonists--the influence of values. N Engl J Med (2009) 3.95
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N Engl J Med (2004) 14.78
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. JAMA (2004) 14.17
Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med (2007) 12.55
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
Letting the genome out of the bottle--will we get our wish? N Engl J Med (2008) 9.10
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. CMAJ (2004) 8.52
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Lancet (2004) 7.18
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med (2009) 5.90
Data Sharing. N Engl J Med (2016) 5.12
Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet (2003) 5.10
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Ann Intern Med (2004) 5.06
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Financial associations of authors. N Engl J Med (2002) 4.85
Expression of concern: Bombardier et al., "Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis," N Engl J Med 2000;343:1520-8. N Engl J Med (2005) 4.48
Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 4.41
Clinical trial registration--looking back and moving ahead. N Engl J Med (2007) 4.07
Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors. Ann Intern Med (2016) 3.95
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91
Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol (2002) 3.66
Registry research and medical privacy. N Engl J Med (2004) 3.49
Is this clinical trial fully registered?--A statement from the International Committee of Medical Journal Editors. N Engl J Med (2005) 3.44
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2002. A 28-year-old woman with ocular inflammation, fever, and headache. N Engl J Med (2002) 3.31
Physicians and execution. N Engl J Med (2008) 3.30
SARS, the Internet, and the Journal. N Engl J Med (2003) 3.16
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol (2010) 3.12
Sharing Clinical Trial Data--A Proposal from the International Committee of Medical Journal Editors. N Engl J Med (2016) 3.06
The safety of long-acting beta-agonists among patients with asthma using inhaled corticosteroids: systematic review and metaanalysis. Am J Respir Crit Care Med (2008) 3.01
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med (2002) 2.94
The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev (2006) 2.80
A sad day for science at the FDA. N Engl J Med (2005) 2.77
Prescriptions, privacy, and the First Amendment. N Engl J Med (2011) 2.75
Data Sharing and the Journal. N Engl J Med (2016) 2.74
Inappropriate advertising of dietary supplements. N Engl J Med (2003) 2.73
A patient with asthma seeks medical advice in 1828, 1928, and 2012. N Engl J Med (2012) 2.72
Controlling research trials. N Engl J Med (2003) 2.70
A pivotal medical-device case. N Engl J Med (2008) 2.69
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med (2014) 2.53
The FDA, politics, and plan B. N Engl J Med (2004) 2.53
Mechanotransduction through growth-factor shedding into the extracellular space. Nature (2004) 2.48
Uniform format for disclosure of competing interests in ICMJE journals. N Engl J Med (2009) 2.46
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nat Med (2007) 2.43
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med (2010) 2.31
Sharing clinical trial data: a proposal from the International Committee of Medical Journal Editors. Lancet (2016) 2.25
Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med (2002) 2.24
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23
Believe the data. N Engl J Med (2012) 2.20
Awake and informed. N Engl J Med (2004) 2.16
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Lancet (2005) 2.15
Public access to biomedical research. N Engl J Med (2004) 2.12
Sharing individual patient data from clinical trials. N Engl J Med (2015) 2.09
Legislative myopia on stem cells. N Engl J Med (2003) 2.03
COX-2 inhibitors--a lesson in unexpected problems. N Engl J Med (2005) 2.01
Expression of concern reaffirmed. N Engl J Med (2006) 1.97
Clinical trial registration. BMJ (2007) 1.95
Trial registration report card. N Engl J Med (2005) 1.89
Clinical trial registration: looking back and moving ahead. Croat Med J (2007) 1.89
Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. Am J Respir Crit Care Med (2002) 1.87
The Medical Device Safety Act of 2009. N Engl J Med (2009) 1.81
Revisiting the commercial-academic interface. N Engl J Med (2015) 1.79
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. Am J Respir Cell Mol Biol (2005) 1.79
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. CMAJ (2005) 1.78
Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma. J Allergy Clin Immunol (2009) 1.76
Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med (2002) 1.76
Leukotriene receptor antagonists for allergic rhinitis: a systematic review and meta-analysis. Am J Med (2004) 1.71
Clinical trial registration: looking back and moving ahead. Ann Intern Med (2007) 1.71
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. JAMA (2005) 1.65
Salvation by registration. N Engl J Med (2007) 1.63
Don't mess with the DSMB. N Engl J Med (2010) 1.60
Informed consent and SUPPORT. N Engl J Med (2013) 1.59
The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol (2008) 1.59
Nitric oxide in exhaled breath is poorly correlated to sputum eosinophils in patients with prednisone-dependent asthma. J Allergy Clin Immunol (2010) 1.58
Influence of zafirlukast and loratadine on exercise-induced bronchoconstriction. J Allergy Clin Immunol (2002) 1.56
Early intervention of recent onset mild persistent asthma in children aged under 11 yrs: the Steroid Treatment As Regular Therapy in early asthma (START) trial. Pediatr Allergy Immunol (2006) 1.54
Toward more uniform conflict disclosures--the updated ICMJE conflict of interest reporting form. N Engl J Med (2010) 1.52
Decisions at the end of life. N Engl J Med (2003) 1.51
Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am J Respir Cell Mol Biol (2002) 1.49
Asthma management by monitoring sputum neutrophil count. Chest (2008) 1.44
Sharing clinical trial data. BMJ (2016) 1.43
Physicians and the First Amendment. N Engl J Med (2008) 1.43
Increased levels of airway neutrophils reduce the inhibitory effects of inhaled glucocorticosteroids on allergen-induced airway eosinophils. Can Respir J (2002) 1.43
Is this clinical trial fully registered? A statement from the International Committee of Medical Journal Editors. Ann Intern Med (2005) 1.42
The FDA and tobacco regulation. N Engl J Med (2008) 1.42
The growth of hospitalists and the changing face of primary care. N Engl J Med (2009) 1.42
Peer review in the balance. N Engl J Med (2008) 1.42
Overall asthma control: the relationship between current control and future risk. J Allergy Clin Immunol (2010) 1.41
Omalizumab and the immune system: an overview of preclinical and clinical data. Ann Allergy Asthma Immunol (2002) 1.41
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Arch Dermatol (2005) 1.41
[Clinical trial registration: a statement from the International Committee of Medical Journal Editors]. Tidsskr Nor Laegeforen (2004) 1.41
Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. Am J Physiol Lung Cell Mol Physiol (2002) 1.40
Choosing asthma step-up care. N Engl J Med (2010) 1.40
Clinical models to compare the safety and efficacy of inhaled corticosteroids in patients with asthma. Can Respir J (2003) 1.40
Embryonic stem-cell research--the case for federal funding. N Engl J Med (2004) 1.40
Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Croat Med J (2004) 1.39
Full disclosure and the funding of biomedical research. N Engl J Med (2008) 1.38
Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. Am J Respir Cell Mol Biol (2003) 1.36
Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet (2002) 1.36
Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol (2003) 1.34