A Prophylactic Trial of Omega-3 Polyunsaturated Fatty Acids in Bipolar Disorder

Clinical Trial ID NCT04210804

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 An inventory for measuring depression. Arch Gen Psychiatry 1961 84.61
2 Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 1999 5.40
3 Fish consumption and major depression. Lancet 1998 3.42
4 Bipolar disorder. N Engl J Med 2004 2.75
5 Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am J Clin Nutr 2006 2.63
6 A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry 2007 2.38
7 Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study. Br J Psychiatry 2006 2.00
8 Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002 1.98
9 The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 1996 1.86
10 Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003 1.84
11 A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry 2002 1.82
12 Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J Clin Psychiatry 2011 1.81
13 Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. Br J Psychiatry 2007 1.75
14 Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry 1998 1.73
15 Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry 2006 1.67
16 Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 2008 1.51
17 Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid? Lipids Health Dis 2007 1.51
18 A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003 1.46
19 Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996 1.44
20 Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry 2006 1.43
21 Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord 2002 1.41
22 Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am J Psychiatry 2003 1.33
23 A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol 2009 1.28
24 The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. J Clin Psychiatry 2010 1.21
25 Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res 2008 1.17
26 Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J Lipid Res 2008 1.14
27 The role of omega-3 fatty acids in mood disorders. Curr Opin Investig Drugs 2008 1.14
28 Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry 2001 1.13
29 Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. Biol Psychiatry 2006 1.13
30 Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. J Lipid Res 2005 1.10
31 Depression in Parkinson's disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. J Affect Disord 2008 1.07
32 Omega-3 fatty acid augmentation of citalopram treatment for patients with major depressive disorder. J Clin Psychopharmacol 2012 1.05
33 Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. J Psychiatr Res 2011 1.00
34 Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr 2010 0.96
35 Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania. Bipolar Disord 2007 0.96
36 Efficacy of omega-3 fatty acids in mood disorders - a systematic review and metaanalysis. Psychopharmacol Bull 2009 0.91
37 Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. Bipolar Disord 2010 0.88
38 The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study. Eur Arch Psychiatry Clin Neurosci 2011 0.86
39 Essential fatty acids in health and chronic diseases. Forum Nutr 2003 0.83
40 Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression. Br J Psychiatry 2016 0.82
41 Omega-3 fatty acid treatment, with or without cytidine, fails to show therapeutic properties in bipolar disorder: a double-blind, randomized add-on clinical trial. J Clin Psychopharmacol 2012 0.80
42 Omega-3 fatty acids are more beneficial in the depressive phase than in the manic phase in patients with bipolar I disorder. J Clin Psychiatry 2005 0.80
43 Plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms. BMC Psychiatry 2012 0.78
44 Omega-3 fatty acids in bipolar disorder: clinical and research considerations. Prostaglandins Leukot Essent Fatty Acids 2006 0.78
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